Pharmaceutical applications. - PDF Download Free (2024)

722

Pharmaceutical applications Proteases

Pharmaceutical applications Proteases Related review: Viral proteases as targets for chemotherapeutic intervention (pp 643-649) AL~XYJC, WYCKOFE EE, YU SYF, LLOYD R, EHRENTELD E: cis C l e a v a g e a n d T r a n s C l e a v a g e Activities o f Poliovirus 2a Protease Expressed in Escherichia Coli. J Viro11991, 6 5 : 6 0 7 7 4 1 0 0 . AUFFRAY C, PIKHER TONNEAU D, KROEM2~RG: CD4targeted Immune Intervention: a Strategy for the T h e r a p y o f AIDS a n d A u t o i m m u n e Disease. 7}'ends Btotechno11991, 9:126-131. BETZ A, HOFSTEENGEJ, STON~ SR: R o l e o f I n t e r a c t i o n s Involving C-Terminal Nonpolar Residues of Hirudin in the Formation of the ThrombinH i r u d i n C o m p l e x . Biochemistry 1991, 30:9848-9853 BETZ A, HOFSTEENGEJ, STONE SR: I n t e r a c t i o n o f t h e NT e r m i n a l R e g i o n o f H i r u d i n w i t h t h e Active-Site Cleft o f T h r o m b i n . BiochemiMry 1992, 31:4557-4562. BLAIR WS, SEMLERBL: R o l e f o r t h e P4 A m i n o Acid • Residue in Substrate utilization by the pollovirus 3 C D P r o t e i n a s e . J Viro11991, 65:6111~5123. [39]. BONT R~ VACCAJP, ANDERSON PS, HOLLOWAY MK: X - r a y • Crystal Structure of the HIV Pro•ease Complex w i t h L-700,417, a n I n h i b i t o r w i t h P s e u d o C 2 S y m m e t r y . J A m Cbem Soc 1991, 113:9382-9384. [25]. BOOT~ DA, WANG MZ, LEE 8%V: I n d u c t i o n o f T i s s u e Type Plasminogen Activator by Ionizing Radiation i n H u m a n M a l i g n a n t M e l a n o m a Cells. Cancer Res 1991, 51:5587-5595. B R I N I ~ X U, P m LtI, FITZGERALD DJ, PASTAN 1: Alteration of a Protease-Sensitive Region of P s e u d o m o n a s E x o t o x i n P r o l o n g s Its S u r v i v a l i n t h e C i r c u l a t i o n o f Mice. Proc Natl Acad Sci U S A 1992, 89:3065~3069. BUCURENCI N, BLAKE DR, CHIDWICK K, WINYARD PG: Inhibition of Neutrophil Superoxide Production b y H t u n a n Plasmta A l p h a l - A n t i t r y p s i n . FEBS Lelt 1992, 300:21-24. BUSBY SJ, MULVIHILLE, RAO D, KUMAR M , I~OLrBIN P, HElPEL M, SPRECHER C, HALFPAP L, PRUNKAPd) D, GAMBLE J, FOSTER DC: E x p r e s s i o n o f R e c o m b i n a n t B , , m ~ . P l a s t n t n o g e n i n M a m m a l i a n Cells is A u g m e n t e d b y S u p p r e s s i o n o f P l a s m i n Activity. JBiol Chem 1991, 266:15286-15292. BUTTLE DJ, SAKL~,TVALAJ, TAMAI M, BARRETTAJ: i n h i b i t i o n of Interleuldn-l-Stimulated Cartilage Proteo#yean Degradation by a Lipophilic Inactivatur of C y a t e i n e E n d o p e p t i d a s e s . Biochem J 1992, 281:175 177 Ct~WG JY: S t a b i l i t y o f H i r u d i n , a T h r o m b i n - S p e c i f i c Inhibitor - the Structure of Alkaline-inactivated Hirudill. J Biol Chem 1991, 266:10839-10843. CHANG JY: D e c i p h e r i n g t h e S t r u c t u r a l E l e m e n t s o f Hirudin C-Terminal Peptide that Bind to the F i b r i n o g e n R e c o g n i t i o n Site o f A l p h a - T h r o m b i n . Biochemistry 1991, 30:6656~5661. CHOI HK, TONG L, ~V~NORW, DUMAS P, BOEGE U, ROSSMANN MG, WENGLER G: S t r u c t u r e o f s i n d b i s Virus Core Protein Reveals a Chymotrypsin-like Serine Proteinase and the Organisation of the V i r i o n . Nature 1991, 354:37. CHOW ~LrVl, MEYER EF, B O D E W, KAM CM, RADI4~MKR]SHNAN R, VIJAYALAKSI~I J, POWERS JC: T h e 2.2oA R e s o l u t i o n X-Ray Crystal Structure of the Complex of Trypsin Inhibited by 4-Chioro-3-Ethoxy-7Guanidinoisocoomarin - a Proposed Model of t h e T h r o m b i n - I n h i b i t o r C o m p l e x . J A m Chem Soc 1990, 112:7783-7789. CLARK ME, HANLMERLET, WIMMER E, DASGUP'IT~A: • P o l i o v i r u s P r o t e i n a s e 3C C o n v e r t s a n Active F o r m o f T r a n s c r i p t i o n F a c t o r IHC t o a n I n a c t i v e F o r m a a M e c h a n i s m f o r I n h i b i t i o n o f H o s t Cell P o l y m e r a s e RI T r a n s c r i p t i o n b y P o l i o v i r u s . EMBO J 199t, 10:2941-2947. [32]. CLISSOLD PM: A CDNA C o n s t r u c t o f T i s s u e I n h i b i t o r o f M e t a l l o p r o t e i n a s e s CRIMP) L i n k e d t o t h e Last E x o n o f T h y-1 C o n f e r s G l y e o p h o s p h o l i p i d Anchorage on This Naturally Secreted Protein. BiocheraJ 1992, 281:129-136. COHEN FE, GR~GORgF LM, AM]R] P, ALDAPE K, RAILEYJ, MCKERROWJH: A r r e s t i n g T i s s u e I n v a s i o n o f a Parasite by Protease Inhibitors Chosen with the A i d o f C o m p u t e r M o d e l i n g . Biochemistry 1991, 30:11221 11229. COLLOPT MJ ETAL.: P r o t e o i y s i s o f H u m a n IgG b y H o u s e D u s t Mite A l l e r g e n s [Letter]. Lancet 1992, 339:746.

CRAIGJC, GR]EF C, MILLSJ, HOCKLEY D, DUNCAN IB, • • ROBERTSNA: Effects o f a SpeeLfie I n h i b i t o r o f H1V Proteinase (RO 31-8959) on Virus Maturation in a C h r o n i c a l l y I n f e c t e d P r o m o n o c y t i c Cell Line (U1). Antivir Chem Chemother 1991, 2:181-186. [21]. CRAVENRC, BENI~ETTRP, X](/ILLSJ~7: Role o f t h e A v i a n Rctroviral Protease in the Activation of Reverse T r a n s c r i p t a s e D u r i l l g V i r i o n A s s e m b l y . J Virol 1991, 65:6205~5217. DEBIASI R, ROCINO A, MIRAGLIA E, MASTRULLOL, QUIPdNO AA: T h e I m p a c t o f a V e r y H i g h P u r i t y FactorVIII C o n c e n t r a t e o n t h e I m m u n e S y s t e m o f Human Immunodeficiency Virus-Infected Hemophiliacs - a Randomized, Prospective, TwoYear C o m p a r i s o n w i t h a n I n t e r m e d i a t e P u r i t y C o n c e n t r a t e . Blood 1991, 78:1919-1922. DINGERMANN"T, TROIDL EM, BROKER M, NERKE K: Expression of Human Antithrombin-llI in the Cellular Slime Mould Dictyosteltum-DiscoideullL Appl Microbiol Biotechno11991, 35:496-503, DOCHERTY AJP, O'CONNELL J, CRABBET, AUGAL S, MURPHY G: T h e M a t r i x M e t a l l o p r o t e i n a s e s a n d T h e i r Natural Inhibitors: Prospects for Treating D e g e n e r a t i v e T i s s u e D i s e a s e s . Trends Biotechnol 1992, 10:200. ENEVOLDSON~P, RUSSELLRWR, LIBERATO NL ETAL.: H e p a r i n i n S i n u s V e n o u s T h r o m b o s i s [Letter]. Lancet 1991, 3 3 8 : 1 1 5 3 ERICKSONJ, NEIDHART DJ, VANDPaEJ, KEMPF DJ, WANG • XC, NORBECK DW, PLATTN~RJJ, PdTTENHOUSEJW, TURON M, WIDEBURG N, ETAL: D e s i g n , Activity a n d 2.8 S t r u c t u r e o f a Ca S y m m e t r i c I n h i b i t o r C o m p l e x e d t o HIV-1 P r o t e a s e . Science 1991, 249:527-533. [24]. FARRELL DH, MULVIHILLER, HUANG SM, CHLrNG DW, DAVIE EW: R e c o m b i n a n t H u m a n F i b r i n o g e n a n d S u l f a t i o u o f t h e ( } ~ m m ~ ' C h a i n . Biochemistry 1991, 30:9414-9420. FREIJE JP, ABRAHAMSONM, OLAFSSONi, VELASCO G, GRUBB A, LOPEZO~N C: S t r u c t u r e a n d E x p r e s s i o n o f t h e G e n e E n c o d i n g Cystatin-D, a N o v e l H u m a n C y s t e i n e P r o t e i n a s e I n h i b i t o r . J Biol Chem 1991, 266:20538-20543. FUSEq&N'I N, MATSUNAGAS, MATSUMOTOH, TAKEBAYASHI Y: Bioactive M a r i n e M e t a b o l i t e s . 33. Cyclotheonamides, Potent Thrombin Inhibitors, f r o m a M a r i n e S p o n g e T h e o n e l l a S p . J Am Chem Soc 1990, 112:7053-7054. GORBALENWAAE, KOONIN EV, LM ~LM-C: P u t a t i v e P a p a i n • r e l a t e d T h i o l P r o t e a s e s o f P o s i t i v e - s t r a n d RNA Vi r u s e s . I d e n t i f i c a t i o n o f Rubi- a n d A p h t h o v i r u s Pro•eases and Delineation of a Novel Conserved D o m a i n A s s o c i a t e d w i t h P r o t e a s e s o f R u b i , c~- a n d C o r o n a v i r u s e s . FEBg Leit 1991, 288:201-205. [37]. GRANqER B, DUEZ C, LEPAGE S, ENGLEBER1 S, DUSARTJ, DIDEBERG O, VANBEEUMENJ, FREREJM, GHUYSENJM: Primary and Predicted Secondary Structures o f t h e A c t i n o m a d u r a - R 3 9 E x t r a c e l l u l a r DDP e p t i d a s e , a P e n i c i l l i n - B i n d i n g P r o t e i n (PBP) Related t o t h e E s c h e r i e h i a - C o l i PllP4. Biochem J 1992, 282:781-788. GR[FHTHSJT, PHYLIP LH, KONVALINKAJ, STROP P~ GUSTCHINAA, WLODAWER A, DAVENPORTRj, BR]GGS R, DUNN BM, KAY J: D i f f e r e n t R e q u i r e m e n t s f o r P r o d u c t i v e I n t e r a c t i o n B e t w e e n t h e Active Site o f tlIV-1 P r o t e i n a s e a n d S u b s t r a t e s C o n t a i n i n g - H y d r o p h o b i c * H y d r o p h o b i e - or-Aacomatie* ProCleavage Sites. Biochemistry 1992, 3 1 : 5 1 9 3 - ~ 0 0 GROO'I~;NHUIS PDJ, VANBOECKEL C~A: C o n s t r u c t i n g a Molecular Model of the Interaction Between Antithrombin-III and a Potent Heparin Analogue. J A m Chem Soc 1991, 113:2743-2747. HACK CE, BT AL.: C 1 - E s t e r a s e I n h i b i t o r S u b s t i t u t i o n i n Sepsis [Letter]. Lancet 1992, 339:378. HANLMERLE~. HELLEN CUT, WIb&MERE: S i t e - d i r e c t e d • M u t a g e n e s i s o f t h e P u t a t i v e Catalytic T r i a d o f P o l i o v i r u s 3C P r o t e i n a s e . J Biol Chem 1991, 266:5412-5416. [33]. HARTE WE, SWAMINATH&NS JR, BEVERIDGE DL: M o l e c u l a r D y n a m i c s o f ILlV-1 P r o t e a s e . Proteins 1992, 13:175-194. HAYAKAWAT, YAMASHH'AK, TA_NZAWAK, UCHIJIMA E, IWATA K: G r o w t h - P r o m o t i n g Activity o f T i s s u e I n h i b i t o r o f M e t a l l o p r o t e i n a s e s - 1 (TIMP-1) f o r a W i d e R a n g e o f Cells - a P o s s i b l e N e w G r o w t h F a c t o r i n S e r u n L FEBS Let• 1992, 298:29-32. HELLEN CUT, FACKE M, KRAUSSLICHH-G, LEE C-K, WIMMER • E: C h a r a c t e r i z a t i o n o f P o l i o v i r u s 2A P r o t e i n a s e by Mutational Analysis: Residues Required for Autocatalytic A c t i v i t y a r e E s s e n t i a l f o r I n d u c t i o n o f Cleavage o f E u k a r y o t i c i n i t i a t i o n F a c t o r P220. J Viro11991, 65:4226~i231. [35].

© Current Biology Ltd ISSN 0958-1669

HELLEN CUT, LEE C-K, WIMMER E: D e t e r m i n a n t s • o f S u b s • r a t e R e c o g n i t i o n b y P o l i o v i r u s 2A P r o t e i n a s e . J Vtro11992, 66:3330-3338. [42]. HELLEN CUT, WINLMERE: M a t u r a t i o n o f P o l i o v i r u s C a p s i d • P r o t e i n s . Virology 1992, 187:391-397. [30]. HERBER WK, BAILEYF], CARTY CE, HEIMBACHJC, MAIG£WFER RZ: P r o d u c t i o n o f C y t o t u x i c P r o t e i n s in Escherichia-Culi - a Fermentation Process for P r o d u c i n g E n z y m a t i c a l l y Active HlV-1 P r o t e a s e . Appl Microbiol Biotechno11991, 36:149-152. HER]~L~NN CH, SULK, HARLOW E: A d e n o v i r u s E I A is Associated with a Serine Threonine Protein Kinase. J Vtro11991, 65:5848. HOLVOp?I"P, LAROCHEY, LIJNEN HR, V A N C A ~ E R G E R, DEMARSIN E, BROUWERSE, MATTHYSSENSG, COLLEN D: C h a r a c t e r i z a t i o n o f a C h i m e r i c P l a s m i n o g e n Activator Consisting of a Sin#e-Chain Fv Fragment Derived from a Fibrin Fragment D-Dimer-Speeific Antibody and a Truncated S i n # e - C h a i n U r o k i n a s e . J Blol Chem 1991, 266:19717 19724. HOLZMAN TF, KOHLBRENNERWE, WHGL D, RITTENHOUSE J, KEMPF D, EPJCKSONJ: I n h i b i t o r S t a b i l i z a t i o n of Human Immunodefteiency Virus Type-2 P r o t e i n a s e D i m e r F o r m a t i o n . J Biol Chem 1991, 266:19217 19220 HOI~YAK TJ, SHAFERJA: R o l e o f C a l c i u m I o n i n t h e G e n e r a t i o n o f F a c t o r - K i l l Activity. Biochemistry 1991, 30:6175~5182 HOWARD EW, BULLEN EC, BANDA MJ: R e g u l a t i o n o f t h e Autoactivation of Human 72-kDa Progelatinase b y T i s s u e I n h i b i t o r o f M e t a l l o p r o t e i n a s e s - 2 . J Btol Chem 1991, 266:13064-13069. HOWARD EW, BULLENEC, BANDA MJ: P r e f e r e n t i a l Inhibition of 72-kDa and 92-kDa Gelatinases by T i s s u e I n h i b i t o r o f M e t u l l o p r o t e i n a s e s - 2 . j Biol Chem 1991, 266:13070-13075. HUANG TF, SHEU JR, TENG CM: A P o t e n t A n t i p l a t e l e t P e p t i d e , Triflavin, f r o m T r i n l e r e s u r u s - F l a v o v i r i d i s S n a k e V e n o m . BiochemJ 1991, 277:351-357. .IASKOLSKIM, TOMASSELLIAG, SAWYERTK, STAPLES DG, • " HEINqR]CKSONRL, SCHNEIDERj , KENT SBH, WLODAWER A: S t r u c t u r e at 2.5 R e s o l u t i o n o f C h e m i c a l l y Synthesized Human Immunodeficiency Virus Type 1 Protease Complexed with a H y d r o x y e t h y l e n e - b a s e d I n h i b i t o r . Biochemistry 1991, 30:1600-1609. [28]. JEWELL DA, SWlETNICI~W, DUNN BM, MALCOM BA: • H e p a t i t i s a V i r u s 3C P r o t e i n a s e S u b s t r a t e Specificity. Biochemistry 1992, 31:7862-7869. [43]. KANO M, REXHAUSENU, DREESSENJ, KON~ERTH A: S y n a p t i e Excitation Produces a Long-lasting Rebound Potentiation of Inhibitory Synaptic Signals [Letter]. Nature 1992, 356:601~603. KLAN KM, TETER]NA N~L, MARC D, GIRARD M: A n a l y s i s o f • P u t a t i v e Active Site R e s i d u e s o f t h e P u l i o v i r u s 3C P r o t e a s e . Virology 1991, 1 9 1 : 6 0 9 4 19 . [34]. KELLEY RF, DEVOS AM, CLEARy S: T h e r m o d y n a m i c s of Ligand Binding and Denaturation for His64 Mutants of Tissue Plasminogen Activator Kringle2 D o m a i n . Proteins 1991, 1 1 : 3 5 4 4 . KEMPE DJ, MARSH KC, PAIo% DA, KNIGGE ME, INORBEGK • DW, KOHLBRENNERWE, CODAVOCl L, VASAVANONDA S, BRYANT p, WANG XC, ETAL: Antiviral and P h a r m o k i n e t i c P r o p e r t i e s o f Ca S y m m e t r i c Inhibitors of the Hmnan Immunodeficiency Virus T y p e 1 Protease. Antimicrob Agents Chemotber 1991, 35:2209-2214. [26]. KING La, KAUR K, ~ SG, LAWR]EAM, STEVe' J, OGDEN JE: S e c r e t i o n o f S i n # e - C h a i n U r o k i n a s e - T y p e P l a s m i n o g e n A c t i v a t o r f r o m I n s e c t Cells. Gene 1991, 106:151-157. KOLODZIEJ MA, VILAIRE G, GONDER D, PONCZ M, B ~ JS: S t u d y o f t h e E n d o p r o t e o l y t i e C l e a v a g e o f Platelet Glyeoprotein-Hb Using oligonucleotideM e d i a t e d M u t a g e n e s i s . J Biol Chem 1991, 266:23499-23504. KONVALINKAJ, HOREJSI M, ANDRE~NSKYM, NOVEK P, PICHOVX I, BtJ~HA I, F/kBRY M, SEDLACEKJ, FOLrNDLING S, STROE P: A n E n g i n e e r e d R e t r o v i r a l P r o t e i n a s e from Myeloblastosis Associated Virus Acquires PH Dependence and Subs•rate Specificity of the HIV-1 P r o t e i n a s e . F~1BOJ1992, 11:1141 1144. KR]EGLSTEIN KG, HENSCHEN AH, WELLER U, ttABERMANLNB: Limited Proteolysis of Tetanus Toxin - Relation to Activity a n d I d e n t i f i c a t i o n o f C l e a v a g e Sites. EurJ Biochem 1991, 202:41-51. KROHN A, REDSHAW S, RITCHIEJC, GRAVESBJ, HATADA • MH: N o v e l B i n d i n g M o d e o f H i g h l y P o t e n t m v p r o t e i n a s e i n h i b i t u r s I n c o r p o r a t i n g t h e (R)H y d r o x y e t h y l ~ m t n e I s o s t e r e . JMed C~Sem 1991, 34:3340-3342. [20].

Pharmaceutical applications LEDERER I1, SCHATZ O, MAY R, CRESPI H, DARLIXJ-L, LE GRICE SFJ, HEUYLANNH: D o l n a i n S t r u c t u r e o f the Human Immunodeficiency Virus Reverse T r a n s c r i p t a s e . EMBOJ 1992, 11:1131-1t40 L U F, ROIZMAN B: D i f f e r e n t i a t i o n o f M u l t i p l e D o m a i n s • in the Herpes Simplex Virus 1 Protease Encoded b y t h e UL26 Gene. Proc Natl Acad Sci USA 1992, 88:2076-2080 [3]. LIU LW, VU TKH, ESMON CT, COUGHHN SR: T h e R e g i o n of the Thrombin Receptor Resembling Htrudin B i n d s t o T h r o m b i n a n d Alters E n z y m e Specificity. J Biol Chem 1991, 266:1697%16980. LOMAS DA, EVANS DL, FINCH JT, CARRELLRW: T h e Mechanism of Z Alphal-Antitrypsin Accumulation i n t h e Liver. Nature 1992, 357:605~06. LOUIS JM, MCDONALD RA, NASHED NT, WONDRAK EM, JERINA DM, OROSZIAN S, MORA PT: A u t o p r o c e s s i n g o f t h e HIV-1 P r o t e a s e U s i n g P u r i f i e d W i l d - T y p e a n d M u t a t e d F u s i o n P r o t e i n s E x p r e s s e d at H i g h Levels i n E s e h e r i c h i a - C o l L E u r J Biochem 1991, 199:361-369. LUKACOVAD, MATSUEDAGR, [LkBER E, REED GL: I n h i b i t i o n o f Factor-XIH A c t i v a t i o n b y a n AntiP e p t i d e M o n o e l o n a l A n t i b o d y . Biochemistry 1991, 30:1016~--10170. LYLE "l~x, WISCOUqN=fCM, GHAREJP, THOMPSON WJ, • ANDERSONPS, DARKE PL, ZUGAY JA, LMLNI EA, SCHLEIF WA, QUINTERO JC, ET AL: B e n z o c y e l o a l k y l A m i n e s as N o v e l C - t e r m i n i f o r HIV-1 P r o t e a s e I n h i h i t o r s . J M e d Chem 1991, 34:1228-1230. [14]. MACH L, STDWE K, HAGEN A, BALLAUNC, GLOSSLJ: Proteolytie Processing and Glycosylation of Cathepaln-B - the Role of the Primary Structure of the Latent Precursor and of the Carbohydrate M o i e t y f o r Cell-Type-Specific M o l e c u l a r F o r m s o f t h e E n z y m e . BiochemJ i992, 282:57~582, MALCOLM BA, CHIN SM, JEWEL DA, STRATTONT H O ~ S JR, • "I}IUDIUMKB~ RALSTONR, ROSENBERGS: E x p r e s s i o n and Characterization of Recombinant Hepatitis a V i r u s 3C P r o t e a s e . Biochemistry 1992, 31:3358-3363. [36]. MURPHY G, WILLENBROCK F, WARD RV, COCKE'vr MI, EATON D, DOCHERTY AJP: T h e C - T e r m i n a l D o m a i n o f 7 2 k D a G e l a t i n a s e - A is n o t R e q u i r e d f o r Catalysis, But is E s s e n t i a l f o r M e m b r a n e A c t i v a t i o n a n d Modulates Interactions with Tissue Inhibitors of M e t a l l o p r o t e i n a s e s . Biochem J 1992, 283:637~541. NESHEIM M, PITTMKN DD, GILES AR, FKSS DN, WANG JH, SLONOSKYD, KAUFMANRJ: T h e Effect o f E l a s n m Von will•brand Factor on the Binding of Human Factor-VIII t o T h r o m b i n - A c t i v a t e d H u m a n Platelets. J B iol Chem 1991, 266:17815-17820. NORBECK DW, KEMPF DJ: H I V P r o t e a s e I n l f i h i t o r s . A n n • Rep Med Chem 1991, 26:141-150. [8]. NOVOKHATNYV, MEDVED L, MAZAR A, MARCOTYE13, HENKIN J, INGHAM K: D o m a i n S t r u c t u r e a n d I n t e r a c t i o n s of Recombinant Urokinase-Type Plasminogen Activator. J Biol Chem 1992, 267:3878-3885. OTTO A, SECKLERR: C h a r a c t e r i z a t i o n , Stability a n d R e f o l d I n g o f R e c o m b i n a n t H i r u d i n . E u r J Biochem t991, 202:67-73 . . . . . PETITHORYJR, MASIARZFR, KIRSCH JF, SAN~ DV, MALCOLM • * BA: A R a p i d M e t h o d f o r D e t e r m i n a t i o n o f E n d o p r o t e i n a s e S u b s • r a t e Specificity: S p e c i f i c i t y o f t h e 3C P r o t e i n a s e f r o m H e p a t i t i s a Virus. Proc Natl A c a d Sci USA 1991, 88:11510-11514 [40]. POLLER L, "]'ABERNERDA: S e t t i n g t h e R e c o r d S t r a i g h t o n L o w - D o s e H e p a r i n [Letter]. Lancet 1991, 3 3 8 : 9 5 8 POORM~N RA, TOMASSELLIAG, HEINRICKSONRL, KUZDY F: A • Cumulative Specificity Model for Proteases from H u m a n l m m , m o d e f i e i e n c y V i r u s T y p e s 1 a n d 2, I n f e r r e d f r o m Statistical A n a l y s i s o f a n E x t e n d e d S u b s • r a t e Base. J B i o l Chem 1991, 266:14554-14561.

[41. POTTS BCM, FAL~KNERDJ~ CHAN JA, SIMOLIKEGC, OPFEN P, HEMLING ME, FRANCISTA: D i d e t n n a k e t a l - A a n d D i d e t n n a k e t a l - R , HlV-1 P r o t e a s e I n h i b i t o r s f r o m t h e A s c i d i a n D i d e m t t m Sp. J A m Chem Soc 1991, 113:632145322. RAJU B, DESHPANDE MS: S u b s • r a t e A n a l o g I n h i b i t o r s o f HIV-1 P r o t e a s e C o n t a i n i n g P h e n y i n o r s t a t i n e as a T r a n s i t i o n State E l e m e n t . Biochem Biophys Res Commun 1991, 180:181-186. RANA TM, MEAKES CF: I r o n C h e l a t e M e d i a t e d P r o t e o l y s i s - P r o t e i n S t r u c t u r e D e p e n d e n c e . J A m Chem Soc 1991, 113:1859-1861. RAO JICM, EPdCFLSONJW, WLODAWER A: S t r u c t u r a l a n d • • Evolutionary Relationships Between Retroviral a n d E u c a r y o t i c A s p a r t i e P r o t e i n a s e s . Biochemistry 1991, 30:4663-4671 [6]. RAO SPS, POOJARY MD, ELLIO'I'F BWJR, MELANSONLA, ORIEL B, COHEN C: F i b r i n o g e n S t r u c t u r e i n P r o j e c t i o n at 18 A R e s o l u t i o n . E l e c t r o n D e n s i t y by Co-ordinated Cryo-electron Microscopy and X - r ay C r y s t a l l o g r a p h y . J Mol Bio11991, 222:89-98. REDDY MR, VISWAaN2LDHANVN, WEINSTEINJN: Re l a t i ve Differences in the Binding Free Energies of

H u m a n l m m , a n o d e f i e i e n c y Virus-1 P r o t e a s e Inhibitors - a Thermodynamic Cycle-Perturbation A p p r o a c h . Proc Natl A c a d Sci U S A t991, 88:10287-10291. RETZIOS AD, MARKLANDFS: P u r i f i c a t i o n , C h a r a c t e r i z a t i o n , a n d F i b r i n o g e n C l e a v a g e Sites of 3 Fibrinolytic Enzymes from the Venom of C r o t a l u s - B a s i l i s c u s - B a s i l i s c u s . Biochemistry 1992, 31:4547-4557. RICH DH, SUN C-Q, PRASADJVN~, PATHIASSERILA, TUTti • MV, MARSHM.LGR, CLAREM, ML~LLER RA, HOUSGMAN K: Effect o f H y d r o x y l G r o u p C o n f i g u r a t i o n i n Hydroxyethyl~mtne Dipeptide Isosteres on HIV Protease Inhibition. Evidence for Multiple B I n d i n g M o d e s . J M e d Chem 1991, 34:1222-1225. [181.

ROBINSONJH, BROWNE MJ: R e d i s i g n i n g T-PA f o r I m p r o v e d T h r o m b o l y t i c T h e r a p y . Trend~ Biotechno11991, 9:86-90. RUFF JR: HIV P r o t e a s e : a N o v e l C h e m o t h e r a p e u t i c • • T a r g c t f o r A I D S . J M e d C h e m 1 9 9 1 , 34:2305-2314. [9]. RUNGE MS, QU~RTERMOUST, ZAVODNW~1, LOVE TW, BODE C, FREITAG M, SHAW SY, HUANG PL, CHOU CC, MULLINS D, SCHN~E JM, SAVARDCE, ROTHENBERG ME, NEWEL• JB, MATSL'EDAGR, HABER E: A R e c o m b i n a n t Chimeric Plasminogen Activator with High Affinity for Fibrin Has Increased Thrombolytic P o t e n c y I n v i t r o a n d I n v i v o . Proc Nat/Acad Sci U S A 1991, 88:10337-10341. SAMUEL SK, HU~RTARAR, KONDAIAH P, KHALIL N, TL~RLEY EA, WRIGHT JA, GREENBERGAH: A u t o c r i n e I n d u c t i o n of Tumor Protease Production and Invasion by a M e t a l l o t h i o n e i n - r e g u l a t e d TGF-~ 1 ( S e t 2 2 3 , 225). E M B O J 1992, 11:1599-1606 SANTORD DG, KANAGY C, SUDMEIERJL, FtJI~E BC, FUPaE B, BACHOVCIIEN ~ : Structure of the Propeptide of Prothrombin Containing the GammaC a r b o x y l a t i o n R e c o g n i t i o n Site D e t e r m i n e d b y Two- D i m e n s i o n a l N M R S p e c t r o s c o p y . Biochemistry 1991, 30:9835-9841. SAWYER RT: T h r o m b o l y t i e s a n d A n t i c o a g u l a n t s f r o m Le e c he s . Biotechnologo/1991, 9:513. SAYERS~i~, WIUFROU"TTA, SOWDER R, MUNGER WL, SMYI'H MJ, HENDERSON LE: P u r i f i c a t i o n o f a F a c t o r f r o m t h e G r a n u l e s o f a Rat N a t u r a l K i l l e r Cell Line (RNK) t h a t R e d u c e s T u m o r Cell G r o w t h a n d Changes Tumor Morphology - Molecular Identity w i t h a G r a n u l e S e r i n e P r o t e a s e (RNKP-1). J Immunol 1992, 148:292-300. SHIMIZU A, NAGEL GM, DOOLITTLE RF: P h o t o a f f i n l t y Labeling of the Primary Fibrin Polymerization Site - i s o l a t i o n a n d C h a r a c t e r i z a t i o n o f a Labeled Cyanogen Bromide Fragment Corresponding to G a m m a - C h a i n R e s i d u e s - 3 3 7 - 3 7 9 . Proc Natl Acad Sci U S A 1992, 89:2888-2892. SH15MANMA, COP.ASH L, ABRAMS DI, HrgI~.LM&'4 KJ: Retraction: Target Plat•let Antigen in Homosexalal M e n w i t h I m m u n e T h r o m b o c y t o p e n i a . N EnglJ Med 1991, 325:1487. SINGH SB, CORDINGLEY MG, BALL RG, SMITHJL, DOMBROWSKI AW, GOETZ MA: S t r u c t u r e a n d Stereoehemistry of Thysananone: a Novel H u m a n R h i n o v i r u s 3C P r o t e a s e I n h i b i t o r F r o m T h y a n o p b o r a Penicilloide$. Tetrahedron Let• 1991, 32:5279-5282. [44]. SIOUD M, NATWGJB, FORRE O: P r e f o r m e d R i b o z y m e D e s t r o y s T u m o u r N e c r o s i s F a c t o r MRNA i n H u m a n Cells. J M o l Bio11992, 223:831-835 SKRZYPCZAKJANKUNE, CARPEROSVE, RAVICHANDRAN KG, "I~INSKY A, WESTBROOK M, MARAGANORE JM: S t r u c t u r e o f t h e H i r u g e n a n d H i r u l o g - 1 C o m p l e x e s o f A l p h a - T h r o m b I n . J Mol Bio11991, 221:1379-1393. SMALL DH, MUIR RD, FULLERSJ, MICHAELSONS, BUSH AI, I5 QX, MILWARDE, HILBICH C, WEIDGMAN~ A, BEYREL~dER K, MASTERSCL: A P r o t e a s e Activity Associated with Acetylcholinesterase Releases the Membrane-Bound Form of the Amyloid Protein P r e c u r s o r o f A l z h e i m e r ' s H i s • a s • . Biochemistry 1991, 30:10795-10799. STAMJ ETAL.: H e p a r i n T r e a t m e n t f o r C e r e b r a l V e n o u s a n d S i n u s T h r o m b o s i s [Letter]. Lancet 1991, 338:1154 STEWART L, VOGT VM: T r a n s A e t i n g V i r a l P r o t e a s e is N e c e s s a r y a n d S u f f t c i e n t f o r A c t i v a t i o n o f Avian L e u k o s i s V i r u s R e v e r s e T r a n s c r i p t a s e . J Viro11991, 65:6218q5282. STIENEKEGROBERA, VEY M, ANGLIKER H, SHAW E, THOMAS G, ROBERTS C, KLENK HD, GARTEN W: I n f l u e n z a Virus Hemagglutinin with Multibasic Cleavage Site is A c t i v a t e d b y F u r i n , a S u b t i l l s i n - L i k e E n d o p r o t e a s e . EMBOJ 1992, 11:2407-2414 STONE 8R, BETZ A, HOFSTEENGEJ: M e c h a n i s t i c S t u d i e s o n T h r o m b i n Catalysis. Biochemistry 1991, 30:9841-9848.

Proteases

STRANDBERG L, LAWRENCEDA, JOHANSSON LBA, NY T: T h e Oxidative Inactivation of Elasminogen Activator I n l t i b i t o r Type-1 Results f r o m a C o n f o r m a t i o n a l C h a n g e i n t h e M o l e c u l e a n d Does n o t R e q u i r e t h e I n v o l v e m e n t o f t h e P I ' M e t h i n n i n e . J Biol Chem 1991, 266:13852-13858. STUBBS MT, OSCHKINATH, MAYR I, HUBER R, ANGLIKER H, STONE SR, BODE W: T h e I n t e r a c t i o n o f T h r o m b i n w i t h F i b r l n o g e n - a S t r u c t u r a l Basis f o r Its Specificity. E u r J B i o c h e m 1992, 206:187-195. SYU WJ, LEE WR, DU B, YU QC, ESSEXM, LEE TH: R o l e of Conserved Gp41 Cysteine Residues In the Processing of Human Immunodeficiency Virus E n v e l o p e P r e c u r s o r a n d V i r a l Infectivity. J Virol 1991, 65:6349q5375 TAYLOR FB JR, CHANG ACK. PEER GT, MA~¢ER T, BHCK K, CATLETT R, LOCKfLARTMS, ESMON CT: D E G R - f a c t o r Xa Blocks Disseminated Intravascnlar Coagulation I n i t i a t e d b y E s c h e r i c h i a Coli W i t h o u t P r e v e n t i n g S h o c k o r O r g a n D a m a g e . Blood 1991, 78:364-368. THAISRWONGS S, TOMASSELLIAG, MOON JB, HUI J, • MCQUADE TJ, TLr~NER SR, STROHBACHJ~g, HOWE WJ, TARPLEY WG, HEINI~CKSON RL: l n h i h i t o r s o f t h e Protease from Human Imlnunodefietency Virus: Design and Modeling of a Compound Containing a Dihydroxyethylene Isostere Insert with High B I n d i n g A f f l n i t y a n d Effective A n t i v i r a l Activity. J Med Chem 1991, 34:2344-2356. [12]. THOMPSON WJ, FITZGERALD PMD, HOLLOWAY MK, ~dlN1 • a EA, DARKE PL, MCKEEVER BM, SCHLEIFw a , QUIN~IlZRO JC, ZUGAYJA, TUCKER TJ, ETA& S y n t h e s i s a n d A n t i v i r a l Activity o f a Series o f HIV-1 P r o t e a s e Inhibitors with Functionality Tethered to the P1 o r P t ' S u b s t i t u e n t s : X - r a y C r y s t a l S t r u c t u r e A s s i s t e d D e s i g n . J M e d Chem 1992, 35:1685-1701. [161. TIIOILNBERRY NA, BULL HG, CALAYCAYJR, CHAPMAN KT, HOWARD AD, KOSTURA MJ, MILLER DK, MOLINEAL"X SM, WHDNER JR, AISNINSJ, ELLISTONKO, AYALAJM, CASANO FJ, CHIN J, DING GJ-E EGGER LA, GAFFNEY EP, IJMJUCO G, PALYHA OC, RAJU SM, ROLANDO AM, SALLEYJP, YA~V~NT-T, LEE D, SI~VELYJE, MACCROSS M, MUMFORDRA, SCHMIDTJA, TOCCI MJ: A N o v e l H e t e r o d i m e r i e C y s t e i n e P r o t e a s e is R e q u i r e d f o r I n t e r l e u l d n - l b e t a P r o c e s s i n g i n M o n o c y t e s . Nature 1992, 356:768-774. TOMASSELH AG, HO~XrEV¢J, SAWYERTK, WLODAWER A, • • HEINRIKSONILL: T h e C o m p l e x i t i e s o f AIDS: a n A s s e s s m e n t o f t h e H I V P r o • e a s e as a T h e r a p e u t i c Target. Chem Today 1991, 9:(~27. [7]. TOZSERJ, WEBER iT, GUSTCHINAA, BLAHA I, COPELAND TD, LOUISJM, OROSZLAN S: K i n e t i c a n d M o d e l i n g S t u d i e s o f $3-$3' S u b s i t e s o f HIV P r o t e i n a s e s . Biochemistry 1992, 31:4793-4800. TREIER M, SEUFERTW, JENTSCH S: D r o s o p h l l a - U b c D 1 Encodes a Highly Conserved UbiquitinC o n j u g a t i n g E n z y m e I n v o l v e d i n Selective P r o t e i n D e g r a d a t i o n . E M B O J 1992, 11:367-372 TUCKER ~J, LUMMAJR WC, PAYNE LS, WAIJM, DE SOLMS • 8J, GIULIANI EA, DARKE PL, HEhMBACHJC, ZUGAY JA, SCHLELFWA, ETAL: A S e r i e s o f P o t e n t HlV-1 Protease inhibitors Containing a Hydroxyethyl S e c o n d a r y A m i n e T r a n s i t i o n State I s o s t e r e : Synthesis, Enzyme Inhibition, and Antiviral Activity. J M e d Chem 1992, 35:2525~2533. [22]. VACCAJP, GUAEEJP, DE SOLMS SJ, SANDERSWM, GIULIANA • EA, YOUNG SD, DARKE PL, ZUGAYJ, SIGAL IS, SCHLEIF WA, ETAL: L-687,908, a P o t e n t H y d r o x y e t h y l e n e c o n t a i n i n g H I V P r o t e a s e I n h i b i t o r . J M e d Chem 1991, 34:1225 1228. [13]. VANKESSELKPM, VANSTRIJPJAG, VEKHOEFJ: I n a c t i v a t i o n o f R e c o m b i n a n t H u m a n T u m o r N e c r o s i s Factoralpha by Proteolytic Enzymes Released from S t i m u l a t e d H u m a n N e u t r o p h i l s . J l m m u n o l 199I, 147:3862 3868. VANSEUNINGENI, AUBERTJP, DAVRILM: I n t e r a c t i o n B e t w e e n S e c r e t o r y Leucocyte P r o t e i n a s e Inhibitor and Bronchial Mucins or Glycopeptides - Physiopathological Implications for the Protection of Mucins Against Proteolysis by H u m a n L e u c o c y t e Elastase. BiochemJ 1992, 281:761-766. VANSEL%qNGENI, DAVRLLM: S e p a r a t i o n o f t h e T w o Domains of Human Mucus Proteinase Inhibitor - I n h i b i t o r y A c t i v i t y is O n l y Located I n t h e C a r b o x y - T e r m i n a l D o m a i n . Biocbem Biophys Res Commun 1991, 179:1587-1592. VONHEIJNE G, IdI~ESTROM P, MIKUS P, ANDEKSSONH, NY T: The Efficiency of the Uncleared Secretion Signal i n t h e P l a s m i n o g e n A c t i v a t o r I n h i b i t o r Type-2 Protein can be Enhanced by Point Mutations that I n c r e a s e Its H y d r o p h o b i c i t y . J B i o l Chem i991, 266:15240-15243. WEIDNXRJR, DUNN BM: D e v e l o p m e n t o f S y n t h e t i c • P e p t i d e S u b s t r a t e s f o r t h e P o l i o v i r u s 3C P r o t e i n a s e . Arch Biochem Biophys 1991, 286:402-408. [41].

723

724

Pharmaceutical applications Vaccines, viruses and AIDS WELCH AR, WOODS AS, MCNALLYLM, COTIER RJ, GIBSON • W: A H e r p e s v i r u s M a t u r a t i o n a l P r o t e i n a s e , Assemblln: I d e n t i f i c a t i o n o f Its Gene, Putative Active Site D o m a i n , a n d C l e a v a g e Site. Proc Natl A c a d Sci USA 1991, 88:10792-10796. [2]. WOLF" 1)L, SIN~tA U, HANCOCK TE, LIN PH, MESSIERTL, ESMON CW, CHURCH \VR: D e s i g n o f Constructs f o r t h e E x p r e s s i o n o f B i o l o g i c a l l y ACtive R e c o m b i n a n t H u m a n FaCtor-X a n d FaCtor-Xa Kinetic Analysis o f t h e E x p r e s s e d Proteins. J Biol Chem 1991, 266:13726-13730. Y&MAZUMIK, DOOLITTLERF: P h o t o a f f i n i t y Labeling o f t h e P r i m a r y F i b r i n P o l y m e r i z a t i o n Site Localization o f t h e Label to G a m m a - C h a i n Tyr363. Proc Nail A c a d Sci U S A 1992, 89:2893-2896. YOUNG SD, PAYNELS, THOMPSON WJ, GAFFIN N, LYLE • TA, BPdTCHERSF, GRAttAM SL, SCHULTZTH, l)~/gA AA, DARKE PL, ETA& HlV-1 P r o t e a s e I n h i b i t o r s B a s e d o n H y d r o x y e t h y l e n e D i p e p t i d e lsosteres: a n I n v e s t i g a t i o n into t h e R o l e o f t h e Pl'Side C h a i n o n Structure-activity. J M e d Chem 1992, 35:1702-1709. [15]. ZHANG L, CASTELLINOFJ: Role o f t h e H e x a p e p t i d e Disulfide Loop P r e s e n t i n t h e Gamm~C a r b o x y g i u t a m i c Acid D o m a i n o f H u m a n P r o t e i n C i n Its Activation P r o p e r t i e s a n d in t h e I n v i t r o A n t i c o a g u l a n t Activity o f ACtivated Protein-C. Biochemistry 1991, 30:6696-6704.

Vaccines, viruses and AIDS Related review: Immunotherapy of AIDS (pp 650-655) AACH RD ETAL.: Hepatitis C v i r u s InfeCtion i n Postt r a n s f u s i o n Hepatitis - - a n Analysis w i t h Firsta n d S e c o n d - g e n e r a t i o n Assays. N E n g I J M e d 1991, 325:1325-1329. AGRAWAL S: Antisense O l i g o n u c l e o t i d e s as A n t i v i r a l Agents. Trends Biotechno11992, 10:152. AHONKHAI VI, LbT~ACSLJ, JONAS LC, CALANDRAGB: CLinical E x p e r i e n c e w i t h P e d v a x h i b , a Conjugate Vaccine o f H a e m o p h i h i s - I r t f l u e n z a e Type-B P o l y s a c c h a r i d e Neisseria-Meningitidis O u t e r M e m b r a n e P r o t e i n . Vaccine 1991, 9:$38-$41. ALDOV1NZA, YOUNG RA: D e v e l o p m e n t o f a BCG • R e c o m b i n a n t v e h i c l e f o r C a n d i d a t e AIDS Vaccines. lnt Rev l m m u n o l 1990, 7:79-83. [31]. AUIIERI DC, ETINGIN OR, FAIRDS, BRUNCKTK, GELTOSKY JE, HAJJARDP, EDGINGTONTS: Structurally H o m o l o g o u s Llga~d B i n d i n g o f I n t e g r i n Mac-1 a n d Viral Glycoprotein-C Receptors. Science 1991, 254:1200-1202. ALVEYJC, WYCKOFF EE, YU SYF, LLOYD R, EHRENFELDE: cis Cleavage a n d T r a n s C l e a v a g e ACtivities o f Poliovirus 21 P r o t e a s e E x p r e s s e d i n E s c h e r i c h i a Colt. J Viro11991, 65:6077-6100. AMADOR R, MOKENO A, VALEROV, MURILLOL, MORA AL, ROJAS M, ROCHA C, SALCEDO M, GUZMANF, ESPEJO F, NUNEZ F, PATA~.ROYOME: T h e 1st Field Trials o f t h e C h e m i c a l l y S y n t h e s i z e d M a l a r i a Vaccine SPf66 Safety, I n l t n u n o g e n i c i t y a n d Protectivity. Vaccine 1992, 10:17~184. ANDREW ME, BOYLEDB, COUPAR BEH, REDDY D, BELLAMyAR, BOI7~ GW: V a e c i n i a Rotavirus-Vlr7 R e e o m b i n a n t s ProteCt M i c e Against RotavirusI n d u c e d D i a r r h o e a . Vaccine 1992, 10:185-191. ANONYMOUS: P r o t e c t i o n o f C h i m p a n z e e s f r o m • I n f e c t i o n by HIV-1 a f t e r V a c c i n a t i o n w i t h R e c o m b i n a n t G l y c o p r o t e i n Gp120 But n o t G p 1 6 0 [Editorial]. Dis Markers 1991, 9:51. [9]. ARNOLD E, JACOBO-MOLINAA, NA~XTX'RG, I WILLIAMSRL, LU X, DING J, CLARKJR AD, ZHANG A, FERRIS AL, CLARK P, I~Z1 A, HUGHES SH: S t r u c t u r e o f HIV-1 Reverse T r a n s c r i p t a s e / D N A C o m p l e x at 7A R e s o l u t i o n S h o w i n g Active Site Locations [Letter]. Nature 1992, 357:85~88. AWYRIDGES: O r a l I m m u n i z a t i o n w i t h S a l m o n e l l a T y p h i Ty21a-Based Clones E x p r e s s i n g VibrioC h o l e r a e O-Antigen - S e r u m BaCtericidal A n t i b o d y R e s p o n s e s i n M a n i n R e l a t i o n to PreI m m u n i z a t i o n A n t i b o d y Levels. Vaccine 1991, 9:877~82, AULLO P, ALCtuM1J, POPOFF MR, KkATZM~NNDR, MI01~PHy • JR, BOQbXT P: A R e c o m b i n a n t D i p h t h e r i a T o x i n Related H u m a n CD4 F u s i o n P r o t e i n Specifically Kills I-HV InfeCted c e l l s Xg~tich E x p r e s s G p 1 2 0 But Selects Fusion T o x i n R e s i s t a n t Cells W h i c h C a r r y HIV. E M B O J 1992, 11:573-583. [22]. AUWIEROM, ABRESCIAP, DETTIN M, DIBELLO C, GUARDIOLA J: B i n d i n g to CD4 o f S y n t h e t i c P e p t i d e s P a t t e r n e d o n t h e P r i n c i p a l N e u t r a l i z i n g D o m a i n o f t h e HIV1 E n v e l o p e P r o t e i n . Virology 1991, 185:820-828. AZAD AA, MCKEKNNM, MACREADIEIG, FAILIA P, HELNEHG, CHAPMAN A, WARD CW, FAHEY KJ: P h y s l c o c h e m i c a l

and I m m u n o l o g i c a l C h a r a C t e r i z a t i o n o f R e c o m b i n a n t Host-Protective A n t i g e n (VP2) o f InfeCtious B u r s a l D i s e a s e Virus. Vaccine 1991, 9:715-722. BADERJP, MGMMIONJB. SCHULTZRJ, NARA't%NANVL, PIERCEJB, tlARRISON \VA, WHSLOW OS, i~2IDELFORTCF, S~NSON SF. BOYD MR: O x a t h i i n C a r b o x a n i l i d e , a Potent I n h i b i t o r o f H u m a n I m m u n o d e f t e i e n c y Virus ReproduCtion. Proc Nail A c a d Sci U S A 1991, 88:6740-6744. BMER M, DITFMART, CICHUTEKK, KURl~d R: D e v e l o p m e n t i n Vivo o f Genetic Variability o f S i m i a n I m m u n o d e f i c i e n c y Virus. Proc Nail A c a d Sci U S A 1991, 88:8126~130. BALLGOODRICH LJ, MOIR RD, TATIXKSALLP: P a r v o v i r a l T a r g e t Cell Specificity - Acquisition o f F i b r o t r o p i s m by a M u t a n t o f t h e L y m p h o t r o p i c Strain o f M i n u t e Virus o f Mice I n v o l v e s M u l t i p l e A m i n o Acid Substitutions W i t h i n t h e Capsid. Virologu 1991, 184:175-186. BALZARINIJ, PEREZPEREZMJ, SANFELIXA, SCHOLS D, PEP~NO CF, VANDAMMEAM, CAMARASAMJ, DECLERCQ E: 2',5'Bis-O-(tert-butyldimcthyisLlyl)-3'-spiro-5"-(4"amino-1', 2" -oxat hiole- 2", 2"- d i o x i d e ) p y r i m i d i n e (TSAO) Nueleoside Analogues - H i g h l y Selective i n h i b i t o r s o f H u m a n I m m u n o d e f i c i e n c y Virus T y p e d t h a t are T a r g e t e d at t h e V i r a l R e v e r s e T r a n s c r i p t a s e . Proc Nail A c a d Sc'i U S A 1992, 89:4392-4396. BARONE GC, PESCE AJ, HALSALLItB, HEINF~VIAN \WR: E l e C t r o c h e m i c a l D e t e r m i n a t i o n o f A z i d o t h y m i d i n e i n H u m a n W h o l e Blood. A n a l Biocbem 1991, 198:6-9. BASU A, AI~LUW&LIAKK, BASU S, MODAK MJ: I d e n t i f i c a t i o n o f t h e P r h l t e r B i n d i n g D o m a i n i n Hunaan I m m u n o d e f i c i e n e y Virus Reverse T r a n s c r i p t a s e . Biochemistry 1992, 31:616~23. BA2"I'EGAYM, OEHEN S, SCHULZ M, HENGARTNERH, ZINKERNAGELRM: V a c c i n a t i o n w i t h a S y n t h e t i c Peptide Modulates Lylnphocytic C h o r i o m e n i n g i t i s Virus-Mediated I m m l u n o p a t h o l o g y . J Viro11992, 66:1199-1201 BAXBYD, PAOLETII E: P o t e n t i a l use o f N o n - R e p l i c a t i n g VeCtors as R e c o m b i n a n t Vaccines. Vaccine 1992, 10:8-9. BECERRASP, KUMARA, LEWIS MS, WIDEN SG, ABBOTTSJ~ KARAWYAEM, HUGHES SH, SHILOACHJ, WILSON SH: P r o t e i n - P r o t e i n InteraCtions o f HIV-1 Reverse T r a n s e r i p t a s e - I m p l i c a t i o n o f C e n t r a l a n d CT e r m i n a l Regions I n Subtmit B i n d i n g . Biochemistry 1991, 30:11707-11719. BECKER KG, ENNISTDL, GLEASONSL, DRIGGERS PH, LEVI BZ, APPELLAE, OZATO K: C l o n i n g o f a Negative T r a n s c r i p t i o n FaCtor t h a t Binds to t h e U p s t r e a m Conserved Region of Moloney Murine Leukemia Virus. ]viol Cell Biol 1992, 12:38~5747. BEDNAREK MA, SALWLASY~ GAMMON MC, PORTER G, T&MHANKARS, WILLIAMSONAR, ZWEERINK HJ: T h e Minimum Peptide Epitope from the Influenza Virus M a t r i x P r o t e i n - E x t r a a n d I n t r a c e l i u l a r Loading o f HI~-A2. J l m m u n o 1 1 9 9 1 , 147:4047~053. BELSHAM GJ: D u a l I n i t i a t i o n Sites o f P r o t e i n Synthesis o n F o o t - a n d - m o u t h Disease Virus RNA a r e SeleCted F o l l o w i n g I n t e r n a l E n t r y a n d S c a n n i n g o f R i b o s o m e s in Vivo. EMBOJ1992, 11:1105-1110. BENDAVIDY, BERNSTEIN A: F r i e n d V i r u s - I n d u c e d E r y t h r o l e u k e m i a a n d t h e Multistage N a t u r e o f Cancer. Cell 1991, 66:831~34. BENJOUAD A, GLUCIGMANJC, ROCHATH, MONrYAGNIER L, BMW,AOLq E: I n f l u e n c e o f C a r b o h y d r a t e Moieties o n t h e I m m u n o g e u i c i t y o f IAuma~ l m m u n o d e f i c i e n c y Virus Type-1 R e c o m b i n a n t G p l 6 0 . J Viro11992, 66:2473-2483. BENM2MNSOL'RA, BRAHLM1M, TUFFEREAUC, COULON P, LAFAY F, FLAM~ND A: R a p i d S e q u e n c e E v o l u t i o n o f Street Rabies G l y e o p r o t e i n is Related to t h e H i g h l y H e t e r o g e n e o u s N a t u r e o f t h e Viral P o p u l a t i o n . Virology 1992, 187:33-45. BENMANSOURA, LEBLOISH, COULON P, TUFFERF~U C, GAUDIN Y, FI~MAND A, LAFAYF: A n t i g e n i c i t y o f Rabies Virus G l y c o p r o t e i n . J Virol 1991, 65:4198~4203. BERKOWER I, MURPHYD, SMITH CC, SMITH GE: A P r e d o m i n a n t G r o u p Specific N e u t r a l i z i n g Epitope o f H u m a n l m m u n o d e f i c i e n c y Virus T y p e 1 Maps to Residue 342 to Residue 511 o f t h e E n v e l o p e G l y e o p r o t e i n Gp120. J Viro11991, 65:5983. BEP~NARDK~V, FISHBEIN DB: P r e - E x p o s u r e Rabies Prophylaxis for Travellers - are the Benefits W o r t h t h e Cost. Vaccine 1991, 9:833-836. BERTOLETTIA, FERRARI C, FIACCADORI F, PENNA A, MARGOLSKEER, SCHLICHT HJ, FOWLER P, GUILHOT S, CHISAR1FV: ~ c l a s s 1-restricted H u m a n Cytotoxic T Cells R e c o g n i z e E n d o g e n o u s l y Synthesized H e p a t i t i s B, Virus N u c l e o c a p s i d

A n t i g e n . Proc Natl A c a d Sci U S A 1991, 88:10445-10449. BHSRA GS, MCNn2ILM, MINNIKIN DE, PORTAELSF, RJDELL

M, ~RE~AN PJ: Sttmctural E l u c i d a t i o n a n d A n t i g e n i c i t y o f a Novel P h e n o l i c Glycolipid Antigen from Mycobacterium-Haemophihim. Biocbemislry 1991, 30:7772-7777. BJORLING E, BROLIDEN K, BERNARDI D, U'IF'I'ER G, TIIOKSTENSSONR, CHIODI F~ NORRBYE: H y p e r i m m u n e A n t i s e r a Against Synthetic Peptides Representing the Glycoprotein of H u n l a n h l l m u n o d e f l c i e n c y Virus Type-2 c a n Mediate Neutralization and Antibody-Dependent Cytotoxic Activity. Proc Nail A c a d Sci U S A 1991, 88:6082-6086. BJUNE G, H~OIBY EA, GR~ON2CESBYJK~ ARNT~EN ~JO, FREDRIKSENJH, HALSTENSENA, IffOLTENE, LINDBAKAK, N~5OKLEBYH, ROSENQVISTE, SOLBERGLK, CLOSS O, ENGJ, FR~DOHOLMLO, LYSTADA, BAKKETEIGLS, HAREIDE B: Effect o f O u t e r M e m b r a n e Vesicle V a c c i n e Against B M e n i n g o c o c c a l Disease i n N o r w a y . Lancet 1991, 338:1093-1095. BLANDER SJ, HORW1TZMA: V a c c i n a t i o n w i t h t h e M a j o r Secretory Protein of Leginnella induces Humoral a n d Cell-Mediated t r a m l i n e R e s p o n s e s a n d P r o t e c t i v e I m m u n i t y Across D i f f e r e n t S e r o g r o u p s o f L e g i o n e l i a - P n e u m o p h l l a a n d D i f f e r e n t Species o f Legionella. J l m m u n o 1 1 9 9 1 , 147:285-291. BLASCO R, MOSS B: E x t r a r e l l d i a r V a e c i n i a Virus F o r m a t i o n a n d Ceil to Cell Virus T r a n s m i s s i o n are Prevented by Deletion of the Gene Encoding t h e 37,000 D a l t o n O u t e r E n v e l o p e P r o t e i n . J Virol 1991, 65:5910-5943. BLOCH-MICIIEL E ETAL.: Measles Virus A n t i b o d y i n A q u e o u s H u m o u r o f Patients w i t h Uveitis Associated w i t h M u l t i p l e Sclerosis [Letter]. Lancet 1992, 339:750. BLOOM DE, GLIED S: Benefits a n d Costs o f I-HV Testing. Science 1991, 252:1798-1804. BLUMENr~AL R, LOYTERA: R e c o n s t i t u t e d Viral E n v e l o p e s - - ' T r o j a n Horses' f o r D r u g D e l i v e r y a n d G e n e T h e r a p y ? Trends" Biotechno11991, 9 : 4 1 4 4 . BONE R, VACCAJP, ANDERSON PS, HOLLOWAYMK: X-Ray C r y s t a l Structure o f t h e HlV P r o t e a s e C o m p l e x w i t h L-700,417, a n I n h i b i t o r w i t h P s e u d o C2 S y n l l n e t r y . J A m Chem Soc 1991, 113:9382 9 3 8 4 BOO"IS AMH, BENMSSATROUW13], HESSELINKW, RIJI~ E, SCHRIER C, HENSEN EJ: I n d u c t i o n o f Anti-Viral I m m u n e Responses b y I m m u n i z a t i o n w i t h Reeombinant-DNA E n c o d e d Avian C o r o n a v i r u s N u e l e o e a p s i d P r o t e i n . Vaccine 1992, 10:119 124. BOOY R, AITKENSJM, TAYLORS, TUDORWILLIAMSG, MACFARI~NEJA, MOXON ER, ASHWORT~I LAE, M-AYON~ITE RT, GRIFFITHSH, CHAPELHM: l m m u n o g e n i e i t y Of C o m b i n e d D i p h t h e r i a , T e t a n u s , and Pertussis Vaccine Given at T w o , T h r e e , a n d F o u r M o n t h s Versus T h r e e , Five, a n d N i n e Months o f Age. Lancet 1992, 339:507-510. BORRESEN AL, ET AL.: P a p i l l o m a v i r t m e s , P53, a n d C e r v i c a l C a n c e r [Letter]. Lancet 1992, 339:1350 BOTARELLI P, HOULDEN BA, HAIGWOOD NL, SERVIS C, MONTAGNA D, ABRIGNAN2S: N-Glycosylation o f HIV-gp120 May C o n s t r a i n R e c o g n i t i o n b y L y t Y a p h o ~ e s - T . J l m m u n o 1 1 9 9 1 , 147:3128-3132. BOURGAULTI, VENET A, LEVYJP: T h r e e E p i t o p i c P e p t i d e s o f t h e Simian I m m u n o d e f i c i e n c y Virtm N e f P r o t e i n Recognized b y M a c a q u e Cytolytic Lymphocytes-T. J Viro11992, 66:750-756. BRESNICK EH, ROPdES C, HAGER GL: E v i d e n c e t h a t N u e l e o s o m e s o n t h e Mouse M ~ m m a r y T u r n o u t V i r u s P r o m o t e r A d o p t Specific T r a n s l a t i o n a l Positions. Nucleic A c i d s Res 1992, 20:865470. BRESSLER p, PANTALEOG, D ~ A, FAUCIAS: AntiCD2 R e c e p t o r Antibodies ACtivate t h e HIV L o n g T e r m i n a l Repeat i n Lynlphocytes-T. J l m m u n o l 1991, 147:2290-2294. BR~7IT SJ, GAO XM, LIEW FY, TITE JP: Selection o f t h e S a m e Major T-Cell Detaerminants o f I n f l u e n z a N u e l e o p r o t e i n a f t e r V a c c i n a t i o n o r E x p o s u r e to InfeCtious Virus. J l m m u n o 1 1 9 9 1 , 147:1647-1652. BRIDEAU Rj, WATHEN MW: A C h i m e r i c G l y e o p r o t e i n o f H , i m a n R e s p i r a t o r y Syncytial Virus T e r m e d F G Induces T-Cell M e d i a t e d I l n m u n i t y i n Mice. Vaccine 1991, 9:863-864. BROCHIER B, KIEN~YMP~ COSTY F, COPPENS P, BAUDLqN B, I~COCQ jP, LANGUETB, CHAPPI]S G, DESMETTR~ P, AFIADEM2LNYOK, LIBOIS R, PASTORETPP: Large Scale E r a d i c a t i o n o f Rabies U s i n g R e c o m b i n a n t V a e c i n i a Rabies Vaccine [Letter]. Nature 1991, 354:520-521. BROWN EG, FURESZJ, DIMOCK K, YAROSH W, CONTRERAS G: N u c l e o t i d e Sequence Analysis o f U r a b e M u m p s V a c c i n e Strain t h a t Caused M e n i n g i t i s i n V a c c i n e R e c i p i e n t s . Vaccine 1991, 9:840~42. BUKRINSKYMI, STANWICKTL, DEMPSEYMP, STEVENSON M: Q u i e s c e n t L y m p h o c y t e s - T as a n I n d u c i b l e

Pharmaceutical applications Vaccines, viruses and AIDS V i r u s R e s e r v o i r i n HIV-1 I n f e c t i o n . Science 1991, 254:423427. BURCH HB, NAGY EV, LUT~ESYG, WARTOFSKY L, B[2RMAN KD: N u c l e o t i d e a n d A m i n o A c i d H o m o l o g y Between the Human Thyrotropin Receptor and t h e HIV-1 a n d A l n i n o Acid H o m o l o g y B e t w e e n t h e H u m a n T h y r o t r o p i n R e c e p t o r a n d t h e HIV1 Nef Protein -Identification and Functional A n a l y s i s . Biochem Biophys Res C o m m u n 1991, 181:498. BLq~GER ICNJ, WHARTON SA, DEMEI. RA, VERKLEIJAJ: interaction of Influenza Virus Hemag#utinin with a Lipid Monolayer - a Comparison of the Surface Activities of Intact Vfrions, Isolated H e m a g # u t i n i n s , a n d a S y n t h e t i c F u s i o n Pept i de . Biochemistry 1991, 30:11173-11180. BU~RMF2STERYqP, RUIGROK RWII, CUSACK S: T h e 2.2 a Resolution Crystal Structure of Influenza B N e u r a m i n i d a s e a n d Its C o m p l e x w i t h Siallc Acid. E M B O J 1992, 11:49-56. BLTWON DR, BARBAS CF, PERSSON MA, KOENIG S, • CHANOCKRM, LEKNERRA: A L a r g e A r r a y o f H u m a n M o n o c l o n a l A n t i b o d i e s to T y p e 1 H u m a n Immunodeficiency Virus from Combintorial Libraries of Asymptumatic Seropositive i n d i v i d u a l s . Proc Nail A c a d 3k;i U S A 1991, 88:10134-10137. [43]. BUSBY-EARLEMC, ET AL.: P a p i l l o m a v i r u s e s , P53, a n d C e r v i c a l C a n c e r [Letter]. Lancet 1992, 339:1350. BUSCH MP, EBLE BE, KIlAYAMBASHIH, HEILBRON D, MU~RPHYEL, KWOK S, SNINSKYJ, PERKINS HA, VYAS GN: E v a l u a t i o n o f S c r e e n e d B l o o d D o n a t i o n s f o r H u m a n I m m u n o d e f i c i e n c y V i r u s Type-1 i n f e c t i o n b y C u l t u r e a n d DNA A m p l i f i c a t i o n o f P o o l e d Cells. N EngI J M e d 1991. 325:1-5. BUSIIMAN FD, CRAIGIE R: I n t e g r a t i o n o f H u n l a n Immunodeficiency Virus DNA - Adduet I n t e r f e r e n c e A n a l y s i s o f R e q u i r e d DNA Sites. Proc Natl A c a d Sci U S A 1992, 89:3458-3462. CADOZ M, STRADYA, MRIGN~ERB, TAYLORJ, TARTAGLIA J, PAOLETI~ E, PLOl~lN S: l m m t l n i s a t i o n w i t h Canarypox Virus Expressing Rabies Glycoprotein. Lancet 1992, 339:1429-1431. CALVERTI, PENG ZQ, KUNG 1IF, RAZIL'DDIN: C l o n i n g a n d Characterization of a Novel Sequcnce-Spceifc D N A - B i n d i n g P r o t e i n R e c o g n i z i n g t h e Negative R e g u l a t o r y E l e m e n t (NRE) R e g i o n o f t h e HIV-1 L o n g T e r m i n a l Repeat. Gene 1991, 101:171 176. CAO M, SASAKI O, YAMADA A, h\IANISHI J: E n h a n c e m e n t o f t h e P r o t e c t i v e Effect o f I n a c t i v a t e d I n f l u e n z a V i r u s V a c c i n e b y C y t o k i n e s . Vaccine 1992, 10:23~242. CARDIN AD, SMITH PL, HYDE L, BLANKENSHIP DT, BOWIAN TL, SCHROEDERK~ STAUDERMANKA, TAYLOR DL, TYMS AS: s t i l b e n e D i s u l f o n i c A ci ds - C D 4 A n t a g o n i s t s t h a t B l o c k H u m a n I m m u n o d e f i c i e n c y V i r u s Type1 G r o w t h at M u l t i p l e S t a g e s o f t h e Wtrus Life Cycle. J B i o l Chem i991, 266:13355-13363. C~O C, ROIG X, CAIRO J, CAMAREROJ, MATEU MG, DOMINGO E, GIRALT E~._~NDREUD: S t u d i e s o n A n t i g e n i c V a r i a b i l i t y 6 f C - S t r a i n s o f Foot-andMouth Disease Virus by Means of Synthetic Peptides and Monoclonal Antibodies. lntjPept Protein Res 1992, 3 9 : 4 1 ~ 7 . CARROLL R, MARTARANOL, DERSE D: I d e n t i f i c a t i o n o f Lentivirus Tat Functional Domains Through Generation of Equine Infectious Anemia V i r u s / H u m a n I m m u n o d e f i c i e n c y V i r u s Type-1 T a t G e n e C h i m e r a s . J Viro11991, 65:3460-3467. CERINO A, MONDELLI MU: I d e n t i f i c a t i o n o f a n I m m u n o d o m i n a n t B-Ceil E p i t o p e o n t h e Hepatitis-C Virus Nonstructural Re#on Defined by Human Monoclonal Antibodies. J Immunol 1991, 147:2692-2696. CH&N CY, LEE SD, TStd YT, LO KJ: B o o s t e r R e s p o n s e t o Recombinant Yeast-Derived Hepatitis-B Vaccine i n V a e c i n e c s W h o s e Anti-ItBs R e s p o n s e s W e r e I n i t i a l l y E l i c i t e d b y a P l a s m a - D e r i v e d Vaccine, Vaccine 1991, 9:765-767. CHATFIELD SN, FAIRWEATHERN, CHARLES I, PICKARD D, LEVIIx'EM, HONE D, POSADA M, STRUGNELLRA, DOUGAN G: C o n s t r u c t i o n o f a G e n e t i c a l l y D e f n e d S a l m o n e l l a T y p h i Ty2 AroA, A r o C M u t a n t f o r t h e Engineering of a Candidate Oral Typhoid Tetanus V a c cin e. Vaccine 1992, 1 0 : 5 3 4 0 . CHEBLOUNT Y, RULKAJ, COSSET FL, VALSESIAS, RONFORT C, LEGRAS C, DRYNDA A, KUZMAKJ, NIGON VM, VERDIER G: i m m u n e R e s p o n s e a n d R e s i s t a n c e t o R o u s Sarcoma virus Challenge of Chickens Immunized with Cell-Associated Glycoproteins Provided with a R e c o m b i n a n t A v i a n L e u k o s i s V i r u s . J Viro11991, 65:5374-5380. CHEN JD, Vt~NDYKE T: U n i f o r m C e l l - a u t o n o m o u s Tumorigenesis of the Choroid Plexus by P a p o v a v i r u s L ar g e T - a n t i g e n s . Mol Cell Biol 1991, 11:5968-5984.

CHEN MS, SUTI'Mt~NNRT, WU JC, PRISBE EJ: M e t a b o l i s m of 4'-Aztdothymidine - a Compound with Potent a n d Selective Activity A g a i n s t t h e H u m a n I m m u n o d e f c i e n c y V i r u s . J Biol Chem 1992, 267:257-260. CHEN YMA, ZHANG XQ, DAHL CE, SAMUELKP, SCHOOLEY RT, *ESSEXM, PAPAS TS: D e l i n e a t i o n o f T F p e - S p e c i f i c Regions on the Envelope Glycoproteins of H u m a n T-Cell L e u k e m i a V i r u s e s . J [mmuno11991, 147:236~2376. CHENGALVALAM, LUBECK MD, DAVIS AR, MIZUrANI S, MOLNARKLMBERK, MOP,IN J, IIUNG PP: E v a l u a t i o n o f A d e n o v i r u s Type-4 a n d Type-7 R e c o m b i n a n t Hepatitis-B V a c c i n e s i n D o g s . Vaccine 1991, 9:485~90. CHERRINGTONJ, GANEaMD: R e g u l a t i o n o f Polyadeoyiation in Human Immunodefiency V i r u s (HIV): C o n t r i b u t i o n s o f P r o m o t e r P r o x i m i t y a n d U p s t r e a m S e q u e n c e s . E M B O J 1992, 11:1513-1524. CFtESBRO B, NISHO J, PERRYMAN S, CAHN A, OBRIEN W, CHEH I, Wt~IRLY K: I d e n t i f i c a t i o n o f H u m a n lmmunodefieieney Virus Envelope Gene S e q u e n c e s I n f l u e n c i n g V i r a l E n t r y i n t o CD4 P o s i t i v e HeLa Cells T L e u k e m i a Cells a n d M a c r o p h a g e s . J Virol 1991, 65:5782 CHINNADURAI G: M o d u L a t i o n o f H I V - E n h a n c e r A c t i v i t y b y H e t e r o l o g o u s A g e n t s - a M i n i r e v i e w . Gene 1991, 101:165~170. CHOI HK, TONG L, MINOR W, DUMAS P, BOEGE U~ ROSSIVIANnNMG, WENGLER G: S t r u c t u r e o f S i n d b i s V i r u s Core P r o t e i n R e v e a l s a C h y m o t r y p s i n d i k e Serine Proteinase and the Organisation of the V i r i o n . Nature 1991, 354:37. CHOI K, FROMMELTO, STERN RK, PEREZ CF, KRIEGLER M, TSURUO T, RON]NSON IB: M u l t i d r u g R e s i s t a n c e a f t e r R e t r o v i r a l T r a n s f e r o f t h e H u m a n MDR1 Gene Correlates with P-Glyeoprotein Density i n t h e P l a s m a M e m b r a n e a n d is n o t A f f e c t e d b y C y t o t o x i c S e l e c t i o n . Proc Natl A c a d Sci U S A 1991, 88:7386 7390. CHLrMAKOVKM, NORWOOD LP, PARKERML, DRAGUNSKY EM, RAN YX, LEVENBOOKIS: RNA S e q u e n c e V a r i a n t s i n Live P o l i o v i r u s V a c c i n e a n d T h e i r R e l a t i o n t o N e u r o v i r u l e n c e . J Viro11992, 66:966-970. CLAPEIAM PR, MCKHIGHT A, WEISS RA: H u m a n I m m u n o d e f i e i e n c y V i r u s Type-2 I n f e c t i o n a n d F u s i o n o f CD4-Negative H u m a n Cell L i n e s I n d u c t i o n a n d E n h a n c e m e n t b y S o l u b l e CD4. J Viro11992, 66:3531-3537. CLARK ME, HSiMMERLET, WIMMER E, DASGUPTAA: P o l l o v i r u s P r o t e i n a s e 3C C o n v e r t s a n Active F o r m o f T r a n s c r i p t i o n F a c t o r IHC t o a n I n a c t i v e F o r m a a M e c h a n i s m f o r I n h i b i t i o n o f H o s t Ceil P o l y m e r a s e n I T r a n s c r i p t i o n b y P o l f o v i r u s . EMBO J 1 9 9 1 , 10:2941 2948. CLEGG JCS: C u r r e n t P r o g r e s s T o w a r d s V a c c i n e s f o r A r e n a v i r u s - C a u s e d D i s e a s e s . Vaccine 1992, 1@89-95. COHEN JI, KIEFF E: A n E p s t e i n B a r r v i r u s N u c l e a r Protein 2 Domain Essential for Transformation is a D i r e c t T r a n s c r i p t i o n a l Activator. J Virol 1991, 65:5880-5885. COLE GA, BALER G, KIRSTEN E, MENDELEYEVJ, BAUER PI, BUKI KG, ~ A, KUN E: I n h i b i t i o n o f m v - l - I I I b R e p l i c a t i o n i n AA-2 a n d MT-2 Cells i n C u l t u r e b y T w o L i g a n d s o f P o l y (ADP-ribose) P o l y m e r a s e - 6Amino-l,2-Benzopyrone And 5-Iodo-6-Amino-l,2B e n z o p y r o n e . Biochem Biophys Res C o m m u n 1991, 180:504-514. CONSTA~NTINESCUSN, CEP~NESCUCD~ POPESCU LM: E f f e ~ of Protein Kinase-C Inhihitors on Viral Entry and Infectivity. FEBSLett 1991, 292:31 33, C O N Z R I . V ~ KK, COX JH, TH/EL HJ: A n L ( P o l y m e r a s e ) D e f i c i e n t R a b i e s V i r u s Defective i n t e r f e r i n g P a r t i c l e RNA i s R e p l i c a t e d a n d T r a n s c r i b e d b y H e t e r o l o g o u s H e l p e r V i r u s L-Proteins. Virology i991, 184:6554563 COOKE SJ, LAMBDEN PR, CAUL EO, CLARKEIN: M o l e c u l a r Cloning, Sequence Analysis and Coding Assignment of the Major Inner Capsid Protein G e n e o f H u m a n G r o u p - C Rotavirus. Virology 1991, 184:781-785, COREY L, COONEY E: HOW G o o d is H I V E n v e l o p e G l y c o p r o t e i n V a c c i n e as a T d y m p b o c y t e S t i m u l a n t ? [Letter]. Lancet 1991, 338:187. COREy L, FLE~aNG TR: T r e a t m e n t o f m v I n f e c t i o n P r o g r e s s i n P e r s p e c t i v e . N e w E n g l J M e d 1992, 326:484~185. COSSET FL, BOUQUET JF, DRYNDA A, CHEBLOUI~TY, REYSENELONGE A, KOHEN G, NIGON VM, DESMET]TKE I~ VERDIERG: N e w c a s t l e D i s e a s e V i r u s (NDV) Vaccine Based on Immunization with Avian Cells E x p r e s s i n g t h e NDV H e m a g g l u t i n t n N e u r a m i u l d a s e G l y c o p r o t e i n . Virology 1991, 185: 862~66.

COULSON BS, NIRKWOOD C: R e l a t i o n o f Vp7 A m i n o Acid S e q u e n c e to M o n o c l o n a l A n t i b o d y N e u t r a l i z a t i o n o f R o t a v i r u s a n d R o t o v i r u s M o n o t y p e . J Viro11991, 65:5968. COURSAGET P, BRINGER L, SARRG, BOURD[L C, FRITZELL B, BLONDEAU C, YVONNET B, CHIRON JP, JEANN~ E, GL~NDO S, DIOPM~R I: C o m p a r a t i v e I m m u n o g e n i c i t y i n C h i l d r e n o f M a m m a l i a n CellDerived Recombinant Hepatitis-B Vaccine and P l a s m a - D e r i v e d Hepatitis-B V a c c i n e . Vaccine 1992, 10:379-382. Cox FEG: M a l a r i a V a c c i n e s - - P r o g r e s s a n d P r o b l e m s . Trends Biotechno11991, 9:389-393. CRAVENRC, B ~ X T T RP, WILLSJW: R o l e o f t h e A v i a n Retroviral Protease in the Activation of Reverse T r a n s c r i p t a s e D u r i n g V i r i o n A s s e m b l y . J Virol 1991, 65:6205-6217. CRESS A, TRIEZEHBERGSJ: N u c l e o t i d e a n d D e d u c e d A m i n o Acid S e q u e n c e s o f t h e G e n e E n c o d i n g v i r i o n P r o t e i n - 1 6 o f H e r p e s S i m p l e x V i r u s Type2. Gene 1991, 103:235-238. CRYZ SJ JR: Live A t t e n u a t e d V a c c i n e s f o r H u m a n Use. Curt Opin Blotechno11992, 3:298-302. CL]NER [%'AX]RAM Z, WALLBRIDGE S, ISHII H, OLDFIELD EH, BLARSE RM: I n Vivo G e n e T r a n s f e r w i t h R e t r o v i r a l V e c t o r P r o d u c e r Cells f o r T r e a t m e n t o f E x p e r i m e n t a l B r a i n T u m o r s . Science 1992, 25fi:1550-1552 CUZICKJ, TERRY G, H O L, HOLLINGWORTtt T, ANDERSON M: H u m a n P a p i i l o m a v i r u s T y p e 1 6 DNA i n C e r v i c a l S m e a r s as P r e d i c t o r o f H i g h - G r a d e C e r v i c a l C a n c e r . Lancet 1992, 339:959-962. CVETKOVICH TA, LAZAR E, BLUMBERG BM, SAITO Y, ESKIN TA, REICHM/uN R, BARAM DA, DELCERRO C, GENDEI3VlANHE, DELCERRO M, EPSTEIN LG: H u m a r l tmm*modeficiency Virus Typed Infection of N e u r a l X e n o g r a f t s . Proc Natl A c a d Sci U S A 1992, 89:516~5166. DADAGLIO G, LEROUX A, LANGLADEDF~MOYENP, BAHRAOLq EM, TRAINCARD F, FISHER R, PLATA F: E p i t o p e Recognition of Conserved HIV Envelope Sequences by Human Cytotoxic Lymphocytes-T. J I m m u n o 1 1 9 9 1 , 147:2302-2309. DAGOS]~NO DM, FELBER BK, }]ARRISONjE, PAVLA~S GN: The Rev Protein of Human Imm,modeficiency V i r u s Type-1 P r o m o t e s P o l y s o m a l A s s o c i a t i o n a n d Translation of Gag/pol and Vpu/env Messenger R N A s . Mol Cell Biol 1992, 12:1375-1386. DALGLEISHAG, WILSON S, GOMPELSM, LUDLAMC, GAZZARD • B, COATES A M HABESHAWJ: T C e l l R e c e p t o r V a r i a b l e G e n e P r o d u c t s a n d E a r l y HlV-1 I n f e c t i o n . Lancet 1992, 339:824~q27. [39]DAN2LA RN ETAL: A L o o k - b a c k I n v e s t i g a t i o n o f P a t i e n t s of an HIV-infected Physician --Public Health I m p l i c a t i o n s . N E n g l J M e d 1991, 325:1406 1411. DAV1SSJ, SCHOCIGMELGA, SOMOZA C, BUCK DW, HEALEY DG, RIEBER EP, REITER C, W~LLIkaMSAF: A n t i b o d y a n d H1V-1 G p l 2 0 R e c o g n i t i o n o f C D 4 U n d e r m i n e s the Concept of Mimicry Between Antibodies and R e c e p t o r s [Letter]. Nature 1992, 358:76-79. DEBIASI R, ROCINO A, MIRAGLIA E, MASTRULLOL, QUtRINO AA: T h e I m p a c t o f a Very H i g h P u r i t y FactorVIII C o n c e n t r a t e o n t h e I m m u n e S y s t e m o f Human Immtmodcficiency Virus-Infected H e m o p h i l i a c s - a R a n d o m i z e d , P r o s p e c t i v e , TwoYear Comparison with an Intermediate Purity C o n c e n t r a t e . Blood 1991, 78:1919-1922. DECLERCO E, Y&MAMOTO N, PAUWELSR, BABA M, SCHOLS D, NAKASHIMAH, BALZARIHIJ, DEBYSER Z, MUT~RER BA, SCHWARTZD, THORNTON D, BRIDGER G, FRICKER S, HENSON G, ABRAMS M, PICKERD: P o t e n t a n d Selective Inhibition of Human Immunodeficiency V i r u s ( m v ) - i a n d HIV-2 R e p l i c a t i o n b y a CLass of Bicyclams interacting with a Viral Uncoating E v e n t . Proc NatI A c a d Sci U S A 1992, 89:5286-5290. DEDERA DA, GU RL, RATNER L: Rule o f A s p a r a # n e - L i n k c d Glycosylation in Human lmmunodeficieney Virus Type 1 Transmembrane Envelope Function. Virology 1992, 187:377-382. DEFOORT J P, NARDELLI B, HUANG W, HO DD, TAM JP: Macromolecular Assemblage in the Design of a S y n t h e t i c AIDS V a c c i n e . Proc Natl A c a d Sci U S A 1992, 89:3879-3883. DEUMA MDP, RAMALHOS~NTOSJ, MAR'IINS MD, DECARVALHO AP, BAIROS V, NIR S: K i n e t i c M o d e l i n g o f S e u d a l V i r u s F u s i o n w i t h PC-12 Cells - Effect o f P H a n d Temperature on Fusion and Viral Inactivation. E u r J B i o c h e m 1992, 205:181 186. DELMAS B, GELFI J, L'}IARIDON R, VOGEL LK, SJOSTROMH, NOREN O, LAL~E H: A m i n o p e p t i d a s e N is a M a j o r Receptor for the Enteropathogenic Coronavirus TGEV [Letter]. Nature 1992, 357:417-419. DELOS S, VILLARMT, HU PS, PZI'ERSON DL: C l o n i n g , Expression, Isolation and Characterization o f t h e Pre-S D o m a i n s o f H e p a t i t t s - B S u r f a c e

725

726

Pharmaceutical applications Vaccines, viruses and AIDS Antigen, Devoid o f t h e S-Protein. Biocbem J 1991, 276:411-416, DELVAL M, SGtlLICHTHJ, VOLKMER H, MESSERLEM, REDDEHASE MJ, KOSZINOWSKI UH: P r o t e c t i o n Against Lethal C y t o m c g a l o v i r u s Infection b y a R e c o m b i n a n t VaccIne C o n t a i n i n g a Single N o n a m e r i c T-Cell Epitope. J Viro11991, 65:3641-3646. DERONDE A, KLAVERB, KELILENW, SMH L, GoLrDSMITJ: N a t u r a l HIV-1 NEF A c c e l e r a t e s Wtrus R e p l i c a t i o n i n P r i m a r y H u m a n L y m p h o c y t e s . Virology 1992, 188:391-395. DEROSSI A, PAS'I1 M, MAMMANOE~ PANOZZO M, DETFIN M, DIBELLO C, CHIECOBIANCIN L: Synthetic P e p t i d e s f r o m t h e Pl-incipal N e u t r a l i z i n g D o m a i n o f H u m a n I m m u n o d e f i c i e n c y Virus Type-1 (HIV1) E n h a n c e HIV-1 I n f e c t i o n T h r o u g h a CD4D e p e n d e n t M e c h a n i s m . Virology 1991, 184:187-196. DESAI K, LOEWENSTEINPM, GREEN M: I s o l a t i o n o f a C e l l u l a r P r o t e i n t h a t B i n d s to t h e H u m a n I m m u n o d e l i c i e n c y Virus T a t P r o t e i n a n d c a n P o t e n t i a t e T r a n s a c t i v a t i o n o f t h e Viral P r o m o t e r . Proc Natl A c a d Sci U S A 1991, 88:8875-8879. DESPRES P, DIETRICHJ, GIRARD M, BOLZOY M: Recombinant Baculoviruses Expressing yellow F e v e r Virus-E a n d NS1 P r o t e i n s Elicit P r o t e c t i v e I n m l u n l i y in Mire. J Gen Viro11991, 72:2811-2816. DETURISOJAL, CORTES E, MARIINEZ C, DEYBANEZRR, StMAI~O I, VELA C, CASAL I: R e c o m b i n a n t V a c c i n e f o r C a n i n e P a r v o v l r u s i n Dogs. J Virol 1992, 66:2748-2753. DEV1 SJN, ROBBINSJB, SCHNEERSON R: Antibodies i n Poly< (2-> 8 ) - a l p h a - N - A c e t y i n e u r a m i n i c Acid> a n d Poly< (2-> 9 ) - a l p h a - N - A c e t y i n e u r a m i n i c Acid> are Eliclicd b y l m m t l n i z a t i o n o f Mice w i t h Escherichia-Coli K92 Conjugates - P o t e n t i a l V a c c i n e s for Group-B a n d Group-C M e n i n g o c o c e i a n d E-Coil K1. Proc Natl A c a d Sci U S A I991, 88:7175-7179. DEWOLF F, MELOENRII, BAKKERM, BARtN i2, GOUDSMITJ: Characterization of Human Antibody-Binding Sites o n the E x t e r n a l E n v e l o p e o f H u m a n I m m u n o d e f i c i e n c y Virus Type-2. J Gen Virol 1991, 72:126I 1267. DILEO AJ, ALLEGREZZAAE, BI~LDER SE: H i g h R e s o l u t i o n R e m o v a l o f v i r u s f r o m P r o t e i n Solutions U s i n g a M e m b r a n e o f U n i q u e Structure. Biotechnology 1992, 10:182-188. DILLON SB, DF~MU'I'HSG, SCHNEIDERMA, \VESTON CB, JONES CS, YOUNG JF, SCOTF M, BHATNAGHARPK, LOCASTRO S, HANNA N: i n d u c t i o n o f P r o t e c t i v e c l a s s - I MHC-Rcstricted CTL I n Mice by a R e c o m b I n a n t I n f l u e n z a Vaccine i n A i n m i n i n m H y d r o x i d e Adjuvant. Vaccine 1992, 10:309-318. DIM1TROV DS, HII2,Mb~ K, MANISCHEWITZJ, BLUMENTHAL R, G O L D I N G H: Kinetics o f Soluble CD4 B i n d i n g to Cells E x p r e s s i n g H R m a ~ I m m l l l t o d e f i c i c n c y Virus T y p e d E n v e l o p e G l y c o p r o t e i n . J Viro11992, 66:132-138. DhMITROV DS, WILLEYRL, MARLIN MA. BLUME>WHALR: K i n e t i c s o f HlV-1 I n t e r a c t i o n s w i t h SCD4 a n d CD4+ Cells - I m p l i c a t i o n s f o r i n h i b i t i o n o f Virus I n f e c t i o n and Initial Steps o f Virus E n t r y i n t o Cells. Virology 1992, 1 8 7 : 3 9 ~ 4 0 6 . DOONG SL, TSAI CH, SCIRNAZI RF, IAOTTADe, CHENG YC: I n h i b i t i o n o f t h e R e p l i c a t i o n o f Hcpatitis-B Virus Invitro b y 2',3'-Dideoxy-3'-Thtacytidine a n d Related Analogues. Proc Natl A c a d Sci U S A 1991, 88:8495-8499. DORMITZER PR, HO DY, MACKOW ER, MOCAESKI ES, GREENBERG IffB: N e u t r a l i z i n g Epitopcs o n H e r p e s S i m p l e x V i r u s - l - E x p r e s s e d Rotavirus VP7 a r e Dependent on Coexprcssion of Other Rotavirus P r o t e i n s . Virology 1992, 187:18-32. DUDDING LR, NKABINDENC, MIZRAHI V: Analysis o f t h e RNA-Dependent a n d D N A - D e p e n d e n t DNA P o l y m e r a s e Activities o f P o i n t Mutants o f m v - 1 Reverse Transcriptase Lacking Ribonuclcase-H Activity. Biochemistry 199i, 30:10498-10506. DUEWEKE TJ, KEZDYFJ, WASZAK GA, DEIBELMR, TARREEYWG: T h e B i n d I n g o f a Novel l i i s h e t e r o a r y l p i p e r a z i n e Mediates h x h i b i t i o n o f H u m a n I m m u n o d e f i c i e n c y Virus Type-1 R e v e r s e T r a n s c r i p t a s e . J B i o l Chem 1992, 267:27-30. DVEKSLER GS, PENSIERO MN, CARDELLICHIOCB, WILLIAMS RK, JIANG GS, HOLMES KV, DIEFFENBACHCW: C l o n i n g o f t h e Mouse Hepatitis Virus (MHV) R e c e p t o r - - E x p r e s s i o n i n H u m a n a n d H a m s t e r Cell Lines Confers S u s c e p t i b i l i t y to MHV. J Virol i991, 65:6881q5891. DYSON HJ, NORRBYE, HOEY K, pARKS DE, LERNERRA, WRIGHT PE: I m m u n o g e n i c P e p t i d e s C o r r e s p o n d i n g to t h e D o m i n a n t A n t i g e n i c R e g i o n A l a n i n e 597 to Cysteine-619 i n t h e T r a n s m e m b r a n e P r o t e i n o f S i m i a n l m m ~ m o d e f i c i e n c y Virus h a v e a P r o p e n s i t y to F o l d i n Aqueous Solution. Biochemistry 1992, 31:1458-1463.

EDGINGTON SM: Biotech Vaccines' P r o b l e m a t i c Prolllise. Biolechnology 1992, 10:763-767. EDGINGTON SM: IS a n AIDS Vaccine Possible? Biolechnology 1992, 10:768-771. EINSELEH, EHNINGERG, STEIDLE M, VALLBRACHTA, M(~-LLER M, SCI-hMIDTH, SAALJG, WALLER]{D, M{~q-LERCA: P o l y m e r a s e Chain R e a c t i o n to Evaluate A n t i v i r a l T h e r a p y for C y t o m e g a l o v i r u s Disease. Lancet 1991, 338:1170-1172. ELDIRANIDIABR, ANDREOLAML, NEVINSKYG, THARAUD D, BARR PJ, LITVAKS, TARRAGOLITVAKL: B i o c h e m i c a l C h a r a c t e r i z a t i o n o f t h e P51 Sub-Unit o f H u m a n I m m u n o d e f i c i e n c y Virus Reverse T r a n s c r i p t a s e in H o m o d i m e t i c a n d H e t e r o d i m e r i c R e c o m b i n a n t F o r m s o f t h e Enzyme. FEBS Letl 1992, 301:23-28. ELEF&NWYAG, CORY S: H e m a t o l o g i c Disease I n d u c e d i n BALB/c Mice by a Bcr-abl R e t r o v i r u s is I n f l u e n c e d b y t h e Infection c o n d i t i o n s . MoI Cell Bio11992, 12:1755-1763. EMINI EA, SCHLEIFWA, NUNBERGJH, CONLEYAJ, EDA Y, TOKIYOSHI S, PbqTNEYSD, MATSUSHITAS, COBB KE, jETT CM, EICHBERGfW, MUR71{y KK: P r e v e n t i o n o f HIV-1 Infection in C h i m p a n z e e s b y Gp120 V3 D o m a i n - s p e c i f i c M o n o c l o n a l A n t i b o d y [Letter]. Nature 1992, 335:728-729. ENGELMANA, MIZUUCHIK, CRMGIE R: ItIV-1 DNA I n t e g r a t i o n - M e c h a n i s m o f Viral DNA C l e a v a g e a n d DNA Strand T r a n s f e r . Cell 1991, 67:1211-1221. ETLINGER HM, ALTENBURGERW: O v e r c o m i n g I n h i b i t i o n o f A n t i b o d y R e s p o n s e s to a M a l a r i a R e c o m b i n a n t V a c e i n i a Virus Caused b y P r i o r E x p o s u r e to W i l d T y p e Virus. Vaccine 1991, 9:470~672. ETLINGER HM, KNORR R: M o d e l U s i n g a P e p t i d e w i t h C a r r i e r F u n c t i o n f o r V a c c i n a t i o n Against D i f f e r e n t Pathogens. Vaccine 1991, 9:512-514. EVERm*r RD, ELLIOTTM, HOPE G, ORR A: I~LIri~catioll o f t h e DNA B i n d i n g D o m a i n o f H e r p e s S i m p l e x Virus T y p e 1 I m m e d i a t e d E a r l y P r o t e i n V m w 1 7 5 as a H o m o d i m c r a n d E x t e n s i v e M u t a g e n e s i s o f Its DNA R e c o g n i t i o n Site. Nucleic Acids Res 1991, 19:4901~4908. EVEREIT RD, ORR A, ELLIOTTM: H i g h Level E x p r e s s i o n a n d PttrLfication o f H e r p e s S i m p l e x Virus T y p e 1 I m m e d i a t e E a r l y P o l y p e p t t d e V m w l l 0 . Nucleic Ac i d s Res 1991, 19:615545160. EWEN ME, FAHA B, HARLOW E, LIVINGSTONDM: I n t e r a c t i o n o f P107 w i t h Cyclin-A I n d e p e n d e n t o f C o m p l e x F o r m a t i o n w i t h Viral O n c o p r o t e t n s . Scierzce 1992, 255:85-87. FAItA B, EWEN ME, TSM LH, LIVINGSTONDM, HARLOW E: I n t e r a c t i o n B e t w e e n H u m a n Cyclin-A a n d A d e n o v i r u s EIA-associated P 1 0 7 P r o t e i n . Science 1992, 255:87. FAHA B, EWEN ME, TSAI LH, LIVINGSTONDM, HARLOW E: i n t e r a c t i o n B e t w e e n H u m a n Cydin-A a n d A d e n o v i r u s EIA-associated P 1 0 7 P r o t e i n . Science 1992, 255:87. FEKADUM, SHADDOCKJH, EKSTROMJ, OS~RHAUS A, SANDERLINDW, SUNDQUISTB, MOREIN B: A n I m m u n e S t i m u l a t i n g C o m p l e x (ISCOM) S u b u n i t Rabies v a c c I n e Protects Dogs a n d Mice Against Street Rabies Challenge. Vaccine 1992, 10:192 197. FEKADUM, SUMNERJXV, SHADDOCKJH, SANDERLINDW, BAER GM: Sickness a n d R e c o v e r y o f D o g s C h a l l e n g e d w i t h a Street Rabies Virus a f t e r V a c c i n a t i o n w i t h a V a e e i n i a Virus R e c o m b i n a n t E x p r e s s i n g Rabies Virus N-Protein. J Virol i992, 66:2601-2604. F~ENOL~LLETE, GLUCKMANJC: I m m u n o l o g i c a l Analysis o f H u m a n I m m u n o d e t i c i e n c y Virus Type-1 E n v e l o p e G l y c o p r o t e i n P r o t e o l y t i c Cleavage. Virology 1992, 187:825-828. FERGUSON A, SALL&MJ: M u c o s a l I m m u n i t y / t o O r a l V a c c i n e s [Letter]. Lancet 1992, 339:179. FERGUSON M: P r o g r e s s T o w a r d s Rabies ControL 1}'ends Biotechno11991, 9:7-10. FIELDER ~], PETERSONEM, DELAMAZALM: Nucleotide S e q u e n c e o f DNA E n c o d i n g t h e M a j o r O u t e r Membrane Protein of Chlamydia-Trachomatis S e r o v a r L3. Gene 1991, 101:159-160. FIKllIG E, BARTHOLDS\V, PERSlNG DH, SUN X, KA~\rfOR FS, FLAX/ELLRA: B o r r c l i a - B u r g d o r f e r i Strain-25015 C h a r a c t e r i z a t i o n o f O u t e r Surface Protein-A a n d V a c c i n a t i o n Against Infection. J I m m u n o 1 1 9 9 2 , 148:2256-2260. FINBERG RW, WAHL SM, ALLENJB, SOMAN G, STROM~ , MURPHYJR, .NICHOLSJC: Selective E l i m i n a t i o n o f HlV-l-Ixffected Cells w i t h a n I n t e r l e u k i n 2 R e c e p t o r Specific Cytotoxin. Science 1991, 252:1703-1705. k~NE PEM: M e n i n g o c o c e a l Vaccine T r i a l in N o r w a y [Letter]. Lancet 1991, 338:1456. I~N'ERTYS, TARLTONJ, MACKE'I~ M, CONWAYM, ARRANDJR, WATKINS PE, MORGAN AJ: P r o t e c t i v e I m m u n i z a t i o n Against Epstein-Barr Virus-Induced Disease i n C o t t o n t o p T a m a t i n s U s i n g t h e Virus E n v e l o p e Glycoprotein Gp340 Produced from a Bovine

P a p t i l o m a v i r u s E x p r e s s i o n Vector. J Gen Virol 1992, 73:449-453. FLEURYS, LAMARRED, MELOCHE S, RYtJ SE, CA2¢IIN C, HENDRICKSON \VA, SEKALYRP: M u t a t i o n a l Allalysis o f t h e I n t e r a c t i o n B e t w e e n CD4 a n d Class-II MHC - Class-II Antigens Contact CD4 o n a Surface O p p o s i t e t h e G p 1 2 0 - B i n d i n g Site. Cell 1991, 66:103%1049 FORREST BD, PRESTON N~(f, ARYA SC: O r a l T y p h o i d Vaccine Ty21A [Letter]. Lancet 1991, 338:1455. FREDHOIaM M, POLICASTROPF, WILSON MC: T h e D i s p e r s i o n o f Defective E n d o g e n o u s M u r i n e R e t r o v i r a l E l e m e n t s Suggests R e t r o t r a n s p o s i t i o n - M e d i a t e d A m p l i f i c a t i o n . DNA Cell Bio11991, 10:713-722. EREED EO, DELWARTEL, BUCHSCHACHERGL, PANGANIBAN AT: A M u t a t i o n i n t h e H n m a n I m m u n o d e f i c i e n c y Virus T y p e d T r a n s m e m b r a n e G l y c o p r o t e i n gp41 D o m i n a n t l y I n t e r f e r e s w i t h F u s i o n a n d Infectivity. Proc N a g A c a d Sci U S A 1992, 89:70-74. FRIES LF, GORDON DM, RICHARDS ILL, EGANJE, ttOLLINGDALE MR, GROSS M, SILVERMANC, ALVING CR: L i p o s o m a l M a l a r i a Vaccine i n H u m a n s - a Safe a n d P o t e n t Adjuvant Strategy. Proc Natl A c a d Sei U S A 1992, 89:358-362. FRISCH SM: A n t i o n c o g e n i c Effect o f A d e n o v i r u s - E 1 A i n H u m a n T u m o r Cells. Proc Natl A c a d Sci U S A 1991, 88:9077-9081. EUJL, TAN BH, YAP EH, CHAN YC, T&N YH: FullL e n g t h CDNA S e q u e n c e o f D e n g u e T y p e d Virus ( S i n g a p o r e Strain $ 2 7 5 / 9 0 ) . Virology 1992, 188:953-958. FUCHS K. MOTZ M, S C H ~ R E, ZACHOVALR, DEINHARDT F, R O G G E N D O R F M: C h a r a c t e r i z a t i o n o f N u d e o t i d c Sequences f r o m E u r o p e a n Hepatitis-C Virus Isolates. Gene 1991, 103:163 169. FULTZ P: Are w e D e t o u r i n g f r o m a D i r e c t R o u t e to D e v e l o p m e n t o f HIV Vaccines. Vaccine 1991, 9:783-787. FULTZ PN, NARA P, BARRESlNOUSSIF, CHAPUF A, GREENBERG ML, MUCHMOREE, KIENWMP, GIRARD M: Vaccine P r o t e c t i o n o f C h i m p a n z e e s Against C h a l l e n g e w i t h HIV-1 I n f e c t e d P e r i p h e r a l B l o o d M o n o n u c l e a r Cells. Science 1992, 256:1687-1690. FUIL~NE ES, REARDONJE: H u m a n I m m u n o d e l i c i e n c y Virus Reverse T r a n s c r i p t a s e R l b o n u c l e a s e - H Specificity o f T r a n s f e r RNALys3-Primer Excision. Biochemistry 1991, 30:7041~046. FURTADO MR, BALACHANDRANR, GUPTA P, WOLINSKY SM: Analysis o f A l t e r n a t i v e l y Spliced H u m a n I m m u n o d e f i c i e n c y Virus T y p e d M e s s e n g e r R N A Species, O n e o f W h i c h Encodes a N o v e l TAT-ENV FUsion P r o t e i n . Virology 1991, 185:258-270. GAO Q, GU ZX, pAKNIAKMA, Lt XG, WAINBERG MA: Invitro Selection of Variants of Human I m m u n o d e f i c i e n c y Virus T y p e d R e s i s t a n t to 3'-Azido-3'-Deoxythymidine A n d 2',3'D i d e o x y i n o s i n e . J Viro11992, 66:12-19. GARCIABLANCOMA, CLZLENBR: M o l e c o l a r Basis o f Latency i n P a t h o g e n i c H u m a n Viruses. Science 1991, 254:815420. GARCIASA1NZJA, ROMEROAV1LANIT, RLqZARRIAGAA, RLqZPUEN~TEJ, AGUNDIS C, ORTIZ V, ISlBASIA: C h a r a c t e r i z a t i o n a n d D e t o x f f i c a t i o n o f a n Easily P r e p a r e d Acellular Pertussis Vaccine - A n t i g e n i c Role o f t h e A - P r o t o m e r o f Pertussis T o x i n . Vaccine i992, 10:341 344. GARCIA-VILLEGASMR, DE LA VEGA FM, GALINDOJM, SEGU~A M, BUCFdNGHAMRH, GUARNEROSG: Peptidyl-tRNA H y d r o l a s e is i n v o l v e d in ~/ i n h i b i t i o n o f H o s t P r o t e i n Synthesis. E3fBO J 1991, 10:3549-3556. GAI~DNERM: SIV Vaccines - C u r r e n t Status. Vaccine 1991, 9:78~791. GHATrAS IR, SA~'~ESJR, MAJORSJE: T h e E n c e p h a l o m y o c a r d i t i s Virus I n t e r n a l R i b o s o m e E n t r y Site Allows Efficient C o e x p r e s s i o n o f T w o C~enes f r o m a R e c o m b i n a n t P r o v i r u s in C u l t u r e d Cells a n d in E m b r y o s . Mol Cell Bio11991, 11:5848-5877. GHIASI H, KAIWAR R, NESBURNAB, SLANINAS, WECHSLER SL: B a c u l o v i r u s - E x p r e s s e d Glycoproteirl-E (gE) o f H e r p e s S i m p l e x Virus Type-1 (HSV-1) Protects Mice Against Lethal I n t r a p e r i t o n e a l a n d Lethal O c u l a r HSV-1 Challenge. Virology 1992, 188:469-476. GIAMMANCO G, LIVOL~ S, MAURO L, BILANCIAGG, S&LEMII, BARO~X P, MUSUMECIS: I m m u n e R e s p o n s e to S i m u l t a n e o u s A d m i n i s t r a t i o n o f a R e c o m b i n a n t DNA Hepatitis-B V a c c i n e a n d Multiple C o m p u l s o r y Vaccines i n I n f a n c y . Vaccine 1991, 9:747-750. GIAVEDONI L, JONES L, MEBUS C, YILVtAT: A V a c c i n i a Virus D o u b l e R e c o m b i n a n t E x p r e s s i n g t h e F-Genes a n d H-Genes o f R i n d e r p e s t Virus P r o t e c t s Cattle Against R i n d e r p e s t a n d Causes n o P o c k Lesions. Proc Natl A c a d Sci U S A 1991, 88:8011-8015. GILHGAN KJ, RAJADURAIP, LIN JC, BUSSON P~ ABDELHAMID M, PRASADU, TURZ T, RAABTRAL~BN: E x p r e s s i o n o f t h e E p s t e i n B a r r Virus BamtII-A F r a g m e n t i n

Pharmaceutical applications Vaccines, viruses and AIDS N a s o p h a r y n g e a l C a r c i n o m a -Evidence f o r a v i r a l P r o t e i n E x p r e s s e d I n v i v o . J Viro11991, 65:6252. GIRARD M: T h e C h a l l e n g e o f H I V Vaccines. Vaccine 1991, 9:781-783. GIZLrRARSON S, TAMURAS, AIZAWA C, KURATAT: Stimulation of the Transepithelial Flux of I n f l u e n z a H A V a c c i n e b y C h o l e r a T o x i n BS u b u n i t . Vaccine 1992, 10:101-106. GLICK GD, K~OWLESJR: M o l e e u l a ~ R e c o g n i t i o n o f B i v a l e n t S i a l o s i d e s b y I n f l u e n z a Virus. J A m C~lern Soc 1991, 113:4701~i703. GOLDM&N ME, NUNBERGJH, OBRIEN JA, QUIi~qt~ROJC, SCHLEIF WA, FRSUND KF, GAUL SL, SAARI WS, WM JS, HOFFMA~"JM, ANDERSON PS, HL~E DJ, EMINI EA, STERNAM: P y r i d i n o n e De ri vat i ve s - S p e c i f i c H u m a n I m m u n o d e f i c i e n c y V i r u s Type-1 R e v e r s e T r a n s c r i p t a s e I u l l i h i t o r s w i t h A n t i v i r a l Activity. Proc Natl A c a d Sci U S A 1991, 88:6863~867. GOLDSTEIN DJ, FINBOW ME, ~NDRESSON T, MCLEAN P, SMrG~ K, BUBB V, SCHLEGELR: B o v i n e P a p i U o l n a v i r u s E50ncoprotein Binds to the 16K Component o f V a c u o l a r H+-ATPases [Letter]. Nature 1991, 352:347 348. GONCZOL E, DETAISNE C, flIRKA G, BEP~NCSI K, LIN WC, PAOLETN E, PLO'r~N S: H i g h E x p r e s s i o n o f H u m a n C y t o m e g a l o v i r u s (HGMV)-gB P r o t e i n i n Cells Infected with a Vaccinia-GB Recombinant - the i m p o r t a n c e o f t h e GB P r o t e i n i n H c m v I m m a n i t y . Vaccine 1991, 9 : 6 3 1 ~ 3 7 . GOODRICH JM, AND OTHERS: E a r l y T r e a t m e n t w i t h G a n c i c l o v i r to P r e v e n t C y t o m e g a l o v i r u s D i s e a s e after Allogencic Bone Marrow Transplantation. N E n g l J M e d 1991, 325:1601-1607. GORDON DM, DANISHEFSKYSJ: S y n t h e s i s o f a Cyanobaeterial Sulfolipid - Confirmation of Its S t r u c t u r e , S t e r e o c h e m i s t r y , a n d Anti-HIV-1 A c t i v i t y . J A m Chem Soc 1992, 114:659q563. GORSE GJ, BELSHE RB, NEWMAN FK, FREY SE: L y m p h o c y t e Proliferative Responses Following lmmllnizatton with Humam Immunodeficiency Virus R e c o m b i n a n t GP160. Vaccine 1992, 10:383-388. GRAHAM NMH ETAL.: T h e Effects o n S u r v i v a l o f E a r l y Treatment of Human Immunodefieiency Virus I n f e c t i o n . N E n g l J M e d 1992, 326:1037-t042. GRANOFF DM, HOI~aES SJ: C o m p a r a t i v e I m m u n o g e n i e i t y o f H a e m o p h i l u s - I n f l u e n z a e Type-B Polysaccharide-protein Conjugate Vaccines. Vaccine 1~)1, 9:$30-$34. GRIFPITH JP, GRIFFtTH DL, R A Y M E N q ~ I, MURAKAMIW'~% CASPER DLD: I n s i d e P o l y o m a v i r u s at 25-AA R e s o l u t i o n . Nature 1992, 335:6524554. GRIFFITHS E: E n v i r o n m e n t a l R e g u l a t i o n o f B a c t e r i a l Wtrulenee - - I m p l i c a t i o n s f o r V a c c i n e D e s i g n a n d P r o d u c t i o n . Trends Biotechno11991, 9:309-3t5. GRIFHTHS JC, BERRIE EL, HOLDSWORTH LN, MOORE JP, HARRIS SJ, SENIORJM, KINGSMAN SM, KINGSM#aN AJ, ADAMS SE: i n d u c t i o n o f H i g h - T i t e r Neutralizing Antibodies, Using Hybrid Human l m m , m o d c f i c i c n c y V i r u s V3-TY V i r u s l i k e P a r t i c l e s i n a C l i n i c a l l y R e l e v a n t A d j u v a n t . J Viro11991, 65:450~56. ~_ GRIFFITHS JT, PHYLIP LH, KONVALINT.AJ, STROP P, GUSTCHINAA, WLODAWER A, DAVENPORTRJ, BRIGGS R, DUNN BM, KAY J: D i f f e r e n t R e q u i r e m e n t s f o r P r o d u c t i v e I n t e r a c t i o n B e t w e e n t h e Active Site o f ItIV-1 P r o t e i n a s e a n d S u b s t r a t e s C o n t a i n i n g - H y d r o p h o b i c * H y d r o p h o b i c - o r -Aromatic* P r o C l e a v a g e Sites. Biochemistry 1992, 31:5193-5200. GROOTHUIS JR, LEVINMJ, LEHR MV, \VESTONJA, HAYWARD AR: I m m u n e R e s p o n s e t o S p l i t - P r u d u c t I n f l u e n z a Vaccine in Preterm and Full-Term Young c h i l d r e n . Vaccine 1992, 10:221 225, GUBERSKI DL, TI~OMASVA, SHEK WI~, LIKE A&, HANDLER ES, ROSSIN1AA, WALLACEJE, WELSH RM: I n d u c t i o n of T y p e - I D i a b e t e s b y K t l h a n l Rat Vi rus i n D i a b e t e s R e s i s t a n t B B / ~ / o r Rats. Science 1991, 254:1010-1013. G u o ZS, DEPAMPHIHS ML: S p e c i f i c T r a n s c r i p t i o n F a c t o r s StImulate Simian Virus 40 and Polyomavirus O r i g i n s o f DNA R e p l i c a t i o n . Mol Cell Biol 1992, 12:2514-2524. GLWI'A CK, SOKHEYJ, GLWI'A RK, SlNGH H: D e v e l o p m e n t of Allogenic Hybridomas for Production of Monoclonal Antibodies Against oral Polio V a c c i n e S t r a i n s [Letter]. Vaccine 1991, 9 : 8 5 3 ~ 5 4 . HABU~ZAN, MIYANO M, KATAOKAJ, TSUGE H, AGO H, NOMA M: S u b s t a n t i a l I n c r e a s e o f t h e I n h i b i t o r y Activity of Mirabllis Antiviral Protein by an Elimination of the Disulfide Bond with Genetic Engineering. J Biol Chem 1991, 266:23558-23560. HABUKA N, M]YANO M, KATOAKAJ, NOMA M: E s c h e r i c h i a C o l i R e i b o s o m e is I n a c t i v a t e d b y M i r a b l l i s A n t i v i r a l P r o t e i n W h i c h Cleaves t h e N - g l y c o s i d i c B o n d at A 2 6 6 0 o f 23 S r i b o s o m a l RNA. J M o / B i o l 1991, 221:737-743, HAFKEMEYER P, NEFTEL K, HOBI R, PFALTZA, Lb~fZ H, LErI~ K, FOCHER F, SPADARIS, HOBSCHER U: E ~ 0.35, a c e p h a l o s p o r i n D e g r a d a t i o n P r o d u c t is a S p e c i f i c

I n h i b i t o r o f L e n t i v i r a l R N A s e s H. Nucleic Acids Res 1991, 19:4059-4065. IIAGER MW, LIOTI"A DC: C y d i z a t i o n P r o t o c o l s f o r Controlling the Glycosidic Stereochemistry of Nucleosides - Application to the Synthesis of the A n t i v i r a l A g e n t 3 ' - A z i d o - 3 ' - D e o x y t h y m i d i n e (AZT). J A m Chem Soc 1991, 113:5117-5119. HAIGWOOD NL, NARA EL, BROOKS E, VANNEST GA, OTr G, HIGGENS K\V, DUNLOP N, SCANDELLACJ, EICHBERG j~Tg, STEIMERKS: N a t i v e B u t n o t D e n a t u r e d Recombinant Human Itllmunodeficteney Virus Typed GEl20 Generates Broad-SpcOa'um N e u t r a l i z i n g A n t i b o d i e s I n B a b o o n s . J Viro11992, 66:17~182, HALL ~¢W', ~2U CRR, SCHNEEW1NDO, TAKAIIASH1H, KAPL~N MH, ROUPE G, VAHLNTA: D e l e t e d ItTLV-I P r o v i r u s in Blood and Cutaneous Lesions of Patients with M y c o s i s F u n g o i d e s . Science 1991, 253:317-320. HALSEY NA, MARKItAMR, WAItREN B, BOULOS R, ROSSI P, X~VlGZELLH: Lack o f A s s o c i a t i o n B e t w e e n M a t e r n a l A n t i b o d i e s t o V3 l o o p P e p t i d e s a n d M a t e r n a l - I n f a n t HIV-1 T r a n s m i s s i o n . J AIDS 1992, 5:153 157. [13]. HAMILTONJD AND OTHEP~S:A C o n t r o l l e d T r i a l o f E a r l y V e r s u s Late T r e a t m e n t w i t h Z i d o v u d i n e in Symptomatic Human lmmunodeficiency Virus Infection - Results of the Veterans Affairs C o o p e r a t i v e S t u d y . N e w E n g l J M e d 1992, 326:437~43. [t&XKE T, SZAWLOWSKIP, RANDALL RE: C o n s t r u c t i o n o f Sol i d M a t r i x - A n t i b o d y - A n t i g e n C o m p l e x e s C o n t a i n i n g S i m i a n I m m u n o d e f i c i e n c y ~rtrus-p27 U s i n g T a g - S p e c i f i c M o n o c l o n a l A n t i b o d y a n d TagL i n k e d A n t i g e n . J Gen Virol 1992, 73:653-660. H&ROUSEJM, BHAT S, SPITALNIKSL, LAUGHLINM, STEFANO K, SILBERBERGDH, GONZALEZSCARANOF: I n h i b i t i o n o f E n t r y o f HIV-1 i n N e u r a l Cell L i n e s b y A n t i b o d i e s A g a i n s t G a l a c t o s y l C e r a m i d e . Science 1991, 253:320-323. HARPER J~q, LOGSDON NJ: R e f o l d e d HIV-1 T a t P r o t e i n Prot e c t s B o t h B u l g e a n d L o o p N u d e o t i d e s i n TAR RNA f r o m R i b o n u c l e o l y t i c Cleavage. Biochemistry 1991, 30:806043066. HART MK, WRINHOLD KJ, SCEARCE tLM, WASHBURN EM, CLARK CA, PALKER ~ , HAYNES BF: p r i m i n g o f Antih u m a n l m m u n o d e f i c i e n e y V i r u s ( H I V ) CD8+ C y t o t o x i c T Cells i n V i v o b y C a r r i e r - f r e e H l V S y n t h e t i c P e p t i d r s . Proc Natl A c a d Sci U S A 1991, 8S:944~9452. HARTE xYJE, SWAMINKpHAN S JR, BEVERIDGE DL: M o l e c u l a r D y n a m i c s o f HIV-1 P r o t e a s e . Proteins 1992, 13:175-194. }tASLrN~LrMAT~ TSUBOTA H, WATANABE M, CHEN ZW~ LORD CI, BURKLYLC, DALEYJF, LETVIN N~: R e g i o n s o f t h e CD4-Molecule not Involved in Virus Binding o r S y n c y t i a F o r m a t i o n a r e R e q u i r e d f o r HIV1 Infection of Lymphocytes. J lmmuno11992, 148:1841-1846. HAUSEN HE: H u m a n P a p i l l o m a v i r u s e s i n t h e P a t h o g e n e s i s o f A n o g e n i t a l C a n c e r . Virology 1991, 184:9-13. HAZU~DADJ, PERRy HC, NAYLOR AM, MCCLEMENTSWL: Characterization of the Herpes Simplex Virus O r i g i n B i n d i n g P r o t e i n I n t e r a c t i o n w i t h OtiS. J Biol C~em 1991, 266:24621-24626. liEDER A, PACAUCCARALERTKUN S, BOROS I: M u t a t i o n a l A n a l y s i s o f t h e HTLV-I T r a n s - A c t i v a t o r , Tax. FEBS Letl 1991, 292:210 212. HERBER \VK, BAILEY ~ , CARTY CE, HELMBACHJC, MAIGETTER RE: P r o d u c t i o n o f C y t o t o x i c P r o t e i n s in Escherichia-Coli - a Fermentation Process for P r o d u c i n g E n z y m a t i c a l l y Active HIV-1 Protease. Appl Microblol Biotechnol 1991, 36:149-152. HERRMA/x:q CH, SULK, HARLOW E: A d e n o v i r u s E I A is Associated with a Serine Threonine Protein K i n a s e . J Viro1199I, 65:5848. HERROELEN L, DE KEYSERJ, EBINGER G: C e n t r a l - n e r v o u s system Demyelination after Immunisatinn with R e c o m b i n a n t H e p a t i t i s B V a c c i n e . Lancet 1991, 338:1174. HINGAMP PM, ARNOLDJE, MAYER RJ, DIXON LK: A Ubtquifin Conjugating E ~ e Encoded b y A f r i c a n S w i n e F e v e r V i r u s . E M B O J 1992, 11:361-366. HIRAMATSUK, MIFL~E I~ MANNEN K, NISHIZONO A, KAWANO H, ITO Y, KAWAI A: M a p p i n g o f t h e Antigenic Determinants Recognized by Monoclonal Antibodies Against the M2 Protein o f R a b i e s V i r u s . Virology 1992, 187:472~479. HIZI A, S~LAIIARABANYM, TAL R, HUGHES StI: T h e Effects o f C y s t e i n e M u t a t i o n s o n t h e R e v e r s e Transcriptases of Human Immunodeficiency V i r u s Type-1 a n d Type-2. J Biol Chem 1992, 267:1293-1297. 1IO DD, FUNG MS, CAO YZ, LI XL, SL%"C, CHANG T~V, • SUN NC: A n o t h e r D i s c o n t i n u o u s E p i t o p e o n Glycoprotein Gpl20 that is Important in Human

InlOlunodeficiency Virus Type 1 Neutralisation is I d e n t i f i e d b y a M o n o c l o n a l A n t i b o d y . Proc Natl A c a d Sci USA 1991, S8:10%108. [20]. HO DD, FZINGMSC, CAO YZ, I~ XL, SUN C, CFLANG"INq, SUN NC: A n o t h e r D i s c o n t i n u o u s E p i t o p e o n G l y c o p r o t e i n G p 1 2 0 t h a t is lamportant i n H u l x m n I m m u n o d e f i c i e n c y v i r u s Type-1 N e u t r a l i z a t i o n i s I d e n t i f i e d b y a M o n o d o n a l A n t i b o d y . Proc N a g A c a d & i U S A 1991, 88:894943952. HO RJY, BURKE RL, MERIGAN TC: L i p o s o m c - F o r m u l a t e d I n t e r i e u k i n - 2 as a n A d j u v a n t o f R e c o m b i n a n t HSV Glycoprotein GD for the Treatment of R e c u r r e n t G e n i t a l HSV-2 i n G u i n e a - P i g s . Vaccine 1992, 10:209-213. HOLLOSI M, ISMAILAA, M.a~N~TSCHHH, pENKE B, VARADI IG, TOTH GK, LACZKO I, KURUCZ I, NAGY Z, FASMAN GD, RAJNAVOLGYIE: C o n f o r m a t i o n a l a n d F u n c t i o n a l Properties of Peptides Covering the Intersubunit R e g i o n o f I n f l u e n z a Virtm H e m a g g i u t i n i n . E u r J Biochem 1992, 2 0 6 : 4 2 1 4 2 5 . HOLZMAN TF, KOHLBRENSNERWE, WEIGL D, RITTENHOUSE J, KFaMPFD, ERICKSONJ: I n h i b i t o r S t a b i l i z a t i o n of Human Imnlunodeficiency Virus Type-2 P r o t c i n a s e D i t h e r F o r m a t i o n . J B i o l Chem 1991, 266:19217-19220. HOLZMANN H, VOROBYOVA MS, I~DYZHENSKAYAIP, FERENCZI E, •UNDI M, KbTqZ C, HEINZ FX: M o l e c u l a r Epidemiology of Tick-Borne Encephalitis Virus - Cross-Protection Between European and Far E a s t e r n S u b t y p e s . Vaccine 1992, 10:345-349. HOM RC, ~NBERG RW, MbqJANEY S, R[2?RECHT RM: Protective C e l l u l a r R e t r o v i r a l I m m u n i t y R e q u i r e s B o t h CD4+ a n d CD8+ I m m u n e T-Cells. J Viro11991, 65:22(~224. HONE DM, HARRISAM, Ct~kTFIELD S, DOUGANG, LEVINE MM: C o n s t r u c t i o n o f G e n e t i c a l l y D e f i n e d D o u b l e A r o M u t a n t s o f S a l m o n e l i a - T y p h i . Vaccine 1991, 9:8104316 HOSTETLERKY, CARSON DA, RICHMAN DD: Phosphatidylazidothymidine - Mechanism of A n t i r e t r o v i r a l A c t i o n i n CEM Cells. J B i o l CDem 1991, 266:11714-11717. HOWARD KJ, FRAW~ KB, SUM IS, LEGRICE SFj: Reconstitution and Properties of Homologous a n d C h i m e r i c m V - I . H I V - 2 P66.p51 R e v e r s e T r a n s c r i p t a s e . J Biol Chem 199I, 266:23003-23009. HSU M C, SCHDTf AD, HOLLY M, SLICE LW, SHERMAN MI, RICHMAN DD, POTASH MJ, VOLSKY DJ: i n h i b i t i o n o f H I V R e p B c a t i o n i n Acute a n d C h r o n i c I n f e c t i o n s i n V i t r o b y a T a t A n t a g o n i s t . Science 1991, 254:1799-1801. HU SL, ABRAMSK, BARBER GN, MORAN P, ZARI/NG JM, LANGLOIS AJ, KUKLERL, MORTON WR, BENVENISTE RE: P r o t e c t i o n o f M a c a q u e s A g a i n s t SIV I n f e c t i o n b y S u b u n i t V a c c i n e s o f SIV E n v e l o p e G l y c o p r o t e i n G p 1 6 0 . Science 1992, 255:456--459. HUANG J, VAN DER ELOEG LHT: R e q u i r e m e n t o f a Polypyrimidine Tract for Trans-splieing in T r y p a n o s o m c s : D i s c r i m i n a t i n g t h e PARE Promoter from the Immediately Adjacent 3' S p l i c e A c e e p t o r Site. E M B O J 1991, 10:3877-3886. HUANG ML, ESSEXM, LEE TH: l o c a l i z a t i o n o f Imamunogenic DomaLqs in the Human I m m u n o d e t i c i e n c y V i r u s Type-2 E n v e l o p e . J Virol 1991, 65:5073-5079. HUANG P, FARQUHARD, PI.UNKETI' W: Selective A c t i o n o f 2', 3 ' - D i d c h y d r o - 2', 3 ' - D i d e o x T t h y m i d i n e Triphosphate on Human Immunodeflciency Virus Reverse Transcriptase and Human DNA P o l y m e r a s e s . J B i o l Chem 1992, 267:2817-2822. HU~BNERA, KRUHOFFERM, GROSSE F, KRAUSSG: F i d e l i t y o f Human Immunodeficiency Virus Type I Reverse T r a n s c r i p t a s e i n C o p y i n g N a t u r a l RNA. JMo113iol 1992, 223:595~600. HUGHES HPA, C&MPOS M, LITfELVANDEN~IURKSVD, ZAMB T, SORDILLO lad, GODSON D, BABIIJK LA: Multiple Administration with Interleukin2 Potentiates Antigen-Specific Responses to Subunit Vaccination with Bovine Herpesvirus-1 G l y e o p r o t e i n - I V . Vaccine 1992, 10:226-230. HbT&~ WM, MILLER WJ: A n a l y s i s o f a V a c c i n e Purification Process by Capillary Electrophoresis. J Chromatogr 1991, 559:337-343. HUTCHINSON DW: N e w A p p r o a c h e s t o t h e S y n t h e s i s o f A n t i v i r a l N u c l e o s i d e s . 7~'ends Biotechnol 1990, 8:348-353. HWANG SS, BOYLE TJ, LYERLYHK, CULLENBR: I d e n t i f i c a t i o n o f t h e E n v e l o p e V3 l o o p as t h e P r i m a r y D e t e r m i n a n t o f Cell T r o p i s m i n HlV-1. Science 1991, 253:71-74. IKEGAMI S, ISOMUP.AH, TSUCI~MORI N, OSANO YT, HAYASE T, YUGAMI T, OHRISHI H, MATSUZAKIT: S t r u c t u r e o f P y r r u l o s i n e - a N o v e l I n h i b i t o r o f RNA S y n t h e s i s , from the Actinomycete Streptomyces-Albus. J Am Chem Soc 1990, 112:9668-9669 IMBEWH L, SOTrINq A, BETTINARDI A, PUO~I M, PRIMI D: Selective D e p l e t i o n i n H I V I n f e c t i o n o f T-

727

728

Pharmaceutical applications Vaccines, viruses and AIDS Cells t h a t B e a r Spe c i fi c T-Cell R e c e p t o r - V b c t a S e q u e n c e s . Science 1991, 254:860-862. INCHAUSPE G, ZEBEDEE S, LEE DH, SUGITANIM, NASOFF M, PRINCE AM: C~enomic S t r u c t u r e o f t h e Human Prototype Strain-H of HepatitisC Virus - Comparison with American and J a p a n e s e Isolates. Proc Natl A c a d Sci U S A 1991, 88:10292-10296. IRIE H, ~IARADA Y, KATAOKAM, NAGAML~IAM, MORIYA Y, HANDA M, SMTO M, MATSUBARAS, KOJlMA K, SUGA\VARAY: Efficacy o f O r a l A d m i n i s t r a t i o n o f Live H e r p e s S i m p l e x V i r u s Type-1 as a Vaccine. J ~ r o l 1992, 66:2428~2434. ISHLMIY, NISIIIZAWA M, ANDOtl T: c h a r a c t e r i z a t i o n o f a C a m p t o t h e e i n - R e s i s t a n t H u m a n DNA Topoisomerase-I in an havitro System for Simian V i r u s - 4 0 DNA R e p l i c a t i o n . E u r J B i o c b e m 1991. 202:835439. ISRAEL S, HON~GM&'q A: A B i o l u m i n e s e e n c e A s s a y f o r Gene Expression by Continuously Growing M ~ m m a l t a n Cell~ - A p p l i c a t i o n f o r D e t e c t i o n o f H u m a n I m m u n o d e f i c i e n c y V i r u s T y p e d (HIV-1). Gene 1991, 104:139-145. ISSEL CJ, HOROHOV DW, I2A DF, ADAMS W'V, HAGIUS SD, MCMANUSJM, ALLISONAC, MON~I~?LARORC: Efficacy of Inactivated Whole-Virus and Subunit Vaccines in Preventing Infection and Disease Caused by E q u i n e I n f e c t i o u s A n e m i a Virus. J Viro11992, 66:339~3408. IVANOFF LA, DUBAY JW, MORRIS JF, ROBERTS SJ, GUTSHALL L, STERNBERG EJ, HUN~XR E, MATITIE\VST~, PETTEWAY SR: V3 L o o p R e g i o n o f t h e HIV-1 G p 1 2 0 E n v e l o p e P r o t e i n is E s s e n t i a l f o r V i r u s Infectivity. Virology 1992, 187:423-432. JACOBOMOLINA A, ARNOLD E: H I V R e v e r s e T r a n s c r i p t a s e S t r u c t u r e - F u n c t i o n R e l a t i o n s h i p s . Biochemistry 1991, 30:6351(o361. JACOBO-MOLINA A, CLARKAD JR, WILLIAMS RL, NA~X RG, CLARK P, FERNS AL, HUGttES SH, ARNOLD E: Crystals of a ternary Complex of Human Immunodeliciency Virus Type 1 Reverse Transeriptase with a Monoclonal Antibody Fab F r a g m e n t a n d D o u b l e - s t r a n d e d DNA Diffract Xr a y s to 3.5-A R e s o l u t i o n . Proc NatI A c a d Sc'~ U S A 1991, 88:10895-10899. JAGADISH MN, LAUGHTON DL, AZAD AA, MACREADIE IG: S t a b l e S y n t h e s i s o f V i r a l P r o t e i n - 2 o f Infectious Bursal Disease Virus in SaccharomycesC e r e v i s i a e . Gene 1991, 108:275-279. JAVAHERIAN K, LANGLOISAJ, SCHMIDT S, KAUFM2LNNM, CA'I~:S N, LANGBDIJKJPM, MELOEN RH, DESROSIERSRC, BURNS DPW, BOLOGNE.SIDP, LAROSA GJ, PUTN~y SD: T h e Principal Neutralization Determinant of Simian I m m u n o d e f i c i e n c y V i r u s Differs f r o m t h a t o f H u m a n I m m u n o d e f i c i e n c y V i r u s Type-1. Proc Natl A c a d Sci U S A 1992, 89:1418-1422. JERTBORN M, SVENN~ERHOLMAM, HOLMGKENJ: Safety a n d Immunogenieity of an Oral Recombinant Cholera B - S u b u n i t - W h o l e Cell V a c c i n e i n S w e d i s h V o l u n t e e r s . Vaccine 1992, 10:130-132. Jl JP, LOBB LA: F i d e l i t y o f HIV-1 R e v e r s e T r a n s c r i p t a s e C o p y i n g RNA I n v i t r o . Biochemistry 1992, 31:954-958. JOHNSON PR, HAMM TE, GOLDSTEIN S, KITOV S, HIRSCH VM: T h e G e n e t i c Fate o f M o l e c u l a r l y C l o n e d S i m i a n lmm,lnodeficiency Virus in Experimentally I n f e c t e d M a c a q u e s . Virology 1991, 185:217-228. JOHNSON PR, MONTEFIOPd DC, GOLDSTEIN S, HAMM TE, ZHOU J, KITOV S, H2dGWOOD NL, MISHER L, LONDON WT, GERIN JL, ALLISONA, PURCELL RH, CHANOCK RM, HIRSCH VM: I n a c t i v a t e d W h o l e - v i r u s V a c c i n e Derived from a Proviral DNA Clone of Simian l m m , m o d ¢ f i c i e n c y V i r u s I n d u c e s H i g h Leveis o f Neutralizing Antibodies and Confers Protection A g a i n s t H e t e r o l o g o u s C h a l l e n g e . Proc Natl A c a d Sci U S A 1992, 89:2175-2179 JOLY E, MUCKE L, OLDSTONE MBA: Vi ral P e r s i s t e n c e i n N e u r o n s E x p l a i n e d b y Lack o f M a j o r H i s t o c o m p a t i b i l l t y Class-1 E x p r e s s i o n . Science 1991, 253:1283 1285. JONES TR, MUZITHRASVP, GLUZMAN Y: R e p l a c e m e n t Mutagenesis of the Human Cytomegalovirus G e n o m e - US10 a n d U S l l G e n e P r o d u c t s are N o n E s s e n t i a l J Viro11991, 65:5860-5879. KALVAKOLANUDVR, ABRAHAM A: P r e p a r a t i o n a n d Characterization of Immtmoliposomes for T a r g e t i n g o f A n t i v i r a l A g e n t s . Biotechniques 1991, 11:218. KALVAKOLANUDVR, BANDYOPADHYAY8K~ HARTER ML, SEN GC: I n h i b i t i o n o f I n t e r f e r o n - i n d u c i b l e G e n e Expression by Adenovtrus EIA Proteins: Block i n T r a n s c r i p t i o n a l C o m p l e x F o r m a t i o n . Proc Natl A c a d Sci U S A 1991, 88:7459-7463. K~NESAKI T, MURPHY BR, COLLINS PL, OGRA PL: Effectiveness of Enteric Immunization in the Development of Secretory ImmunogiobulinA Response and the Outcome of Infection

w i t h R e s p i r a t o r y S y n c y t i a l Virus. J Viro11991, 65:657~63. K&NG CY, NARA P, CHAMATS, CARALLIV, CHEN A, NGLWEN ML, YOSHIYAMAH, MORROW WJ~V, HO DD, KOHLER H: A n t i - I d i o t y p e M o n o c i o n a l A n t i b o d y Elicits Broadly Neutralizing Anti-gpl20 Antibodies i n M o n k e y s . Proc Natl A c a d Sci U S A 1992, 89:2546-2550. KARAYI~NNIS P, OROURKE 8, MCGARVEYMJ, LUTIIER S, WATERS J, GOLDIN R, THOMAS HC: A R e c o m b i n a n t Vaccinia Virus Expressing Hepatitis-A Virus Structural Polypeptides -Characterization and Demonstration of Protective Immunogenicity. J Gen Viro11991, 72:2167-2172. KARPATKIN S, NARDI M: A u t o i m m t m e A n t i HlV-1 G p l 2 0 A n t i b o d y w i t h A n t i I d i o t y p e Like A c t i v i t y i n S e r a a n d I m m u n e C o m p l e x e s o f HIV-1 R e l a t e d I m m u n o l o g i c T h r o m b o c y t u p e n i a . J Clin Invest 1992, 89:356-364. [36]. KARPATKIN S, NABDI idA, KOURI YH: i n t e r n a l I m a g e A n t i - i d i o t y p e tIIV-1 G p 1 2 0 A n t i b o d y i n H u m a n I m m u n o d e f l c i e n c y V i r u s 1 (HIV-1) S e r o p o s i t i v e I n d i v i d u a l s w i t h T h r o m b o e y t o p e n i a . Proc Natl A c a d Sci USA 1992, 89:148~1491. [35]. KARUHAH G, WOODHAMS CE, BLANDEN RV, RAMSHAWIA: lmmunohiology of Infection with Recombinant V a c e i n i a V i r u s E n c o d i n g M u r i n e IL-2 Mechanisms of Rapid Viral Clearance in l m m u n o e o m p c t e n t Mice. J l m m u n o 1 1 9 9 1 , 147:4327~332. I~AUMAYAPTP, VANBUSKIRKAM, GOLDBERG E, FIERCE SK: D e s i g n a n d I m m u n o l o g i c a l P r o p e r t i e s o f Topographic Immlmogenie Determinants of a P r o t e i n A n t i g e n (LDH-C4) as V a c c i n e s . J Biol Chem 1992, 267:6338~6346. KEHOE MA: G r o u p - A S t r e p t o c o c c a l A n t i g e n s a n d V a c c i n e PotentiaL Vaccine 1991, 9 : 7 9 7 4 0 6 . KELM S, PALrLSONJC, ROSE U, BROSSMERR, SCHMID W, BANDGAR BP, SCHREINERE, HARTM~NN M, ZBIRAL E: Use o f Sialic Acid A n a l o g u e s to D e f i n e F u n c t i o n a l G r o u p s i n v o l v e d i n B i n d i n g to t h e I n f l u e n z a V i r u s H e m a g g i u t i n i n . E u r J Biocbern 1992, 205:147-153. KERR SM, JOHNS'ION LH, ODELL M, DUNCAN SA, LAW KM, SMITH GL: V a c c i n i a D N A Ligase C o m p l e m e n t s S a c e h a r o m y e e s C e r e v i s i a e Cdc9 L o c a l i z e s i n C y t o p l a s m i c F a c t o r i e s a n d Affects V i r u l e n c e a n d V i r u s S e n s i t i v i t y t o D N A D a m a g i n g A g e n t s . EMBO J 1991, 10:43434350. K I ~ A N TG: C o m p a r a t i v e Efficacy o f 3 D o s e s o f the Genetically Engineered Aujeszky's Disease V i r u s V a c c i n e S t r a i n 783 i n Pigs w i t h M a t e r n a l A n t i b o d i e s . Vaccine t992, 10:363-365. KION T, HOFFMAN G: A n t i - H I V a n d A n t i A n t i - M H C e. Antibodies in Alloimmune and Autoimmune Mice. Science 1991, 253:1138-1139. [2]. KJEMSJ, CALNANBJ, FRANKELAD, SHARP PA: S p e c i f i c B i n d i n g o f a B a s i c P e p t i d e f r o m HlV-1 Rev. EMBO J 1992, 11:1119-1130. KNOWI~:S DP, CHEEVERSWP, McGUIRE TC, BRASSFIELD AL, HARWOOD WG, STEM TA: S t r u c t u r e a n d Genetic variability of Envelope Glycoproteins of Two Antigenic Variants of Caprine Arthritis E n c e p h a l i t i s L e n t t v t r u s . J Viro11991, 65:5744. KONVALINKAJ, HOtLEJSIM, ANDR~tNSKY M, NOVEK P, PICHOVA I, BLgMA I, FABRY M, SEDI~CEK J, FOUNDLING S, STROP P: A n E n g i n e e r e d R c t r o v i r a l P r o t e i n a s e from Mycioblastusis Associated Virus Acquires PH D e p e n d e n c e a n d S u b s t r a t e S p e c i f i c i t y o f t h e HIV-1 P r o t e i n a s e . E M B O J 1992, 11:114i-1144. KRUG MS, BERGER SL: R e v e r s e T r a n s c r i p t a s e f r o m Human Immunodeficiency Virus - a ~ingle T e m p l a t e - P r i m e r B i n d i n g Site S e r v e s 2 P H y s i c a l l y S e p a r a b l e Catalytic F u n c t i o n s . Biochemistry 1991, 30:10614-10623. KULKOSKYJ, JONTS KS, KATZ RA, MACKJPG, SKALKA AM: R e s i d u e s C r i t i c a l f o r R e t r o v i r a l i n t e g r a t i v e R e c o m b i n a t i o n i n a R e g i o n t h a t is H i g h l y Conserved Among Retroviral/Retrotransposon Integrases and Bacterial Insertion Sequence T r a n s p o s a s e s . Mol Cell Biol 1992, 12:2331-2338. KUMARV, BANSALVJ, RAO KVS, JAMEEL S: H e p a t i t i s B Virus Envelope Epitopes - Gene Assembly and Expression in Escherichia-Coli of an Immunologically Reactive Novel Multiple-Epitope P o l y p e p t i d e - 1 (MEP-1). Gene 1992, 110:13%144. KUO LY, KANATZIDISMG, SABATM, TIPTON AL, MARKS ~3: M e t a l l o c e n e A n t i t u m o r A g e n t s - S o l u t i o n a n d Solid-State M o l y b d e n o c e n e C o o r d i n a t i o n C h e m i s t r y o f D N A C o n s t i t u e n t s . J A m Chem Soc 1991, 113:9027-9045. KLrYER BJ, WHBEL RE, GUESS HA, MATI~IBWS H, MORTON DH, NEFF BJ, PROVOS] PJ, WATSON BA, STARR SE, PLOTKIN SA: O k a / M e r c k V a r i c e l l a V a c c i n e i n H e a l t h y C h i l d r e n - F i n a l R e p o r t o f a 2-Year Efficacy S t u d y a n d 7-Year F o l l o w - U p S t u d i e s . Vaccine 1991, 9 : 6 4 3 ~ 4 7 .

IACZKO I, HOLLOSI M, URGE L, UGEN KE, WEtNER DB, MANTSCH ttH, THURIN J, OTVOS L: S y n t h e s i s a n d Conformational Studies of N-Glycosylated A n a l o g u e s o f t h e HIV-1 P r i n c i p a l N e u t r a l i z i n g D e t e r m i n a n t . Biochemistry 1992, 31:4282-4288, I ~ ME, MELIS A, MAZZOLENI2~P, FARCI P, BALESTRIERIA: Sequence Analysis of Hepatitis B Virus Genome of a New Mutant of Ayw Subtype Isolated in S a r d i n i a . Nucleic A c i d s Res 1991, 19:5078. LAL RB, RUDOLPH DL, GPdFHS KP, KrFAMURAK, HONDA M, COLIGAN JE, FOLKS TM: C h a r a c t e r i z a t i o n o f Immllnodominant Epitopes of Gag and Pol GeneE n c o d e d P r o t e i n s o f H u m a n T-Cell L y m p h o t r o p i c V i r u s T y p e - I. J Viro11991, 65:t870-1876. LANGEDIJKJPM, BACK NKT, DU'RDA PJ, GOUDSMITJ, MELOEN RH: N e u t r a l i z i n g Activity o f A n t i - P e p t i d e Antibodies Against the Principal Neutralization D o m a i n o f H u m a n I m m u n o d e f i c i e n c y V i r u s Type1. J Gera Virol 1991, 72:2519-2526. LANGFORD PR, WILLIAMSAE, MOXON ER: I m m l l n o g e n t c Outer-Membrane Proteins of HaemophilusI n f l u e n z a e Type-b i n I n f e c t i o n . J Gen Microbiol 1992, 138:155-159. L&NGHOFF E, TERWILLIGER EF, BOS Hj, KALLANDKH, POZNANSKY Me, BACON OML, HASELTINEWA: Replication of Human Immunodeficiency Virus Type-1 i n P r i m a r y D e n d r i t i c Cell C u l t u r e s . Proc Natl A c a d Sci U S A 1991, 88:7998~002. LARSONJK, WUN1N2RXX/tt, OTVOS L, ERTL HC: Identification of an Immunodominant Epitope within the Phosphoprotein of Rabies Virus that is R e c o g n i z e d b y B o t h C l a s s 1 R e s t r i c t e d a n d c l a s s 11 R e s t r i c t e d T Cells. J Viro11991, 65:5673. LATHEYJL, SPECTOR SA: U n r e s t r i c t e d R e p l i c a t i o n t o Human Cytomegalovirus in Hydrocortisone T r e a t e d M a c r o p h a g e s . J Viro11991, 65:6371. LAURENTCRAWFORDAG, KRUST B, MLZLER S, PJVIERE Y) REYCUILLE MA, BECHET JM, MONTAGNIERL, HOVANESSIANAG: T h e C y t o p a t h i c Effect o f H I V is A s s o c i a t e d w i t h A p o p t u s i s . Virology 1991, 185:829439. LE GRICE SFJ, NAAST, WOHLGENSINGER B, SCHKI'Z O: Subunit-selective Mutagenesis Indicates Minimal P o l y m e r a s e Activity i n H e t e r o d i m e r - a s s o c i a t e d PS1 I-IlV-1 Reverse T r a n s c r i p t a s e . E M B O J 1991, 10:3905-3912. LEBLANCJF, HISCO1TJ: D i f f e r e n t i a l R e s p o n s e o f H u m a n Interferon-beta Promoter Elements to TransA c t i v a t i o n b y HSV-VP16 a n d IRF-1. Virology 1992, 186:760-763. LEBOWITZ JH, COBUI~N CM, BEVERLEYSM: S i m u l t a n e o u s Transient Expression Assays of the T r y p a n o s o m a t i d P a r a s i t e L e i s h m a n i a U s i n g BetaG a l a c t o a l d a s e a n d B e t a - G l u c u r o n i d a s e as R e p o r t e r E n z y m e s . Gene 1991, 103:119-123. LEDERER 1I, SCHATZ O, MAY R, CRESPI H, DARLIXJ L, LB GPdCE SFJ, HEL~AAN~ H: n o n l a i l l S t r u c t u r e o f the Human Immunodeficiency Virus Reverse T r a n s c r i p t a s e . E M B O J 1992, 11:1131 1140. LEE MGS, VANDERPLOEG LHT: T h e M y g r o m y c i n - B R e s i s t a n c e - E n c o d i n g G e n e as a S e l e c t a b l e M a r k e r for Stable Transformation of TrypanosomaB r u c e L Gene 1991, 105:255-257. LEE WR, SYIJ wJ, DU B, MATSUDAM, TAN S, WOLF A, ESSEX M, LEE TH: N o n r a n d o m D i s t r i b u t i o n o f G p 1 2 0 N - l i n k e d G l y c o s y l a t i o n Sites I m p o r t a n t f o r Infectivity of Human lmmunodeficiency Virus T y p e 1. Proc Natl A c a d Sci U S A 1992, 89:2213-2217. LEENUANG S, HUANG PL, KUNG HF, I2 BQ, HUANG PL, HUANG P, HUANG HI, CHEN HC: TAP-29 - a n AntiHuman Immunodeticiency Virus Protein from T r i c h o s a n t h e s - K i r t l o w l i t h a t is N o n t o x i c t o i n t a c t Cells. Proc Natl A c a d Sci U S A 1991, 88:657045574. LEEHUANG S, KISNG HF~ HUANG PL, HUANG PL, LI BQ, HUANG P, HU&NG HI, CHFaNHC: A N e w c l a s s o f AntiH I V A g e n t s -GAP-31, DAP-30 a n d DAP-32. FEI3S Lett 1991, 291:139-144. LEGUEP~NM, LEVYJA: H u m a n I m m l l n o d e f i e i e n c y V i r l ~ ( H I V ) Type-1 c a n S u p e r i n f e c t H 1 V - 2 J n f e c t e d Cells - Pseudotype Virions Produced with Expanded C e l l u l a r H o s t R a n g e . Proc Natl A c a d Sci U S A 1992, 89:363-367. LENTZ TL: S t r u c t u r e - F u n c t i o n R e l a t i o n s h i p s o f C u r a r e m i m e t i c N e u r o t o x i n Loop-2 a n d o f a Structurally Similar Segment of Rabies Virus Glyeoprotein in Their Interaction with the N i c o t i n i c A c e t y l c h o l i n e R e c e p t o r . Biochemistry 1991, 30:10949-10957. LEVINE B, HARDWICKJM, TRAPP BD, CRAWFORDTO, BOLLINGER RC, GPdFHN DE: A n t i b o d y - M e d i a t e d Clearance of Alphavirus Infection from Neurons. Science 1991, 2 5 4 : 8 5 6 4 6 0 . LEWNNJD, ALLANJD, TESSITOREJH, FALCONE N, GALASSO F, ISRAELRJ, GROOPMANJE: R e c o m b i n a n t Human Granulocyte-macrophage Colonystimulating Factor Ameliorates Zidovlldineinduced Neutropenia in Patients with Acquired

Pharmaceutical applications Vaccines, viruses and AIDS lmm~modeficiency Syndrome (AIDS)/AIDS-related C o m p l e x . Blood i991, 78:3148-3154. LI JS, TONG SP, VY[W1TSKJL, I2~POT D, TI~:PO C: T w o French Genotypes of Hepatitis-C Virus Homology of the Predominant Genotype with t h e P r o t o t y p e A m e r i c a n S t r a i n . Gene 1991, 105:167-172. LI QX, YOUNG LS, NIEDOBITEK G, DAWSON CW, BIRKENBACII M, WANG F, RICKINSONAB: E p s t e i n Barr Virus Infection and Replication in a Human E p i t h e l i a l Cell S y s t e m [Letter]. Nature 1992, 356:347-349. La T, ZHANG A, IIZU~A N, NOMOTO A, AILNOLD E: C r y s t a l l i z a t i o n a n d P r e l i m i n a r y X-ray D i f f r a c t i o n S t u d i e s o f C o x s a c k i e v i r u s B1. JMol Bio11992, 223:1171-1175. LIAW YC, GAO YG, MARQI~Z VE, WANG AHJ: M o l e c u l a r Structures of Two New Anti HlV Nucleoside A n a l o g s : 9 - ( 2 , 3 - d i d e o x y - 2-fl uoro-Bct a -D-t hreol~ntofuranysyl)hypoxanthine. Nucleic Acids Res 1992, 20:459-465. LIAW YC, GAO YG, ROBINSON H, WANG AVlJ: M o l e c u l a r S t r u c t u r e o f a P o t e n t HIV-1 I n h i b i t o r B e l o n g i n g to the TIBO Family. J A m Chem Soc 1991, 113:1857-1859. LIDDINGTON RC, WAN Y, MOULM J, SAHLI R, BE?qJ&MINTL, HARRISON SC: S t r u c t u r e o f S i m i a n V i r u s 40 at 3.8-A R e s o l u t i o n . Nature 1991, 354: 27~283. LINDER M, LANDERD, HAHNEN J, SCHOTT HH, STIPaMS: Localization of the Intrachain Disulfide Bonds o f t h e E n v e l o p e G l y e o p r o t e i n 71 f r o m F r i e n d M u r i n e L e u k e m i a V i r u s . EurJ Biochem 1992, 203:65-73. LLNDSTROME, KOGA Y, WIGZELL H: HIV-1 G e n e R e v Responsible for Accumulated Heterodisperse RNAs S e e n i n I n f e c t e d T-Cells. Virology 1992, 186:335-338. LI'UI%ERE, STUARTAD, CHEE MS: H u m a n C y t o m e g a l o v t r u s UL97 O p e n R e a d i n g F r a m e Encodes a Protein that Phosphorylates the Antiviral Nueleoside Analogues Ganciclovir [Letter]. Nature 1992, 358:160~161. LIU DX, CAVKNAGHD, GREEN P, INGLIS SC: A P o l y c i s t r o n i e MRNA S p e c i f i e d b y t h e C o r o n a v i r u s I n f e c t i o u s B r o n c h i t i s V i r u s . Virology 1991, 184:531-544. LODMELL DL, SL~LNERJW, ESPOSITO JJ, BELLI,N~WJ, EWALT LC: R a c c o o n P o x v i r u s R e c o m b i n a n t s E x p r e s s i n g t h e R a b i e s V i r u s N u d e o p r o t e i n P r o t e c t Mice A g a i n s t L e t h a l R a b i e s V i r u s I n f e c t i o n . J Viro11991, 65:3400-3405. LOEB DD, HIRSCH RC, GANEM D: S e q u e n c e - i n d e p e n d e n t RNA Cleavages G e n e r a t e t h e P r i m e r s f o r Plus S t r a n d DNA S y n t h e s i s i n H e p a t i t i s B V i r u s e s : Impilcatious for Other Reverse Transcribing E l e m e n t s . EMBOJ 1991, 10:3533-3540. LOHMAN KL, CARPdLLOMA, K~WN'EDYRC: S e q u e n c e Analysis of the variable Region of a Mouse Gene Encoding a Monoclonal Anti-Idiotypie Antibody t h a t Detects a R e s t r i c t e d I d i o t y p e o n Anti-HIV-1 G p 1 6 0 . Gene 199i, 105:283-284. LORET EP, VIVES E~ HO laS~ ROC~LATH, VANPdETSCHOTEN J, JOHNSON w e : A c t i v a t i n g R e g i o n o f HIV-1 Tat Protein - Vacuum UV Circular Dichroism a n d E n e r g y M i n i m i z a t i o n . Biochemistry 1991, 30:6013q5023. LOb'DON RP, MORASKAAF, HUBER SA, SCHWLMMBECK P, SCIIULTHEISSP: A n A t t e n u a t e d V a r i a n t o f C o x s a c k i e v i r u s B3 P r e f e r e n t i a l l y I n d u c e s I m m u n o r e g u l a t o r y T Cells Invivo. J Virol 1991, 65:5813 LOUIS JM, MCDONALD RA, NASH~D NT~ WONDRAK EM, JERINA DM, OROSZLAN S, MORA PT: A u t o p r o c e s s i n g o f t h e HIV-1 P r o t e a s e U s i n g P u r i f i e d W i l d - T y p e a n d M u t a t e d F u s i o n P r o t e i n s E x p r e s s e d at H i g h Levels i n E s c h e r i c h i a - C o l L EurJ Biochem 1991, 199:361-369. LUBER B, BURGELT E, FROMENTAL C, KANNO M, KOCH W: Mulliple Simian Virus 40 Enhancer Elements Mediate the Trans-Activating Function of the X - P r o t e i n o f H e p a t i t i s - B V i r u s . Virology 1991, 184:808~13. MA QF, BATHL~RSTIC, BARR PJ, KENYON GL: T h e O b s e r v e d Inhibitory Potency of 3'-Azido-3'-D¢oxythyma'dine 5 ' - T r i p h o s p h a t e f o r HIV-1 R e v e r s e T r a n s c r i p t a s e D e p e n d s o n t h e L e n g t h o f t h e Pol y(rA) R e g i o n o f t h e T e m p l a t e . Biochemistry 1992, 31:t375-1379. MACE K, SEIF I, ANJARD C, DEMAEYERGLqGNARDJ, DODON 3/if), GAZZOLO L, DEMAEYERE: E n h a n c e d R e s i s t a n c e t o HIV-1 R e p l i c a t i o n i n U 9 3 7 Ceils S t a b l y T r a n s f e c t e d w i t h t h e H u m a n IFN-beta G e n e B e h i n d a n M H C P r o m o t e r F r a g m e n t . JImmunol 1991, 147:3553-3559. MADY BJ, ERBE DV, KURANE I, FANGER M~v~, ENNIS FA: Antibody-Dependent Enhancement of Dengue Virus Infection Mediated by Bispeeific Antibodies A g a i n s t Cell S u r f a c e M o l e c u l e s O t h e r T h a n Fcg a m m a R e c e p t o r s . J lmmuno11991, 147:3139-3144,

MAEKAWA T, SUDO T, KU'RIMOTOM, ISHII S: U S F R e l a t e d T r a n s c r i p t i o n Factor, HIV-TF1, S t i m u l a t e s Transcription of Human Immunodeficiency virus 1. Nucleic Acids Res 1991, 19:4689-4694. MALDARELLI F, MAR'I1N .VIA, STREBELK: I d e n t i f i c a t i o n o f P o s t t r a n s c r i p t i o n a l l y Active I n h i b i t o r y S e q u e n c e s i n H u m a n I m m u n o d e f i c i c n c y V i r u s T y p e 1 RNA - N o v e l Level o f G e n e R e g u l a t i o n . J Viro11991, 65:5732-5756. I'VIAN'CAF, HABESHAWJ, DALGLEISH A: T h e N a i v e • R e p e r t o i r e o f H u m a n T H e l p e r Cells Specific f o r G p 1 2 0 t h e E n v e l o p e G l y c o p r o t e i n o f HlV. J Immunol 1991, 146:1964-1971. [38]. MARCHhN1 A, TOMKINSON B, COHEN JI, KIEFF E: BHRF1 t h e Epstein Barr Virus Gene with Homology to Bc12 is D i s p e n s i b l e f o r L y m p h o c y t e B T r a n s f o r m a t i o n a n d V i r u s R e p l i c a t i o n . J Virol 1991, 6 5 : 5 9 9 1 4 0 0 0 . MARCINIAK RA, SHARP PA: I-HV-1 T a t P r o t e i n P r o m o t e s Formation of More Procassive Elongation C o m p l e x e s . EMBOJ 1991, 10:4189-4196. MATSUURAY, MAEKAWAM, HATTORI S~ IKEGAMI N, ttAYASHI A, YAMAZAKIS, MORITA C, TAKEBE Y: Purification and Characterization of Human I m n l u n o d e f i c i e n c y V i r u s Type-1 N e f G e n e P r o d u c t E x p r e s s e d b y a R e c o m b i n a n t B a c u l o v i r u s . Virology 1991, 184:580-586. MATrHEWS MAH, MARKOWITZ RB, DYNlhN WS: I n v i t r o Activation of Transcription by the Human T-Cell l a e u k e m l a V i r u s Typc-I T a x P r o t e I n . Mol Cell Biol 1992, 12:1986-1996. MCCUNE J, KANESHIMAH, KROWKAJ, NAMIKAWAR, OUTZEN "" M, PEAULT B, RABIN L, SHIH CC, YEE E, LIEBEMMNM, ET A£: T h e SCID H u M o u s e : a S m a l l A n i m a l M o d e l f o r H I V I n f e c t i o n a n d P a t h o g e n e s i s . Annu Rev lmmuno11991, 9 : 3 9 9 4 2 9 . [45]. MCEWEN J, LEVI R, HORWITZ RJ, ARNON R: S y n t h e t i c Recombinant Vaccine Expressing Influenza Haemaggiutinin Epitope in Salmonella Flagellin Le a ds t o P a r t i a l P r o t e c t i o n i n Mice. Vaccine 1992, 10:405-411. MCGHEE JR, MESTECKYJ, DERTZBAUGH MT, ELDRIDGEJH, HIRASAWA M , K I Y O N O H: T h e M u c o s a l I m m u n e System -from Fundamental Concepts to Vaccine D e v e l o p m e n t . Vaccine 1992, 1 0 : 7 5 4 8 , MCGREGOR JM, ET AL.: P a p i l l o m a v i r u s e s , P53, a n d C e r v i c a l C a n c e r [Letter]. Lancet 1992, 339:1350. MCIAIN L, MORGAN DJ, DLMMOCKNJ: P r o t e c t i o n o f M i c e from Lethal Influenza by Defective Interfering V i r u s - T-Ceil R e s p o n s e s . J Gen Viro11992, 73:375-381. MCLINDENJH, PLOPLIS VA, FRASERMJ, ROSEN ED: Expression of Foreign Epitopcs on Recombinant O c c l u s i o n B o d i e s o f B a c u l o v i r u s e s . Vaccine 1992, 10:231-237. MCSHAN WM, ROSSEN RD, LAUGHTERAH, TRIA£ J, KESSLER DJ, ZENDEGL~JG, HOGAN ME, ORSON FM: I n h i b i t i o n o f T r a n s c r i p t i o n o f HIV-1 i n I n f e c t e d H u m a n Cells b y O l i g o d e o x y n u e l e o t i d e s D e s i g n e d t o F o r m D N A T r i p l e H e l i c e s . JBiol Cbem 1992, 267:5712-5721. MEEROVITCH K, NICHOLSON R, SON~NBERG N: I n v i t r o M u t a t i o n a l A n a l y s i s o f Cis A c t i n g RNA Translational Elements within the Poliovirus T y p e 2 5' U n t r a n s l a t e d R e g i o n . J Viro11991, 65:5895-5909. MEITIN CA, BENDER BS, SMALL PA: I n f l u e n z a I m m u n i z a t i o n - I n t r a n a s a l Live V a c e l n i a Recombinant Contrasted with Parenteral i n a c t i v a t e d Vaccine. Vaccine 1991, 9:751-756. ~MENDELSONE, GROSSMANZ, MILEGLRRF, RECHAVIG, CARTER BJ: R e p l i c a t i o n o f A d e n o - A s s o c l a t e d V i r u s T y p e 2 i n H n m a n L y m p h o c y t i c Cells a n d I n t e r a c t i o n w i t h HIV-1. Virology 1992, 187:453~i63. MERGENER K, FACKE M, WELKER R, BmlXrKM&NNV, GELDERBLOM HR, KRAUSSLICHHG: A n a l y s i s o f H I V Particle Formation Using Transient Expression of S u b v i r a l C o n s t r u c t s i n M a m m a l i a n Cells. Virology 1992, 186:25-39. MERIGAN TC, AND OTHERS: A C o n t r o l l e d T r i a l o f Gancielovir to Prevent Cytoraegalovtrus Disease a f t e r H e a r t T r a n s p l a n t a t i o n . New EnglJ Med 1992, 326:1182-1186. METCALF P, CYRKIAFF M, ADPa~N M: T h e T h r e e dimensional Structure of Reovirus Obtained b y C r y o - e l e c t r o n M i c r o s c o p y . EMBO J 1991, 10:3129-3136. MEYERS G, WIRBLICH C. THIEL HJ: R a b b i t H e m o r r h a g i c Disease virus - Molecular Cloning and Nueleotide S e q u e n c i n g o f a C a l l c i v i r u s G e n o m e . Virology 1991, 184:6644576. MICHIE C ET AL.: H o w G o o d is H l V E n v e l o p e G l y c o p r o t e i n V a c c i n e as a T - l y m p h o c y t e S t i m u l a n t ? [Letter]. Lancet 1991, 338:187. MIETZ JA, FEWELLJW, KITFFEL: Selective A c t i v a t i o n of a Discrete Family of Endogeneous Proviral E l e m e n t s i n N o r m a l BALB/c L y m p h o c y t e s . Mol Cell Bio11992, 12:220-247.

*~/ilLESSA, LEE K, HU~FLINI., ZSEBO KM, MITSUYASU RT: P o t e n t i a l u s e o f H u m a n S t e m C e l l F a c t o r as A d j u n c t i v e T h e r a p y f o r H u m a n Immunodeficiency Virus-related Cytopcnias. Blood 1991, 78:3200-3208. MILLS KHG, BAP~NARDRE, WILLIAMS M, PAGE M, LING C, STOTF EJ, SII.VERAP, T ~ F S F, K I N G S , ~ AS, ADAMS SE, ALMOND N, IQTCHIN PA, JONES WC: V a c c i n e I n d u c e d CD4+ T-Cells A g a i n s t t h e S i m i a n Immunodefieiency Virus Gag Protein - Epitope Specificity and Relevance to Protective Immunity. J lmmuno11991, 147:3560-3567. MJZRACHI Y, STERNASL, VOLSKYDJ: T h e E s t a b l i s l x m e n t o f R o d e n t Cell L i n e s P e r s i s t e n t l y P r o d u c i n g H1V-1. Virolog~y 1992, 186:167-174. MOFENSON LM: I n t r a v e n o u s l m m t m e G l o b u l i n f o r t h e Prevention of Bacterial Infections in children with Symptomatic Human Immunodeficiency V i r u s I n f e c t i o n . NEngIJMed 1991, 325:73-80. MOLLA A, JANG SK, PALq~AV, REUER Q, WL~LMERE: C a r d i o v i r a l I n t e r n a l R i b o s o m a l E n t r y Site is F u n c t i o n a l i n a G e n e t i c a l l y E n g i n e e r e d D i c i s t r o n i c P o l i v i r u s . Nature 1992, 356:255-257. MOLLA A, PAUL AV, WIMMER E: Cell-free, D e N o v o S y n t h e s i s o f P o H o v i r u s . Science 1991, 254:1647-1650. MOOKE JP, MCKEATINGJA, NORTON WA, SATTENTAUQJ: Direct Measurement of Soluble CD4 Binding to H u m a n I m m l m o d e f i c i e n c y V i r u s Type-1 V i r i o n s - G p 1 2 0 D i s s o c i a t i o n a n d Its I m p l i c a t i o n s f o r Virus-Cell B i n d i n g a n d F u s i o n R e a c t i o n s a n d T h e i r N e u t r a l i z a t i o n b y S o l u b l e CD4. J Viro11991, 65:1133-1140. MORONA R, YEADON J, CONSIDIN~ A, MORONA JK, MAN.'N1NG PA: C o n s t r u c t i o n o f P l a s m i d V e c t o r s w i t h a Non-Antibiotic Selection System Based on the E s c h e r i c h l a - C o l i ThyA+ G e n e - A p p l i c a t i o n t o C h o l e r a V a c c i n e D e v e l o p m e n t . Gene 1991, 107:139-144. MOSlER DE: A d o p t i v e T r a n s f e r o f H u m a n L y m p h o i d • Cells t o S e v e r e l y I m m u n o d e f i c i e n t Mice: Models for Normal Human Immune Function A u t o i m m u n i t y , L y m p h o m a g c n e s i s a n d AIDS. Adv Immuno11991, 50:303-325. [44]. MUL YM, VAN DER VLIET PC: N u c l e a r F a c t o r I E n h a n c e s Adenovirus DNA Replication by increasing the Stability o f a P r e i n i t i a t i o n C o m p l e x . EMBOJ 1992, 11:751-760. MULUGANMJ, RITTER GD, CHAIKIN MA, YAMSHCHIKOV GV, KUMARP, HAHN BH, SWEET RW, COMPANS RW: Human Immunodeflciency virus Type 2 Envelope Glycoprotein - Differential CD4 interactions of Soluble Gp120 Versus the Assembled Envelope C o m p l e x . Virology 1992, 187:233-241. MUR~ KG, BROWN PS, BE&N WJ, WEBSTER RG: Composition of the Helical internal Components o f I n f l u e n z a V i r u s as R e v e a l e d b y I m m u n o g o l d L a b e l i n g / E l e c t r o n M i c r o s c o p y . Virology 1992, 186:294-299. NAKAN~SHIY, MASAMUN~Y, KOBAYASHI N: A N o v e l Cis Acting Element that Controls Transcription of H u m a n l m m * m o d e f i c i e n c y V i r u s T y p e 1 DNA D e p e n d i n g o n Cell Type..f Viro11991, 65:6334. NARDELLI B, LU YA, SHIU DR, DELPIERREDEFOORT C, PROFY AT, TAM JP: A C h e m i c a l l y D e f i n e d S y n t h e t i c V a c c i n e M o d e l f o r ltlV-1. J Immuno11992, 148:914-920. NASSALM, PdEGER A, 8TEINAU O: T o p o l o g i c a l A n a l y s i s of the Hepatitis-B Virus Core Particle by C y s t e i n e - C y s t e i n e C r o s s - L i n k l n g . J Mol Bio11992, 225:1013-1025. NATSOUI.ISG, BOEKE JD: N e w A n t i v i r a l S t r a t e g y U s i n g C a p s i d N u e l e a s e F u s i o n P r o t e i n s . Nature 1991, 352:6324535. NAZERIAN K, LEE LF, YANAGIDA N, OGAWA R: P r o t e c t i o n Against Marek's Disease by a Fowlpox Virus Recombinant Expressing the Glycoprotein-B of M a r e k ' s D i s e a s e Virus. J Viro11992, 66:140~1413. NEMEROFF ME, UTANS U, KRAMS~A, KRUG RM: I d e n t i f i c a t i o n o f Cis-Acting I n t r o n a n d E x o n R e g i o n s i n I n f l u e n z a V i r u s NS1 M e s s e n g e r RNA that Inhibit Splicing and Cause the Formation of Aberrantly sedimenting Presplicing Complexes. Mol Cell Bio11992, 12:962-970. NEURATH AR, STRICK N, JIANG S: S y n t h e t i c P e p t i d e s a n d A n t i - P c p t i d e A n t i b o d i e s as P r o b e s t o Study interdomain Interactions Involved in Virus Assembly - the Envelope of the Human l m m u n o d e f i c i e n c y V i r u s (I-IIV-1). Virology 1992, 188:1-13. NICHOLASJ, CAMERON KR, HONESS RW: H e r p e s v i r u s Saimiri Encodes Homologues of G Protein C o u p l e d R e c e p t o r s a n d C y e l l n s [Letter]. Nature 1992, 3 5 5 : 3 6 ~ 3 6 4 , NICHOLSON R, PELLETIERJ, LE SY, SONENBERG N: S t r u c t u r a l and Functional Analysis of the Ribosome Landing

729

730

Pharmaceutical applications Vaccines, viruses and AIDS Pad of Poliovirus Type 2 - Invivo Translation Stu d ies. J Viro11991, 65:5886-5894. NOKES DJ, ANDERSON RM: V a c c i n e S a f e t y V e r s u s V a c c i n e Efficacy i n Mass l m m ~ m i s a t i o n P r o g r a m m e s . Lancet 1991, 338:I309-1312. NOVAK TJ, YOSH]MURAFK, RO'I~tENBERG EV: I n v i t r o T r a n s f e c t i o n o f F r e s h T h y m o c y t e s a n d T-Cells S h o w s S u b s e t - S p e c i f i c E x p r e s s i o n o f Vi ral P r o m o t e r s . Mol CellBiol 1992, 12:1515 1527. NOWAK MA, ANDERSON RM, MCLEAN AR, WOLFS "I*F~V, GOUDSMIT J, MAY RM: A n t i g e n i c D i v e r s i t y T h r e s h o l d s a n d t h e D e v e l o p m e n t o f AIDS. Science t991, 254:963~969, OHAG2~N DT, JEFFERY H, ROBERTS MJj, MCGEE JP, DAVIS SS: C o n t r o l l e d Release M i c r o p a r t i c l e s f o r V a c c i n e D e v e l o p m e n t . Vaccine 1991, 9:768-771. OHARE P, WILLIAMSG: S t r u c t u r a l S t u d i e s o f t h e A c i d i c Transactivation Domain of the Vmw65 Protein o f H e r p e s S i m p l e x V i r u s U s i n g H-1 Biochemistry 1992, 31:4150-4156. OHISHI K, SUZLrKI H, YAMAMOTO T, MARUYAMAT, MIYd K, IKAWA Y, NUMAKUNAIS, OKADA K, OHSHIMA K, SUGIMOTO M: Protective I m m u n i t y A g a i n s t B o v i n e L e u k a e m i a v i r u s (BLV) I n d u c e d i n C a r r i e r S h e e p b y I n o c u l a t i o n w i t h a V a c e i n i a Virus-BLV E n v Recombinant - Association with Cell-Mediated I m m u n i t y . J Gen Virol 1991, 72:188%1892. OHNO T, TERADA M, YONnEDAY, SHEA K~g, CHAMBERS RF, STROKA DM, NAKAMUBAM, KUFE DW: A Broadly Neutralizing Monodonal Antibody that Recognizes the V3 Region of Human Immunodeficiency Virus Type I Glyeoprotein G p 1 2 0 . Proc Nail Acad Sci U S A 1991, 88:10726-10729. OKAMOTO Y ETAL.: G e n o m i c S e q u e n c e s o f R e s p i r a t o r y S y n c y t l a l V i r u s in O t i t i s M e d i a w i t h E f f u s i o n [Letter]. Lancet 1991, 338:1025. OLDSTONE MBA, TISHON A, LEWICK1 H, DYSON t~I , FEHER VA, ASSAMUNTN, WRIGHT PE: M a p p i n g t h e A n a t o m y of the Lmmunodominant Domain of the Human Immunodeftciency Virus-gp41 Transmembrane Protein - Peptide Conformation Analysis Using Monoclonal Antibodies and Proton Nuclear M a g n e t i c R e s o n a n c e S p e c t r o s c o p y . J Viro11991, 65:172~1734. OMATA M, YOKOSUKA O, TAKANO S, KATO N, HOSODA K, IMAZEK1 F, TADA M, ITO Y, OHTO M: R e s o l u t i o n o f A cu te H ep atttis- C a ft er T h e r a p y w i t h N a t u r a l B e t a I n t e r f e r o n . Lancet 1991, 338:914-915. OOSTERLAKEN"rAM, HARMSENM, JHAGJHOORSINGH SS, EKSTIJN GL, KRAAIJEVtmDG& SNIPPE H: A P r o t e c t i v e Monoelonal Anti-Idiotypic Vaccine to Lethal S e m l i k i F o r e s t Vi rus I n f e c t i o n i n BALB/c Mice. J Viro11991, 65:98-102. OWENS RA, GESELLCHENPD, HOUCHINS BJ, DhMARCHI RD: T h e R a p i d I d e n t i f i c a t i o n o f H I V P r o t e a s e Inhibitors Through the Synthesis and Screening o f D e f i n e d P e p t i d e M i x t u r e s . Biochem Biophys Res Commun 1991, 181:402~408, PARADIS H, LANGELIERY, MICHAUD J, BRAZEAUP, GAUDREAU P: S t u d i e s o n I n v i t r o P r o t e o l y t t c S e n s i t i v i t y of Peptides Inhibiting Herpes Simplex Virus R i b o n u e l e o t i d e R e d u c t a s e s Lead t o D i s c o v e r y o f a S t a b l e a n d P o t e n t I n h i b i t o r . Inl J Pept Protein Res 1991, 37:72-79. PAREKtt BS, SHAFFERN, CHOU PONG P, ABRAMS E, THOMAS • t3, POLLACH H, BAMJI M, KAUL A, SCHOCHETMANG, ROGERS M, ETAL: Lack o f C o r r e l a t i o n B e t w e e n M a t e r n a l A n t i b o d i e s t o V3 L o o p P e p t i d e s o f G p 1 2 0 a n d P e r i n a t a l Hl V-1 T r a n s m i s s i o n . AIDS 1991, 5:1179-1184 [12]. PARTIDOS CD, STANLEYCM, STEWARD 3/PvV: l m m q n e R e s p o n s e s i n Mice F o l l o w i n g I m m u n i z a t i o n w i t h C h i m e r i c S y n t h e t i c P e p t i d e s R e p r e s e n t i n g B-Cell a n d T-Cell E p l t o p e s o f M e a s l e s V i r u s P r o t e i n s . J Gen Viro11991, 72:1293-1299. PATARROYO G, FRANCO L, AMADOR R, MURILLO LA, ROCHA CL, ROJAS M, PATARROYOME: S t u d y o f t h e S a f e t y and Lmmunogenicity of the Synthetic Malaria SPf66 V a c c i n e i n C h i l d r e n A g e d 1-14 Years. Vaccine 1992, 10:175-178. PEDEN K, EMEPaMANM, MONTAGN~ERL: C h a n g e s i n Growth Properties on Passage in Tissue Culture of Viruses Derived from Infectious Molecular C l o n e s o f HlV-ILAI, HIV-1MAL, a n d HIV-1ELI. Virology 1991, 185:661~572. PEETERS CCAM, TENBERGENMEEKESAM, HEIJNEN CJ, POOLMAN y1~ ZEGEKS BJM, RIJKERSGT: I n v i t r o I n d u c t i o n o f a H a e m o p h i h t s - I n f l u e n z a e Typeb Polysaccharide-Specific Antibody Response in Human Peripheral Blood Lymphocytes of Individuals Recently Vaccinated with an O l i g o s a c c h a r i d e - P r o t e i n C o n j u g a t e . J Immunol 1991, 147:4192-4199. PELTOLA H, SIITONEN A, KYRONSEPPAH, SIMISLAI, MATRILA L, OKS&NEN P, KATAJAMJ, CADOZ M: P r e v e n t i o n o f

Travellers Diarrhoea by Oral B Subtmit/whole Cell C h o l e r a V a c c i n e . Lancet 1991, 338:1285-1288. PERLMANN T, WRANGE O: I n h i b i t i o n o f C h r o m a t i n Assembly in Xenopus-Oocytes Correlates with Derepression of the Mouse Mammary Tumor V i r u s P r o m o t e r . 34ol Cell Biol i991, 11:5259-5265. PERROTI"A AT, BEEN MD: Cleavage o f O l i g o r i b o n u eleotides by a Ribozyme Derived from the H e p a t i t i s - d e l t a v i r u s RNA S e q u e n c e . Biochemistry 1992, 31:16-21. PETIIT SC, SLMSICJ, LOEB DD, EVERI~T L, HlYFCHISON CA, 8WANSTROM R: A n a l y s i s o f R c t r o v i r a l P r o t e a s e Cl e a v a g e Sites R e v e a l s T w o T y p e s o f C l e a v a g e Sites a n d t h e S t r u c t u r a l R e q u i r e m e n t s o f t h e P1 A m i n o Acid. J B i o l Chem 1991, 266:14539-14547. PETI'OELLOMANTOVANIM, CASADEVALLA, KOIZMA~ TR, RUBINSTEINA, GOLDSTEIN H: E n h a n c e m e n t o f HIV1 Infection by the Capsular Polysaceharide of C r y p t o c o c c u s - N e o f o r m a n s . Lancet 1992, 339:21-23. PHILLIPS B, ABRAVAYAK, MORhMOTORI: A n a l y s i s o f t h e Specificity and Mechanism of Transcriptional Activation of the Human Hsp 70 Gene During I n f e c t i o n b y D N A V i r u s e s . J Virol 1991, 65:5680. PHILLIPS DM, BOU~RINBAIARAS: M e c h a n i s m o f ~ Spread f r o m L y m p h o c y t e s t o E p i t h e l l m Virology 1992, lS6:261-273. PHILMPS NJ, APICELLA MA, GRIFHSSjM, GIBSON BW: S t r u c t u r a l C h a r a c t e r i z a t i o n o f t h e Cell S u r f a c e Lipooligosaecharides from a Nontypable Strain o f H a e m o p h i i n s - I n f l u e n z a e . Biochemistry 1992, 31:4515~4526. PIIILLIPS RE, ROWLANDJON%~ S, NIXON DF, GOTCH FM, EDWARDSJP, OGUNLESI AO, EININ JG, ROTHBARDJA, BANGHAM CRM, RIZZA CR, MCMICHAELAJ: I-luInan Immunodeficiency Virus Genetic Variation that c a n E s c a p e C y t o x i c T Cell R e c o g n i t i o n . Nature 1991, 354:453--459. PILIPENKO EV, MASLOVASV, 81NYAKOVAN, AGOL VI: Towards Identification of Cis-acting Elements Involved in the Replication of Enterovirus and R h i n o v i r u s RigA.s: a P r o p o s a l f o r t h e E x i s t e n c e o f TRNA-Iikc T e e m i n a l S t r u c t u r e s . Nucleic Acids Res 1992, 20:1739-1745. PODDA A, NENCIONI L~ MARSILI I, PEPPOLON1 S, VOLPINI G, DONA22 D, DITOMMASO A, DEMAGISTRISMT, RAPPUOLI R: P h a s e - I c l i n i c a l T r i a l o f a n A e e l l u l a r P e r t u a s i s Vaccine Composed of Genetically Detuxified P e r t u s s i s T o x i n C o m b i n e d w i t h F H A A n d 69-kDa. Vaccine 1991, 9 : 7 4 1 ~ 4 5 . POLLARD SR, ROSA MD, WILEY DC: T r u n c a t e d V a r i a n t s o f Gp120 Bind CD4 with High Affinity and Suggest a M i n i m u m C D 4 B i n d i n g R e g i o n . EMBOJ1992, 11:585-592. POLO JM, JOHNSTON RE: M u t a t i o n a l A n a l y s i s o f a V i r u l e n c e L o c u s i n t h e E2 G l y c o p r o t e i n G e n e o f S i n d b i s Virus. J Viro11991, 65:6358. POORMAN RA, TOMASSELLIAG, HEINRIKSON RL, KEZDY FJ: A Cumulative Specificity Model for Proteases from Human Immunodeficiency Virus Typed and Type-2, I n f e r r e d f r o m Statistical A n a l y s i s o f a n E x t e n d e d S u b s t r a t e Data Base. J Biol Chem 1991, 266:14554-14561. POSKITT DC, JEANFRAA~COISMJB, TURNBULLS, MACDONALD L, YASMEEND: i n t e r n a l I m a g e ( A b 2 b c t a ) Antildiotype Vaccines - Theoretical and Practical As p e c t s . Vaccin'e 1991, 9:792-796. POWDmLL TF, JOHNSTON JM: I m m u n o l o g i c P r i m i n g with Recombinant Hepatitis-A Virus Capsid P r o t e i n s P r o d u c e d i n E s c h e r i c h l a - C o l i . J Virol 1991, 65:2686-2690. POWERS R, CLORE GM, BAX A, GARRETT DS,'STAtIL SJ, WINGHELD PT, GRONENBORN AM: S e c o n d a r y Structure of the Ribonuclease-H Domain of the Human Immlmodefieiency Virus Reverse Transeriptase In Solution Using ThreeDimensional Double and Triple Resonance Heteronuclear Magnetic Resonance Spectroscopy. J Mol Bio11991, 221:1081-1090. pRASAD VR, LOWY I, DELOSSAN~rOST, CIIIANG L, GOFF SP: I s o l a t i o n a n d C h a r a c t e r i z a t i o n o f a Dideoxyguanosine Triphosphate-Resistant Mutant of Human Immunodeficiency Virus Reverse T r a n s c r i p t a s e . Proc Nail Acad Sci U S A 1991, 88:11363 11367. PRESTON .NIY~:T y p h o i d V a c c i n e a n d L a b o r a t o r y I n d i c a t o r s o f C l i n i c a l P r o t e c t i o n [Letter]. Lancet 1992, 339:555. PRUSIN~ERSB: M o l e c u l a r B i o l o g y o f P r i o r i D i s e a s e s . Science 1991, 252:1515-1522. PRYCHIAK PM, SIL A, VARMUSHE: R e t r o v i r a l i n t e g r a t i o n i n t o M i n i c h r o m o s o m e s i n Vitro. ~ O J 1992, 11:291-304. p1YI'KONEN P, THORS'I~NSSON R, GHAVAMZADEHL, ALBERTJ, HILD K, BIBERFELD G, NORRBy E: P r e v e n t i o n o f I-IIV2 and SlVsm Infection by Passive Immunization

i n C y n o m o l g u s M o n k e y s [Letter]. Nature 1991, 352:436-437. PUTNEY S: HOW A n t i b o d i e s B l o c k H I V I n f e c t i o n - P a t h s t o a n AIDS V a c c i n e . 7~ends Biochem Sci 1992, 17:191 196. RAJU ]3, DESHP&NDEMS: S u b s t r a t e A n a l o g I n h i h i t u r s o f HIV-1 P r o t e a s e C o n t a i n i n g P h e n y i n o r s t a t i n e as a T r a n s i t i o n State E l e m e n t . Biochem Biophys Res Commun 1991, 180:181 186. RAMIS I, ROSELLOCATAFAUj , GOMEZ G, ZABAYJM, CRUZ EF, GELPI E: C y c l o o x y g e n a s e a n d I A p o x y g e n a s e A r a c h i d o n i c Acid M e t a b o l i s m b y M o n o c y t e s f r o m Human Immune Deficiency Virus-Infected Drug U s e r s . J Cbromatogr 1991, 557:507-513. RANDALL RE, YOUNG DF: S o l i d M a t r i x - A n t i b o d y - A n t i g e n C o m p l e x e s I n d u c e A n t i g e n - S p e c i f i c CD8+ C e l l s that Clear a Persistent Paramyxovirus Infection. j Virol t991, 65:719-726. RAPPUOI.I R, PIZZA M, PODDA A, DE MAGISTRISMT, NENCION? L: T o w a r d s T h i r d - g e n e r a t i o n W h o o p i n g C o u g h V a c c i n e s . Trends Biotecbno11991, 9 : 2 3 2 - 2 3 7 RAVINDRANA~HtRMH, GRAVESMC: M o n o c l o n a l IgM Antibodies from Cytomegalovtrus-IiLfected Mice Recognize the GlcNAc-Contalning Receptor D e t e r m i n a n t o f M u r i n e CMV as Well as N e u t r a l i z i n g Anti-CMV I g G A n t i b o d i e s . Virology 1992, 188:143-151. REARDON • JE: H u m a n I m m u n o d e f i c i e n c y V i r u s R e v e r s e T r a n s c r i p t a s e - Steady-State a n d Pee-Steady-State K i n e t i c s o f N u c l e o t i d e I n c o r p o r a t i o n . Biochemistry 1992, 31:4473--4479. REDDY G, NANDURIVB, BASU A, MODAK MJ: F e r r a t e Oxidation of Murine Leukemia Virus Reverse Transeriptase -Identification of the TemplateP r i m e r B i n d i n g D o m a i n . Biochemistry 1991, 30:819543201. REDDY MR, VISWANADHANVN, WEINSTEINJN: R e l a t i v e Differences in the Binding Free Energies of H u m a n I m m u n o d e f i c i e n c y Virus-1 P r o t e a s e Inhihiturs - a Thermodynamic Cycle-Perturbation A p p r o a c h . Proc Nail A c a d Sci U S A t991, 88:10287-10291. REILLY LM, RALL G, LOMNICZI B, METTENLEITERTC, KUPERSHMIDTS, BENPORAT T: T h e A b i l i t y o f Pseudorabies Virus to Grow in Different Hosts is Affected b y t h e D u p l i c a t i o n a n d T r a n s l o e a t i o n o f S e q u e n c e s f r o m t h e Left E n d o f t h e G e n o m e t o t h e U1-Us J u n c t i o n . J Viro11991, 65:5839. REN R, MOSS EG, RACANIELLOVR: I d e n t i f i c a t i o n o f T w o D e t e r m i n a n t s t h a t A t t e n u a t e V a c ci n e - R e l a t e d T y p e - 2 P o l i o v i r u s . J Viro11991, 65:1377-1382. RENSHAW RW, GONDA MA, CASEYJxvV:S t r u c t u r e a n d Transcriptional Status of Bovine Syncytial Virus i n C y t o p a t h i e I n f e c t i o n s . Gene 1991, 105:179-184. REUSS FU, SCHALLERHC: eDNA S e q u e n c e a n d G e n o m i c Characterization of Intracisternal a Particle R e l a t e d R e t r o v i r a l FAements C o n t a i n i n g a n E n v e l o p e G e n e . J Viro11991, 65:5702. R1CE AP, CHAN F: T a t P r o t e i n o f H u m a n l l l l I n n n o d e f i c i e n c y V i r u s T y p e d is a M o n o m e r w h e n E x p r e s s e d i n M a m m a l i a n Cells. Virology 1991, 185:451~454. RICHM&N D, SHIH CK, LOWY I, ROSE J, PRODANOVICH P, GOFF S, GRIFFINJ: H u m a n I m m u n o d e f i c i e n c y Virus Typed Mutants Resistant to Nonnueleoside Inhibiturs of Reverse Transcriptase Arise in T i s s u e C u l t u r e . Proc Nail Acad Sci U S A 1991, 88:11241-11245. ROBERTS N, BARNnESP, LENOX RH: T r i a z a l o a m a n d PAF [Letter]. Lancet 1991, 338:1459. ROBINSON A, FUN'NELLSGP: P o t e n c y T e s t i n g o f A c e l l u l a r P e r t u s s i s V a c c i n e s . Vaccine1992, 10:139-141. RODRIGUEZ JR, RODRIGL~Z D, ESTEBANM: I n t e r f e r o n Treatment Inhibits Early Events in Vaccinla Virus G e n e E x p r e s s i o n i n I n f e c t e d Mice. Virology 1991, 185:929 9 3 3 ROGERS M, SERBAND, GYURIS T, SCO'TI' M, TORCHIA "I~ PRUSINER SB: E p i t o p e M a p p i n g o f t h e S y r i a n Hamster Prion Protein utilizing Chimeric and Mutant Genes in a Vaccinia Virus Expression S y s t e m . J l m m u n o l 1991,147:3568-3574. ROU~NAND, REDDEHASEMJ, KOSZINOWSYdUH, FOLKERS G: Molecular Modeling of an Antigenic Complex Between a Viral Peptide and a Class 1 Major H i s t o c o m p a t i b i l i t y G l y c o p r o t e i n . Proteins 1992, 13:7045. ROMANOS MA, CLAREJJ, BEESLEYK3d, RAYMENTFB, BALI.ANTIN~ SP, MAKOFF AJ, DOUGA.N G, FAIRWEATHER NF, CI4~,LES IG: R e c o m b i n a n t B o r d e t e l l a - P e r t u s s i s P e r t a c t i n (P69) f r o m t h e Yeast P i c h i a - P a s t o r i s - High-Level Production and Immunological P r o p e r t i e s . Vaccine 1991, 9:901-906. ROMERO DL, BUSSO M, TAN CK, REUSSERF, PALV2~ JR, POPPE SM, ARISTOFF PA, DOWNEY KM, SO AG, RESNICK L, TARPLEYWG: N o n n u c l e o s i d e R e v e r s e Transcriptase Inhihitors that Potently and

Pharmaceutical applications Vaccines, viruses and AIDS Specifically B l o c k H u m a n I m m u n o d e f i c i e n c y Virus Type-1 Replication. Proc Natl A c a d Sci U S A 1991, 88:88064810. ROSE CSP, EVANS DJ: P o l i o v i r u s Antigen C h i m e r a s . Trends Blotecbno11991, 9:415-421. RUPPREC~IT CE, HAN1ON CA, CU,~IMINSLB, KOPROWSK] H: P r i m a t e R e s p o n s e s to a Vaccinia-Rabies G l y c o p r o t e i n R e c o m b i n a n t Virus Vaccine. Vaccine 1992, 10:368-374. RZEPCZYKCM, CSURItESPA, SAU. AJ, JONES GL, DYER S, CHEE D, GOSS N, IRVING DO: C o m p a r a t i v e Study o f t h e T-cell R e s p o n s e to Two Allelic F o r m s o f a M a l a r i a l Vaccine C a n d i d a t e Protein. J l m m u n o l 1992, 148:1197-1204. SABESANS, DUUS JO, DOMAILLEP, KELM S, PAULSON JC: Synthesis o f C l u s t e r Sialoside I n h i b i t o r s f o r I n f l u e n z a Virus. J A m Chem Soc 1991, 113:5865-5866. SADAIEMR, KALYANARAMANVS, MUKOPADItAYAYAR, TSCI£ACHLERE, GALLO RC, WONGSTAALE: Biological C h a r a c t e r i z a t i o n o f Nonin£ectious HIV-1 Particles Lacking t h e E n v e l o p e P r o t e i n . Virology 1992, 187:60~611. SAKA~ H, SHIBATAR, SAKUI~GI J, K~YOMASUT, KAW~URA M, HAYAMIM, ISHIMOTO A, ADACH] A: C o m p a t i b i l i t y o f Rev G e n e Activity I n t h e F o u r G r o u p s o f P r i m a t e Lentiviruses. Virology 1991, 184:51~520, SAKM K, MA XY, GORDIEN~KOI, VOLSKYDJ: R e c o m b i n a t i o n a l Analysis o f a N a t u r a l N o n c T t o p a t h i e H u m a n I m m u n o d e f i c i e n c y Virus Type 1 ( m v - 1 ) Isolate - Role o f t h e Vif G e n e in HIV1 Infection K i n e t i c s a n d Cytopathicity. J Virol 1991, 65:5765-5773. SAMULSKIRJ, ZHU X, XlAO X, BROOK JD, HOUSMAN DE, EPSTEIN N, ilL?X-fERLA: T a r g e t e d I n t e g r a t i o n o f Adeno-associated Virus (AAV) into H u m a n C h r o m o s o m e 19. E M B O J 1991, 10:3941-3950. SANTOSHAMM, WOLFF M, REID R, HOHENBOKENM, BA'I~.AV~ANM, GOEPP J, CORTESEM, SACK D, HILL J, NEWCOMERW, CAPPdOTI'I L, SMITHJ, OWEN M, GAHAGAN S, HU D, KLING R, LUKACSL, ELLIS RW, VELLA PP, CALANDIIAG, MA'rTHEWSH, AIIONKH~ V: T h e Efficacy i n Navajo I n f a n t s o f a Conjugate Vaccine Consisting o f H a e m o p h i l u s - I n l l u e n z a c Type-b P o l y s a c c h a r i d e a n d Neisseria-Meningitidis OuterM e m b r a n e P r o t e i n C o m p l e x [in English]. N E n g l J M e d 1991, 324:1767-1772. SATO H, H/RATAJ; FURD](AWAM, KURODA N, SHIRAKI H, 3AAEDAY, OKOCHI K: I d e n t i f i c a t i o n o f t h e R e g i o n Including the Epitope for a Monoclonal Antibody W h i c h c a n Neutralize H u m n n Parvovirus-B19. ] Virol 1991, 65:1667-1672. SATO H, ORENSTEINJ, DIMITROVD, MARTINM: Cell-to-Celi Spread o f ItIV-1 O c c u r s W i t h i n Minutes a n d May n o t Involve t h e P a r t i c i p a t i o n o f Virus Particles. Virology 1992, 186:712~24. SATYENTAUQ, MOOREJP: C o n f o r m a t i o n a l C h a n g e s • I n d u c e d i n t h e H u m a n I m m u f l o d e f l c i e n c y Vir~s E n v e l o p e G l y c o p r o t e I n b y Soluble CD4 B i n d i n g . f Exp M e d 1991, 174:407~15. [23]. SCHAAD UB, LANG AB, WEDGEWOODJ, RUEDEBERGA, QUE JU, FUllER E, CRYZJR SJ: Safety a n d I m m u n o g e n i c i t y o f P s e u d o m o n a s A e r u g i n o s a Conjugate a Vaccine i n Cystic Eibrosis. Lancet 1991, 338:1236-1237. SCHAFER V, VONBRIESENH, ANDREESENR, STEFFANAM, ROYER C, TROSTERS, KREUTERJ, RUBSAMENWMGMANN H: Phagocytosis o f Nanopat'tietes b y H u m a n I m m u n o d e f i c i e n c y Virus (HlV)-lnfected M a c r o p h a g e s - a Possibility for A n t i v i r a l D r u g Targeting. P h a r m Res 1992, 9:541-546. SCHIFF P, K~LMEA: Safety o f M G Made f r o m HCVa n t i b o d y - s c r e e n e d P l a s m a [Letter]. Lancet 1991, 338:1076. SCEIILD GC, STOTT EJ: T h e Quest for Vaccines Against AIDS - P r o g r e s s a n d C h a l l e n g e s - a n O v e r v i e w . Vaccine 1991, 9:779-781. SCHMALJOHN CS, HASTY SE, DALRYMPLEJM: P r e p a r a t i o n o f Candidate Vaecinia-Vectored Vaccines f o r I-Iaemorrhagic F e v e r w i t h R e n a l S y n d r o m e . Vaccine 1992, 10:10~13. SCFLMIDRM~ PEILKINSND, DL'CKETTCS, ANDREWS PC, NABEL GJ: C l o n i n g o f a n NF-gB Subunit W h i c h Stimulates HIV T r a n s c r i p t i o n i n S y n e r g y w i t h P65 [Letter]. Nature 1991, 352:733~35. SCHRECK R, RIEBERP, BAEUERLEPA: Reactive O x F g e n I n t e r m e d i a t e s as A p p a r e n t l y Widely u s e d Messengers i n t h e Activation o f t h e NF-KB T r a n s c r i p t i o n F a c t o r a n d HIV-1. E M B O J 1991, 10:2247-2258 SCHUBERT U, SCfEX~IDER"I. I~EN~LLEINP, HOFFMANN K, BERTHOLD E, HAUSER H, PAULI G, PORSTMAMNT: H u m a n - I r a munodefleiency-Virus -Type- 1 -Encoded Vpu-Protein is P h o s p h o r y l a t e d b y Casein KinaseR. E u r J Biochem 1992, 204:875~83, SCHLXTZEB, GROSS HJ, BROSSMERR, HERRI,ERG: T h e S P r o t e i n o f B o v i n e C o r o n o v i r u s is a H e m a g g i u t i n i n R e c o g n i z i n g 9-0 Acetylated Sialic

Acid as a R e c e p t o r D e t e r m i n a n t . J Viro11991, 65:6232-6311. SCHULZ "IT, CALABROML, HOAD JG. CARRINGTONCVF, MATUTESE, CAlOVSKYD, WEISS RA: HTLV-1 E n v e l o p e Sequences f r o m Brazil, t h e C a r i b b e a n , a n d R o m a n i a - C l u s t e r i n g o f Sequences A c c o r d i n g to Geographic Origin and variability in an Antibody Epitope. Virology 1991, 184:483~i91. SCHWARTZHE, ULFELDERK, SUNZEPdFJ, BUSCH MP, BROWN~EE RG: Analysis o f DNA Restriction Fragments and Polymerase Chain Reaction Products T o w a r d s D e t e c t i o n o f t h e AIDS (HIV-1) Virus i n Blood. J Cbromatogr 1991, 559:267-283. SCHWARTZ S, FELBERBK, PAVLAKISGN: M e c h a n i s m o f Translation of Monocistronic and Mutlicistronic H u m a n I m u n o d e f i c i e n c y Virus T y p e d MRNAs. Mol Cell Biol 1992, 12:207-219. SECNIKJ, GELFAND CA, JENTOFT JE: R c t r o v i r a l N u c l e o c a p s i d P r o t e i n Specit~cally R e c o g n i z e s t h e Base a n d the R i b o s e o f M o n o n u c l e o t i d e s a n d M o n o n u c l e o t i d e C o m p o n e n t s . Biochemistry 1992, 31:2982-2988. SEIYFMNEV, BRAKENHOFFJ, DEWIT L, ARCONE R, CILIBERTO G, COnTeNT J: I n t e r n a l Deletions i n H u m a n I n t e r i e u k i n - 6 - S t r u c t u r e - F u n c t i o n Analysis. Gene 1991, 104:227-234. FRENCH RR, COURTENAYAE, INGAMELLSS, STEVENSON GT, GLENNqE MJ: C o o p e r a t i v e M i x t u r e s o f Bispecific F(ab')2 A n t i b o d i e s f o r D e l i v e r i n g S a p o r i n to L y m p h o m a Inviteo a n d Invivo. Cancer Res 1991, 51:2353-2361. FRETZ t1, ALBERSM~/, GALATA, STANDAERTRF, LANE WS, BURAKOFF SJ, BIERERBE, SCHREIBERSL: R a p a m y c i n a n d FKS06 B i n d i n g P r o t e i n s ( l m m n n o p h i l i n s ) . j A m Cbem Soc 1991, 113:14091411. FRL~IAN DA, KLEE CB, BIERERBE, BURAKOFFSJ: C a l e i n e u r i n P h o s p h a t a s e Activity i n T L y m p h o c y t e s is I n h i b i t e d by FK 506 a n d C y c i o s p o r t n A. Proc Natl A c a d Sci U S A 1992, 89:3686-3690. FUASTMAND, LI X, LIN }t"Y, FU Y, EISFaNBARTHG, AVRUCHJ, GUO J: L i n k a g e o f Faulty M a j o r H i s t o c o m p a t i b i l i t y C o m p l e x Class I to A u t o i m m u n e D i a b e t e s . Science 1991, 254:1756 1761. FUCH5 P, BREITLINGF, DUBEL S, SEEHAUST, LITTLEM: T a r g e t i n g R e c o m b i n a n t Antibodies to t h e Surface o f E s e h e r i c h i a - C u l i - Fusion to a P e p t i d o g l y c a n Associated L i p o p r o t e i n . Biotechnology 1991, 9:1369-1372. FUJtMOPd K. FISHER DR, WRINSTEINJN: I n t e g r a t e d Microscopic-Macroscopic Pharmacology of Monoclonal Antibody Radioconjugates - the R a d i a t i o n D o s e D i s t r i b u t i o n . Cancer Res 1991, 51:4821~t827. GAWINOWICZ MA, MERLINI G, BIRIZENS, OSSERMANEF, KABATEA: Axlxino Acid S e q u e n c e o f t h e FV R e g i o n o f a H u m a n M o n o c l o n a l IgM (NOV) w i t h Specificity f o r t h e C a p s u l a r P o l y s a c c h a r i d e o f t h e Group B-Meningococcus and of Escherichia-Coli K1, W h i c h Cross-Reacts w i t h P o l y n u c i e o t i d e s and w i t h D e n a t u r e d DNA. J I m m u n o 1 1 9 9 1 , 147:915-920. GEARING DP, THLTFCJ, VANDENBOS"F~ GLMPELSD, DELANEYPB, KING J, PRICE V, COSMAND, BECKaMANN MP: L e u k e m i a I n h i b i t o r y F a c t o r R e c e p t o r is Structurally R e l a t e d to t h e EL-6 S i g n a l T r a n s d u c e r , G p l 3 0 . E M B O J 1991, 10:2839-2848. GEIGER MJ, GORSKI J, ECKELS DD: T-Cell R e c e p t o r G e n e S e g m e n t u t i l i z a t i o n b y HIA-DR1-Alloreactive TCell Clones. J I m m u n o 1 1 9 9 1 , 147:2082-2087. GRISOW MJ: I m p r o v e d S e l e c t i o n Systems f o r M a n - m a d e Antibodies. Trends Biotechno11992, 10:75-76. GERAGH~f DE, PEIJ, LIPSKYB, IIANSENJA, TAILLONMILLER P, BRONSON SK, CHAPLINDD: C l o n i n g a n d P h y s i c a l M a p p i n g o f t h e I-ILA class-I R e g i o n S p a n n i n g t h e HLA-E-tO-HLA-F I n t e r v a l b y U s i n g Yeast Artificial C h r o m o s o m e s . Proc Natl A c a d Sci U S A 1992, 89:2669-2673. GHERARDI E, BOWYER DE, FITZSLMMONSC, LECRAS T, HUTCI41NGSA, BUTCHERG: P r o b i n g o f t h e E x p r e s s i o n o f t h e Low-Density L i p o p r o t e i n Receptor Invivo Using an Anti-Receptor M o n o c l o n a l A n t i b o d y . B i o c h o n J 1991, 2 8 0 : 1 - 7 GHE~E MA, UHR JXvV,VITETI'A ES: C o v a l e n t B i n d i n g o f H u m a n A l p h a 2 - M a e r o g l o b u l l n to D e g l y c o s y l a t e d Ricin-A C h a i n a n d Its I m m u n o t o x i n s . CancerRes 1991, 51:1482-1487. GHOSH B, pERRY MP, MARSH DG: C l o n i n g t h e CDNA Encoding the Ambtv Allergen from Giant R a g w e e d ( A m b r o s i a - T r i f i d a ) pollen. Gene 1991, 101:231-238. GIBBS VC, WILLIAMSSR, GRAY PW, SCHREIBER RD, PEN2qlCA D, RICE G, GOEDDEL DV: T h e E x t r a e e l l u l a r Domain of the Human Interferon Gamma R e c e p t o r I n t e r a c t s w i t h a Species-specific S i g n a l T r a n s d u c e r . Mol Cell Bio11991, 11:5860-5866. GILLIES SD, REILLYEB, LO KM, RRISFP1DRA: AntibodyT a r g e t e d I n t e r i e u k i n - 2 Stimulates T-Cell K i l l i n g o f Autulogous T u m o r Cells. Proc NatI A c a d Sci U S A 1992, 89:1428-1432. GIVON T, SLAVINS, HARAN GHERA N, MICHALEVICZR, REVEL M: A n t i t u m o u r Effects o f H u m a n R e c o m b i n a n t I n t e r l e u k i n - 6 o n Acute Myeloid L e u k e m i a i n Mice a n d i n Cell C u l t u r e s . Blood 1992, 79:2392-2398. GOLUMBEKPT, LAZENBYAJ, LEVITSKYH, JAFFEE LM, KARASUYAMAH, BAKER M, PARDOLL DM: T r e a t m e n t o f E s t a b l i s h e d R e n a l C a n c e r b y T u m o r Cells E n g i n e e r e d to S e c r e t e I n t e r l e u k i n - 4 . Science 1991, 254:713. GOVONI D, COLOTTA ~. MANTOVANIA: m o n o c y t e Chemotactic Cytokine Gene Transfer Modulates M a c r o p h a g e I n f i l t r a t i o n , Growth, a n d

Pharmaceutical applications T cells and immunomodulation S u s c e p t i b i l i t y to IL-2 T h e r a p y o f a M u r i n e M e l a n o m a . J lmmuno11992, 148:1280 GRANOWITZ EV, SANTOSAA, POL'rSIAKADD, CANNONJG, WILMORE DW, WOLFF SM, DINARELLOCA: P r o d u c t i o n o f I n t e r l e u k i n 1 R e c e p t o r Antagonist D u r i n g E x p e r i m e n t a l E n d o t o x a e m l a . Lancet 1991, 338:1423-1424. GREENE WK, CYSTERJG, CHUA KY, OBRLENRM, "i~-IO*MAS WR: IgE a n d IgG B i n d i n g o f Peptides E x p r e s s e d f r o m Fragnmcnts o f CDNA E n c o d i n g t h e M a j o r H o u s e D u s t Mite A l l e r g e n D e r P I. JImmuno11991, 147:376~3773. GRGNETr HE, DANLEYDE, STRICK CA, OTrEKNESSIG, FUENTES N, NESBITTJE, FUI.LERGM: Isolation a n d C h a r a c t e r i z a t i o n o f Biologically Active M u r i n e I n t e r l e u k i n - 6 P r o d u c e d i n Escherichia-ColL Gene 1991, 101:267-271 GRIFFIN T, RASO V: M o n e n s i n i n Lipid E m u l s i o n f o r t h e P o t e n t i a t i o n o f Ricin-A C h a i n I m m u n o t u x i n s . CancerRes 1991, 51:4316--4322. GRIGGS ND, PONTZER CH, JARPE MA~ JOHNSON HM: M a p p I n g o f Multiple B i n d i n g D o m a i n s o f t h e S u p e r a n t i g e n S t a p h y l o c o c c a l Enterotoxin-A f o r H I A . J lmmuno11992, 148:2516 2521. GRUAZCHATELLARDD, BAUMBERGERC, SAL~ATJH, DAYER JM: I n t e r l e u k i n - 1 R e c e p t o r Antagonist in H u m a n E p i d e r m i s a n d Cultured Keratinocytes. FEBS Lett 1991, 294:137-140. ]IAASEMANNM, BUSCHKOJ, FAUSSNERA, ROSCHERAA, HOEBEKE J, BURCH RM, MULLERESTERLW: AntiI d i o t y p i c Antibodies B e a r i n g t h e I n t e r n a l I m a g e o f a B r a d y k i n i n E p i t u p e -production, Characterization, and Interaction with the Kinin Receptor. J lmmuno11991, 1 4 7 : 3 8 8 ~ 3 8 9 2 HAENSELERE, ESSWEINA, VITOLS KS, MONTEJANOY, MUELLERBM, REISFELDRA, HUENNEKENSFM: A c t i v a t i o n o f M c t h o t r e x a t e - a l p h a - A l a n i n e by Carboxypeptidase-A M o n o c l o n a l Antibody Conjugate. Biochemistry 1992, 31:891-897. HAMAWYM.M, OLIVER C, SIRAGANLANRP: I n h i b i t i o n o f IgE B i n d i n g to RBL-2H3 Cells b y a M o n o d o n a l A n t i b o d y (BD6) to a Surface P r o t e i n O t h e r T h a n t h e H i g h Af~nity IgE Receptor. J lmmuno11992, 148:524-531. HANCOCK MC, LANGTONBC, CHAN T, TOY P, MONAH&NJJ, MlSCtJAK RP, SIIAW~'ERLK: A M o n o c l o n a l A n t i b o d y A g a i n s t t h e C-erbB-2 P r o t e i n E n h a n c e s t h e Cytotoxicity o f C i s - D J n m m l n e d i c h i o r o p l a t i n u m A g a i n s t H u m a n Breast a n d O v a r i a n T u m o r Cell Lines. CancerRes 1991, 51:4575~580. HAN'~ M EI'AL.: L o n g - t e r m Safety and Tulerabillty o f I n t r a v e n o u s l m m u n o g l o b u l l n [Letter]. Lancet 1991, 338:194. HARRIS DP, VORDERMEIERHM, ROMAN E, LATHIGRAR, BRETT SJ, MORENO C, IVANYIJ: Z u r i n e T-CellS t i m u l a t o r y Peptides f r o m t h e 19-kDa A n t i g e n o f M y c o b a c t e r i u m - T u b e r c u l o s i s -EpitopeR e s t r i c t e d H o m o l o g y w i t h t h e 28-kDa P r o t e i n o f M y c o b a c t e r i u m - L e p r ae. J lmmuno11991, 147:2706-2712. HATAKEY~MAM, KONO~T, KOBAYASHIN, KAWAStARAA, LEVIN SD, PERLMUTTERR~M,TANIGUCHIT: I n t e r a c t i o n o f t h e IL-2 R e c e p t o r w i t h t h e Src-Family KinaseP561ck - I d e n t i f i c a t i o n o f Novel I n t e r m o l e c u l a r Association. Science 1991, 252:1523-1528. HATANO M, ROBERTSCWM, MINDEN M, CPdSTWM, KORSMEYERSJ: D e r e g u l a t i o n o f a H o m e o b o x Geae, HOX11, b y t h e T(10-14) i n T-Cell Leukemia. Science 1991, 253:79-82. HAYrER PM, CURLINGEMA, BMN~S AJ, JENYdNSN, SALMON I, STRANGEPG, TONGJM, BULLAT: Glucose-Limited C h e m o s t a t Culture o f C h i n e s e H a m s t e r O v a r y Cells P r o d u c i n g R e c o m b i n a n t H u m a n I n t e r f e r o n g a m m a . Biozechnol Bioeng 1992, 39:327 335. HEDLUND G, DOHLSTENM, HERRMANNT, BUELLG, LANDO PA, SEGREN S, SCHRIMSHERJ, MACDONALDHR, SJOGREN HO, KALLANDT: A R e c o m b i n a n t C - T e r m i n a l F r a g m e n t o f Staphylococcal Enterotoxin-A Binds to H u m a n MHC Class-H P r o d u c t s But D o e s n o t Activate T-Cells. Jlmmuno11991, 147:4082~1085. HENDERSON GS, LU XT, MCCURLEYTL, COLLEYDG: I n v i v o M o l e c u l a r Analysis o f L y m p h o k i n e s Involved In the Murine Immune Response During S c h i s t o s o m a - M a n s o n i Infection. 2. Q u a n t i f i c a t i o n o f IL-4 M e s s e n g e r RNA, IFN-gamma M e s s e n g e r RNA, a n d IL-2 M e s s e n g e r RNA Levels i n t h e G r a n u l o m a t o u s Livers, M e s e n t e r i c L y m p h Nodes, a n d S p l e e n s D u r i n g t h e C o u r s e o f Modulation. J I m m u n o l 1992, 148:2261-2269 tlEI~IAN A, LABRECQUEN, THIBODEAUJ, MARRACKP, KAPPLERJ~V, SEKALYRP: I d e n t i f i c a t i o n o f t h e S t a p h y l o c o c c a l Entcrotoxin-A S u p e r a n t i g e n B I n d i n g Site i n the Beta1 D o m a i n o f t h e H u m a n H i s t o c o m p a t i b i l i t y A n t i g e n HLA-DR. Proc Nail A c a d Sci U S A 1991, 8 8 : 9 9 5 4 ~ 9 5 8 HEP~MA.NNGG, GEERTSENPF, VONDERMAASEH, STEVEN K, ANDERSEN C, HALD "i*,ZEU'I~IENJ: R e c o m b I n a n t

Interieukin-2 and Lymphokine-Activated Killer Cell T r e a t m e n t o f A d v a n c e d B l a d d e r C a n c e r - Clinical Results a n d I m m u n o l o g i c a l Effects. Cancer Res 1992, 52:726-733 HIEPB F, AND OTHERS:T r e a t m e n t o f Severe Systemic Lupus E r t h e m a t o s u s w i t h Anti CD4 M o n o c l o n a l Antibody [Letter]. Lancet 1991, 338:1529. HIRSCH R, ARCHIBALDJ, GRESS P~E: Differential TCell H y p o r e s p o n s i v e n e s s Induced b y I n v i v o A d m i n i s t r a t i o n o f I n t a c t o r F(ab')2 F r a g m e n t s o f Anti-CD3 M o n o c l o n a l Antibody - F(ab')2 F r a g m e n t s I n d u c e a Selective T - H e l p e r Dysfunction. J Iramuno11991, 1 4 7 : 2 0 8 ~ 2 0 9 3 HOLLEY LH, GOUDSMITJ, KARPLUSM: P r e d i c t i o n o f O p t i m a l P e p t i d e M i x t u r e s to I n d u c e Broadly N e u t r a l i z i n g Antibodies to H u m a n I m m u n o d e f i c i e n c y Virus Type-1. Proc Natl A cad Sci U S A 1991, 88:68004804. HOM Re, FINBERG RW, MULLANEYS~ RUPRECHTRM: Protective C e l l u l a r R e t r o v i r a l I m m u n i t y R e q u i r e s B o t h CD4+ a n d CD8+ I m m u n e T-Cells. J Viro11991, 65:220-224. HOOK WA, BERENSTEINEH, ZINSSERFU, FISCHLERC, SIRAGANI/LNRP: M o n o e l o n a l Antibodies to t h e Leukocyte C o m m o n Antigen (CD45) I n h i b i t IgE-Mediated H i s t a m i n e Release f r o m H u m a n Basophlls. J I m m u n o l 1991, 147:2670-2676. ]~[ORIGUCHIY, MATSUDAH, KOYAMAIt, NAKAI T, KUMB K: B o r d c t e l l a - b r o n c h i s e p t i c a D e r m o n e c r o t i z i n g T o x i n S u p p r e s s e s I n v i v o Antibody R e s p o n s e s In Mice. FEMS Microbiol Leil 1992, 90:229-234. HOWARD AD, KOSTURAMJ, THOKNBERRYN, DING GJF, LIMJUCO G, WEIDNBRJ, SALLEYJP, HOGQUIST KA, CHAPLIN DD, MUMFORD RA, SCbL~IIDTJA, TOCCI MJ: IL-1-Convcrting E n z y m e Requires A s p a r t i e Acid Residues for P r o c e s s i n g o f the l D l - b e t a P r e c u r s o r at Two Distinct Sites a n d Does n o t Cleave 31-kDa IL-l-alpha. J l m m u n o l 1991, 147:2964-2969. HOWELL MD, DIVELEYJp, LUNDEENKA, ESTY A, WINTERS ST, CARLO DJ, BROSTOFF SW: Limited T-cell R e c e p t o r p-chain H e t e r o g e n e i t y A m o n g I n t e r l e u l d n 2 Receptor-positivesylaovial T cells Suggests a Role f o r S u p e r a n t i g e n i n R h e y m a t o i d Arthritis. Proc Natl A c a d Sci U S A 1991, 88:10921-10925. HUTCHINGS P, O'REILLy L, PAPdSHNM, WALDMANNH, • * COOKE A : The u s e o f a N o n - d e p l e t i n g AntiCD4 M o n o c l o n a l A n t i b o d y to Re-establish T o l e r a n c e to ~Cells I n NOD Mice. E u r J Irnunol 1992, 22:1913-1918 [36]. ISAACSJD, wATrs RA, HAZLEMANBL, HALB G, KEOGAN MT, oo COBBOLDSP, WALDMANN H: H u m a n i s e d m o n o c l o n a l A n t i b o d y T h e r a p y f o r R h e u m a t o i d Arthritis. Lancet 1992, 3 4 0 : 7 4 ~ 7 5 2 . [41]. ISVa'fANI A, GERAGHTYDE: Alternative s p l i c i n g o f HLAG T r a n s c r i p t s Yields P r o t e i n s w i t h P r i m a r y Structures R e s e m b l i n g Both Class I a n d Class II Antigens. I°roc Nail A c i d Sci U S A 1992, 89:394~3951 ITO T, QIu H, COLLINSJA, BRILLAB, JOHNSON DK, GRIFFIN TW: P r c c l i n i c a l Assessments o f Y-90-Labeled C l 1 0 Anti- C a r c i n o e m b r y o n i e Antigen I m m u n o t u x i n - a Therapeutic Immunoconjugate for Human C o l o n Cancer. Cancer Res 1991, 51:255-260. IWAKURAY, TOSU M, YOSHIDA E, TARIGUCHIM, SATO K, KITAJIMAI, NISHIOKA 1(, YAMAMOTOK: I n d u c t i o n of Inflammatory Arthropathy Resembling R h e u m a t o i d A r t h r i t i s i n Mice T r a n s g e n i c for HTLV1. Science 1991, 253:1026-1027 JACOB J, KELSOEG, RAJEWSKYK, WEISS U: I n t r a c l o n a l G e n e r a t i o n o f A n t i b o d y Mutants i n G e r m i n a l Centres [L~ter]. Nature 1991, 354:389-391. JAIN J, MCCAFFREYPG, VALGE-ARCHERvg, RAO A: N u c l e a r Factor o f Activated T Cells Contains Fos a n d J i m [LeRer]. Nature 1992, 356:801-803. JANDA KD, WEINHOUSEMI, DANON T, PACELLIKA, SCHLOEDER DM: A n t i b o d y Bait and S w i t c h Catalysis - a Survey o f A n t i g e n s Capable o f I n d u c i n g Abzymes w i t h Acyl-Transfer P r o p e r t i e s . j A m C%em 5be 1991, 113:5427-5434. JANSEN B, VALLERADA, JASZCZ WB, NGUYEND, K~'R5EY JH: Successful T r e a t m e n t o f H u m a n Acute TCell L e u k e m i a I n SCID Mice Using t h e Anti-CD7Deglycosylated R i c i n A-Chain I m m u n o t o x i n Do7. Cancer Res 1992, 52:1314-1321. J ~ L-FL, MURPtIYJR: D i p h t h e r i a T o x i n Receptorb i n d i n g D o m a i n Substitution w i t h I n t e r l e u k i n 6: Genetic C o n s t r u c t i o n a n d I n t e r l e u k t n 6 Receptorspecific Action o f a d i p h t h e r i a T o x i n - r e l a t e d I n t e r l e u k i n 6 F u s i o n Protein. f+otein Eng 1991, 4:989-994 JOHN J, MCKENDRYR~ PELLEGRINIS, FLAVELLD, KERR IM, S'[ARK GR: I s o l a t i o n a n d C h a r a c t e r i z a t i o n o f a New M u t a n t H u m a n Cell Line U n r e s p o n s i v e to AlphaI n t e r f e r o n s a n d Beta-Interferons. Mol Cell Biol 1991, 11:4189~195.

JONES AL, ET AL.: Infectious C o m p l i c a t i o n s o f Subcutaneous lnterleukin-2 and Interferon-alpha [Letter]. Lancet 1992, 339:181. JUSTEMENTLB, CAMPBELLKS, CHIEN NC, CAMBIERJC: R e g u l a t i o n o f B-Cell A n t i g e n Receptor Signal T r a n s d u c t i o n a n d P h o s p h o r y l a t i o n by CD45. Science 1991, 252:1839-1842. KALUZAB, LENZ It, RUSSMANNE, HOCK H, RFININOP O, MAJDIC O, I~LNAPPW, WEIDLE UII: Synthesis a n d Functional Characterization of a Recombinant M o n o c l o n a l A n t i b o d y D i r e c t e d Against t h e AlphaC h a i n o f the H u l n a n I n t e r l e u k i n - 2 Receptor. Uene 1991, 107:297-305. KAMAYAS, Y&MAKAWAK, MENG XQ, OGU~A H, NAKAMURA S: P r o d u c t i o n o f M o n o c l o n a l Antibody to Clostridium-Difflcile Toxin-A W h i c h Neutralises E n t e r o t o x i c i t y But n o t H a e m a g g i u t i n a t i o n Activity. FEMS Microbiol Left 1991, 81:311-316 KANG AS, JONES TiM, BL'RTONDR: Antibody R e d e s i g n b y C h a i n Sinfffling f r o m R a n d o m C o m b i n a t o r i a l I m m l l n o g l o b u l i n Libraries. Proc Natl A c i d Sei U S A 1991, 88:11120-11123. KAPLAN G, COHN ZA, SMI~ KA: R a t i o n a l I m m u n o t h e r a p y w i t h Interfeukin-2. Biotechnology 1992, 10:157-162. KASPRZYK PG, SONG SU, DIHORE PP~ KING CR: T h e r a p y o f a n A n i m a l Model o f H u m a n Gastric C a n c e r U s i n g a C o m b I n a t i o n o f Anti-erbB-2 M o n o c l o n a l Antibodies. CancerRes 1992, 52:2771-2776. KASUKABET, OKABEKADOJ, HONMA Y, HOZUMI M: I n t e r l e u k i n - 4 I n h i b i t s t h e Differentiation o f M o u s e Myeloid L e u k e m i a M1-Celis I n d u c e d by Dexamethasone, D-Factor/Leukemia Inhibitory F a c t o r a n d I n t e r l e u k i n - 6 , But not By l a l p h a , 2 5 D i h y d r o x y v i t a m i n - D 3 . FEBS Left 1991, 291:181-184. KAUFMANNY, TSENG E, SPRINGERTA: Cloning o f t h e M u r i n e L y m p h o c y t e Function-Aasociated Molecule-1 A l p h a - S u b u n i t a n d Its E x p r e s s i o n i n COS Cells. J lmmuno11991, 147:369-374. KAWASHIMAH, YAMAGISHIJI, YAMAYOSHIM, OIIUE M, FUKI~ T, KOTANI H, YAMADAM: Structure - Activity Relationships in Human Interleukin-lalpha: I d e n t i f i c a t i o n o f Key R e s i d u e s for E x p r e s s i o n o f B i o l o g i c a l Activities. Protein Eng 1992, 5:171-176. KAWASHIMA I, OHSUMIJ, MITAHONJO K, SHIMODATAKA2NO K, ISHIKAWAH, SAKAKIBARAS, MIYADA1K, TAFAGUCHI Y: M o l e c u l a r C l o n i n g o f CDNA E n c o d i n g A d i p o g e n e s i s I n h i b i t o r y F a c t o r and Identity w i t h I n t e r l e u k i n - 1 1 . FEBS Left 1991, 283:199-202. KAY MA, BALEy p, ROTHENBERGS, LELANDF, FLEMINGL, PONDER KP, LIU TJ, F~NEGOLD M, DARLINGTONG, POKORN~YW , WOO SLC: E x p r e s s i o n o f H u m a n A l p h a - l - A n t i t r y p s i n i n D o g s after Autulogous Transplantation of Retroviral Transduced Hepatocytes. Proc Nail A c a d Sci U S A 1992, 89:89-93 KAY R, ROSTER PM, HUMPHRIESRK: CD24, a Signal T r a n s d u c e r M o d u l a t i n g B-Cell Activation R e s p o n s e s , ts a Very S h o r t Peptide w i t h a Glycosyl P h o s p h a t i d y l l n o s i t o l M e m b r a n e A n c h o r . J l m m u n o l i991, 147:1412-1416. KAZATCHKINEM, PAUL WE, KISHIMOTOT, MELCHERSF, MFfCALF ]3, MOSMANN T, OPPENIIEIMJ, Rbq)DLE N, VANSI~CKJ, MOSMANNT: N o m e n c l a t u r e for S e c r e t e d R e g u l a t o r y P r o t e i n s o f t h e I m m u n e System ( I n t e r l e u k i n s ) - t h e WHO-IUIS N o m e n c l a t u r e S u b c o m m i t t e e o n l n t e r l e n k i n Designation. Blood 1992, 79:1645-1646. ICE HM, ZYDOWSKYLD, IAUJ, WALSH CT: Crystal S t r u c t u r e o f R e c o m b i n a n t H u m a n T-Cell Cyclophilin-A At 2.5-A Resolution. Proc Natl A c a d Sci U S A 1991, 88:9483-9487. KELLY RW, LEASKR, CALDERAA: C h o r i o d e c i d u a l Production of Interleukin-8 and Mechanism of P a r t u r i t i o n . Lancet 1992, 339:776. KENNEL SJ: Effects o f T a r g e t A n t i g e n C o m p e t i t i o n o n D i s t r i b u t i o n o f M o n o c l o n a l Antibody to Solid T u m o r s . Cancer Res 1992, 52:1284-1290 K14AZAELIMB, SALH~ MR, LIU TP, MEREDITH RF, WHEELER RH, BAKERTS, KING D, SECHER D, ALLENL, ROGERS K, COLCHERD, SCHLOMJ, SHOCHATD, LOBUGLIOAF: P h a r m a c o k i n e t i c s a n d I m m u n e Response o f 1131-Chimeric Mouse/Human-B72.3 (Human G;tmm~4) M o n o c l o n a l A n t i b o d y i n H u m a n s . CancerRes 1991, 51:5461-5466. KaLI2LNPL, KAFFKA KL, BIONDI DA, LIP~'&L\JM, BENJAMIN WR, FELDMAND, CAMPER CA: Antiproliferative Effect o f I n t e r l e u k i n - 1 o n H u m a n Ovarian C a r c i n o m a Cell Line (NIH:OVCAR-3). Cancer Res 1991, 51:1823 1828. KING DJ, ADMR JR, 2MNGALS, LOW DC, PROUDFOOTKA, LLOYDJC, BODMERMW, YARRAN~rONGT: E x p r e s s i o n , P u r i f i c a t i o n a n d C h a r a c t e r i z a t i o n o f a Mouse Human C~eric A n t i b o d y and C h i m e r i c Fab' F r a g m e n t . B i o c h e m J 1992, 281:317-323

737

738

Pharmaceutical applications T cells and immunomodulation KION TA, HOFFMANN GW: A n t i - H I V a n d A n t t - a n t i - M H C Antibodies in Alioiml~une and Autuimmune Mice. Science 1991, 253:1138-1139. KLEIN B, WIIDENES J, ZHANG XG, JOZTRDANM, BOIRON JM, BROCHIERJ, I~A'I'ARDJ, MERLIN M, CLRMENT C, MOREL FOURN1ER B, I.U ZY, MANNONI P, SANYJ, BATAILLE R: Murine Anti Interleuldn 6 Monoclonal Antibody T h e r a p y f o r a P a t i e n t w i t h P l a s m a Cell L e u k e n l i a . Blood 1991, 78:119W1204. KLLNGEMA~N2q1t-G, GRIGG AP, WILKIE BOYD K, BARNETI'I' MJ, EAVESAC, REECE DE, SHEPHERDJD, PHILLIPS GL: T r e a t m e n t w i t h R e c o m b i n a n t I n t e r f e r o n (ct2~) E a r l y a f t e r B o n e M a r r o w T r a n s p l a n t a t i o n i n P a t i e n t s at H i g h R i s k f o r R e l a p s e . Blood 1991, 78:3306-3311. KLUGE M, ELGER B, ENGEL T, SCHAEFERC, 8EEGA J, VAUPEL P: Acute Effects o f T u m o r N e c r o s i s F a c t o r alpha or Lymphotoxin on Global Blood Flow, Laser D o p p l e r Fl ux, a n d B i o e n e r g c t i c Status o f S u b c u t a n e o u s R o d e n t T u m o r s . C~ncer Res 1992, 52:2167-2173. KLUIN-NELEMANS HC, AND OTHERS: R e s p o n s e t o I n t e r f e r o n Alfa-2b i n a P a t i e n t w i t h S y s t e m i c M a s t o c y t o s i s . N Engl J M e d 1992, 326:619-623. KODAMA S, TSURUOKA N, TSUJIMOTO M: R o l e o f t h e CT e r m i n u s i n t h e B i o l o g i c a l Activity o f H u m a n i n t e r l e u k t n - 5 . Biochem Biophys Res C o m m u n t991, 178:514-519. KOLLER E ET AL.: R e s t o r a t i o n o f A l l - t r a n s R e t i n o i c A c i d S e n s i t i v i t y b y I n t e r f e r o n i n Acute P r o m y e l o c y t i c L e u k a e m i a [Letter]. Lancel 1991, 338:1154. KOOLWIJK P~ VANDEWhNKELJGJ, PFEFFERKOKNLC, JACOBS CWM, OTTEN I, SPIERENBURGGT, BAST BJEG: i n d u c t i o n o f I n t r a c e l l u l a r Ca2+ M o b i l i z a t i o n and Cytotoxicity by Hybrid Mouse Monoclonal Antibodies - Fcg~mmnRH Regulation of FcgammaRLTriggered Functions or Signaling. J Bnmuno11991, 147:595-602. KORNER H, SCHLIEPHAKEA, WINTER J, ZIMPRICH F, LASSMANNH, SEDGWICKJ, SlDDELL S, WEGE H: N u c l e o c a p s i d o r S p i k e P r o t e i n - S p e c i f i c CD4+ Lymphocytes-T Protect Against CoronavirusInduced Encephalomyelitis in the Absence of CD8+ Cells-T. J l m m u n o 1 1 9 9 1 , 147:231~2323. KOSTELNWSA, COLE MS, TSO JY: F o r m a t i o n o f a Bispecific A n t i b o d y b y t h e u s e o f L e u c i n e Z i p p e r s . J I m m u n o 1 1 9 9 2 , 148:1547-1553. KRATJE RB, WAGNER R: E v a l u a t i o n o f P r o d u c t i o n o f Recombinant Human Interleukin-2 in Fluidized Bed B i o r e a c t o r . Biotechnol Bioeng 1992, 39:233-242. KRZYCH U, JA~EED T, I2NK 11T, LOO~S LD, BALLOL"WR: Distinct T-Cell Specificities are Induced with the Authentic Versus Recombinant PlasmodiumB e r g h e i C l r c u m s p o r o z o i t e Protein. J l m m u n o l 1992, 148:2530-2538. KUMAR A, ARORA R, KAUR P, CHAUHAN VS, SHARMAP: U n i v e r s a l T H e l p e r Cell D e t e r m i n a n t s E n h a n c e Itnnlunogenicity of a Plasmoditma-Falciparum M e r o z o i t e S u r f a c e A n t i g e n Pe pt i de . j I m m u n o l 1992, 148:1499 1505. LABRIOLATOMPKINSE, CHANDRAN C, KAKFKAKL, BIONDt D, G~AVES BJ, HATADA M, ~VIADISONVS, KARASJ, KILIAN PL, J u G: I d e n t i f i c a t i o n o f t h e D i s c o n t i n u o u s B i n d i n g Site i n H u m a n I n t e r l e u k i n - l b e t a f o r t h e Type-I I n t e r i e u k i n - 1 R e c e p t o r . Proc Natl A c a d Sci U S A 1991, 88:1118~11186. LAMPE MA, PATARCAR, IREGHI MV, CAN~TORH: P o l y c l o n a l B-Cell A c t i v a t i o n b y t h e Eta-1 C y t o k i n e a n d t h e Development of Systemic Autuimmune Disease. J Immuno11991, 147:2902-2906. LAPIDOT T, PFLUMIO F, DOEDENS M, MURDOCH B, WILLIAMS DE, DICK JE: C y t o k i n e S t i l n u l a t i o n o f Multilineage Hematupoiesis from Immature H u m a n Cells E n g r a f t e d i n SCED Mice. Science 1992, 255:1137-1141. LE HV, SEELIG GF, SYI~) R, RAMANA~4ANL, WINDSOR x~/T, BOKKOWSKI D, TROTTA PP: Selective P r o t e o l y t i c Cleavage o f R e c o m b i n a n t H . m = n I n t e r l e u k i n . 4. Evidence for a Critical Role of the C-Terminus. Biochemistry 1991, 30:9576-9582. LEAIIY DJ, ~ R, ~NDKICKSON WA: C r y s t a l S t r u c t u r e o f a S o l u b l e F o r m o f t h e H u m a n T-Celi C o r e c e p t o r CD8 at 2.6 A - R e s o l u t i o n . Cell 1992, 68:1145-1162. LEBERTHON B, KHAWLI LA, ALAUDDIN M, MILLER GK, CHARAK BS, MAZUMDERA, EPSTEIN AL: E n h a n c e d Tumor Uptake of Macromoleeules Induced by a Novel V a s o a c t i v e I n t e r l e d i d n - 2 l m m ~ m o c o n j u g a t e . Cancer Res 1991, 51:2694-2698. LEg M.4, KANTARJlANH, TAI,PAZ M, FREIREICH EJ, DEISSEROTHA, TRDJILLOJM, STASSSA: D e t e c t i o n o f Minimal Residual Disease by Polymerase Chain Reaction in philadelphia Chromosome-positive Chronic Myelogenous Leukemia Following I n t e r f e r o n T h e r a p y , Blood 1992, 79:1920-1923. LENSCHOW DJ, ZENG Y, THISTLEW~dTEJR, MONTAG A, BRADY • W, GIBSON MG, LINSLEYPS, BLL~STONEJA: L o n g T e r m S u r v i v a l o f X e n o g e n e i c P a n c r e a s I s l e t Grafts

i n d u c e d b y CTLA41g. Science 1992, 2 5 7 : 7 8 ~ 7 9 2 , [201.

LERNER RA, BARBAS CF II1, KANO AS, BURTON DR: O n the use of Combinatorial Antibody Libraries to Clone The 'fossil Record' of an Individual's l m m l l n e R e s p o n s e . Proc Natl A c a d Sci U S A 1991, 88:9705-9706. LETOURNEUR O, KENNEDY ICS, BP~NI AT, ORTALDOJR, OSHEA JJ, KINETJP: C h a r a c t e r i z a t i o n o f t h e F a m i l y o f D i m e r s A s s o c i a t e d w i t h Fc R e c e p t o r s (FcepsllonRI and FcgammaRIH). J Immuno11991, 147:2652-2656. LEWIS C, KP.AMERT, ROBINSON S, HILVERT D: M e d i u m Effects i n A n t i b o d y C a t a l y z e d R e a c t i o n s . Science 1991, 253:1019-1021. LINARDOS TI, KALOGERAYdSN, BEHIE LA, LAMONWAGNELR: Monoclonal Antibody Production in Dialyzed C o n t i n u o u s S u s p e n s i o n c u l t u r e . Biotechnol Bioeng 1992, 39:504-510. LtNDSTROM E, KOGA Y, WIGZELL H: HIV-1 G e n e Rev Responsible for Accumulated Heterodisperse RNAs S e e n i n I n f e c t e d T-Cells. Virology 1992, 186:335-338. LINGWOOD CA, YIU SK: G l y c o l l p i d M o d i f i c a t i o n o f Alpha2 interferon Binding - Sequence Similarity Between the Alpha2 Interferon Receptor and V e r o t o x i n ( S h l g a - L i k e T o x i n ) B-Subunit. Biochem J 1992, 283:25-26. LISTJ, MOSER RP, STEUERM, LOUDON WG, BLACKLOCK.IB, GRIMM EA: C y t o k i n e R e s p o n s e s to I n t r a v e n t r i c u l a r Injection of Interleukin-2 into Patients with Leptomeningeal Carcinomatosis - Rapid Induction of Tumor Necrosis Factor-alpha, Interleukin-lbeta, Interleukin-6, G~mmaInterferon, and Soluble Interleuldn-2 Receptor ( M r 5 5 , 0 0 0 - P r o t e i n ) . C a n c e r R e s 1992, 52:1123-1128. LIu Y, jA~WAY CA JR: Cells t h a t P r e s e n t B o t h S p e c i f i c i t y L i g a n d a n d C o s t t m d i a t o r y Activity a r e t h e M o s t Efficient I n d u c e r s o f C l o n a l E x p a n s i o n o f N o r m a l CD4 T Cells. Proc Natl A c a d Sci U S A 1992, 89:3845 3849. LORD KA, ABDOLLAHI A, THOMAS SM, DEMAXCOM, BRUGGE JS, HOFFM&NLIEBERMANNB, IJEBE~MANN DA: L e u k e m i a Inhibitory Factor and Interleukin-6 Trigger the Same Immediate Early Response, Including Tyrosine Phosphorylation, Upon induction of M y e l o i d L e u k e m i a D i f f e r e n t i a t i o n . Mol Cell Biol 1991, 11:4371~379. LORIJN RHW: M o n o c l o n a l E n d o t o x i n A n t i b o d y i n M e n i n g o c o e c a l S e p s i s [Letter]. Lancet 1992, 339:930. L O m J N RHW: E n d o t o x i n A n t i b o d y f o r Sepsis i n I n f a n t s [Letter]. Lancet 1992, 339:1414. LOS/vLANMj, FASY "I\M, NOVICK KE, MONESTIERM: Monoclonal Autoantibodies to Subnucleosomas f r o m a MRL/Mp-+/+ M o u s e - O l l g o c l o n a l i t y o f the Antibody Response and Recognition of a D c t e r n l i n a n t C o m p o s e d o f H t s t o n e s H2A, H2B, a n d DNA. J f m m u n o 1 1 9 9 2 , 148:1561-1569. LU GZ, TSANG RSW, CHAU PY, CHOI D, LAW D, NG MH: Characterization and Application of a Murine Monoclonal Antibody that Reacts Specifically w i t h t h e S e r o g r o u p - D 1 s a l m o n e l l a . FEMS Microbiol Lett 1991, 80:135-140. LU S, REYES VE, BOSITIS CM, GOLDSCHMIDT TG, LAM V, TORGERSON RR, CIARDELLI T, HARDY L, LEW RA, HUMPHREYS RE: B i o p h y s i c a l M e c h a n i s m o f t h e S c a v e n g e r Site N e a r T - C e l I - P r e s e n t e d E p i t o p e s . Vaccine 1992, 10:3-7. LUND J, WINWER G, JONES PT, POUND JD, T&NAKAT, WALKER MR, ARTYMII=~KPJ, ARATAV, BURTON DR, JEFFEPdS R, WOOF JM: H u m a n F c g a m m ~ R I a n d Fcg~amm~RII Interact with Distinct But Overlapptng'SRes¢on H u m a n lgG. J I m m u n o 1 1 9 9 1 , 147:2657-2662. MAGEE G D FT AL.: E n d o t o x i n A n t i b o d y f o r S e p s i s i n I n f a n t s [Letter]. Lancet 1992, 339:1414. MAGRIN S ETAL; HOSEIN B ETAL.; LENZI METAL.: A n t i HCV, Anti-GOR, a n d A u t o t m m , l n i t y [Letter]. Lancet 1992, 339:871. MARCHALONISJJ, KAYMAZH, DEDEOGLU F, SCHLUTERSF~ YOCIM DE, EDMUNDSONAB: H u n ~ a n A o t o a n t i b o d i e s R e a c t i v e w i t h S y n t h e t i c A u t o a n t i g e n s f r o m T-Cell R e c e p t o r B e t a - C h a i n . Proc Natl A c a d Sci U S A 1992, 89:3325-3329. MARIANI M, TARDI~ L: v a l i d a t i n g t h e P r e p a r a t i o n o f clinical Monoclonal Antibodies. Biotechnolo~ IcY)2, 10:391-398. MARKSJD ET AL.: B y - p a s s i n g I n a n a u n i z a t i o n : B u i l d i n g High-Affinity Human Antibodies by Chain Shag. Biotechnolog~ 1992, 10:779-783. MARKSJD, HOOGENBOOM HR, BONNERT TP, MCCAFFERTYJ, GRIFYrrHs AD, WINTER G: B y - p a a s i n g I m m u n i z a t i o n . t I u n l a n A n t i b o d i e s f r o m V - g e n e Libraries D i s p l a y e d o n P h a g e . J Mol Bio11991, 222:581-597. MATSUI M, YOSHEMURAS, NAKAN~SHIT, FERRON~ S: Effect o f T u m o r Size o n t h e E n h a n c e m e n t b y G a m m a Interferon of the Localization of Radioiabcled

F(ab')2 Fragments of Antiintercellular Adhesion

Molecule-1 M o n o c l o n a l A n t i b o d i e s i n H u m a n C o l o n C a r c i n o m a Cells G r a f t e d i n N u d e Mice. C~ncer Res 1992, 52:1309-1313. MATI~IEWS DC, BADGER CC, FISHERDR, HL~ TE, NOLr~GAT C, APPELBAUM FR, MARTIN PJ, BERNSTELNID: Selective Radiation of Hematolymphoid Tissue Delivered b y A n t i - C D 4 5 A n t i b o d y . CancerRes 1992, 52:1228-1234. MAZZOLLA R, BARLUZZIR, ROMANI L, MOSCI P, BISTONI F: A n t i - C a n d i d a R e s i s t a n c e i n t h e M o u s e B r a i n a n d Effect o f I n t r a c e r e b r a l A d m i n i s t r a t i o n o f I n t e r l e u k i n - 1 . J Gen Microbio11991, 137:1799-1804. MCKEON F: W h e n W o r l d s Collide 4 m m u n o s u p p r e s s a n t s M e e t P r o t e i n P h o s p h a t a s a s . Cell 1991, 66:823426. M~SER BM, BILLINGHAM ME, MORRIS RE: Effects o f Cyclosporin FKS06 and Rapamycin on Graft Vessel D i s e a s e . Lancet 1991, 338:1297-1298. MENDELSON E, GROSSMAN Z, MILEGI01RF, RECHAVI G, CARTER BJ: R e p l i c a t i o n o f A d e n o - A s s o c i a t e d V i r u s Type2 i n H u m a n L y m p h o c y t i c Cells a n d i n t e r a c t i o n w i t h HIV-1. Vtrology 1992, 187:453-463. MERIDA I, DIEZ E, GAULTON GN: IL-2 B i n d i n g Activates a Tyrosine-Phosphorylated Pho sphatidylinositoL3Kinase. J l m m u n o 1 1 9 9 1 , 147:2202-2207. MESKAUSKASA, CITAVICIUSD: T h e K 2 - T y p e K i l l e r T o x i n Encoding and hnnlunity-Encoding Region from Saccharomyces-Cerevisiae - Structure and E x p r e s s i o n i n Yeast. Gene 1992, 111:135-139. MILRS DW: T o x i c i t y a n d R e e o n s t i t u t i o n o f R e c o m b i n a n t l m t e r l e u k i n 2 w i t h A l b u m i n [Letter]. Lancet 1991, 338:1464. MIRKOVITCH, DECKER T, DARNJELLJE: I n t e r f e r o n Induction of Gene Transcription Analyzed by I n v i v o F o o t p r i n t i n g . Mol Cell Bio11992, 12:1-29247. MIYAZAKI K, YASUMOTO K, YANO T, MATSUZAKIG, SUGIMACHI K, NOMOTO K: S y n e r g i s t i c Effect o f N o c a r d i a - R u b r a Cell W a l l S k e l e t o n a n d Recombinant Interleukin-2 for Invivo Induction o f L y m p h o k i n e - A c t i v a t e d K i l l e r Cells. Cancer Res 1991, 51:5261-5265. MON~FEIRORe, COOPER MD, KUBAGAWA H: M o l e c u l a r Heterogeneity of Fcalpha Receptors Detected by Receptor-Specific Monoclonal Antibodies. J Irnmunol 1992, 148:1764-1770. MOOREJP, MCKEATINGJA, NORTON WA, SAT]TEN-[AUO~: Direct Measurement of Soluble CD4 Binding to H u m a n I m m u n o d e f i c i e n c y V i r u s Type-1 V i c i o n s - G p 1 2 0 D i s s o c i a t i o n a n d Its I m p l i c a t i o n s f o r Virus-Cell B i n d i n g a n d F u s i o n R e a c t i o n s a n d T h e i r N e u t r a l i z a t i o n b y S o l u b l e CD4. J Viro11991, 65:1133-1140. MOLW R, WILLEMZE R, LANDEGE,~fl' JE: R e p e a t P o l y m o r p h l s m s i n t h e I n t e r l e u k i n - 4 G e n e (HA). Nucleic A c i d s Res 1991, 19:3763. MUJOO K, ROSENBLUMMG, MURRAYJL: A u g n a e n t e d Binding of Radiolabeled Monoclonal Antibodies to M e l a n o m a Cells U s i n g S p e c i f i c A n t i b o d y C o m b i n a t i o n s . CancerRes 1991, 51:2768-2772. MULEJJ, COSTER MC, ~RAVISX.VD, ROSENBERGSA: C e l l u l a r Mechanlanxs of the Antitumor Activity of R e c o m b i n a n t ED6 i n Mice. J l m m u n o 1 1 9 9 2 , 148:2622-2629. ML~LIGAN MS, YEH CG, RUDOLPH AR, WARD PA: P r o t e c t i v e Effects o f S o l u b l e CR1 i n C o m p l e m e n t - M e d i a t e d and Neutrophil-Mediated Tissue Injury. J Immunol 1992, 1 4 8 : 1 4 7 9 1 4 8 5 . NADEL S ET AL.: E n d o t o x i n A n t i b o d y f o r S e p s i s i n I n f a n t s [Letter]. Lancet 1992, 339:678. NASSANDERUK~ STEERENBERGPA, POPPE H, STORM G, POELS LG, DEJONG WH, CBOMMELrNDJA: I n v i v o T a r g e t i n g o f OV-TL-3 l m m u n o l i p o s o m e s t o Ascitic O v a r i a n C a r c l n o n a a Cells (OVCAR-3) i n A t h y n l i c N u d e Mice. Cancer Res 1992, 52:64(~653. NAUME ]3, ESPEVIK T: Effects o f I D 7 a n d IL-2 o n H i g h l y E n r i c h e d CD56+ N a t u r a l K i l l e r Cells - a C o m p a r a t i v e Study. J I m m u n o 1 1 9 9 1 , 147:2208-2214. NE~qLLE DM, SCHAR~ J, SPdN~VASACHARK: Lqvivo TCell A b l a t i o n b y a H o l o - I m m u n o t o x i n D i r e c t e d at H u m a n CD3. Proc Natl A c a d Sci U S A 1992, 89:2585-2589. NIELSENJB, HSU MJ, BYRNE KM, KAPLAN L: B i o s y n t h e s i s of the lmmtlnosuppressant Imnlunomyein the Enzymulogy of Pipecolate Incorporation. Biochemistry 1991, 30:5789-5796. NISIIIKAWA S, KUSAKABEM, YOSHINAGA K, OGAWA M, HAYSAHI SI, KUNISADAT, ERA T, SAKAKURAT, NIS~EKAWA SI: I n Utreo M a n i p u l a t i o n o f Coat C o l o r F o r m a t i o n b y a m o n o c l o n a l a n d Antic-kit A n t i b o d y : T w o D i s t i n c t W a v e s o r e - k i t dependency During Melanocyte Development. E M B O J 1991, 10:2111-2118. NISHLMLrRAH, KUZUYA H, KOSAKI A, OKAMOTO M, OKAMOTO M, KONO S, INOL~ G, MAEDA I, IMURA H: M o n o e l o n a l A n t i b o d i e s P o s s i b l y R e c o g n i z e Conformational Changes in the Human

Pharmaceutical applications T cells and immunomodulation E r y t h r o c y t e G l u c o s e T r a n s p o r t e r . BiochemJ 1992, 281:103-106. NISHIMURAT, NAKAMU]~AY, TAKEUCHAy, TOKUDA Y, IWASAWA M, KAWASAKIA, OKUMURA K, HABU S: Generation, Propagation, and Targeting of H u m a n CD4+ H e l p e r / K i l l e r T-Cells I n d u c e d b y A n t i - C D 3 M o n o c l o n a l A n t i b o d y Plus R e c o m b i n a n t IL-2 - a n Efficient S t r a t e g y f o r Adopt i ve T u m o r I m m u n o t h e r a p y . J l m m u n o l 1992, 148:285-291. NOSSAL GJV: T h e M o l e c u l a r a n d C e l l u l a r Basis o f Affinity Maturation in the Antibody Response. Cell 1992, 68:1-2. NOSSAL GJV: M o l e c u l a r a n d C e l l u l a r Aspects o f I m l ~ u n o l o g i c T o l e r a n c e . E u r J B i o c h e m 1991, 202:729-737. NUNEZ G, HOCKENBERYD, MCDONNELL q], SORENSENCM, KORSMEYER SJ: Bcl-2 M a i n t a i n s B-Cell M e m o r y . Nature 1991, 353:71 73. .NYKJAERA, PETERSEN CM, MOLLER B, ANDREASENPA, GLIEMAN~ J: I d e n t i f i c a t i o n a n d C h a r a c t e r i z a t i o n o f U r o k i n a s e R e c e p t o r s i n N a t u r a l K i l l e r Cells a n d T - C e l l - D e r i v e d L y m p h o k i n e Activated K i l l e r Cells. FEBS Lett 1992, 300:13-17. OBBOLD SP, QIN S, LEONG LYX~, MAR2~N G, WALDM/LNN • • H: R e p r o g r s m m l n g t h e I m m u n e S y s t e m f o r P e r i p h e r a l T o l e r a n c e w i t h C D 4 a n d CD8 M o n o e l o n a l A n tib o d ies. l m m u n o l Rev 1992, ( i n P r e s s ) : . [33]. OGUMA N, SEIIGETAC, TAKAUCHIK, TANAKAK, KAMADAN, KAWANO H, KURAMOTOA: M o l e c u l a r l¢llm{rlation o f the Minimal Residual Phl Clone with IFNalpha in CML [Letter]. Lancet 1992, 339:557-559. OVLNO S: HOW C y t o t o x i c T-Cell~ M a n a g e to D i s c r i m i n a t e N o n s e l f f r o m S e l f at t h e N o n a p e p t i d e Level. Proc Natl A c a d Sci U S A 1992, 89:4643--4647. OKEEFE SJ, TAMU~RAj, KINCAID RL, TOCCI MJ, ONEILL EA: F K - 5 0 6 - S e n s i t i v e a n d CsA-Sensitive A c t i v a t i o n o f t h e I n t e r l e u k i n - 2 P r o m o t e r b y C a l e l n e u r i n . Nature 1992, 3 5 7 : 6 9 2 ~ 9 4 . OLSEN E, ZHANG L, HILL RD, KISIL FT, SEHON AH, MOHAPATRA SS: I d e n t i f i c a t i o n a n d C h a r a c t e r i z a t i o n o f t h e Poa-p-IX G r o u p o f B a s i c A l l e r g e n s o f K e n t u c k y B l u e g r a s s P o l l e n . J Immuno11991, 147:205-211. OPALKA B, WANDL UB, BECHER R, KLORE O, NAGEL-HIEMKE M, MOR/TZ T, BEER U, SEEBER S, NIEDERLE N: M i n i l n a t Residual Disease in Patients with Chronic Myelogenous Leukemia Undergoing Long-term T r e a t m e n t w i t h R e c o m b i n a n t I n t e r f e r o n ~-2b A l o n e o r i n C o m b i n a t i o n w i t h I n t e r f e r o n y. Blood 1991, 78:2198-2193. ORLANDO C, DALAVERJ, BMLLAT G, CASTETSF, JEANNEQUIN O, MAZIE JC, MONNERON A: A M o n o c l o n a l A n t i b o d y D i r e c t e d A g a i n s t t h e C a t a l y t i c Site o f BacillusAnthracis Adenylyl Cyclase Identifies a Novel M a m m a l i a n B r a i n Catalytic S u b u n i t . Biochemtstry 1992, 31:3215-3222. OSTRANDROSENBERGS, ROBY CA, CLEMENTSVK: A b r o g a t i o n o f T u m o r i g e n i c i t y b y MHC Class-H Antigen Expression Requires the Cytoplasmic D o m a i n o f t h e Claas-H M o l e c u l e . J l m m u n o l 1991, 147:2419-2422. OTTO G: M o n o c l o n a l Anti-CD25 f o r Acute R e j e c t i o n a f t e r L iv er T r a n s p l a n t a t i o n [Letter]. Lancet 1991, 338:195. OZAKI Y, MATSUMOTOY, YATOMIY, HIGASHIHARAM, KUSMRS: T w o - S t e p M o b i l i z a t i o n o f A r a c h i d o n i c A c i d i n Platelet A c t i v a t i o n I n d u c e d b y L o w C o n c e n t r a t i o n s o f TP-82, a M o n o c l o n a l A n t i b o d y A g a i n s t CD9 A n t i g e n . E u r J Biocbem 1991, 199:347 354. PAGANELLI G, NIAGNA~NqP, ZITO F, VILLA E, SUDKF~P, LOPALCO L, ROSSETII C, MALCOVAT1M, CHIOLERIO F, SECCAMANI E ET AL,: T h r e e S t e p M o n o c l o n a l Antibody Tumor Targeting in CarcInoembryonic A n t i g e n P o s i t i v e Patients. Cancer Res'1991, 51:5960-5966. PALIARD X, WEST SG, LAFFERTYJA, CLEMEN~fSJR, KAPPLER JW, MARRACK P, KOTZlN BL: E v i d e n c e f o r t h e Effects o f a S u p e r a n t i g e l l i n R h e u m a t o i d Arthritis. Science 1991, 253:325-329. pAMER EG, HARTYJT, BEVA~NMJ: P r e c i s e P r e d i c t i o n o f a D o m i n a n t Class 1 M H C - r e s t r i c t e d E p i t o p e o f L i s t e r i a M o n o c y t o g e n e s . Nature 1991, 353:852. PAREY-M RB, DWEK RA, RADEMACHER"IN~, OPDENAKKER G, V&NDAMMEJ: G l y c o s y l a t i o n o f i n t e r l e u k i n - 6 Purified from Normal Human Blood Mononuclear Cells. E u r J B i o c h e m 1992, 203:135-141, PEREY L, HAYES DF, MAIMONISP, ABE M, OFIARAC, KUFE DW: T u m o r Selective R e a c t i v i t y o f a M o n o c l o n a l Antibody Prepared Against a Recombinant Peptide Derived from the DF3 Human Breast C a r c I n o m a - A s s o c i a t e d A n t i g e n . Cancer Res 1992, 52:2563-2568. PFEIKSCH]FTERJ, ROB P, MULSCHA, FANDREYJ, VOSBECK K, BUSSE R: I n t e r l e u k i n 1 b e t a a n d T u r n o u t N e c r o s i s

Factor Alpha Induce a Macrophage-Type of Nitric O x i d e S y n t h a s e i n Rat R e n a l M e s a n g i a l Cells. Eur J Biocbem 1992, 2 0 3 : 2 5 1 ~ 5 5 . PICCIOLI P, RUBERTI F~ BIOCCA S, DILUZIO A, WERGE TM, BRADBURYA, CATY~NEO A: N e u r o a n t i b o d i e s Molecular Cloning of a Monoclonal Antibody Against Substance-P for Expression in the Central N e r v o u s S y s t e n L Proc Natl A c a d Sci U S A 1991, 88:5611-5615. POPIENqEK PH, PRATT RF: K i n e t i c s a n d M e c h a n i s m o f Binding of Specific Peptides to Vancomychl and O t h e r G l y c o p e p t i d e A n t i b i o t i c s . J A m Cbem Soc t991, 113:2264-2270. PROUDFOOT AEI, DAVIESJG, TURCATn G, WINGFIELD PT: Human Interleukin-5 Expressed in EscherichiaColi - A s s i g n m e n t o f t h e D i s u l f i d e B r i d g e s o f t h e P u r i f i e d U n g l y e o s y l a t e d P r o t e i n . FEBS Lett 1991, 283:61~54. PURE E, TARDELLI L: T y r o s i n e P h o s p h o r y l a t i o n is Required for Ligand-Induccd Internalization of t h e A n t i g e n R e c e p t o r o n L y m p h o c y t e s - B . Proc Natl A c a d Sci U S A 1992, 89:11/~117. pURl RK, OGATA M, -IATZANDP, FELDMANGM, FITZGERALDD, PASTAN 1: E x p r e s s i o n o f H i s h - A f i q n i t y i n t c r l e u k i n 4 Receptors on Murine Sarcoma Cells and R e c e p t o r - M e d i a t e d C y t o t o x i d t y o f T u m o r Ceils to C h i m e r i c P r o t e i n B e t w e e n I n t e r i e u k i n - 4 a n d P s e u d o m o n a s E x o t o x i n . Cancer Res i991, 51:3011-3017. QUIGG RJ, CYBULSKYAV, SALANWDJ: Effect o f Nephritogenie Antibody on Complement Regulation in Cultured Rat GIomcrular Epithelial c e l l s . Jlmmuno11991, 147:838-845. RAASVELDMHM, ET AL.: T h r o m b o e m b o l i c C o m p l i c a t i o n s a n d D o s e o f M o n o c l o n a l OKT3 A n t i b o d y [Letter]. Lancet 1992, 339:1363. RAMBALDI A, TORCIA M, BETrON~ S, VANNIER E, BARBUI T, SHAW AR, DINARELLO CA, COZZOLINO F: M o d u l a t i o n o f Cell P r o l i f e r a t i o n a n d C y t o k i n e P r o d u c t i o n i n Acute M y e l o b l a a t i c L e u k e m i a b y I n t e r l e u k i n 1 R e c e p t o r A n t a g o n i s t a n d Lack o f Its E x p r e s s i o n b y L e u k e m i c Cells. Blood 1991, 7 8 : 3 2 4 9 3 2 5 3 . RANSOMJH, PELLE B, HANNA MG: E x p r e s s i o n o f ClassH Major Histocompatibility Complex Molecules Correlates with Human Colon Tumor Vaccine Efficacy. Cancer Res 1992, 52:3460-346@ RAVEL S, COLOMBATTt M, CASELLASP: I n t e r n a l i z a t i o n a n d I n t r a c e l l u l a r Fate o f Anti-CD5 M o n o c l o n a l Antibody and Anti-CD5 Ricin A-chain I m m u n o t o x i n i n H u m a n L e u k e m i c T cells. Blood 1991, 79:1511-1517. RAVINDRANATHRMH, GRAVESMC: M o n o d o n a l IgM A n t i b o d i e s f r o m C y t o m c g a l o v i r t m - I n f e c t e d Mice Recognize the GlcNAc-containing Receptor D e t e r m i n a n t o f M u r t n c CMV as Well as N e u t r a l i z i n g Anti-CMV IgG A n t i b o d i e s . Virology 1992, 188:143-151. RECHT M, BORDEN EC, KNIGHT E: A H u m a n 1 5 - k D a IFNI n d u c e d P r o t e i n I n d u c e s t h e S e c r e t i o n o f IFNg a m m a . J lmmuno11991, 147:261~2623. REID I, LUNDYJ, DONOHUE JH: E n h a n c e m e n t o f I n v i t r o Tumor-Infiltrating Lymphocyte Cytotoxicity by H e t e r o c o n j u g a t e d A n t i b o d i e s . J Immuno11992, 148:2630-2635. RESNITZK¥ D, TIEFENBRUN N, BERISSI H, KIMCHI A: Interferons and Interleukin-6 Suppress Phosphorylation of the Retinoblastoma Protein i n G r o w t h - S e n s i t i v e H e m a t o p o i e t i c Cells. Proc Natl Acad Sci U S A 1992, 8 9 : 4 0 2 ~ 0 6 . ~CHES P ET AL.: E n d o t o x i n A n t i b o d y f o r S e p s i s i n I n f a n t s [LetterJ. Lancet 1992, 339:1414. ROBERTS M, TITE JP, FAIRWEATrtERNP, DOUGAN G, CI~RLES IG: R e c o m b i n a n t P 6 9 / P e r t a c t i n - I m m u n o g e n i e l t y a n d P r o t e c t i o n o f Mice A g a i n s t B o r d e t c l l a P e r t u s s i s I n f e c t i o n . Vaccine 1992, 10:43-52. ROBINS RA, DENTON GWL, HARDCASTLEJD, AUSTIN EB, BALDWIN RW, DURR~NT LG: A n t i t u m o r I m m , l n e Response and Interleukin-2 Production Induced in Colorectal Cancer Patients by Immunization with Human Monoclonal Anti-Idiotypic Antibody. CancerRes 1991, 51:5425-5429. ROBINS RA, DENTON GWL, HARDCASTLEJD, AUSTIN EB, BALDWIN RW, DURR~NT LG: A n t i t u m o r ] m m l t u e Response and Interleukin-2 Production Induced in Coloreetul Cancer Fatients by Immunization with Hunlan Monoclonal Anti-Idiotypic Antibody. Cancer Res 1991, 51:5425-5429. ROFFLER SR, YU MH, CHEN BM, TUNG E, YEH MY: T h e r a p y of Human Cervical Carcinoma with Monoclonal Antibody-Pseudomonas Exotoxin Conjugates. Cancer Res 1991, 51:40014007, ROGERS BL, MORGENSTERNJP, GRIFFITH IJ, Yu XB, COLrNSELL CM, BRAUERAW, KING TP, GARM~N RD, KUO MC: Complete Sequence of the Allergen Arab-all R e c o m b i n a n t E x p r e s s i o n a n d R e a c t i v i t y w i t h TCeils f r o m R a g w e e d A l l e r g i c P a t i e n t s . J I m m u n o l 1991, 1 4 % 2 5 4 7 - 2 5 5 2

ROGERS ~IXV, SHEEHAN KCF, BRUNT LM, DOWER SK, UNANL7r: ER, SCHREIBERRD: I n t e r l e u k i n 1 P a r t i c i p a t e s i n the Development of Anti-listeria Responses in N o r m a l a n d SCID Mice. Proc Nail Acad Sci U S A 1992, 89:1011-1015. ROKEACH Ixk, HASELBYJA, MEILOFJF, SMEENKRJT, UNNASCH TR, GREE.NrEBM, HOCH SO: C h a r a c t e r i z a t i o n o f t h e A u t o a n t i g e n C a l r e t i c u l i n . J Immuno11991, 147:3031-3039. RYBAK SM, HOOGENBOOM HR, MEADE HIM, RAUS JCM, SCHWARTZD, YOULE 1~1: H u m a n i z a t i o n o f Imamunotoxials. Proc Natl A c a d Set U S A 1992, 89:3165-3169. SAGONE AL, HUSN~:YRM, TRIOZZI PL, RINEIqARTJ: I n t e r l e u k i n - 2 T h e r a p y E n h a n c e s Salicylate O x i d a t i o n b y B l o o d G r a n u l o c y t e s . Blood 1991, 78:2931-2936. SALA A, GRESSERI, CHASSOUXD, MAURY C, SANWODONATO L, EID P, MAtmOURY MT, BARCA S, CIANFRXGLIAM, BELARDELU F: I n h i b i t i o n o f F r i e n d L e u k e m i a Cell V i s c e r a l M e t a s t a s e s b y a N e w M o n o d o n a l Antibody and Role of the Immune System of the H o s t ill Its A c t i o n . Cancer Res 1992, 52:299(~2899. SAMBHARA SR, MILLER RG: P r o g r a m m e d Cell D e a t h o f T-Cells S i g n a l e d b y t h e T-Cell R e c e p t o r a n d t h e A l p h a 3 D o m a i n o f Class-I MHC. Science 1991, 252:1424-1427. SCHLOM J, EGGENSPERGERD, COLCHER D, MOLINOLO A, HOUCHENS D, MILLER LS, HINKLE G, SILER K: T h e r a p e u t i c A d v a n t a g e o f H i g h - A f f i n i t y A n t i c a r c i n o m a R a d i o i m m u n o c o n j u g a t c s . Cancer Res 1992, 52:1067-1072. SCHLOMJ, SILERK, MILENTCDE, EGGENSPERGERD, COLCHER D, MILLER LS, HOUCHENS D, ClIENG R, KAPLAN D, GOECKELER W: M o n o c l o n a l A n t i b o d y - B a s e d Therapy of a H.ma. Tumor Xenograft with a L u t e t i u m - 1 7 7 - L a b e l e d l m m t m o c o n j u g a t e . Cancer Res 1991, 51:2899-2896. SCFLMIDBERGERH, BUCHSBAUMDJ, BLAZARBR, EVERSON P, VALLERADA: R a d i o t h e r a p y i n Mice w i t h Y t t r i u m 90-Labeled A n t i - L y l M o n o d o n a l A n t i b o d y T h e r a p y o f t h e T-Cell L y m p h o m a - E L 4 . Cancer Res 1991, 51:1883-1890. SCHON~ICH JT, WILKINSON"VL, KADOFONG H, PKESKY DH, KOCHANJP: A s s o c i a t i o n o f t h e H u m a n FeepsilonRIgamma Subunit with Novel Cell S u r f a c e P o l y p e p t i d e s . Jlmrnunol 1992, 148:2191-2185. SCHREIBER GJ, HELLSTROMKE, HELLS~I~OMI: All Unmodified Anticarelnoma Antibody, BR96, Localizes t o a n d I n h i b i t s t h e O u t g r o w t h o f H u m a n T u m o r s i n N u d e Mice. Cancer Res 1992, 52:3262-3266. SCHUSTERJM, GARG PK, BIGN~R DD, ZALL'FSKYMR: Improved Therapeutic Efficacy of a Monoclonal Antibody Radioiodinated Using N-Succinimidyl3 - ( t r i - n o r m a l - b u t y l s t a n n y l ) B e n z o a t e . Cancer Res 1991, 51:4164--4169. SELIGER B, PFIZENMAIER K, SCHAFER R: S h o r t T e r m T r e a t m e n t w i t h G a m m a I n t e r f e r o n I n d u c e s Stable R e v e r s i o n o f Ras T r a n s f o r m e d M o u s e F i b r o b l a s t s . J Virol 1991, 65:6307. SELVAKUMARANM~ LIEBEBaMA~WNDA, HOFFMANLIEBEBaMANN B: D e r e g u l a t e d C - m y b D i s r u p t s i n t e r l e u k i n - 6 Induced or Leukemia Inhibitory Factor-induced M y c l o i d D i f f e r e n t i a t i o n P r i o r t o C-myc - R o l e i n L e u k e m o g e n c s i s . Mol Cell Bio11992, 12:2493-2500. SEN~HvIANeL, SNISTTERJR, HOCKENBERY D~ KANAGAWA O~ KORSMEYERSJ: bel-2 I n h i b i t s M u l t i p l e F o r m s of Apoptosis But not Negative Selection in T h y m o c y t e s . Cell 1991, 67:879-888. SHAN2LFELTMe, ANZOLAJ, SODERBERG C~ YSSELH, TL~RCK CW, PELTZ G: E p i t o p e s o n t h e O u t e r S u r f a c e Protein-A of Borrelia-Burgdorferi Recognized by Antibodies and T-Cdis of Patients with Lyme D i s e a s e . J Immuno11992, 148:218-224. SNARMA SD, NAG B, SU XM, GREEN D, SPACK E, CLARK BR, SmRAM S: A n t i g e n - S p e c i f i c T h e r a p y o f Experimental Allergic Encephalomyelitis b y S o l u b l e Class-H M a j o r H i s t o c o m p a t i b i l i t y C o m p l e x - P e p t i d c C o m p l e x e s . Proc Natl A c a d Sci U S A 1991, 88:11465-11469. SHEARM/LNCW, POLLOCK D, WHITE G, HEHIR K, MOORE GP, KANZY EJ, KUT&LER: C o n s t r u c t i o n , E x p r e s s i o n and Characterization of Humanized Antibodies Directed Against the Human Alpha/beta-T-Cell R e c e p t o r . J Imrnunol 1991, 147:4366~373. SHIOHARA T, P~ND O2~ERS: S y s t e m i c Release o f Interferon G~mm~ in Drug-Induced Cutaneous V a s c u l i t i s [Letter]. Lancet 1992, 339:933. SHOCKLEY TR, LtN JK, NAGY JA, TOMPKINS RG, YA2~MUSH ML, DVORAK HF: S p a t i a l D i s t r i b u t i o n o f T u m o r Specific Monoclonal Antibodies in Human M e l a n o m a X e n o g r a f t s . Cancer Res 1992, 52:367-376. SHOCKLEY TR, LIN K, SUNG C, NAGY JA, TOMPKINS RG, DEDRICK RL, DVORAK HP, YARMUSHML: A Quantitative Analysis of Tumor-Specific

739

740

Pharmaceutical applications T cells and immunomodulation M o n o c l o n a l A n t i b o d y U p t a k e by H u m a n M e l a n o m a X e n o g r a f t s - Effects o f A n t i b o d y I m m u n o l o g i c a l P r o p e r t i e s a n d T u m o r Antigen E x p r e s s i o n Levels. Cancer Res 1992, 52:357-366. SHOKAT K/M, SCHULTZPG: R e d i r e c t i n g t h e I m m u n e R e s p o n s e - Ligand-Mediated I t n m u n o g e n i c i t y . J A m Chem Soc 1991, 113:1861-1862. SIDRA~SKY E, GI?.~S El, Fe.ENKELE, BENEARJB: Anemic G a u c h e r Patients w i t h Elevated E n d o g e n o u s E r y t h r o p o i c t i n Levels May n o t R e s p o n d to R e c o m b i n a n t E r y t h r o p o i e t i n T h e r a p y [Letter]. Blood 1992, 79:532-533. SIEGALLCB, KREITMANRJ, FITZGERALDDJ, PASTAN I: A n t i t u m o r Effects o f I n t e r l e u k i n - 6 - P s e u d o m o n a s E x o t o x i n C h i m e r i c Molecules A g a i n s t t h e H u m a n H e p a t o e e l l u l a r C a r c i n o m a , PLC/PRF/5 i n Mice. Cancer Res 1991, 51:2831-2836. SIEMIONIZ, KUBIK A, LISOWSKI M. SZEWCZUKZ, ZIMECY-/ M, WIECZOREK Z: I m m u n o s u p p r e s s i v e Analogues o f H e x a p e p t i d e Tyr-Val-Pro-Leu-Phe-Pro, an I m m u n e S y s t e m Stimulant. Int J Pept Protein Res 1991, 3 8 : 5 ~ 6 1 . SJOBERG K, LEPERSJP, RAHARIMALALAL, LARSSONA, OLERLT' O, MARBtAH NT, TROYE-BLOMBERGM, PERLMANN P: Genetic R e g u l a t i o n o f Hun3ala A n t i - m a l a r i a l Antibodies i n Twins. Proc Natl A c a d Sci U S A 1992, 89:2101 2104. SKUBITZKM, DUCKERTP, GOUELI SA: CD66 M o n o c l o n a l Antibodies Recognize a P h o s p h o t y r o s i n e Containing Protein Bearing a Carcinoembryonic Antigen Cross-Reacting Antigen o n t h e Surface o f H u m a n N e u t r o p h i l s . J l m m u n o 1 1 9 9 2 , 148:852-860. SMALLEYRV, ANDERSON SA, TISITLE RL, CONNORS J, THU'RMONDLM, ItUANG A, CASTLEK, MAGERS C, WHISNAN~rJK: A R a n d o m i z e d C o m p a r i s o n o f T w o Doses o f H u m a n L y m p h o b l a a t o i d Interferon-c~ I n H a i r y Cell Leukemia~ Blood 1991, 78:3133-3141. SMrrH JW, LONGO DL, URBAWJ, CLARKJXV, WATSON T, BEVERIDOEJ, CONLON KC, SZNOLM, CREEIGMORESP, ALVORD WG, LAWRENCEJB, STHS RG: P r o l o n g e d , C o n t i n u o u s T r e a t m e n t o f H a i r y Cell L e u k e m i a Patients w i t h R e c o m b i n a n t I n t e r f e r o n - a l p h a 2 a . Blood 1991, 78:1664-1671. SMITH LJ, R~DFIELD C, BOYD J, LAWRENCEGMP, EDWARDS RG, SMITH RAG, DOBSON CM: H u n l a n I n t e r l e u k i n 4. T h e S o l u t i o n S t r u c t u r e o f a F o u r - H e l i x B u n d l e Protein. J Mol Bio11992, 224:899-904. SNIDER DP: I m m u n i z a t i o n w i t h A n t i g e n B o u n d to Bispecific A n t i b o d y I n d u c e s A n t i b o d y t h a t is Restricted i n Epitope Specificity a n d Contains A n t B d i o t y p e . J lmmuno11992, 148:1163-1170. SOIFFER RJ, MURB~Y C, COCHRAN K, CAMERON C, WANG E, SCHOW PW, DALEYJF, RITZ J: C l i n i c a l a n d I m m u n o l o g i c Effects o f P r o l o n g e d I n f u s i o n o f Low-Dose R e c o m b i n a n t I n t e r l e u k i n - 2 after Autologous a n d T-Cell D e p l e t e d A l l o g e n e i e B o n e M a r r o w T r a n s p l a n t a t i o n . Blood 1992, 79:517-526. SOMERS PK, WANDLESS TJ, SCHREIBERSL: Synthesis a n d Analysis o f 506BD, a High-Affinity Ltgand for t h e I m m u n o p h i l l n FKBP. J A m Cbem Soc 1991, 113:8045-8056. SPERTINI O, KANSAS GS, REIM~N2qKA, MACKAY CR~ TEDDER TF: F u n c t i o n a n d E v o l u t i o n a r y C o n s e r v a t i o n o f Distinct E p i t o p e s o n t h e Leukocyte A d h e s i o n Molecule-1 (TQ-1, Leu-8) t h a t Regulate Leukocyte Migration. Jlmmuno119¢)1, 147:942-949. SPITSIN SV, DROBYSHEVSKAYAEI, BARKHATOVAO1, BELYIYF, ~RTAKOVSKY IS, NESTERENKOVG: I n d u c t i o n o f t h e I m m u n e R e s p o n s e to L e g i o n e l l a - p n e u m o p h i l a Cytolysin b y M o n o c l o n a l Anti-Idiotypic Antibodies. J l m m u n o l 1991, 147:2001-2005. STAHLHENNqGC, VOSS G, NICK S, PETRYtI, FUCHS D, WACHTER H, COULIBALYC, LUKEW, HUNSMAN~NG: I m m u n i z a t i o n w i t h T w e e n E t h e r - T r e a t e d SIV A d s o r b e d O n t o A l u m i n u m H y d r o x i d e Protects Monkeys Against E x p e r i m e n t a l SIV Infection. Virology 1992, 186:588-596. STARLINGJJ, MACIAKRS, LAW KL, ttINSON NA, BRIGGS SL, LAGUZZABC, JOHNSON DA: I n v i v o A n t i i n m o r ACtivity o f a M o n o c l o n a l AntibodyVinca A l k a l o i d I m m u n o c o u j u g a t e D i r e c t e d Against a Solid T u m o r M e m b r a n e A n t i g e n Characterized by Heterogeneous Expression and N o n t n t e r n a l i z a t i o n o f Antibody-Antigen Complexes. CancerRes 1991, 51:2965-2972. S'ITdlNRS, ABETS RI, KRAN=YZSB: P h a r m a c o l o g i c Doses o f R e c o m b i n a n t H u m a n E r y t h r o p o i c t i n in t h e T r e a t m e n t o f Myelodysplaatic S y n d r o m e s . Blood 1991, 78:1658-1663. S~EVL~aER: N e w uses f o r I n t r a v e n o u s I m m u n e Globulin. N E n g l J M e d 1991, 325:123-125. STRASSERA, HARI~S AW, CORY S: bel-2 T r a n s g e n e Inhibits T-Cell D e a t h a n d P e r t u r b s T h y m J c SelfC e n s o r s h i p . Cell 1991, 67:889-899. STREILEINJW: I m m u n o g e n e t i e Factors i n S k i n Cancer. N E n g I J M e d 1991, 325:884~86.

SUN SC, FAYE i: C e c r o p i a I m m u n o r e s p o n s i v e Factor, a n Insect I m m u n o r e s p o n s i v e Factor w i t h DNAB i n d i n g P r o p e r t i e s s i m i l a r to Nuclear-Factor KappaB. E u r J B i o c b e m 1992, 204:885-892. SUNG C, SHOCKLEYTR, MORRISON PF, DVORAK HF, YAP~MUSH ML, DEDRICK RL: P r e d i c t e d a n d O b s e r v e d Effects o f Antibody Affinity a n d A n t i g e n D e n s i t y o n M o n o ¢ l o n a l A n t i b o d y U p t a k e in Solid T u m o r s . CancerRes 1992, 52:377-384. SLFFTERTR, GUZMAN K, DeED KM, GREENZEEWF: T a r g e t s for Dioxin - Genes for Plasminogen Activator I n h i b i t o r - 2 a n d I n t e r l e u k i n - l b c t a . Science 1991, 254:415-418. SVENSSON U, HOLST E, SUNDLERR: Protein-Kinase-CI n d e p e n d e n t A c t i v a t i o n o f A r a c h i d o n a t e Release and Prostaglandin-E2 Formation in Macrophages I n t e r a c t i n g w i t h C e r t a i n Bacteria. E u r J Biocbem 1991, 200:699-705. SVETIC A, FINTKELMA~FD, JIAN YC, DIEFFENBACHCW, SCOTT DE, MCCARTHYKE, S~INBERG AD, GAUSE WC: Cytokine Gene Expression after Invivo Primary I m m u n i z a t i o n w i t h G o a t A n t i b o d y to M o u s e IgD A n t i b o d y . J l m m u n o 1 1 9 9 1 , 147:2391-2397. SVOBODA M, PRZYBYLSFAM, SCHREURSJ, MIYAJIMAA, HOGELAND K, DEINZER M: Mass S p e c t r o m e t r i c D e t e r m i n a t i o n o f G l y c o s y l a t i o n Sites a n d Ollgosaccharide Composition of Insect-Expressed Mouse i n t e r l e u k i n - 3 . J Cbromatogr [Biomed Appl] 1991, 562:403-419. SWAIN XVF: Antibodies i n Plants. 7~ends Biotechno11991, 9:107-108. SYED SA, ET AL.: Successful u s e o f M o n o c l o n a l Antilipid-A IgM i n I n f a n t w i t h M e n i n g o e o c c a l Sepsis. Lancet t992, 339:496. TABATAY, UNO K, YA~MAOKA"i; IKADA Y, MLrRAMATSUS: Effects o f R e c o m b i n a n t A l p h a - I n t e r f e r o n G e l a t i n Conjugate o n I n v i v o M u r t n e T u m o r Cell G r o w t h . CancerRes 1991, 51:5532-5538. TAHTINE,NM, GOMBERTP, HYYTINEN ER. JU%'G G, RANK/ A, KROHN KJE: F i n e Spee3~lcity o f t h e B-Cell E p i t o p e s R e c o g n i z e d I n HIV-1 NEF b y H u m a n Serm Virology 1992, 187:156 164. TAMPE R, TYVOLLD, MCCONNELL HM: Reactions o f t h e Subunits o f t h e Class H M a j o r H i s t o c o m p a t i b i l i t y C o m p l e x M o l e c u l e IA d. Proc Natl A c a d Sci U S A 1991, 88:10667-10670. TAN LJ, KENNEDYMK, DALCANTO Me, MILLERSD: Successful T r e a t m e n t o f P a r a l y t i c Relapses i n Adoptive E x p e r i m e n t a l A u t o i m m m n e E n c e p h a l o m y e l i t i s Via N e u r o a n t i g e n - S p e e i f i c T o l e r a n c e . J I m m u n o 1 1 9 9 1 , 147:1797-1802. TANG D-C, DE VIT M, JONHNSTON SA: Genetic I m m u n i z a t i o n is a S i m p l e M e t h o d f o r E l i c i t i n g a n I m m u n e R e s p o n s e [Letter]. Nature 1992, 356:152-153. TANKERSLEYDL, FINLAYSONJS: H o u s e d u s t Mite A l l e r g e n s a n d IgG [Letter]. Lancet lCY)2, 339:1364. TEITELBAUMD, MILe R, ARNON R, SEIA M: S y n t h e t i c C o p o l y m e r d I n h i b i t s H u m a n T-Cell Lines Specific f o r M y e l i n B ~ i c P r o t e I n . Proc Natl A c a d Sci U S A 1992, 89:137-141. TEXIER B, BEDIN C, ROUBATYC, BREZIN C, CHARREIREJ: Protection from Experhnental Autoimmune Thyrniditis Conferred by a Mono¢lonal Antibody to T-Ceti R e c e p t o r f r o m a Cytotoxic H y b r i d o m a Specific for T h y r o g i o b n l i n . J I m m u n o 1 1 9 9 2 , 148:439-444. TORENSMA R, FLUITA: M e c h a n i s m f o r M o n o c l o n a l Antibody Mediated Treatment of Gram-negative S h o c k [Letter]. Lancet 1991, 338:186. TSUJISAK/ M, IMM K, TOKUCHI S, HANZAWAY, ISHIDA "I'~ KITAGAWAH, |-I]NODA Y~ YACI-~A: I n d u e [ i o n o f Antigen-Specific I m m t m e R e s p o n s e w i t h use o f Anti-Idiotypic M o n o c l o n a l Antibodies to AntiC a r c i n o e m b r y o n i c A n t i g e n Antibodies. Cancer Res 19¢)1, 51:2599-2604. TUIT A, STEVENSONGT, GLENNIEMJ: T r i s p e c i f i c F(ab')3 Derivatives t h a t use C o o p e r a t i v e S i g n a l i n g Via t h e TCR/CD3 C o m p l e x a n d CD2 to Activate a n d R e d i r e c t Resting C y t o t o x i c T-Cells. J I m m u n o 1 1 9 9 1 , 147:60~59. UBERTIJ, MARq~LOTI2F, CHOU TH, KAPLANJ: H u l n a n L y m p h o k i n e Activated K i l l e r (LAK) Cells S u p p r e s s G e n e r a t i o n o f Allospecific Cytotoxic T-Cells - I m p l i c a t i o n s f o r u s e o f LAK Cells to P r e v e n t Graft-Versus-Host Disease i n A l l o g e n e i c B o n e M a r r o w T r a n s p l a n t a t i o n . Blood 1992, 79:261-268. UCKUN FM, KERSEYJH, HAP2~ R, WEISDORF D, RAMSAY NKC: Autologous B o n e M a r r o w T r a n s p l a n t a t i o n i n H i g h - r i s k R e m i s s i o n B-lineage Acute Lymphoblastic Leukemia Using a Cocktail of T h r e e M o n o c l o n a l A n t i b o d i e s (BA-1/CD24, BA2/CD9, and BA-3/CDIO) Plus C o m p l e m e n t a n d 4h y d r o p e r o x y c y e l o p h o s p h a m i d e for EX Vivo B o n e M a r r o w P u r g i n g . Blood 1992, 79:1094-1104.

ULAETOD, LACY PE, FAPNIS DM, KANAGAWA O, UNANXIE ER: A T-Cell D o r m a n t State i n t h e A u t o i m m u n e P r o c e s s o f N o n o b e s e Diabetic Mice T r e a t e d w i t h C o m p l e t e F r e u n d ' s Adjuvant. Proc Natt A c a d Sci U S A 1992, 89:3927-3931. UNSWORTH DJ ET AL.: R1 A n t i - r e t i c u l i n A n t i b o d y as M a r k e r o f Subclinical Gluten E n t e r o p a t h y [Letter]. Lancet t992, 339:684. URDAL D, THOMPSON R, WlTr D, GREY H: R e s e a r c h R o u n d t a b l e o n l n l l a m m ~ d i o n . Biotechnology 1991, 9:520. VACtlINO G, GELFANDJA, A~KINS MB, TAMEPdUSJD, DEMCHAK P, MIERJW: C o m p l e m e n t Activation in C a n c e r Patients U n d e r g o i n g I m m u n o t h e r a p y w i t h I n t e r l e u k i n - 2 (IL-2) - B i n d i n g o f C o m p l e m e n t a n d C-Reactive P r o t e i n b y IL-2-Activated Lymphocytes. Blood 1991, 78:2505-2513. MALLERADA, SCHMIDBERGERH, BUCHSBAUMDJ, EVERSON P, SNOVER DC, BLAZARBR: R a d i o t h e r a p y i n Mice w i t h Yttrinm-90-Labeled Anti-Lyl M o n o c l o n a l A n t i b o d y - T h e r a p y o f E s t a b l i s h e d Graftv e r s u s - H o s t Disease I n d u c e d A c r o s s t h e M a j o r H i s t o c o m p a t i b i l i t y Barrier. Cancer Res 1991, 51:1891-1897. VAN DER POLL T, VAN DEVEN~ER SJH, HACK CE, WOLBINK OJ, AARDEN LA, BUTLERHR, TEN CATEJW: Effects o n L e u k o c y t e s after I n j e c t i o n o f T u m o r Necrosis F a c t o r i n t o Healthy H u m a n s . Blood 1992, 79:693--698. VAN GELDER T ETAL.: R e v e r s a l o f G r a f t Rejection w i t h M o n o c l o n a l Anti-interleukin-2 [letter]. Lancet 1992, 339:873. VANMOORSELA.&RRJA, I~ENDRIKS BT, VANSTRATUMP, VANDERMEIDE PH, DEBRUYN~FMJ, SCHALKENJA: S y n e r g i s t i c A n t i t u m o r Effects o f Rat GammaI n t e r f e r o n a n d H u m a n T u m o r N e c r o s i s Factoralpha Against Androgen-Dependent and A n d r o g e n - I n d e p e n d e n t Rat P r o s t a t i c T u m o r s . Cancer Res 1991, 51:2329-2334. VANZEE KJ, FISCHERE, HAWES AS, HEBERT CA, TERRELL TG, BAKERJB, LOWRYSF, MOLDAWERLL: Effects o f I n t r a v e n o u s 1L-8 A d m i n i s t r a t i o n i n N o n h u m a n P r i m a t e s . J l m m u n o 1 1 9 9 2 , 148:1746-1752. VEDANTHAMS, GAMLIELH, GOLOMB HM: M e c h a n i s m o f I n t e r f e r o n Action i n H a i r y Cell L e u k e m i a - a M o d e l o f Effective C a n c e r B i o t h e r a p y . Cancer Res 1992, 52:10561066. VELANDERxj~{, SUBRAMANIANA, MADURAWERD, ORTI-LNER CL: T h e u s e o f Fab-Masking A n t i g e n s to E n h a n c e t h e Activity o f I m m o b i l i z e d Antibodies. Biotechnol Bioeng 1992, 39:1013-1023. VELOTTIF, STOPPACCIAROA, RUCO L, "I~3BAROA, PEITINATO A, MORRONE S, NAPOLITANOT, BOSSOLA PC, FRAN%S CR, PALMERP, POURKEAUCN, PICCOLI M, BARONI CD, FRATI L, MI&NO L, SANTONIA: Local Activation of Immune Response in Bladder Caueer Patients T r e a t e d w i t h I n t r a a r t e r i a l I n f u s i o n o f R e c o m b i n a n t Interleuldn-2. C a n c e r R e s 1991, 51:2456-2462. VITEqTFAES, STONE M, AMLOTP, FAYJ, MAY R, TILL M, NEW/V~NJ, CLARKp, COLLINSR, CUNNINGHAM D, GHE~E V, UHR JXV, THORPE PE: Phase-I I t n u l u n o t o x i n T r i a l i n Patients w i t h B-Cell L y m p h o m a . CancerRes 1991, 51:4052-4058. V1VIER E, ROCHe7 N, KOCHANJP, PRESKYDH, SCItLOSSMAN SF, ANDERSON P: Structural S t m i l ~ ' i t y B e t w e e n FC R e c e p t o r s a n d T-Cell R e c e p t o r s - E x p r e s s i o n o f the G=mm~-Subunit o f lacepstlonRl i n H u m a n T-Cells, N a t u r a l K i l l e r Cells a n d T h y m o c y t e s . J I m m u n o l 1991, 147:4263-4270. VONWAJSSOWP, PRALLEH, HOCHKEPPELHK, JAKSCHIES D, SONNEN S, SCHMIDTtI, MULLERROSENAUD~ FRAN~KE M, HAFERLACHT, Zgr[NGERST, RAPP U, DEICHER H: Effective N a t u r a l I n t e r f e r o n - a l p h a T h e r a p y i n R e c o m b i n a n t I n t e r f e r o n - a l p h a R e s i s t a n t Patients w i t h H a i r y Cell Leukemia. Blood 1991, 7 8 : 3 8 4 3 . WALDMANN H, COBBOLD S, QIN S, LEONG L: Transplantation Tolerance with Monoelonal Antibodies. In a Critical Analysis of Monoclonal A n t i b o d y Therapy in Trana~Olantation. Edited by B u r l i n g h a m WM. Boca Raton: CRC Pres 19¢)2, :67-78. [32]. WALDMAN~ TA: M o n o c l o n a l Antibodies i n Diagnosis a n d T h e r a p y [in English]. Science 1991, 252:1657-1662. WALDMAN2qTA: I m m u n e Receptors: T a r g e t s for • Therapy of Leukaemia/Lymphoma. Autoimmune Diseases a n d for t h e P r e v e n t i o n o f Allograft R q e c t i o n . A n n u Rev I m m u n o 1 1 9 9 2 , 10:675-704. [21], WANG PL, OFARRELLS, CLAYBERGERC, KRENSKYAM: I d e n t i f i c a t i o n a n d M o l e c u l a r C l o n i n g o f Tactile - a N o v e l H u m a n T-Cell Activation A n t i g e n t h a t is a M e m b e r o f t h e Ig G r n e Superfamily. J I m m u n o l 1992, 148:2600-2608. WEBB CF, DAS C, EATON S, CALAMEK, TUCKER PW: Novel Protein-DNA I n t e r a c t i o n s Associated w i t h

Pharmaceutical applications Peptides, growth factors, hormones and receptors Increased Immunoglobulin Transcription in R e s p o n s e to A n t i g e n Plus I n t e r l e u k i n - 5 . Mol Cell Bio11991, 11:5197-5205. WEEKSJC, TIERNEYMR, WEINS'I~N MC: COst Effectiveness of Prophylactic Intravenous Immune Globulin i n C h r o n i c L y m p h o c y t i c Leukemia. N EngIJ Med 1991, 3 2 5 : 8 1 ~ 6 . WEINER GJ, HILLSTROMJR: Bispecific Anti-Idiotype Anti-CD3 A n t i b o d y T h e r a p y o f M u r i n e B Cell L y m p h o m a . J I m m u n o 1 1 9 9 1 , 147:4035~t044. WEINER L.~d, PADAV1CSHALLERK, KITSONJ, WATTS P, KRIGEL RL, LYI'WINS: Phase-I E v a l u a t i o n o f C o m b i n a t i o n Therapy with Interieukin-2 and GammaI n t e r f e r o n . Cancer Res 1991, 51:3910-3918. WEISBART RH, WONG AL, NORITAKED, KACENAA, CttAN G, RUL&NDC, CHIN E, CHEN ISV, ROSENBLATTJD: T h e R h e u m a t o i d Factor Reactivity o f a H u m a n l e g M o n o c l o n a l A u t o a n t i b o d y is E n c o d e d b y a V a r i a n t VkappaI1 L-Chain Gene. J Immuno11991, 147:2795-2801. WERENSKIOLD AK: C h a r a c t e r i z a t i o n o f a Secreted Glycoprotein of the Immunoglobulin Superfamily Inducible by Mitogen and Oncogene. EurJ Biochem i992, 204:104i-1047. WERFEL T, OPPERMANN M, SCHULZEM, KRIEGERG, WEBER M, GOTZE O: B i n d i n g o f Fluoreseein-Labeled A n a p h y l a t o x i n - C S a to H u m a n P e r i p h e r a l Blood, Spleen, a n d B o n e M a r r o w Leukocytes. Blood 1992, 79:152-160. WIEDLOCHAA, SANDVIG K, WALZELH, RADZIKOWSKY C, OLSNES S: I n t e r n a l i z a t i o n a n d Action o f a n I m m u n o t o x i n C o n t a i n i n g Mistletoe Lectin Ac h a i n . C a n c e r R e s 1991, 51:916 920. WILLIAMSONRA, PERSSON MAA, BURTON DR: E x p r e s s i o n o f a H u m a n M o n o c l o n a l Anti-(Rhesus-D) Fab F r a g m e n t I n E s e h e r i c h i a - c o l i w i t h t h e use o f B a c t e r i o p h a g e - l a m b d a Vectors. Biochem J 1991, 277:561-563. WUCHERPFENNIG Ik~d, HOLLSBERGP, RICHARDSONJH, BENJAMIN D, HAFLER DA: T-cell Activation b y Autologous H u m a n T-ceB L e u k e m i a Virus Type 1-infected. Proc Natl A c a d Sci U S A 1992, 89:211(~2114. WYLIE DE, LU D, CARLSONLD, CARLSONR, BABACANKF, SCHUSTER SM, WAGNER F~V: M o n o c l o n a l Antibodies Specific f o r M e r c u r i c Ions. Proc Natl A c a d Sci U S A 1992, 89:4104--4108. XlONG LM, KASUYAJ, L1 SL, KATOJ, FUJITAYAMAGUCHI Y: G r o w t h - S t i m u l a t o r y M o n o d o n a l Antibodies Against H u m a n Insulin-IAke G r o w t h EactorI Receptor. Proc N a t l A c a d Sci U S A 1992, 89:5356-5360. YAMAMURAM, UYEMURAK, DEANS RJ, WEINBERG K, REA TH, BLOOM BR, MODUN RL: D e f i n i n g Protective R e s p o n s e s to P a t h o g e n s - C y t o k i n e Profiles in L e p r o s y Lesions. Science 1991, 254:277-279. YAMOAKA KA, AND OTHERS: L T r y p t o p h a n C o n t a m i n a n t " p e a k E" a n d I n t e r l e u k i n 5 P r o d u c t i o n f r o m T Cells [Letter]. Lancet 1991, 338:1468. YANG SC, GRIMM EA, PARKINSONDR, CARINHASJ, FRY I{D, ~MENDIGURENRODRIGL]~ZA, LICCIARDELLOJ, OWF=NSCtIAUBLB, HONG WK, RoqT~jA: c l i n i c a l a n d I m m u n o m o d u l a t o r y Effects o f C o m b i n a t i o n I m m u n o t h e r a p y w i t h Low-Dose I n t e r i e u k i n - 2 a n d T u m o r NecrosIs F a c t o r - a l p h a in Patients w i t h A d v a n c e d Non-Small-Cell L u n g C a n c e r - a Phase-I TriaL Cancer Res 1991, 51:3669-3676. YASUEDAH, KIKUCHI Y, KOJIMAH, NAGASEK: "in Vivo Processing of the Initiator Methionine from Recombinant Methionyl Human Interleukin-6 S y n t h e s i z e d i n Escherichia-Coli O v e r p r o d u c i n g A m i n o p e p t i d a s c - P . Appl Microbiol Biotechno11991, 36:211-215. YEDNOCK EA, CANNON C, FRJTZ LC, SANC>IEZ-MADRIDF, STEINMAN L, KAPdN N: P r e v e n t i o n o f E x p e r i m e n t a l A u t o i m m u n e E n c e p h a l o m y e l i t i s by Antibodies Against a 4 ~ 1 I n t e g r i n [Letter]. Nature 1992, 356:63455. YONISH-ROUACHE, RESNITZKYD, LOT~MJ, SACHS L, KIMICHI A, OREN M: Wild-type P53 I n d u c e s ApoptosIs o f Myeloid L e u k a e m i c Cells t h a t is I n h i b i t e d b y I n t e r l e u k i n - 6 [Letter]. Nature 1991, 352:345-346. YOSHINO I, YANO T, MURA+I~M, ISHIDA T, SUGIMACHI K, KE'dURA G, NOMOTO K: Cytolytic P o t e n t i a l o f P e r i p h e r a l B l o o d T-Lymphocytes E o l i o w i n g Adoptive l m m u n o t h e r a p y w i t h L y m p h o k i n e Activated K i l l e r Cells a n d Low-Dose I n t e r l e u k i n - 2 . Cancer Res 1991, 51:t494-1496. YOSHIZAWAH, CHANG AE, SHU SY: C e l l u l a r I n t e r a c t i o n s i n Effector Cell G e n e r a t i o n a n d T u m o r Regression Mediated by Anti-CD3/Interleukln2-Activated T u m o r - D r a i n i n g L y m p h N o d e cells. Cancer Res 1992, 52:1129-1136. YSSEL It, JOHNSON KE, SCItNEIDER PV, WIDEMA~"J, TERRA, KASTELEINR, DEVRIESJE: T-Cell Activation-Inducing Epitopes o f t h e H o u s e Dust Mite A l l e r g e n Derp-I - P r o l i f e r a t i o n and L y m p h o k i n e P r o d u c t i o n

P a t t e r n s by Der-p-I-Specific CD4+ T-Cell Clones. J Immuno11992, 148:738-745. ZAML'DIO F, SAAVEDRAR, MARTIN BM, GURROLABRIONESG, HERION P, POSS&N~ LD: A m i n o Acid Sequence a n d Immunological Characterization with Monoclonal Antibodies o f 2 T o x i n s f r o m t h e V e n o m o f t h e Scorpion Centruroides-Noxius Hoffmann. EurJ Biochem 1992, 204:281 292. ZEBEDEE8L, BARBAS CF, ]-IOM YL, CAOTHIEN RH, GRAFF R, DEGRAWJ, PYA~IJ, LAPOLLAR, BURTON DR, LERNTRRA, TIIORNTON GB: H u m a n C o m b i n a t o r i a l A n t i b o d y Libraries to HepatitIs-B Surface Antigen. Proc Natl A c a d Sci U S A 1992, 89:3175-3179. ZI-LANGXH, WERNERFAVREC, TANG HY, BROL~VERSN, BONNEFOYJY, ZUBLERRH: l I : 4 - D e p e n d e n t lgE S w i t c h in M e m b r a n e IgA-Positive H u m a n B-Cdls. J Immuno11991, 147:3001-3004. ZURAWSKI G: A n a l y s i n g L y m p h o k i n e - r e c e p t o r I n t e r a c t i o n s o f IL-1 a n d EL-2 b y R e c o m b i n a n t - D N A Technology. Trends Biotecbno11991, 9:250-256.

Pepfides, growth factors, hormones and receptors Related review: Families of twelve transmembrane domain transporters

(pp 675-682) AARONSON SA: G r o w t h Factors a n d Cancer. Science 1991, 254:1146-1153 AGERBERTHB, LEEJY, BERGMAN T, CARLQLqSTM, BOMAN HG, MUTT V, JOKNVALLH: A m i n o Acid S e q u e n c e o f PR-39 -Isolation f r o m Pig I n t e s t i n e o f a N e w Member of the Family of Proline-ArginineR i c h Antibacterial P e p t i d e s . E u r J Biochem 1991, 202:849454. AINEMRI ES~ MAI~qYMOWYCHAB, ROBERTSONNM, LITWACK G: O v e r e x p r e s s i o n a n d C h a r a c t e r i z a t i o n o f t h e H u m a n M i n e r a l o c o r t i c o i d Receptor. J Biol Chem 1991, 266:18072-18081. ALROY I, P~REEDMANLP: DNA B I n d I n g Analysis o f Glueoeorticoid R e c e p t o r Specificity Mutants. Nucleic Acids Res 1992, 20:1045-1052. ALTIERI DC: O c c u p a n c y o f C D l l b / C D 1 8 (Mac-l) D i v a l e n t Ion B i n d i n g Site(s) Induces L e u k o c y t e Adhesion. J l m m u n o l 1991, 147:1891 1898. ALTIERI DC, ETING~ OR, FAIR DS, BRUNCKTK, GELTOSKY JE, HAJJARDP, EDGINGTON TS: Sttucttlrally H o m o l o g o u s Ligand B i n d i n g o f I n t e g r i n Mac-1 a n d Viral G l y c o p r o t e i n - C Receptors. Science 1991, 254:1200-1202. AMIRI P, LOCKSLEYRM, PARSLOWTG, SADICKM, RECTOR E, RITI~R D, MCKERROWJH: T u r n o u t NecrosIs F a c t o r A l p h a Restores G r a n u l o m a s a n d Induces P a r a s i t e Egg-laying in S e h i s t o s o m e - i n f e c t e d SCID Mice [Letter]. Nature 1992, 356:60~606. ANAND R, CONROYWG, SCHOEPFERR, WHITING P, LINDSTROMJ: N e u r o n a l N i c o t i n i c A c e t y l c h o l i n e R e c e p t o r s E x p r e s s e d i n X e n o p u s Oocytes h a v e a P e n t a m e r i c Q u a t e r n a r y Structure. J Biol Chem 199i, 266:11192-11198. ANO~X~MOUS: G r o w t h Factors a n d C a n c e r C h e m o t h e r a p y [editorial]. Lancet 1991, 338:217. ARNOLD RS, NEWTONAC: I n h i b i t i o n o f t h e I n s u l i n Receptor TFrosine Kinase by Sphingosine. Biochemistry 1991, 30:7747-7754. ASHBRIDGE KR, BACKSTROMBT, IdU HX, VIKERFORS T, ENGLEBRETSENDR, HARDING DRK, WATSONJD: M a p p i n g o f T - H e l p e r Cell E p i t o p e s by U s i n g P e p t i d e s S p a n n i n g t h e 19-kDa P r o t e i n o f Mycobacterium-TubercnlosIs - Evidence for U n i q u e and S h a r e d E p i t o p e s i n t h e S t i m u l a t i o n o f Antibody and Delayed-Type H y p e r s e n s i t i v i t y Responses. J I m r a u n o 1 1 9 9 2 , 148:224P~2255. ASttlZAWA K, FUKUDAT, CHENG SY: T r a n s c r i p t i o n a l Stimulation by T h y r o i d H o r m o n e o f a Cytosolic T h y r o i d H o r m o n e B i n d i n g P r o t e i n W h i c h Is H o m o l o g o u s to a Subtmit o f Pyruvate Kinase-M1. Biochemistry 1992, 31:2774--2778. BADASSO M, ET AL: C r y s t a l l i z a t i o n a n d P r e l i m i n a r y X-ray AnalysIs o f C o m p l e x e s o f Peptide Inhibitors with Human Recombinant and Mouse S u b m a n d i b u l a r Renins. J Mol Biol 1992, 223:447453. BAGCHI MK, TSRI SY, TSAI MJ, OMALLEYBW: Ligand a n d DNA-Dependent P h o s p h o r y l a t i o n o f H u m a n P r o g e s t e r o n e R e c e p t o r l n v i t r o . Proc Natl A c a d Sci U S A 1992, 89:2664-2668. BAHR BA, LYNCH G: P u r i f i c a t i o n o f a n Arg-Gly-Asp Selective M a t r i x R e c e p t o r f r o m B r a i n S y n a p t i c P l a s m a M e m b r a n e s . Biochem J 1992, 281:137-i42. BALCEWICZSABLINSKAMK, WOLDd~N EE, GOR31 R, SlLBEP~STEINDS: H u m a n E o s i n o p h i l CytotoxieityE n h a n c i n g Factor. 2. M u l t i p l e F o r m s S y n t h e s i z e d b y U937 Cells a n d T h e i r R e l a t i o n s h i p to

T h i o r e d o x i n / A d u l t T-Ceil L e u k e m i a - D e r i v e d Factor. J l m m u n o 1 1 9 9 1 , 147:2170-2174. BANtAMMADA, KOHNE AC, RENqfAWITZR: A T r a t l s f e r a b l e S i l e n c i n g D o m a i n is P r e s e n t in t h e T h y r o i d H o r m o n e R e c e p t o r , in t h e V-erbA O n c o g e n e P r o d u c t a n d i n t h e Refinoic Acid Receptor. EMBO J 1992, 11:1015-1024. BANO M, LUPU R, KIDWELLWR, LIPPMANME, DICKSON RB: Production and Characterization of MammaryD e r i v e d G r o w t h Factor-1 in M a m m a r y E p i t h e l i a l Ceil Lines. BioehemisOy 1992, 31:610~16. BARON V, GAUTIERN, KAIkMANP, DOLAISK/TABGIJ, VANOBBERGEIENE: T h e C a r b o x y l - T e r m i n a l D o m a i n o f t h e I n s u l i n R e c e p t o r - lts P o t e n t i a l Role in G r o w t h - P r o m o t i n g Effects. Biochemistry 1991, 30:9365-9370. BECIGMANNMP, MUNGERWE, KOZLOSKYC, VANDENBOST~ PRICE V, LYMAN8, GERARDNP, GERARDC, CERRETTIDP: Molecular Characterization of the Interieukin8 Receptor. Biochem Biophys Res C o m m u n 1991, 179:784-789. BECKSICKINGERAG, GAIDA W, SCI~NORRENBERGG, L&NG R, JUNG G: N e u r o p e p t i d e - Y - I d e n t i f i c a t i o n o f t h e B i n d i n g Site. I n t J P e p t Protein Res 1990, 36:522-530. BEISIEGELU, WEBER W, BENGTSSONOLIVECRONAG: L i p o p r o t e i n Ltpase E n h a n c e s t h e B i n d i n g o f C h y l o m i c r o n s t o Low Density L i p o p r o t c i n Receptor-Related Protein. Proc N a g A c a d Sci U S A 1991, 8 8 : 8 3 4 2 4 3 4 6 . BELLIVEAUJ'~, KENNEDYDN, MCKINS]I/Y RC, BUCHBINDER BR, WRISSKOFF RM, COHEN MS, VEVEAJM, BRADYTJ, ROSEN BR: F u n c t i o n a l M a p p i n g o f t h e H u m a n Visual C o r t e x b y Magnetic R e s o n a n c e Imaging. Science 1991, 254:716. BENDER H, TAKAHASHIH, ADACHI K, BELSERP, LIAN'GSH, PREWETF M, SCFLRAPPEM, SUTTERA, RODECK U, HERLYN D: I m m u n o t h e r a p y o f H u m a n G l i o m a Xenografts w i t h U n l a b e l e d , 131I-Labeled, o r 125I-Labeled M o n o c l o n a l Antibody-425 to E p i d e r m a l G r o w t h Factor Receptor. Cancer Res 1992, 52:121-126. BENOVICJL, ONORATOJJ, ARRIZAJL, STONE WC, LOHSE M, JENKINS NA, GILBERS"DJ, COPELAND NG, CARON MG, LEFKOWITZRJ: Cloning, E x p r e s s i o n , and C h r o m o s o m a l Localization o f Beta-Adrenergic R e c e p t o r K i n a s e - 2 - a New M e m b e r o f t h e R e c e p t o r K i n a s e Family. J B i o l Chem 1991, 266:1493~14946. BETBEDERD, CACCIA P, NITrI G, BERTOLEROF, SARMIENTOS P, PAUL P~ MONSAN P, CALrETG, MAZUE G: P r o d u c t i o n o f H o m o g e n e o u s Basis F i b r o b l a s t G r o w t h Factor b y Specific E n z y m a t i c Hydrolysis o f Larger M i c r o h e t e r o g e n o u s M o l e c u l a r F o r m s . J Biotechnol 1991, 21:83-92. BEVAN S, RAYNESJG: IL-1 R e c e p t o r A n t a g o n i s t Regulation o f Acute Phase P r o t e i n Synthesis i n H u m a n H e p a t o m a Cells. J l m m u n o 1 1 9 9 1 , 147:2574-2578. BIANCHI E, DELGIOTglCEG, VERDIN1AS, PESSI A: Synthetic Peptides f o r P l a s m o d i u m Vivax M a l a r i a SeroEpidemiology - Application of Emoc-Polyamide a n d D i s p l a c e m e n t C h r o m a t o g r a p h y . l n t J Pept Protein Res 1991, 37:7-13. BIGLERJ, HOKANSON W, E I S E N ~ RN: T h y r o i d H o r m o n e R e c e p t o r T r a n s c r i p t i o n a l Activity is Potentially Autoregnlated by Truncated Forms of the Receptor. Mol Cell Bio11992, 12:240~2417, BLOUN~rP, MEE~LIEJP: C h a r a c t e r i z a t i o n o f a n Adult Muscle A c e t y l e h o l l n e R e c e p t o r Suhunit b y E x p r e s s i o n i n Fibroblasts. J Biol Chem 1991, 266:14692-i4696. BOCH~I' P, DLHRIAUXA, LAMBOLEZB, NALIVAIKOE, ROSSIER J, DECARVALHOLP: A C b l m e r i c G l u t a m a t e R e c e p t o r Subunit - D i s c r e t e Changes Modify t h e P r o p e r t i e s o f t h e C h a n n e l Btochem Biopbys Res C o m m u n 1991, 177:1183-1187. BOJA JVT, PATELA CARROLL PI, RAHM~" MA, PHILIP A, • LEWINAH, KOPAJTIC TA, KUHAR MJ: [ 125 I]RTI-55: a Potent L i g a n d f o r D o p a m i n e T r a n s p o r t e r s . £ i t r J Pharmaco11991, 194:133-134. [48]. BOND HM, MORRON~ G, VENq3TAS, HOWELL If.E: Characterization and Furifieation of Proteins W h i c h B i n d H i g h - D e n s i t y L i p o p r o t e i n - a Putative Cell-Surface Receptor. Biochem J 1991, 279:633~41. BORGNAJL, SCALIJ: D i f f e r e n t i a l I n t e r a c t i o n s o f E s t r o g e n s a n d A n t i e s t r o g e n s at t h e 17betaHydroxy or Counterpart Function with t h e E s t r o g e n Receptor. E u r J B i o c h e m 1991, 199:575-585. BOLTdNBAIARAS, NAGORNWR, TAN X: P r e g n a n c y H o r m o n e s , E s t r o g e n and P r o g e s t e r o n e , P r e v e n t HIV-1 Synthesis i n Monocytes But n o t in Lymphocytes. FEBS Lett 1992, 302:206-208 BRADER ML, DUNN MF: I n s u l i n H e x a m e r s -New C o n f o r m a t i o n s a n d Applications. Trends Biochem Sci 1991, 16:341-345. BRADER ML, KAARSHOI~MNC, LEE RWK, DUNN MF: C h a r a c t e r i z a t i o n o f t h e R-State I n s u l i n H e x a m e r

741

742

Pharmaceutical applications Peptides, growth factors, hormones and receptors a n d Its D e r i v a t i v e s - t h e H e x a m e r is S t a b i l i z e d by Heterotrupic Ligand Rinding Interactions. Biochemistry I991, 30:6636~645. BRAKEBUSCH C, _NOPHARY, KEM~ER O, ENGELMANLNH, WALLACH D: C y t o p L a s m i c T r u n c a t i o n o f t h e P55 T u m o u r N e c r o s i s F a c t o r (TNF) R e c e p t o r Abolishes Signalling, But not Induced Shedding o f t h e Receptor. B M B O J 1992, 11:943-950. BRAMSON HN, CASN~LLIEJE, NACHOD H, REGAN IAM, SOMMEI~SC: S y n t h e t i c F r a g m e n t s o f t h e C D 4 Receptor Cytoplasmic Domain and Large P o l y c a t i o n s A lter t h e Activities o f t h e P p 5 6 1 c k T y r o s i n e P r o t e i n Y.dnase. J Biol Cbem 1991, 266:16219-16225. BRAUNSCHWEIGERPG, JONES SA, JOHNSON CS, FL3RMANSKIP: Potentiation of Mitomycin-C and poriflromycin A n t i t o m o r Activity i n S o l i d T u m o r M o d e l s b y R e c o m b i n a n t H u m a n I n t c r l c u k i n 1 - a l p h a . Cancer Res 1991, 51:5456-5460. BROEKAERT \VF, MARIEN W, "[~RRAS FRG, DEBOLLE MFC, PROOST P, VANDAMMEJ, DILLEN L, CLAEYSM, REES SB, VANDERLEYDENJ, CAMML~EBPA: A n t i m i c r o b i a l Peptidcs from Amaranthus-Caudatus Seeds with Sequence Homology to the Cysteine/Glycine-Rich D o m a i n o f C h i t i n - B i n d i n g P r o t e i n s . Biochemistry 1992, 31:4308~314. BUGGE TH, POHLJ, LONNOY O, STD%IN~ENBERGHG: RXRc~, a Promiscuous Partner of Rctinoic Acid and T h y r o i d H o r m o n e R e c e p t o r s . E M B O J 1992, 11:1409-1418. BD~RDICK D. SOREGI4ANB, KWON M, KOSMOSKIJ, KNAUER M, HENSCHENA, YATESJ, COTMAN C, GLABE C: Assembly and Aggregation Properties of Synthetic Alzheimcr's A4/bcta Amyloid Peptide Analogs. J Biol Chem 1992, 267:546-554. BLinK O, KL~MPNAUERK-H: E s t r o g e n - d e p e n d e n t A l t e r a t i o n s in D i f f e r e n t i a t i o n State o f M y e l o i d Cells C a u s e d b y a V - m y b / e s t r o g e n R e c e p t o r F u s i o n Pr o tein . E M B O J 1991, 10:3713-3720. BURE~EJR, SILVEP~Vi2LNRB: M e c h a n i s m o f I n a c t i v a t i o n o f G a m m a - A m i n o b u t y r i c Acid A m i n o t r a n s f e r a s e By 4 - A m i n o - 5 - H e x ~ n o i c A c i d ( g ~ m m ~ - E t h y n y l GABA). J A m Chem Soc 1991, 113:9329-9340. CACCIA P, NITII G, CLETINI O, PUCCI P, RUOPPOLO M, BERTOLERO F, MALSASINAB, ROHI'ITO F, C'PJSTIANI C, CAIo~T G, SARMIENTOSP~ .~V~kLORNIA, ~La~RINO G: S t a b i l i z a t i o n o f R e c o m b i n a n t H u m a n Basic F i b r o b l a s t G r o w t h F a c t o r b y C h e m i c a l Modifications of Cysteinc Residues. EurJ Biocbem 1992, 2 0 4 :6 4 9 6 5 5 . CALCAGM A, GAVUZZOE, LUCENTE G, MAZZA F, PINSNXNF, POCHEIE1 G, ROSSI D: S t r u c t n r c a n d C o n f o r n l a t i o n of Peptides Containing the Sulphonamide J u n c t i o n . I n t J Pept Protean Res 1991, 37:16%173. CAMERINI D, WALZ G, LOENEN WAM, BORST J, SEED B: T h e T-Cell A c t i v a t i o n A n t i g e n CD27 is a M e m b e r o f t h e Nerve G r o w t h F a c t o r T u m o r N e c r o s i s F a c t o r R e c e p t o r G e n e F a m i l y . J I m m u n o l 1991, 147:3165-3169. CAMPOS SP, BAUMANNH: I n s n l i n i s a P r o m i n e n t Modulator of the Cytokine-Stimulated Expression o f Acute-Phase P l a s m a P r o t e i n G e n e s . Mol Cell Bio/ 1992, 12:1789-1797. CAMUSSIG, ALBINO E, TETRA C, BDSSOLINO F: T h e Molecular Action of Tumor Necrosis Factor-alpha. E u r J Biochem 1991, 202:3-14. CANALS F: S i g n a l T r a n s m i s s i o n b y E p i d e r m a l G r o w t h Factor Receptor - Coincidence of Activation and D i m e r i z a t l o n . Biochemistry 1992, 31:4493~4501. CAO L, FAHA B, DEMBSKI M, TSAI LH, HARLOW E, DYSON N: I n d e p e n d e n t B i n d i n g o f t h e R c t i n o b l a s t o m a P r o t e i n a n d P 1 0 7 t o t h e T r a n s c r i p t i o n F a c t o r E2F [Letter]. Nature 1992, 355:176-178. CARPENTER JL, PACCAUDJP, GORDEN P, RLTIER \VJ, ORCI L: Insulin-induced Surface Redistribution Regulates Internalization of the Insulin Receptor and R e q u i r e s Its A u t o p h o s p h o r y l a t i n n . Proc.Natl A c a d Sci U S A 1992, 89:162-166. CARSON DA, \VASSONDB, ESPARZAIAM, CARRERA CJ, KIPPS TJ, COTRAMHB: O r a l A n t i l y m p h o c y t c A c t i v i t y a n d Induction of Apoptosis by 2-Chioro-2'-arabinof l u o r o - 2 ' - d e o x y a d e n o s i n c . Proc Natl A c a d Sci U S A 1992, 89:2970-2974. CASTRONOVOV, TARABOLgI~ G, SOBEL M~: L a n t i n i n Receptor Complementary DNA-Deduced Synthetic P e p t i d e I n h i b i t s C a n c e r Cell A t t a c h m e n t t o E n d o t h c l i u t m Cancer Res 1991, 51:5672-5678. CASWELLAH, BRAND'F NR, BRUNSCHWIGJP, PURKERSON S: L o c a l i z a t i o n a n d P a r t i a l C h a r a c t e r i z a t i o n of the Ollgomeric Disulfide-Linked Molecular W e i g h t 95000 P r o t e i n ( T r i a d i n ) W h i c h B i n d s t h e Ryanodine and Dthydropyridine Receptors in S k e l e t a l Muscle T r i a d i c Vesicles. Biochemistry 1991, 30:7507-7513. CAUGHEY BW, DONG A, BHA'F KS, ERNST D, ItAYES SF, CAUGHEY WS: S e c o n d a r y S t r u c t u r e A n a l y s i s o f t h e S c r u p i e - A s s o c i a t e d P r o t e i n P r P 27-30 i n W a t e r

b y I n f r a r e d S p e c t r o s c o p y . Biochemistry 1991, 30:7672-7680. CHAMPIGNY O, RICQUIER D, BLONDEL O, MAYERS ItM, BRISCOE MG, HOLLOWAY BR: } 3 - a d r c n e r g i e R e c e p t o r Stimulation Restores Message and Expression of Brown-fat Mitochondrial Uncoupling Protein i n A d u l t D o g s . Proc Nail A c a d Sci U S A 1991, 88:10774-10777. CHANDRASEKHARK, PROFY AT, DYSON HJ: S o l u t i o n Conformational Preferences of Immunogcnic Pcptides Derived from the Principal Neutralizing D e t e r m i n a n t o f t h e HIV-1 E n v e l o p e G l y c o p r o t e i n G p l 2 0 . Biochemistry 1991, 30:9187-9194 CHANG JY, NGAI PK, PRIESTLEJP, Joss U, VOSBECK KD, VANOOSTRUMJ: I d e n t i f i c a t i o n o f a R e a c t i v e L y s y l Residue (Lysl03) of Recombinant Human I n t e r l e u k i n - l b e t a - M e c h a n i s m o f Its R e a c t i v i t y a n d I m p l i c a t i o n o f Its F u n c t i n o a l R o l e i n R e c e p t o r B i n d i n g . Biochemistry 1992, 31:2874-2878. CHAPEKAR MS, HUGGETT AC, CHENG C: D e x a m e t h a s o n e P r e v e n t s t h e G r o w t h I n h i b i t o r y Effects o f R e c o m b i n a n t T u m o r N e c r o s i s F a c t o r i n a Rat H e p a t o m a Cell Line Reuber-RC-3 - a n ~Lssociation w i t h t h e C h a n g e s i n t h e M e s s e n g e r RNA Levels f o r M u l t i d r u g R e s i s t a n c e G e n e . Biocbem Biophys Res C o m m u n 1991, 181:1526--1531. C}IATURVEDIV, DONN2LLYROBERTSDL, LENTZ TL: Substitution of Torpedo Acetylcholine Receptor Alphal-Subunit Residues with Snake AlphalS u b u n i t a n d Rat N e r v e A l p h a 3 - S u b u n i t R e s i d u e s i n R e c o m b i n a n t F u s i o n P r o t e i n s - Effect o n A l p h a - B u n g a r o t o x i n B i n d i n g . Biochemistry 1992, 31:1370-1375. CHAUCHEREAUA, LOOSFELT H, MILGROM E: Phosphorylation of Transfected Wild Type and M u t a t e d P r o g e s t e r o n e R e c e p t o r s . J Biol Chem 1991, 266:18280-18286. CHAVEZ hA, t~LL ZW: T h e T r a n s m e m b r a n e T o p o l o g y o f the Amino Terminus of the Alpha-Subunit of the N i c o t i n i c A c c t y l c h o l i n e R e c e p t o r . J Biol Chem 1991, 266:15532 15538. C~tEN F, PUETT D: C o n t r i b u t i o n s o f A r g i n i n e - 4 3 a n d Argininc-94 of Human Choriogonadotropinbeta to Receptor Binding and Activation as D e t e r m i n e d b y O l i g o n u c l c o t i d e - B a s e d M t u a g c n c s i s . Biochemisiry 1991, 30:10171-10175. CHEN F, WANG Y. PUETr D: R o l e o f t h e I n v a r i a n t A s p a r t i c Acid-99 o f H u m a n C h o r l o g o n a d o t r o p i n b e t a i n R e c e p t o r B i n d i n g a n d B i o l o g i c a l Activity. J Biol Chem 1991, 266:19357-19361. CHO SW, KIM GY: A l u m i n u m I n t e r r u p t s t h e F o r m a t i o n of Alkaline-Rtbonuclease-lnhibitor Complex from B o v i n e B r a i n . E u r J B i o c h e m i991, 2 0 2 : 1 0 ~ 1 1 1 . CHUNG SK, REINHART PH, MAR~N BL, BRAUTIGAN D, LEVlTAN IB: P r o t e i n K i n a s e Activity C l o s e l y Associated with a Reconstituted Calcium-Activated P o t a s s i u m C h a n n e l Science t991, 253:560-562. CL.M~KLEWISI, SCItUMACHERC, BAGGIOI2~ M, MOSER B: Structure-activity Relationships of Intcrleukin8 Determined Using Chemically Synthesized Analogs - Critical Role of NH2-terminal Residues and Evidence for Uncoupling of Neutrophil Chcmotaxis, Exocytosis, and Receptor Binding Activities. J Biol Cbem 1991, 266:23128. CLEMENTSJM, BAWDEN Lj, BLOXBRIDGE RE, CATLIN G, COOK AL, CRAIG S, DRUMMONDAH, EDWARDS RM, FALLON A, GREEN DR, HELLEWELL PG, KIRWIN PM, NAYEE PD, RICHARDSON SJ, BROWN D, CHAHWALA SB, SNAREy M, WINSLOW D: TWO PDGFB C h a i n R e s i d u e s A ~ g i n i n e 27 a n d I s o l e u e i n e 30 M e d i a t e R e c e p t o r B i n d i n g a n d A c t i v a t i o n . F2FIBOJ 1991, 10:4113-~120. COLAMON1CI OR, PFEFFER LM, DALESSANDRO~ PLA~f~IAS LC, GREGORY SA, ROSOLENA, NORDAN R, CRUCI~NI RA, DIAZ MO: M u l t i c h a i n S t r u c t u r e o f t h e I F N - a l p h a R e c e p t o r o n H e m a t o p o i e t i c Cells. J I m m u n o l 1992, 148:2126-2132. COLLINS FS: C y s t i c F i b r o s i s : M o l e c u l a r Biology • • a n d T h e r a p e u t i c I m p l i c a t i o n s . Science 1992, 256;776-779. [2]. COOK AL, KIRWIN PM, CRAIG S, BAWDEN LJ, GREEN DR, PRICE MJ, RICHARDSONSJ, FALLON A~ DRUMMOND AH, EDWARDS P~M, eLEMENTSJM: P u r i f i c a t i o n a n d Analysis of Proteinase-Resistant Mutants of R e c o m b i n a n t P l a t e l e t - D e r i v e d G r o w t h Factor-BB E x h i b i t i n g I m p r o v e d B i o l o g i c a l Activity. B i o c h e m J 1992, 2 8 1 : 5 7 4 5 . COOKE I~M, CARTER BG, MARTIN DMA, MURRAYRUSTP, WEIR MP: N u c l e a r M a g n e t i c R e s o n a n c e S t u d i e s o f t h e S n a k e T o x i n E c h i s t a t i n - H-1 R e s o n a n c e Assignments and Secondary Structure. EurJ Biochem 1991, 202:323-328. CORINALLRJ, PRINS J B, TODD JA, PRESSEYA, DELARATO NH, WICKER LS, PE'FEP~ON LB: T y p e I D i a b e t e s i n Mice is L i n k e d t o t h e i n t e r l c u k i n - 1 R e c e p t o r a n d L s h / I t y / B c g G e n e s o n C h r o m o s o m e 1 [Letter]. Nature 1991, 353:262-264.

COSIC I, HEARN MTW: S t u d i e s o n P r o t e i n - D N A Interactions Using the Resonant Recognition Model -Application to Repressors and T r a n s f o r m i n g P r o t e i n s . E u r J Biochem 1992, 205:6134519. CRAIG A~M, DENHARDT DT: T h e M u r i n e G e n e E n c o d i n g Secreted Phosphoprotein-1 (Osteopontin) P r o m o t e r S t r u c t u r e , Activity, a n d I n d u c t i o n I n v i v o b y E s t r o g e n a n d P r o g e s t e r o n e . Gene 1991, 100:163-171. CRAIG S, CLEME,VL'SJM, COOK AL, DRYDEN DTF, GREEN DR, ttEREMK'¢S K, KIRWIN PM, PRICE MJ, FALLON A: C h a r a c t e r i z a t i o n o f t h e S t r u c t u r e a n d Conformation of PlatelevDerived Growth FactorBB (PDGF-BB) a n d P r o t c i n a s c - R e s t s t a n t M u t a n t s o f PDGF-BB E x p r e s s e d i n S a c c h a r o m y c e s C c r e v i s i a e . Biocbem J 1992, 281:67 72. CROWN J, JAKL23OWSR2A, KEMENY N, GORDON M, GASPARKITO C, WONG G, SHERIDAN C, TONER G, MRISENBERG B, BOTET J, APPLEWHITEJ, SINHA S, MOORS M, KELSEND, BUHLES W, GABRILOVEJ: A P h a s e - I T r i a l of Recombinant Human Interleukin-lbeta Alone and in Combination with Myelosuppressivc Doses of 5-Fluorouracil in Patients with G a s t r o i n t e s t i n a l C a n c e r . Blood 1991, "78:1420-1427. CHEVAS P, CARCELLERF~ ORTEGA S, ZAZO M, NIETO I, GIMENEZGALLEGOG: H y p o t e n s i v e Activity o f F i b r o b l a s t G r o w t h Factor. Science 1991, 254:1208-1210. CUNNINGHAM BC, ULTSCH M, DEVOS AM, MULKERRIN MG, CLt~USERKR, WELLS JA: D i m c r i z a t i o n o f t h e Extraeellular Domain of the Human Growth Hormone Receptor by a Single Hormone M o l e c u l e . Science 1991, 254:821-825. DAHIELIAN PS, WHITE R, LEESJA, PARKERMG: Identification of a Conserved Region Required for Hormone Dependent Transcriptional Activation b y S t e r o i d H o r m o n e R e c e p t o r s . E M B O J 1992, 11:1025-1034. DAUM G, ZANDER NF, MORSE B, HURWITZ D, SCHLESSINGER J, FISCHER EH: C h a r a c t e r i z a t i o n o f a H u m a n Recombinant Receptor-Linked Protein Tyrosine P h o s p h a t a s e . J Biol C~em 1991, 266:12211 12215. DAUVOIS S, DANIELIANPS, WHITE R, PARKER MG: A n t i e s t r o g e n ICI-164,384 R e d u c e s C e l l u l a r Estrogen Receptor Content by Increasing Its T u r n o v e r . Proc Natl A c a d Sci U S A 1992, 89:40374041. DAVID C, EWERT M, SEEBURG PH, FUCHS S: A n t i p e p t i d e Antibodies Differentiate Between Long and Short t s o f o r m s o f t h e D 2 D o p a m i n e R e c e p t o r . Biochem Biophys Res C o m m u n 1991, 179:8244329. DAVIS BH. RAPP UR, DAVIDSON NO: R e t i n o i c A c i d a n d Transforming Growth Factor-beta Differentially Inhibit Platelct-Derived- Growt h-Factor-Induced Ito-Cell A c t i v a t i o n . BiochemJ1991, 278:43-47. I)AV[S S, ALDRICH TH, VALENZIAELADM, WONG V, FUTITH ME, SQUINq'O SP, YANCOPOLR,OSGD: T h e R e c e p t o r f o r C i l i a r y N e u r o t r o p h i c Factor. Science t991, 253:59-63. DE VRIES C, ESCOBEDOJA, UENO H, HOUCK K, FERRARA N, WILLI~tS LT: T h c f i n s - l i k e T y r o s t n e K t n a s e , a R e c e p t o r f o r V a s c u l a r E n d o t h e l i a l G r o w t h Factor. Science t992, 255:989-990. DECLUEJE, COtIEN BD, LOWY DR: I d e n t i f i c a t i o n a n d Characterization of the Neurofibromatosis Typc1 P r o t e i n P r o d u c t . Proc N a t l A c a d Sci U S A 1991, 88:9914-9918. DEMEYTS P: S t r u c t u r e o f G r o w t h H o r m o n e a n d Its R e c e p t o r - a n U n e x p e c t e d S t o i c h i o m e t r y . Trends Biochem Sci 1992, 17:169-170. DEVINE PL, LAYTON GT, CLARK BA, BIRRELL GW, WARD BG, XlNG PX, MCKENZIE IFC: P r o d u c t i o n o f MUC1 a n d MUC2 M u c i n s b y H u m a n T u m o r Cell Lines. Biochem Biophys Res C o m m u n 1991, 178:593 599. DEVOS AM, ULTSCH M, KOSSIAKOFFAA: H u m a n G r o w t h H o r m o n e a n d E x t r a c c l l a l a r D o m a i n o f Its Receptor - Crystal Structure of the Complex. Science 1992, 255:306-312. DHANARAJ V, DEALWIS CG, FRAZAO C, BADASSO M, SIBANDA BL, TICKLE IJ, COOPER JB, DRIESSENHPC, NEWMAN M, AGUILARC, WOOD SP, BLUNDELLTL, HOBART PM, GEOGHEGAN KF, AMMIRATIMJ, DANLEY DE, O'CONNOR BA, HOOVER DJ: X - r a y A n a l y s i s o f P e p t i d e - i n h i b i t o r Complexes Define the Structural Basis of S p e c i f i c i t y f o r H u m a n a n d M o u s e R e n i n s . Nature 1992, 3 5 7 : 4 6 6 ~ 7 1 . DIAZMECO M'I. DOMINGUEZ I, SANZ L, MUNICIO MM, BERRA E, CORNET ME, DEHERREROS AG, JOHANSEN T, MOSCAT J: P h o s p h o l t p a s c C - m e d i a t e d H y d r o l y s i s o f P h o s p h a t i d y l c h o l i n e is a T a r g e t o f T r a n s f o r m i n g G r o w t h F a c t o r - b e t a I i n h i b i t o r y S i g n a l s . Mol Cell Bio11992, 12:302-320. DIEKEN ES, MIESFELDRL: T r a n s c r i p t i o n a l T r a n s a c t i v a t i o n Functions Localized to the Glucocorticoid Receptor-N Terminus are Necessary for Steroid

Pharmaceutical applications Peptides, growth factors, hormones and receptors 743 I n d u c t i o n o f L y m p h o c y t e Apoptosis. Mol Cell Biol 1992, 12:589-597. DOBROWOLSY-JZ, XU GQ, CHEN W, HITCHCOCKDEGREGORI SE: Analysis o f the R e g u l a t o r y a n d Structural Defects o f T r o p o n i n - C C e n t r a l H e l i x Mutants. Biochemistry 1991, 30:7089-7096. DOLCI S, WILLIAMSDE, ERNSTMK, RgSNICKJL, BRANN~N CI, LOCK LF, LYMANSD, BOSWELl.HS, DONOVAN PJ: R e q u i r e m e n t for Mast C e l l G r o w t h Factor f o r P r i m o r d i a l G e r m c e l l S u r v i v a l in Culture [Letter]. Nature 1991, 352:8094310. DONNELLYROBERTSDL, LENTZTL: B i n d i n g Sites f o r AlphaB u n g a r o t o x i n and t h e N o n c o m p e t i t i v e I n h i b i t o r P h c n c y c l i d i n e o n a S y n t h e t i c Peptide C o m p r i s I n g Residues 172-227 o f t h e Alpha-Subunit o f t h e N i c o t i n i c Acetylchollne Receptor. Biochemistry 1991, 30:7484-7491. DOUCAS V, SPYROU G, YANW M: U n r e g u l a t e d E x p r e s s i o n o f C-Jun o r C-Fos P r o t e i n s But n o t J u n D i n h i b i t s O e s t r o g e n Receptor Activity in H u m a n B r e a s t C a n c e r Derived Cells. E M B O J 1991, 10:223~2246. EASTON AM, GIERSEJK, SEETHAR~MR, KLEINBK, KOTrS CE: P r o d u c t i o n o f B o v i n e Insulin-Like G r o w t h Factor-2 (bIGF2) in Eseherichia-Coli. Gene I991, 101:291-295. EDELBERGJM, CONRAD HE, PIZZO SV: H c p a r i n Ollgosaccharides E n h a n c e Tissue-Type P l a s m i n o g e n Activator - a C o r r e l a t i o n B e t w e e n O l i g o s a c c h a r i d e L e n g t h a n d Stimulation o f E l a s m i n o g e n Activation. Biochemistry 1991, 30:10999-11003. ELBATTARIA, FORGL*I'P, POUCHIER F, PIC P: Effect o f I n h i b i t i n g N-Glyeosylation o r O l i g o s a e c h a r i d e P r o c e s s i n g o n Vasoactive I n t e s t i n a l Peptide R e c e p t o r BInding Activity a n d Structure. Biochem J 1991, 27S:52%533. ENDO T, OHMORI M, IKEDAM, ONAYA T;' Rabbit Antibodies T o w a r d E x t r a c e l l u l a r Loops o f the Membrane Spanning Region of Human Thyrotropin Receptor Possess Thyroid Stixnulating Activities. B i o c h e m Bfophys Res C o m m u n 1991, 181:1035-1041. ERVASTIJM, C~MPBELLKP: M e m b r a n e O r g a n i z a t i o n o f t h e D y s t r o p h i n - G l y c o p r o t e i n Complex. Cell 1991, 66:1121 1131. ESTROV Z, KURZROCKR, WETZLERM, KAN-fARJIANH, BLAKE M, HARRIS D, GUITERMANJU, TALPAZM: Suppression of Chronic Myelogenous Leukemia C o l o n y G r o w t h by I n t e r l e u k i n - 1 (IL-1) R e c e p t o r A n t a g o n i s t a n d Soluble EL-1 R e c e p t o r s - a N o v e l A p p B c a t i o n for i n h i b i t u r s o f IL-1 Activity. Blood 1991, 78:1476-I484. EUROPEAN CGRP IN SUBARACIINOIDHAEMORRHAGESTUDY GROUP: Effect o f C a l c i t o n i n - g e n e - r e l a t e d P e p t l d e i n Patients w i t h Delayed P o s t o p e r a t i v e C e r e b r a l I s c h a e m i a after A n e u r y s m a l Subat'aclmoid H a e m o r r h a g e . Lancet 1992, 339:831833. FAULKNrEROBRIENLA, BEWHAH, PAPAYANNOPOULOSIA, ANJAN~EYL1LUPSR, STAROSJV: P r e p a r a t i o n a n d C h a r a c t e r i z a t i o n o f Spin-Labeled Derivatives o f E p i d e r m a l G r o w t h - F a c t o r (EGF) f o r I n v e s t i g a t i o n s o f t h e Intaractions o f EGF w i t h Its R e c e p t o r b y E l e c t r o n Paramaomaetic R e s o n a n c e S p e c t r o s c o p y . Biochemistry 1991, 30:8976~3985. FELICI F, CASTAGNOHL, MUSACCHIOA, JAPPELLIR, CESAREN1 G: Selection o f A n t i b o d y Ligands f r o m a Large L i b r a r y o f Oligopeptides E x p r e s s e d o n a Multivalent E x p o s i t i o n Vector. J M o l Bio11991, 222:30t-310. FERN J, GOOD MF: P r o m i s c u o u s Malaria Peptide E p i t o p e Stilnulates C D 4 5 R a T-Cells f r o m P e r i p h e r a l Blood o f N o n e x p o s e d D o n o r s . J I m m u n o 1 1 9 9 2 , 148:907-913. FERRAN DS, SOBELM, HARRIS RB: D e s i g n and Synthesis o f a H e l i x H e p a r i n - B i n d i n g Peptide. Biochemistry 1992, 31:5010-5016. FEYENJHM, EVANS DB, BINKERT C, HEIN~ICH GF, GEISSE S, KOCHER HP: R e c o m b i n a n t H u m a n < Cys281> Insulin-Like G r o w t h Factor-Binding P r o t e i n - 2 Inhibits B o t h B a s a l a n d Insulin-Like G r o w t h Factor-I-Stimulated P r o l i f e r a t i o n a n d C o l l a g e n Synthesis In F e t a l Rat Calvariae. J Biol Chem 1991, 266:19469-19474. FLANAGAN \VM, CORTHESYB, BRAM Rj, CRABTREEGR: N u c l e a r Association o f a T-cell T r a n s c r i p t i o n F a c t o r Blocked by FK-506 a n d C y c l o s p o r i n a [Letter]. Nature, 1991, 352:803~q06. PLECtGNERJ, RASMUSSENHH, JUSTESENJ: H u t n a u I n t e r f e r o n - g ~ m m a P o t e n t l y Induces t h e Synthesis o f a 55-kDa P r o t e I n ( g a m m a 2 ) H i g h l y H o m o l o g o u s to Rabbit P e p t i d e C h a i n Release F a c t o r a n d Bovine T r y p t o p h a n y l o T r a n s f e r RNA Synthctase. Proc Natl A c a d Sci U S A 1991, 88:11520-11524. FLORENCE AT, GEGORIADISG: T a r g e t i n g Peptides a n d Proteins= NATO ASL Trends Biotechno11991, 9:295-296.

FOUNTOUZAKISM, LAItM HW, MAPdSA, FRIEDLEINA, MANNEBERGM, STUEBERD, GAROTFAG: A 25-kDa Stretch of the Extracelhilar Domain of the H u m a n I n t e r f e r o n - g a m m a R e c e p t o r is R e q u i r e d f o r Full Ligand B i n d i n g Capacity. J Biol Ch6-~n 1991, 266:14970-14977. FRANXS NP, LIEB WR: Stereospecific Effects o f I n h a l a t i o n a l G e n e r a l Anesthetic O p t i c a l I s o m e r s o n Nerve I o n c h a n n e l s . Science 1991, 254:427430. PUJIl J, TANIGUCH1N: P h o r b o l Ester I n d u c e s M a n g a n e s e S u p e r o x i d e D i s m u t a s e i n T u m o r Necrosis FactorR e s i s t a n t Cells. J Biol Chem 1991, 266:23142-23146. FLING MR, SCEARCE RM, HOFFMANJA, PEFFER NJ, HAMMES SR, HOSKINGJB, SCHMANDTR, KUZIELWA, HAYNES BY, MILLS GB, GKEF~NEWC: A T y r o s i n e K i n a s e P h y s i c a l l y Associates w i t h t h e Beta-Subunit o f t h e H u m a n EL-2 Receptor. J I m m u n o 1 1 9 9 1 , 147:1253-1260. GAIAN JE, PACE J, ttAYM~N MJ: I n v o l v e m e n t o f t h e E p i d e r m a l G r o w t h Factor R e c e p t o r i n t h e Invasion of Cultured M~mmal|an cells by S a l m o n e l l a T y p h i m u r i u n x Nature 1992, 357:588. GAO XM, ZHENG B, DEW FY, BRVWFS, TITE J: P ~ g of I n f l u e n z a Virus-Specific Cytotuxic LymphocytesT I n v i v o b y S h o r t Synthetic Peptides. J l m m u n o l 1991, 147:3268-3273. GARCHON H-J, BEDOSSA P, ELOY L, BACIt J-F: I d e n t i f i c a t i o n a n d M a p p i n g to C h r o m o s o m e I o f a Susceptibility Locus f o r P e r i i n s u l i t i s i n Non-obese D i a b e t i c Mice [Letter]. Nature 1991, 353:260-261. GARCIACALVOM, VAZQUEZJ, SMI~d M, KACZOROWSKIGJ, GARCIA ML: C h a r a c t e r i z a t i o n o f t h e Solubillzed C h a r y b d o t o x i n R e c e p t o r f r o m B o v i n e Aortic S m o o t h Muscle. Biochemistry 1991, 30:11157-11164. GARRET C, CARRUETTEA~ FARDINV, MOUSSAOL1S, PEYRONEL JF, BLANCHARDJC, IADURON PM: P h a r m a c o l o g i c a l P r o p e r t i e s o f a P o t e n t a n d Selective N o n p e p t i d e Substance-P AntagonisL Proc Natl A c a d Sci U S A 1991, 88:10208-10212. GARRETM, MCHENDRYRINDEB, SPICKOFSKYN, MARGOLSKEE RF: I s o l a t i o n o f a Clone W h i c h I n d u c e s Expression of the Gene EncodIng the Human T u m o r N e c r o s i s F a c t o r Receptor. Gene 1992, 111:215 222. GATELYMK, DESAI BB, WOLITZKYAG, QL~NN PM, DWYER CM, PODLASKI PJ, FAM2LLETUPC, SINIGAGLIAF, CHIZONN1TER, GUBLER U, SlI~RN AS: R e g u l a t i o n of Human Lymphocyte Proliferation by a H e t e r o d i m e r i c Cytoldne, 1L-12 (Cytotoxic L y m p h o c y t e M a t u r a t i o n Factor). J l m m u n o 1 1 9 9 1 , 147:8744382. GAVUZZOE, LUCENTEG, MAZZAF, ZECCHINI GP, PARADISI MP, PocHE'raa G, TORR~ h Synthesis a n d P r o p e r t i e s o f C h e m o t a c t i c P c p t i d c Analogs. 1. Crystal S t r u c t u r e a n d M o l e c u l a r C o n f o r m a t i o n o f HCOMct-Leu- Ain-OMe. Int J Pept Protein Res 1991, 37:268-276. GERMOND MET AL., DEVROEYPET AL.: Successfnl InVitro F e r O l i s a t i o n a n d E m b r y o T r a n s f e r a f t e r T r e a t m e n t w i t h R e c o m b i n a n t H u m a n FSH [Letter]. Lancel 1992, 339:1170. GETHER U, MARRAYT, SCHWARTZT~V,JOHANSEN TE: Stable E x p r e s s i o n o f H i g h Affinity NK1 (SubstanceP) a n d NK2 ( N e u r o k i n i n - A ) R e c e p t o r s But Low Affinity NK3 ( N c u r o k i n i n - B ) R e c e p t o r s In T r a n s f e c t e d CHO Cells. FEBS Lett 1992, 296:241-244. GHETIE MA, PdCHARDSONJ, TUCKER% JONES D, UHR J~g, VITETTAES: A n t i t u m o r Activity o f Fab' a n d I g G A n t i Cd22 I m m t m o t o x i l l S ill D i s s e m i n a t e d H u m a n L y m p h o m a B G r o w n i n Mice w i t h Severe C o m b I n e d I m m u n o d e f i c i e n c y Disease - Effect o n T u m o r Cells I n E x t r a n o d a l Sites. Cancer Res 1991, 51:5876-5880. GIBBONS IR, GIBBOUS BH, MOCZ G, ASAI DJ: M u l t i p l e N u c l e o t i d e - b I n d i n g Sites i n t h e S e q u e n c e o f S y n e i n ~ H e a v y C h a i n [Letter]. Nature 1991, 352:640~%42. GLASS CK, DIRENZOJ, KUROKAWAR, HAN Z: R e g u l a t i o n o f G e n e E x p r e s s i o n b y R c t i n o i c Acid Receptors. DNA C~ll Bfol 1991, 10:623~38. GOMEZFOIXAM, RODRIGUEZGILJE, GULNOVA2TJJ: AntiI n s u l i n Effects o f A m y l i n a n d Calcitonin-GeneRelated P e p t i d e o n H e p a t i c G l y c o g e n Metabolism. B iochem J 1991, 276:6074310. GOLXLI SA: I s o l a t i o n a n d I d e n t i f i c a t i o n o f a Novel C e l l u l a r P r o t e i n t h a t P o t e n t l y Activates C a 2 + / P h o s p h o l l p i d - D e p e n d e n t P r o t e i n Kina.~e ( P r o t e i n Kinase-C). B i o c h e m J 1991, 2 7 9 : 6 9 5 4 9 8 . GRANOWITZ EV, CLARKBD, MANCILLAJ, DINARELLOCA: Interleukin-1 Receptor Antagonist Competitively I n h i b i t s t h e B I n d i n g o f I n t e r l e u k i n - 1 to t h e Type-H I n t e r l e u k i n - 1 Receptor. J Biol (.'hem 1991, 266:14147-14150. GREVEJM, FORTE CP, MAKLORCW, MEYER CW, MEYERAzM, HOOVERLtTTYII, ~gi3NDERLICHD, MCCLELLANDA: Mechanisms of Receptor Mediated Rhmovirus

N e u t r a l i z a t i o n D e f i n e d b y Two Soluble F o r m s o f ICAM-1. J Virol 1991, 65:6015. GROSS L, DL~N MF: S p e c t r o s c o p i c Evidence for a n I n t e r m e d i a t e i n t h e T6 to R6 Allosteric T r a n s i t i o n o f t h e Co(lI)-Substituted I n s u l i n H e x a m e r . Biochemistry 1992, 31:1295-1301. GRUAZCHATELLARDD, BAUMBERGERC, SAURATJH, DAYER JM: I n t e r l e u k i n - 1 R e c e p t o r Antagonist i n H u m a n E p i d e r m i s a n d C u l t u r e d Keratinocytes. FEBS Lett 1991, 294:137-140. GUDMUNDSSON GH, LIDHOLM DA, ASLINGB, GAN RB, BOMAN HG: T h e C e c r o p i n Locus - C l o n i n g a n d E x p r e s s i o n o f a G e n e Cluster E n c o d i n g 3 Antibacterial P e p t i d e s i n H y a l o p h o r a - C e c r o p i a . J B i o l Chem 1991, 266:11510 11517 GUOCHON MAN-EELA, LESCOP P, CHRIS~IN-MAITRES, LOOSFELT H, PERROT-APPLANATM, MJLGROME: Nueleocytoplasmic Shuttling of the Progesterone Receptor. E M B O J 1991, 10:3851-3860. GETOWSKI MC, BRIGGS SL, JOHNSON DA: E p i d e r m a l G r o w t h Factor Receptor-Reactive M o n o c l o n a l Antibodies -Xenograft A n t i t u m o r Activity A l o n e a n d as D r u g I m m t m o c o n j u g a t e s . Cancer Res 1991, 51:5471-5475. HADJIIVANOVA C, DUFRESNE M, POIROT S, SOZZAN~P, VAYSSE N, MORODER L, FOURMYD: P h a r m a c o l o g i c a l a n d Biochemical Characterization of Cholecystukinin Gastrin R e c e p t o r s i n D e v e l o p i n g Rat P a n c r e a s - Age-Related E x p r e s s i o n o f Distinct R e c e p t o r Glycoforms. E u r J Biochem 1992, 204:273-279. tIAIT X0gN,AFTAB DT: R a t i o n a l D e s i g n a n d P r e - c l l n i c a l • Pharmacology of Drugs for Reversing Multidrug Resistance. Biochem Pharmaco11992, 43:103-107. [221. HAMMOND KB ABMAN SH, SOKOL RJ, ACCURSO FJ: Efficacy o f Statewide N e o n a t a l S c r e e n i n g f o r Cystic Fibrosis by Assay o f T r y p s i n o g e n C o n c e n t r a t i o n s . N E n g I J M e d 1991, 325:769-774, HAMY F, HELBECQL~ N, HENICHARTJP: C o m p a r i s o n B e t w e e n Synthetic N u c l e a r Localization S i g n a l Peptides f r o m t h e S t e r o i d T h y r o i d H o r m o n e R e c e p t o r s Superfamlly. Biochem Biophys Res C o m m u n 1992, 182:289-293. HANEY PM, SLOTJng7, PIPER Re, JAMES DE, MUECKLERM: • Itttracellular T a r g e t i n g o f t h e lmsulin-regulatable Glucose T r a n s p o r t e r (GLUT4) is I s o f o r m Specific a n d I n d e p e n d e n t o f Cell Type. J Cell Bio11991, 114:689-699 [6]. HARFST E, ET AL.: I n t e r a c t i o n o f T h y r o t r o p i n a n d T h y r o i d - s t i m u l a t i n g Antibodies w i t h R e c o m b i n a n t E x t r a c e l l u l a r Region o f H u m a n TSH R e c e p t o r [Letter]. Lancet 1992, 339:193. tIARFaS PE, GUTIERREZMC, REED E, KING DW, SUCIUFOCAN: Biosynthesis a n d P a r t i a l A m i n o Acid S e q u e n c e o f t h e H u m a n NDA4 A n t i g e n - a n Activation A n t i g e n C o m m o n to B-Cell a n d T-Cell Lineages. J I m m u n o l 1991, 147:1299-1306. HARI~SON SC: A S t r u c t u r a l T a x o n o m y o f DNA-binding D o m a i n s . Nature 1991, 353:715-719. }IARVEYTS, WILI~JNSONAJ, TAPPIN MJ, COOKE RM, CAMPBELLID: T h e S o l u t i o n Structure o f H u m a n T r a n s f o r m i n g G r o w t h Factor-alpha. E u r J Biochem 1991, 19S:555-562. HAYAKAWAT~ YAMASHITAK, TANZAWAK, [ICHIJIMAE, IWATA K: G r o w t h - P r o m o t i n g Activity o f Tissue I n h i b i t o r o f M e t a l l o p r o t e i n a s r s - 1 (TIMP-1) f o r a Wide R a n g e o f Cells - a Possible N e w G r o w t h Factor In Serum. FEBS Lett 1992, 298:29-32. HAYDOCK SF, DOWSONJA, DtMLLONN, ROBERTS GA, CORTESJ, LEADLAYPF: C l o n i n g and S e q u e n c e Analysis o f Genes I n v o l v e d in E r y t h r o m y c i n Biosynthesis in S a e c h a r o p o l y s p o r a - E r y t h r a e a - Sequence S i m i l a r i t i e s B e t w e e n EryG a n d a Family o f S - A d e n o s y l m e t h i o n i n c - D e p e n d e n t Methyltransferases. Mol Gem Genet 1991, 230:120-128. HEATH XXPF,BELAGAJERM, BROOKE GS, CHANCE RE, HOFFMAN."IJA, LONG }iB, REAMS SG, ROUNDTREEC, SHAW WN, SLIEKERLJ, SI0~NDELLKL, DIMARCHI RD: (AC-B) H m P r o i n s u l i n , a Novel I n s u l i n Agonist a n d I n t e r m e d i a t e i n t h e Synthesis o f B i o s y n t h e t i c H u m a n Insulin. J B i o l Chem 1992, 2 6 7 : 4 1 9 4 2 5 . HEBERT CA, VITANGCOLRV, BAKERJB: S c a n n i n g Mutagenesis o f I n t e r l e u k i n - 8 Identifies a Cluster o f Residues R e q u i r e d f o r R e c e p t o r B i n d i n g . J Biol Chem 1991, 266:18989-18994. HECHTMAN DH, CYBL~LSKYMI, FUCHS HJ, BAY~:RJB, GIMBRONEMA: I n t r a v a s c u l a r IL-8 - I n h i b i t o r o f P o l y m o r p h o n u c l e a r Leukocyte A c c u m u l a t i o n .at Sites o f Acute I n f l a m m a t i o n . J l m m u n o 1 1 9 9 1 , 147:883-892. HEGDE R, PODDER SK: Studies o n the Variants o f t h e P r o t e i n Toxins R i c i n a n d Abrin. E u r J Biochem 1992, 204:155-164. tIEINZEL FP, SADICKMD, MUTHA SS, LOCKSLEYRM: P r o d u c t i o n o f I n t e r f e r o n Gamma> I n t e r l e u k i n 2, I n t e r l e u k i n 4, a n d I n t e r l e u k i n 10 b y CD4+

744

Pharmaceutical applications Peptides, growth factors, hormones and receptors L y m p h o c y t e s i n Vivo D u r i n g H e a l i n g a n d P r o g r e s s i v e M u r i n e LeishmanLa$is. Proc Nail A c a d &'i U S A 1991, 88:7011-7015. HEM=VUS, MERLIN G, AGUET M: F u n c t i o n a l Characterization of a Hybrid Human-Mouse interferon-gamma Receptor -Evidence for Species-Specific Interaction of the Extracellular Receptor Domain with a Putative Signal T r a n s d u c e r . Proc Nail A c a d Sci U S A 1992, 89:2737-2741. IIEYL DL, OMNAASJR, SOBCZYKKOJIROK, MEDZIHRADSKYF, SMITH CB, MOSBERG tII: O p i o i d R e c e p t o r A f f i n i t y a n d S e l e c t i v i t y Effects o f S e c o n d R e s i d u e a n d C a r b o x y T e r m i n a l R e s i d u e V a r i a t i o n i n a Cyclic Disulfide-Containing Opioid Tetrapeptide. IntJ Pept Protein Res 1991, 37:224-229. HIGGINS CF, GOTTESMAN MM: Is t h e M u l t i d r u g • T r a n s p o r t e r a F l i p p a s e ? Trends Biochem Sci 1992, 1 7 : i 8 - 2 I . [20]. HIGUCHI M, AGGARWAL BB: I n h i b i t i o n o f IAgand B i n d i n g a n d A n t i p r o l i f e r a t l v e Effects o f T u m o r N e c r o s i s Factor and Lymphotoxin by Soluble Forms of R e c o m b i n a n t P60 a n d 1"80 R e c e p t o r s . Biocbem Biopbys Res Cbmraun 1992, 182:6384543. HIRAI Y, TAKEBE K, TAKASHINAM, KOBAYASHI S, TAKEICHI M: E p l m o r p h i n - a M e s e n c h y m a l P r o t e i n E s s e n t i a l f o r E p i t h e l i a l M o r p h o g e n e s i s . Cell 1992, 69:471481. H2RAYAMAN, KASAI M, SHIRAHATAK: S t r u c t u r e a n d C o n f o r m a t i o n o f a Novel I n h i b i t o r o f Angiotensin-I Converting Enzyme - a Tripeptide C o n t a i n i n g P h o s p h o n i c Acid. I n t J Pept Protein Res 1991, 38:20-24. I-IOBER S, FORSBERG G, PAIM G, HARTMANISM, NILSSON B: D i s u l f i d e E x c h a n g e F o l d i n g o f I n s u l i n - L i k e G r o w t h Factor-I. Biochemistry 1992, 3 1 : ] 7 4 ~ 1 7 5 6 . HOEKMAN K, VON BLOMBERG VAN DER FLIER BME, WAGSTAFFJ, DREXHAGEHA, PLNEDO HM: R e v e r s i b l e T h y r o i d D y s f u n c t i o n D u r i n g T r e a t m e n t w i t h GMCSF. Lancet 1991, 338:541 542. HOFFMAN BJ, MEZEY E, BROWNSTEIN MJ: C l o n i n g of a Serotonin Transporter Affected by A n t i d e p r e s s a n t s . Science 1991, 254:579-580. HOKKEN-KOELEGA ACS, 872JNEN T, DE MUINCK KEIZERSCItRAMA SMPF, WIT JM, \VLFF ED, DE JONG MCJW, DONCKERWOLCKE RA, ABBAD NCB, BOT A, BLUM WF, DROP SLS: P l a c e b o - c o n t r o l l e d , D o u b l e - b l i n d , C r o s s over Trial of Growth Hormone Treatment in Prepubertal Children with Chronic Renal Failure. Lancet 1991, 338:585-589. HOLBROOK NJ, CARLSONSG, CHOI AMK. FARGNOLIJ: Induction of HSP70 Gene Expression by the A n t i p r o l i f e r a t i v e P r o s t a g i a n d i n PGA2 - a G r o w t h Dependent Response Mediated by Activation of H e a t S h o c k T r a n s c r i p t i o n Factor. Mol Cell Biol 1992, 12:1528-1534. HOLLOSI M, ISMAILAA, M&NTSCHHH, PENKE B~ VARADI IG, TOTH GK, LACZKO I, KU~UCZ I, NAGY Z, FASMANGD, RAJNAVOLGYIE: C o n f o r n l a t i o n a l a r i d F u n c t i o n a l Properties of Peptides Covering the Intersubunit Region of Influenza Virus Hemagglutinin. EurJ Biochem 1992, 2 06: 421425. HOLTRICH U, BI~I3NINGER A, STREBHARDTK, RI)BSAMENWAIG~ H: T w o A d d i t i o n a l P r o t e i n - t y r o s i n c IOnases Expressed in Human Lung: Fourth Member of the Fibroblast Growth Factor Receptor Family and an intracelinlar Proteint y r o s i n e K i n a s e . Proc Nall A c a d Sci U S A 1991, 88:10411-10415. HOMMEL U, DUDGEON ~J, FALLONA, EDWARDS RM, CAMPBELL ID: S t r u c t u r e - F u n c t i o n R e l a t i o n s h i p s i n H u m a n E p i d e r m a l G r o w t h F a c t o r S t u d i e d b y SiteD i r e c t e d M u t a g e n e s i s a n d H-1 ~ Biochemistry 1991, 3 0 : 8 8 9 1 ~ 8 9 8 . HOPE TJ, BOND BL, MCDONALD D, KLEIN NP, PARSLOW TG: Effector Domains of Human Immunodeficiency Virus Type 1 Rev and Human T Cell Leukemia Virus Type 1 Rex are Fttnctionally i n t e r c h a n g e a b l e a n d S h a r e all E s s e n t i a l P e p t i d e Motifi J Virol I ~ ) t , 65:60014023. HORA MS, RANA RK, SMITH F~vV:L y o p h i l i z e d Formulations of Recombinant Tumor Necrosis Factor. P h a r m Res 1992, 9 : 3 ~ 3 6 . HORDIJK PL, SCHALHG HDFH, EBBERINK RHM, DEIONGBRINK M, JOOSSE J: P r i m a r y S t r u c t u r e a n d O r i g i n of Schistosomin, an Anti-Gonadotropie Neuropeptide of the Pond Snail LymnaeaS t a g n a l i s . B i o c b e m J 1991, 279:837 842. HORNYAK TJ, SHAFERJA: I n t e r a c t i o n s o f Factor-XIII w i t h F i b r i n as S u b s t r a t e a n d Cofactor. Biochemistry 1992, 3 1 : 4 2 3 ~ 2 9 . HOUGHTEN RA, PliX~LLAC, BLONDELLE SE, APPEL JR, DOOLEY CT, CUERVOJH: G e n e r a t i o n a n d u s e o f Synthetic Peptide Combinatorial Libraries for Basic R e s e a r c h a n d D r u g D i s c o v e r y . Nature 199I, 354:84.

HU P, MARGOLISB, SKOLNIK EY, LAMMERSR, ULLRICHA, SCHLESSINGERJ: I n t e r a c t i o n o f P h o s p h a t i d y l i n o s i t o l 3 - K i n a s e - A s s o c i a t e d P85 w i t h E p i d e r m a l G r o w t h Factor aud Platelet-Derived Growth Factor R e c e p t o r s . Mol Cell Biol 1992, 12:981 990, HU QJ, BAUFISTAC, EDWARDS GM, DEFEOJONES D, JON~ESRE, tIARLOW E: A n t i b o d i e s S p e c i f i c f o r the Human Retinoblastoma Protein Identify a F a m i l y o f R e l a t e d P o l y p e p t i d e s . Mol 6~lt Biol 1991, 11:5792 5799. HUA QX, SHOELSONSE, KOCHOYA.NM, WEISS MA: R e c e p t o r Binding Redefined by a Structural Switch in a M u t a n t H u m a n i n s u l i n [Letter]. Nature 1991, 354:238-240. HUANG LH, CHENG H, PARDI A, TAM JP, SWEENEYWV: S e q u e n c e - S p e c i f i c H-1 N M R A s s i g n m e n t s , Secondary Structure, and Location of the Calcium B i n d i n g Site i n t h e F i r s t E p i d e r m a l G r o w t h F a c t o r Like D o m a i n o f B l o o d C o a g u l a t i o n Factor-IX. Biochemistry 1991, 30:7402-7409. HUPaNG SS, HU~NG JS: P u r i f i c a t i o n a n d C h a r a c t e r i z a t i o n o f t h e N c u / e r b B2 L i g a n d - G r o w t h F a c t o r f r o m B o v i n e K i d n e y . J Biol Chem 1992, 267:11508-11512. HUGUES M, CRANE M, HAKKI S, OHANLEY P, WALDMAN SA: Identification and Characterization of a New Family of High-Affinity Receptors for E$cherichiaColi Heat-Stable E n t c r o t o x i n i n R a t I n t e s t i n a l M e m b r a n e s . Biochemistry 199I, 30:10738-10745. HUGUES M, CRANEMR, TI-IOMASBR, ROBERTSOND, GAZZ&NO It, OHANLEY P~ WAI,DMAN SA: Af~luity Purification of Functional Receptors for Escherichia-Coli Heat-Stable Enterotoxin from Rat I n t e s t i n e . Biochemistry 1992, 31:12-16. HD~ME M, SILJANDERP, ANT~LA H: R e g u l a t i o n o f Interleukin-lbeta Production by Glucocorticoids in Human Monocytes - the Mechanism of Action D e p e n d s o n t h e A c t i v a t i o n S i g n a l Biochem Biophys Res C o m m u n 199t, 1S0:1383-1389. HUSMANN M, LEHMANNJ, HOFFMAN~ B, HERMAN~NT, TZUT~EP~MANM, PFAHL M: A l l t a g o n i s m B e t w e e n R e t i n o i c Acid R e c e p t o r s . Mol Cell Bio11991, 11:40974103. HLWGHE BG, KLINMANJP: A c t i v i t y o f M e m b r a n o u s Dopamine Bcta-Monooxygenase Within Chromaffm Granule Ghosts - Interaction with A s c o r b a t e . J Biol Cbem 1991, 266:11544-11550. LLLUML: T h e N a s a l D e l i v e r y o f P e p t i d c s a n d P r o t e i n s . Trends Biotechno11991, 9:284-289. IMLERJ-L, iV~IYAJIMAA, ZURAWSKIG: I d e n t i f i c a t i o n o f Three Adjacent Amino Acids of Interleukin-2 Receptor ~ Chain Which Control the Affinity and the Specificity of the Interaction with InterIeukin2. E M B O J 1992, 11:2047-2054. ISHAIMICHAELI R, SVAHN CM, WEBER M, CHAJEKSHAULT, KOP.NER G, EKIm HP, VLODAVSKYI: I n l p o r t a n c e o f Size a n d s u l f a t i o n o f H e p a r i n i n R e l e a s e o f Basic F i h r o b l a s t G r o w t h F a c t o r f r o m t h e Vascular Endothelium and Extracellular Matrix. Biochemistry 1992, 31:2080-2088. ISHIZAKdJ, T~MAKI M, SHIN M, TSUZUKI H, YOSHIKAWA K, TERAOKA H, YOSHIDA N: P r o d u c t i o n o f Recombinant Human Gincagon in the Form of a F u s i o n P r o t e i n i n E s c h e r i c i f i a CoIl - R e c o v e r y o f G l u c a g o n b y S e q u e n c e - S p e c i f i c D i g e s t i o n . Appl Microbiol Biotechno11992, 36:483~i86. IYER KSN, UPADHYE S, KADAM LR, MAHALE SD, DHANASEKHARANS, NATRAJ U, ~NANDEDKARTD: S e a r c h for Peptide Immunogens of the Beta-Subunit of Human Chorionie Gonadotropin (hCG) Capable of Eliciting Hormone Specific and Neutralizing Antisera -Identification of an Undecapeptide E l i c i t i n g H C G - S p e c i f i c A n t i s e r a . Int # Pepk Protein Res 1992, 39:137-144. JANAKY T, JUHASZ A, BMUSZ S, CSER~S V, SRKALOVlCG, BOKSER L, MILOVANOV1CS, REDDING TXV, REKASI Z, NAGY A, SCHALLYAV: A n a l o g u e s o f L u t e i n i z i n g Hormone-Releasing Hormone Containing C y t o t o x i c G r o u p s . Proc Nail A c a d Sci U S A 1992, 89:972-976. jANSEN R, DAMIA G, USLI N, KELLERJ, FL~rAMI H, GOEY H, BACK TT, LONGO DL, RUSCETTI F~V, WILI'ROUT RH: Effects o f R e c o m b I n a n t T r a n s f o r m i n g G r o w t h Factor-beta1 on Hematologic Recovery after T r e a t m e n t o f Mice w i t h 5 - F l a o r o u r a e l i . J I m m u n o l 1991, 147:3342-3347. JARDETZKY TS, LANE WS, ROBINSON RA, MADDEN DR, WILEY De: I d e n t i f i c a t i o n o f Self P e p t i d e s B o u n d t o P u r i f i e d IlIA-B27. Nature 1991, 353:326-328. JOHNS LD, FLANDERSKC, RANGES GE, SRIRAM S: Successful Treatment of Experimental Allergic Encephalomyelitis with Transforming Growth Factor-hera1. J I m m u n o l 1991,147:1792-1796. JOHNSON DE, LUJ, CHEN H, WERNTR S, WILLIAMS LT: T h e Human Fibroblast Growth Factor Receptor Genes - a Common Structural Arrangement Underlies the Mechanisms for Generating Receptor Forms

that Differ in Their Third lmm,tnoglobulin D o m a i n . Mol Cell Bfo11991, 1 1 : 4 6 2 7 4 6 3 4 . JORGENSEN XYgL:R u s t i n g o f t h e L o c k a n d K e y M o d e l f o r P r o t e i n - I A g a n d B i n d i n g . Science 1991, 254:954-955. JISPPNER H, ABOUSAMRAAB, FREEMANM, KONG KF, SCHIPAaN~ E~ RICHARDSJ, KOIAKOWSFa LF, HOCK J, POTrS JT, KRONENBERG HM, SEGRE GV: A G - P r o t e i n Linked Receptor for Parathyroid Hormone and P a r a t h y r o i d H o r m o n e R e l a t e d P c p t i d c . Science 1991, 254:1024-1026 KALLMANP, ERMACORA MR, NOWICKI C, WOLFENSTEINOI'ODEL C, SANTOMEJA: C h e m i c a l M o d i f i c a t i o n o f H u m a n Growth Hormone with N-Acetylimidazole Effect o n B i n d i n g C a p a c i t y t o L a c t o g e n i c a n d S o m a t o g e n i e R e c e p t o r s . l n t j Pept Protein Res 1991, 38:38~16. KANG Y, YOON JW: D e v e l o p m e n t o f a h i g h - e x p r e s s i o n V e c t o r (PYKIO-9) o f H u m a n P r o i n s u l i n G e n e . Biotecbnol Lett 1991, 13:755-760. KASTNER P, PEREZ A, LUTZ Y, R O ~ - E G L Y C, GAUB M.-P, DUR&ND B, LANOTIE M, BERGER R, CH~MBON P: S t r u c t u r e , L o c a l i z a t i o n a n d T r a n s c r i p t i o n a l P r o p e r t i e s o f T w o Classes o f R e t i n o i c A c i d R e c e p t o r A l p h a F u s i o n . E M B O J 1992, 11:629-642. KEIDEL S, RL~PP E, ST~A~DENINGSM: R e c o m b i n a n t H u m a n R e t i n o i c Acid R e c e p t o r - a l p h a - B i n d i n g o f DNA and Synthetic Rctinoids to the Protein E x p r e s s e d i n E s c h e r i e h l a - C o l i . E u r J B f o c b e m 1992, 204:1141-1148. KELLER A, E[STETYERHR, VOSS ] . SCHAFER KP: T h e P u l m o n a r y S u f f a c t a t u P r o t e i n - C (SP-C) P r e c u r s o r is a T y p e - l I T r a n s m e m b r a n e P r o t e i n . B i o c h e m J 1991, 277:493~i99. KELLERER M, LAMMERSR, ERMELB, TIPPMER S, VOGT B, OBERMAIERKL'SSERB, ULLRICHA, HARING HU: D i s t i n c t Alpha-Sublmit Structures of Human Insulin Receptor-A and Rcceptor-B Variants Determine D i f f e r e n c e s i n T g r o s i n e K i n a s e Activities. Biochemistry 1992, 31:4588--4596. KIL'I~ JE, LORANG D, AMARA SG: C l o n h l g a n d E x p r e s s i o n of a Cocaine-Sensitlve Rat Dopamine Transporter. Science 1991, 254:578-579. KIM JW, GLOSS EI, ALBEITTONLM, CUNIx~NGHAMJM: • Transport of Cationic Amino Acids by the Mouse E c o t r o p i c R e t r o v i r u s R e c e p t o r . Nature 1991, 3 5 2 : 7 2 5 ~ 2 8 . [10]. KIRKNTSSEF, KUSIAKJW, FLGVANGJT, MENNINGERJ, GOCAYNE JD, WARD DC, VENTERJC: I s o l a t i o n , Characterization, and Localization of Human G e n o m i c DNA E n c o d i n g t h e Beta1 Subtttlit o f t h e GABAA R e c e p t o r (GABRB1). Genomics 1991, 10:985-995. KLAUS W, DIECKMANNT, WRAY V, SCHOMBURG D, \VINGENDER E, MAYER H: I n v e s t i g a t i o n o f t h e Solution Structure of the Human Parathyroid H o r m o n e F r a g m e n t (1-34) b y H-1 N M R Spectroscopy, Distance Geometry, and Molecular D y l l a m i c s C a l c u l a t i o n s . Biochemistry 1991, 30:693645942. KLIEWER SA, UMESONO K, MANGELSDORFDJ, EVANS RM: Retinoid X Receptor interacts with Nuclear R e c e p t o r s i n R e t i n o i c Acid, T h y r o i d H o r m o n e a n d V i t a m i n D< 3> S i g n a l l i n g [Letter]. Nature 1992, 335:446~648. K>,rEGTEL RMA, BOELENS R, GANADU ML, KAPTEIN R: T h e Solution Structure of a Monomeric Insulin - a T w o - D i m e n s i o n a l H-1-NMR S t u d y o f Des-(B26B30)-Insulin in Combination with Distance Geometry and Restrained Molecular Dynamics. E u r J B i o c h e m 1991, 2 0 2 : 4 4 7 4 5 8 . KNIGHTON DR, ZHENG J, TEN EYCK LF, XUONG N, TAYLOR SS, SOWADSKIJM: S t r u c t u r e o f a P e p t i d e i n h i b i t o r B o u n d t o t h e C a t a l y t i c S u b t m i t o f Cyclic Adenosine Monophosphate-dependcnt Protein K i n a s e . Science 1991, 253:414--420. KOELLE MR, TALBOT WS, SEGRAVESWA, BENDER MT, CHERBAS P, HOG~SS DS: T h e D r o s o p h i l a E c R G e n e Encodes an Ecdysone Receptor, a New Member o f t h e S t e r o i d R e c e p t o r S u p e r f a m i l y . Cell 1991, 67:59-77. KOHDA D, INAGAYd F: S t r u c t u r e o f E p i d e r m a l Growth Factor Bound to Perdeuterated Dodecylphosphocholine Micelles Determined by T w o - D i m e n s i o n a l NMR a n d S i m u l a t e d A n n e a l i n g C a l c u l a t i o n s . Biochemistry 1992, 31:6774585. KOLI K, LOHI J, HAUTA~XNA, KESKIOJAJ: E n h a n c e m e n t of Vitronectin Expression in Human HepG2 H e p a t o m a Cells b y T r a n s f o r m i n g G r o w t h Factorbeta-1. E u r J B i o c b e m 1991, 199:337-345. KOMADA M, MIYAZAWAK, ISHII T, KITAMU'RAN: Characterization of Hepatocyte-Growth-Factor R e c e p t o r s o n Meth-A Cells. E u r J Biocbem 1992, 204:857464. KOMATSUS, HIR&NO H: P l a n t Basic-7 S - G l o b u l i n Like Proteins have Insulin and Insulin-Like

Pharmaceutical applications Peptides, growth factors, hormones and receptors G r o w t h F a c t o r B i n d i n g Activity. FEBS Leit 1991, 294:210-212. KOSlTAL DA, BEEZHOLD DH, [{ALL RE: D i f f e r e n t i a t i o n I n d u c i n g C y t o k i n e P48 E x i s t s i n a M e m b r a n e A s s o c i a t e d For*iL J l m m u n o 1 1 9 9 1 , 147:893-898. KRIEGER M: M o l e c u l a r F l y p a p e r a n d A t h e r o s c l e r o s i s Structure of the Macrophage Scavenger Receptor. Trends Biochem 3~i 1992, 17:141-146. KLEJPERS T~(/, HAKKERTBC, HOOGERWERE M, LEEU~rENBERG JFM, RODS D: Role o f E n d o t h e l i a l Leukocyte A d h e s i o n Molecule-1 a n d Platelet-Activating F a c t o r i n N e u t r o p h i l A d h e r e n c e to IL-1P r e s t i m u l a t e d E n d o t h e l i a l Cells - E n d o t h e l i a l Leukocyte Adhesion Molecule-l-Mediated CD18 A c t i v a t i o n . J lmmuno11991, 147:1369-1376. KUMAGAI H, TAJIMA M, UENO Y, YUHKO GH, OHBA M: Effect o f Cyclic RGD P e p t i d e o n Cell A d h e s i o n a n d T u m o r Metastasis. Biochem Biophys Res C o m m u n 1991, 1 7 7 : 7 4 ~ 2 . KUNA P, REDDIGARI SR, KORNFELD D, KAPLANAP: I128 Inhibits Histamine Release from Human Basophils Induced by Histamine-Releasing F a c t o r s , C o n n e c t i v e T i s s u e Activating Peptide-111, a n d IL-3. J Immuno11991, 147:1920-1924. KUO CJ, CHUNG J, FIOI1ENT~NOFLANAGANWM, BLENIS J, CRABTR~E GR: R a p a m y e i n Selectively I n h i b i t s I n t e r l e u k i n - 2 A c t i v a t i o n o f P 7 0 $6 K i n a s e [Letter]. N a t u r e 1992, 358:70-72. KUI'SUWADA T, KASHIWABUCHIN, MORI H, SAKIMURAK, KUSHIYA E, ARAKI K, MEGLrRO I-i, MASAKIti, KUMA~"aSHI T, ARAKAWA M, MISHINA M: M o l e c u l a r D i v e r s i t y o f t h e N M D A R e c e p t o r C h a n n e l Nature 1992, 358:36-41. LABRIOLATOMPKINSE, CHANDRAN C, KAFEKAKL, BIONDI D, GRAVES gJ, HATADA M, MADISON VS, KARASJ, KILIAN PL, J u G: I d e n t i f i c a t i o n o f t h e D i s c o n t i n u o u s B i n d i n g Site i n H u m a n I n t e r l e u k i n - l b c t a f o r t h e T y p e - I I n t e r i e u k i n - 1 R e c e p t o r . Proc Natl A c a d Sci U S A 1991, 88:11182 11186. LACYJ, RUDNICK H: T r a n s c r i p t i o n a l R e g u l a t i o n o f t h e H u m a n IgE R e c e p t o r ( F e e p s i l o n R I I / C D 2 3 ) b y EBV - I d e n t i f i c a t i o n o f EBV-Res pous i ve R e g u l a t o r y E l e m e n t s i n I n t r o n 1. J I m m u n o l 1992, 148:1554-1560. LAL RB, RUDOLPH DL, PALKER~ , COLIGANJE, FOLKS "[~A: A S y n t h e t i c P e p t i d e Elicits A n t i b o d i e s R e a c t i v e w i t h t h e E x t e r n a l G l y c o p r o t e i n o f H u m a n TC e l l L y m p h o t r o p i c V i r u s Type-L J Gen Vtro11991, 72:2321-2324. LAM KS, SALMON SE, HERSH EM, HRUBY X[I, KAZMIERSKIWM, KNAPP RJ: A N e w Type o f S y n t h e t i c P e p t i d e L i b r a r y f o r I d e n t i f y i n g L i g a n d - b i n d i n g Activity. Nature 1991, 354:82. LAMBALLE F, KLEIN R, BARBACID M: trkC, a N e w M e m b e r of the Trk Family of Tyrosine Protein Kinases, i s a R e c e p t o r f o r N e u r o t r o p h i n - 3 . Cell 199i, 66:967-979. LAMBF~AUG, BARHANINJ, LAZDUNSKIM: I d e n t i f i c a t i o n of Different Receptor Types for Toxic P h o s p h o l i p a s e s - A 2 i n R a b b i t Ske l e t a l Muscle. FEBS Lett 1991, 29~29-33. L&NGEDIJKJPM, BACK NKT, DURDA PJ, GOL~)S*~TJ, MELOEN RH: N e u t r a l i z i n g Activity o f A n t i - P e p t i d e Antibodies Against the Principal Neutralization Domain of Human Immunodeficiency Virus Type1. J Gen Viro11991, 72:2519-2526. LARON Z, ANIN S, KI.IPPER-AURBACHY, KLINGER B: Effects o f I n s u l i n - l i k e G r o w t h F a c t o r L i n e a r G r o w t h , H e a d C i r c u m f e r e n c e , a n d B o d y Fat i n P a t i e n t s w i t h L a r o n - t y p e D w a r f i s m . Lancet 1992, 339:1258.1260. I~AVOINNEA, ERIKSON E, MAILERJL, PRICE DJ, AVRUCHJ, COHEN" P: P u r i f i c a t i o n a n d C h a r a c t e r i s a t i o n o f t h e Insulin-Stimulated Protein Klnase from Rabbit S k e l e t a l M u s c l e - Clo se S i m i l a r i t y t o $6 Ktnase-H. E u r J B i o c h e m 1991, 199:723-728. LAWRENCE MC, DAVIS PC: CLIX: a S e a r c h A l g o r i t h m f o r F i n d i n g N o v el L i g a n d s C a p a b l e o f B i n d i n g Proteins of Known Three-dimensional Structure. Proteins 1992, 12:31-41. LAX I, MITRA AK, RAYERAC, HURWlTZ DR, RUBINSTEINM, ULLRICH A, STROUD PdM, SCHLESSINGERj: E p i d e r m a l G r o w t h F a c t o r (EGF) I n d u c e s O l l g o m e r i z a t i o n o f Soluble, Extraecllular, Ligand-Binding Domain o f EGF R e c e p t o r - a L o w R e s o l u t i o n P r o j e c t i o n S t r u c t u r e o f t h e L i g a n d - B i n d i n g D o m a i n . J Biol Chem 1991, 266:13828-13833. LAZAR MA, BERRODIN qJ, HARDING HP: D i f f e r e n t i a l DNA Binding by Monomeric, Homodimeric, and Potentially Hcteromeric Forms of the T h y r o i d H o r m o n e R e c e p t o r . Mol Cell Bio11991, 11:5005 5015. LRIIIVIANED, SCHAEFERTF, pRZYSLECFACT, JOYCE JG, BAILEY FJ, SCIIL~M~N CA, Bb~d~ CJ, RAMJITHG, MmLER WJ: L ar g e- Scale P u r i f i c a t i o n a n d C h a r a c t e r i z a t i o n o f R e c o m b i n a n t T i c k A n t i c o a g u l a n t Peptide. J C'bromatogr [Biomed Appl] 1992, 574:225-235.

LEMAISTRECF, MENEGHETH C, ROSENBLI2MM, REL~3ENJ, PARKER K, SHAWJ, DEISSEROTHA, WOODWORTH T, PARKINSON DR: P h a s e I T r i a l o f a n I n t e r l e u k i n - 2 (EL-2) F u s i o n T o x i n (DAB4861L-2) i n H e m a t o l o g i c M a l i g n a n c i e s E x p r e s s i n g t h e I D 2 R e c e p t o r . Blood 1992, 79:2547-2554. LENARDJ: M a t n m a l l a n H o r m o n e s i n M i c r o b i a l Cells. Trends Biochem Sci i992, 17:147-150. LEILNER EA, StlOGMAK~RCB: M a x a d i l a n - C l o n i n g a n d Functional Expression of the Gene Encoding T h i s P o t e n t V a s o d i l a t o r P e p t i d e . J BioI Cbem 1992, 267:1062-1066. LEW R, VAUGHN R, SIMAN'IOV R, WILSON A, KLlqAR • MJ: D o p a m i n e T r a n s p o r t e r s i n t h e N u c l e u s Aceumbens and the Striamm have Different A p p a r e n t M o l e c u l a r W e i g h t s . Synapse 1991, 8:t52-153. [52]. L1 KNV, GERAERTSW~PM: I s o l a t i o n a n d C h e m i c a l Characterization of a Novel Insulin-Related N e u r o p e p t i d e f r o m t h e F r e s h w a t e r Snail, L y m n a e a - S t a g n a l i s . B u r J Biochera 1992, 205:67~678. i2 W, SCHLESSINGERJ: P l a t e l e t - D e r i v e d G r o w t h F a c t o r (PDGF)-Induced Disulfide-Linked Dtmerization of P D G F R e c e p t o r i n Liming Cells. Mol Cell Bio11991, 11:3756-3761. LIN }IY, HARRIS TL, FL/MNI~ERYMS, ARLq%'O A, KAJ1 EH, GOKN A, KOLAKOWSKILF~ LODISH HF, GOLDRING SR: E x p r e s s i o n C l o n i n g o f a n A d e n y l a t e Cyelase C o u p l e d C a l c i t o n i n R e c e p t o r . Science 1991, 254:1022-1024. IANDH I, HINDSGAUL O: S y n t h e s i s a n d E n z y m a t i c Evaluation of 2 Conformationally Restricted T r i s a e e h a r i d e A n a l o g u e s as S u b s t r a t e s f o r NA e e t y l g t u c o s a m i n y l t r a n s f e r a s e - V . J A m Chem Soc 1991, 113:216-223. LIU YH, TENG CT: C h a r a c t e r i z a t i o n o f E s t r o g e n R e s p o n s i v e M o u s e L a c t o f e r r i n P r o m o t e r . J Biol Chem 1991, 266:21880-21885. LIVINGSTONEDA, PETRE JE, BERGH eL: I n t r a l n o l e c u l a r Cyanohydrin Elaboration. Construction of C o r t i c o s t e r o i d s f r o m 1 7 - k c t o s t e r o i d s . J A m Chem Soc 1990, 112:6449-6450. LOETSCHER H, GEN~rZ R, ZUIALT M, LUSTIG A, TABUCHI H, SCHLAEGER EJ, BROCKHAUSM, GALLATI H, MANNEBERG 51, LESSLAUERW: R e c o m b i n a n t 5 5 - 1 O a T u m o r N e c r o s i s F a c t o r (TNF) R e c e p t o r - S t o i c h i o m e t r y o f Binding to TNFalpha and TNFbeta and Inhibition o f TNF Activity. J B i o l Chem 1991, 266:18324-18329. LOKKER NA, MARK MR, LUIS EA, BENNETT GL, ROBBINS KA, BAKERJB, GODOWSKI PJ: S t r u c t u r e - F u n c t i o n Analysis of Hepatocyte Growth Factor Identification of variants that Lack Mitogenic Activity Yet R e t a i n H i g h A f f i n i t y R e c e p t o r B i n d i n g . E M B O J 1992, 11:2503-2510. LONGO N, LANGLEYSD, GRIFFIN LD, ELSAS II LJ: R e d u c e d MRNA a N o n s e n s e M u t a t i o n i n t h e I n s u l i n receptor Gene Produce Heritable Severe Insulin R e s i s t a n c e . A m J H u m Genet 1992, 5 0 : 9 9 ~1 0 0 7 . LOPEZ AR, COOK J, DRININGERPL, DERYNCK R: D o m i n a n t Negative Mutants of Transforming Growth Factor-beta1 Inhibit the Secretion of Different T r a n s f o r m i n g G r o w t h F a c t o r - b c t a I s o f o r m s . Mol Cell Bio11992, 12:1674-1679. LORENZO F, JAULIN C, VITA N, FROUSSARDP, FERRARAP, JA~KOVIC DL, THEZE J: S t r u c t u r e - F u n c t i o n S t u d y o f t h e P55 S u b u n i t o f M u r i n e IL-2 R e c e p t o r b y E p i t o p e M a p p i n g . J I m m u n o 1 1 9 9 1 , 147:2970-2977. LUND LR, ROOMER J, ROONNE E, ELUS V, BIASI F, DANOO K: U r o k i n a s e - r e e e p t o r B i o s y n t h e s i s , MRNA Level a n d G e n e T r a n s c r i p t i o n a r e I n c r e a s e d b y T r a n s f o r m i n g G r o w t h F a c t o r ~ 1 i n H u m a n A549 L u n g C a r c i n o m a Cells. E M B O J 1991, 10:3399-3408. MAASSENJA, VANDERVORMER, VANDERZON GCM, KLINYdtAMERMP, IGRANSHMJ, MOLLER W: A L e u c i n e t o P r o l i n e M u t a t i o n at P o s i t i o n 233 i n t h e I n s u l i n Receptor Inhibits Cleavage of the Proreceptor a n d T r a n s p o r t t o t h e Cell S u r f a c e . Biochemistry 1991, 30:10778-10783. MABJEESH NJ, FRESE M, RAUE~ T, JESERICH G, KANNTR • BI: N e u r o n a l a n d G l l a l GABA T r a n s p o r t e r s a r e D i s t i n c t P r o t e i n s . FEBSLeit 1992, 299:99-i02. [50], MABJEESH NJ, KANNER BI: N e i t h e r A n l i n o N o r C a r b o x y l • Termini are Required for Function of the Sodiuma n d C h i o r i d e - e o u p l e d G a m m a - a * n i n o b u t y r i c Acid T r a n s p o r t e r f r o m Rat Brain. J B i o l Chem 1992, 267:2563-2568. [57]. MADDEN DR, GORGA JC, STROMINGERJL, WILEY DC: T h e S t r u c t u r e o f HLA-B27 R e v e a l s N o n a n a e r Selfpeptides Bound in an Extended Conformation. Nature 1991, 353:321-325. MADDEN KB, URBANJF, ZILTENERHJ, SCHRADERJW, FINKELMAN FD, KATONA IM: A n t i b o d i e s t o IL-3 and ID4 Suppress Helminth-Induced Intestinal M a s t o c y t o s t s . J l m m u n o 1 1 9 9 1 , 147:138~1391. MAEKAWA T, SUDO T, KLqRIMOTOM, ISI-I~ S: U S F R e l a t e d T r a n s c r i p t i o n Factor, HIV-TF1, S t i t n u l a t e s

Transcription of Human Immunodeficiency Virus 1. Nucleic A c i d s Res 1991, 19:4689-4694. MAGNq M, PANDIELI,A A, HELIN K, MELDOLESIJ, BEGUINOT L: T r a n s m e m b r a n e S i g n a l l i n g at t h e E p i d e r m a l G r o w t h F a c t o r R e c e p t o r - Positive R e g u l a t i o n by the C-Terminal Phosphotyrosine Residues. Biochem J 1991, 277:305 311. M 2 ~ M, tlfi.LLSTROMO, MARTTINENA: R e a c t i o n o f H u m a n Non-collagenous Polypeptides with Coellac D i s e a s e A u t o a n t i b o d i e s . Lancet 1~)1, 338:724. MAKRIS M, PRESTON FE, TRIGER DR, UNDERWOOD JCE, WES~AKE L, ADELvIAN MI: A R a n d o m i z e d C o n t r o l l e d Trial of Recombinant Interferon-alpha in C h r o n i c H e p a t i t i s - C i n H e m o p h i l i a c s . Blood 1991, 78:1672-1677. MALIK R, GOPE M, WOMER RB, NAGASHUNMUGAMT, MARGOLLNJF, BASU A, SCH~R CD: S t r u c t u r e a n d Expression of the Bcta-Platelet-Derived Growth F a c t o r R e c e p t o r G e n e i n H u m a n T u m o r Cell Lines. Cancer Res 1991, 51:5626-5631. MARICQ AV, PETERSON AS, BRAKE AJ, MYERS P~M, JUHUS D: Primary Structure and Functional Expression o f T h e 5HT3 R e c e p t o r , a S e r o t o n i n - G a t e d i o n C h a n n e L Science 1991, 254:432-437. MARK AE, BERENDSEN HJC, VANGU~SI~I1ENx~(/'F: Conformational Flexibility of Aqueous Monomeric and Dinleric Insulin - a Molecular D y n a m i c s S t u d y . Biochemistry 1991, 30:10866 10871. MARKS MS, HALLENBECK PL, NAGATA T, SEGARSJH, APPELLA E, NIKODEM VM, OZATO K: H-2RIIBP ( R X R ~ ) Hcterodimerization Provides a Mechanism for Combinatorial Diversity in the Regulation of Retinoic Acid and Thyroid Hormone Responsive Genes. E M B O J 1992, 11:1419-1436. MARSTERSSA, FRUTKIN AD, SIMPSON"NJ, FENDLY BM, ASHKENAZIA: I d e n t i f i c a t i o n o f C y s t e i n e - R i c h D o m a i n s o f t h e Type-1 T u m o r N e c r o s i s F a c t o r R e c e p t o r I n v o l v e d i n L i g a n d B i n d i n g . J Biol Chem 1992, 267:574~5750. MAR71NEZ E, MORALESJ, AGLTARJ, PLNEDAY, IZQLqERDO M, FEPmEYRE G: C l o n i n g a n d E x p r e s s i o n o f H e p a t i t i s B Surface A n t i g e n i n t h e Yeast K i n y v e r o m y e e s Lactis. Biotechnol Lett 1992, 14:83-86. MASSERINIM, FREIRE E, PALES~INI P, CAIAPPI E, TETTAMANTI G: Fuc-GM1 G a n g l l o s i d e M i m i c s t h e R e c e p t o r F u n c t i o n o f GM1 f o r C h o l e r a T o x i n . Biochemistry 1992, 31:2422-2426. MASTERSONWJ, FERGUSON MAJ: P h e n y l m e t h a n e s u l p h o n y l F l u o r i d e I n h i b i t s GP1 A n c h o r B i o s y n t h e sis i n t h e A f r i c a n T r y p a n o s o m e . E M B O J 1991, 10:2041-2046. MATSUI Y, TOKSOZ D, NISHIKAWAS, NISHIKAWAS-I, WILLIAMS D, ZSEBO K, HOGAN BLM: Effect o f S t e e l Factor and Leukaemla Inhibitory Factor on M u r i n e P r i t l a o r d i a l G e r m Cells i n C u l t u r e [Letter]. Nature 1991, 353:75(~751. MCDONALD NQ, LAPATTO R, MURRA~RUST J, GUN2NING J, WLODAWER A, BLUNDELLTL: N e w P r o t e i n F o l d R e v e a l e d b y a 2.3-4 R e s o l u t i o n C r y s t a l S t r u c t u r e o f N c r v e G r o w t h F a c t o r [Letter]. Nature 1991, 354:411-414. MCDONNELL DP, NAWAZ Z, OMALLEY BW: i n s i t u Distinction Between Steroid Receptor Binding a n d T r a n s a c t i v a t i o n at a T a r g e t G e n e . Mol Cell Biol 1991, 11:4350--4355. MCFADDEN HJ, KOSHL&ND ME: I n t e r l e u k i n - 2 - I n d u c e d a n d interleukin-5-Indueed Changes in the Binding of Regulatory Factors to the J-Chain Gene Promoter. Proc Natl A c a d Sci U S A 1991, 88:11027-11031. MCGLADE CJ, ELLIS C, REEDIJK M, ANDERSOND, MBAMALU G, REITH AD, FANAYOTOU G, END P, BERNSTEIN A, KAZLAUSKASA, WATERFIELD MD, PAWSON T: SH2 D o m a i n s o f t h e P 8 5 a l p h a S u b u n i t o f Phosphatidylinositol 3-Kinase Regulate Binding t o G r o w t h F a c t o r R e c e p t o r s . Mol Cell Bio11992, 12:991-997. MCL&XE KE, WU XD, CONTITRONCONI BM: S t r u c t u r a l D e t e r m i n a n t s w i t h i n R e s i d u e s 180-199 o f t h e Rodent-alpha5 Nicotinic Acetylcholine Receptor Subunit Involved in Alpha-Bungarotoxin Binding. Biochemistry 1991, 30:10730 10738. MEIKRANTZ W~ F E L D * ~ RP, SIADICKA ~VLM,HO D, KRUPNICK J, ANDERSON K, SCHLEGELRA: I s o l a t i o n o f Mitotic P34cdc2 A p o e n z y m e f r o m H u m a n Cells. FEB3" Lett 1991, 291:192-194. MILBURN MV, PRIVE GG, MILLIGAN DL, SCOT~ WG, YEH J, JANCAPaKJ, KOSHLAND DE, KIM SII: 3 - D i t l l e n s i o n a l Structures of the Ligand-Binding Domain of the Bacterial A s p a r t a t e R e c e p t o r w i t h a n d W i t h o u t a IAgand. Science 1991, 254:1342 1347. MILLER A, LIDER O, ROBERTS AB, SPOKN MB, WEINER HL: S u p p r e s s o r T-Cells G e n e r a t e d b y O r a l Tolerization to Myelin Basic Protein Suppress B o t h i n v i t r o a n d I n v i v o I11amune R e s p o n s e s b y t h e Release o f T r a n s f o r m i n g G r o w t h F a c t o r - b e t a after A n t i g e n - S p e c i f i c T r i g g e r i n g . Proc Natl A c a d Sei U S A 1992, 89:421~i25,

745

746

Pharmaceutical applications Peptides, growth factors, hormones and receptors MILLER B, SARAN~ISM, TRAYNXLISSF, ATTWELL D: P o t e n t i a t i o n o f NMDA R e c e p t o r C u r r e n t s b y A r a c h i d o n i c A c i d [Letter]. Nature 1992, 335:722-724. M/RMIRA RG, TAGER HS: D i s p o s i t i o n o f t h e Phenyiaianlilc-B25 Side Chain During InsulinReceptor and Insulin-Insulin Interactions. Biochemistry 1991, 30:8222~229. MIZUKAMI IF, VINJAMUPd SD, PERLNI F, LIU DY, TODD RF: Purification, Biochemical Composition, and Biosynthesis of the Mo3 Activation Antigen Expressed on the Plasma Membrane of Human M o n o n u c l e a r P h a g o c y t e s . JImraunol 1991, 147:1331 1337. M/zImo K, GONZALEZ FJ, KLMURAS: T h y r o i d - S p e c i f i c E n h a n c e r - B i n d i n g P r o t e i n (T/EBP) - CDNA Cloning, Functional Characterization, and Structural Identity with Thyroid Transcription E a c t o r TTF-1. 114o1Cell Bio11991, 11:4927~933. MONWELIONE GT, WLrTH~CH K, BURGESSAW, NICE EC, WAGNER G, GIBSON KD, SCHERAGAHA: S o l u t i o n Structure of Murine Epidermal Growth Factor Determined by NMR Spectroscopy and Refined by Energy Minimization with Restraints. Biochemistry 1992, 31:236-249. MOON jB, HOWE WJ: C o m p u t e r D e s i g n o f Bioactivc Molecules - a Method for Receptor-Based Dcnovo L i g a n d D e s i g n . Proteins 1991, 11:314--328. MOORE AS, THEILEN GH, NEWELL AD, MADEWELL BR, RUDOI.F ARI P r c e l i n i c a l S t u d y o f S e q u e n t i a l Tumor Necrosis Eactor and Interieukin-2 in the Treatment of Spontaneous Canine Neoplasms. Cancer Res 1991, 51:233-238. MOR A, NGUYEN VH~ DELFOL~RA, MIGLIORESAMOURD, NICOLAS P: I s o l a t i o n , A m i n o Acid S e q u e n c e , a n d Synthesis of Dermaseptin, a Novel Antimicrobial P e p t i d e o f A m p h i b i a n Skin. Biochemistry 1991, 30:882443830. MORhMOTO H, SRERITJT, BONAVIDAB: S y n e r g i s t i c Effect of Tumor Necrosis Factor-alpha-Mediated and Diphtheria Toxin-Mediated Cytotoxicity in Sensitive and Resistant Human Ovarian Tumor Cell Lines. J Immuno11991, 147:2609-2616. MOR/SHIGE KI, KUT~ACHIH, AMEMIYAK~ FU~TA Y, YAMAMOTO T, MIYAKE A, T&'glZAWA O: E v i d e n c e for the Involvement of Transforming Growth Factor-alpha and Epidermal Growth Factor Receptor Autocrine Growth Mechanism in P r i m a r y H u m a n O v a r i a n C a n c e r s I n v i t r o . Cancer Res 1991, 51:532~5328. MORO£~ MC, WILI2NGHAM MC, BEGUINOT L: EGFR A n t i s e n s e RNA B l o c k s E x p r e s s i o n o f t h e Epidermal Growth Factor Receptor and Suppresses the Transforming Phenotype of a H u m a n C a r c i n o m a Cell Line. J Biol Chem 1992, 267:2714-2722. MORBISON G, AND OTHERS: P a n c r e a t i c E n z y m e S u p p l e m e n t s i n Cystic F i b r o s i s [Letter]. Lancet 1991, 338:1596. MbqD RE, DALE MM, DAVIS PD, ELLIOTT LH, HILL CH, KUMAR H, LAWTON G, TWOMEY BM, WADSWORTH J, WILEaNSON SE, NIXON JS: A N o v e l C o n f o r m a t i o n a l l y R e s t r i c t e d P r o t e i n K i n a s c - C I n h i b i t o r , RO-318425, I n h i b i t s H u m a n N e u t r o p h l l S u p e r o x i d e G e n e r a t i o n b y S o l u b l e , P a r t i c u l a t e a n d PostR e c e p t o r S t i m u l i . FEBS Lett 1991, 293:169-172. MLLLER D, BAUMEISTERH, BUCK F, RICHTER D: Atrial N a t r i n r e t i c P e p t i d e (ANP) is a H i g h - A f f i n i t y S u b s t r a t e f o r R a t I n s u l i n - D e g r a d i n g E n z y m e . EurJ Bfochem I991, 202:285-292. MURAMATSUH, MURAMATSUT: P u r i f i c a t i o n o f R e c o m b i n a n t M i d k i n e a n d E x a m i n a t i o n o f Its B i o l o g i c a l Activities - F u n c t i o n a l C o m p a r i s o n o f N e w H e p a r i n B i n d i n g Fa c t ors . Biochem Biophys Res Commun 1991, 177:6524558. MURPHY D, PARDY K, SEAH V, CARTER D: Posttranscriptional Regulation of Rat Growth Hormone Gene Expression - Increased Message Stability and Nuclear Polyadcnyiation Accompany T h y r o i d H o r m o n e D e p l e t i o n . Mol Cell Bio11992, 12:2624-2632. MLXZIN AG, LESKAM, CHOTttIA C: b e t a - T r e f o i l Fold. Patterns of Structure and Sequence in the Kunitz Inhibitors Interleukins-lbeta and lalpha a n d F i b r o b i a s t G r o w t h Fa c t ors . J Mol Biol 1992, 223:531-543. MYERS RA, ZAFARALLAGC, GRAY WR, ABBOTT J, CRUZ LJ, OLIVERA BM: a l p h a - C o n o t u x i n s , S m a l l P e p t i d e Probes of Nicotinic Acetylcholine Receptors. Biochemistry 1991, 30:9370-9377. NAGASAKI K, YAMAGUCHI K, WATANABE K, E'IO S, ABE K: I n t e r l e u k i n - 4 B l o c k s P a r a t h y r o i d H o r m o n e ReLated P r o t e i n - I n d u c e d H y p e r c a l c e m i a Invivo. Biochem Biophys Res Commun 1991, 178:69d~698. NAGASAKI K, YAMAGUCPIIK, WATANABE K, ETO S, ABE K: I n t e r l e u k i n - 4 B l o c k s P a r a t h y r o i d H o r m o n e -

Related Protdn-indueed Hypercalcemia Invivo. Biochem Biophys Res 6bmmun 1991, 1 7 8 : 6 9 4 ~ 9 8 . NMR N, DAVISRJ, ROBINSON ltL: P r o t e i n T y r o s i n e K i n a s e Activities o f t h e E p i d e r m a l G r o w t h F a c t o r Receptor and ErbB Proteins - CorreLation of O n e o g e n i e A c t i v a t i o n w i t h A l t e r e d K i n e t i c s . Mol CDllBio11992, 12:2010-2016. NAKAGAYdT, FOSTER DC, BERK~T~RKL, KISIEL W: I n i t i a t i o n of the Extrinsic Pathway of Blood Coagulation -Evidence f o r t h e T i s s u e F a c t o r D e p e n d e n t A u t o a c t i v a t i o n o f H u m a n C o a g u l a t i o n Eactor-VIL Biochemistry 1991, 30:10819-10824. NAKAGAWA $1t, TAGER }IS: I n l p o r t a n c e o f A l i p h a f i c S i d e - C h a i n S t r u c t u r e at P o s i t i o n - 2 a n d P o s i t i o n 3 of the Insulin-A Chain in Insulin-Receptor I n t e r a c t i o n s . Biochemistry 1992, 31:3204-3214. NAKAML~FAM~ TAKAYANAGIR, SAKAIY~ SAKAMOTO S, HAGIWARA H, MIZUNO T, SAITOY, HIROSE S, YAMAMOTO M, ]N-AWATAH: C l o n i n g a n d S e q u e n c e Analysis of a CDNA Encoding Human NonSelective T y p e o f E n d o t h e l i n R e c e p t o r . Biochem Biophys Res Commun 1991, 177:34-39. NEDELEC J, PIERRES M, MOt~AU H, BARBETJ, NAQUET P, FMVRESARKA2LHC, ROUGON G: I s o l a t i o n and Characterization of a Novel GlycosylPho sphatidylinositol-Anchored Glycoconjugate E x p r e s s e d b y D e v e l o p i n g N e u r o n s . E u r J Biochem 1992, 203:433/+42 NEGRO A, MARTLNII, BIGON E, CAZZOLAF, MINOZZI C, SKAPERSD, CALLEGAROL: S y n t h e s i s o f t h e Biologically Active Beta-Sublmit of Human Nerve G r o w t h F a c t o r I n E s c h e r i c h i a - C o l l . Gene 1992, 110:251-256. NEUGEBAUERW, SUREWICZWK, GORDON HL, SOMORJM ILL, SUNG W, WILLICK GE: S t r u c t u r a l E l e m e n t s o f Human Parathyroid Hormone and Their Possible R e l a t i o n to B i o l o g i c a l Activities. Biochemistry 1992, 31:2056-2063. NICOLA NA, METCALFD: S u b u n i t p r o m i s c u i t y A m o n g H e m o p o i e t i c G r o w t h F a c t o r R e c e p t o r s . Cell 1991, 67:1~. NORRIS KA, BRADT B, COOPER NR, SO M: C h a r a c t e r i z a t i o n o f a T r y p a n o s o m a - C r u z i C3 B i n d i n g P r o t e i n with Functional and Genetic Similarities to the H u m a n C o m p l e m e n t R e g u l a t o r y P r o t e i n , DecayA c c e l e r a t i n g F a c t o r . Jlmmuno11991, 147:2240-2247. NUMAN~ R, CATTERALLWA 0 SCHEUERT: F u n ~ d o n a l Modulation of Brain Sodium Channels by P r o t e i n K i n a s e - C P h o s p h o r y i a t i o n . Science 1991, 254:115-118. NYKJAER A, PETERSEN CM, MOLLER B, ANDREASENPA, GLIF~VlA.X~J: I d e n t i f i c a t i o n a n d C h a r a c t e r i z a t i o n o f u r o k i n a s e R e c e p t o r s i n N a t u r a l K i l l e r Cells a n d T-Cell-Derived L y m p h o k i n e A c t i v a t e d K i l l e r Cells. FEBS Lett 1992, 300:13-17. OBRYAN JP, FRYE RA, COGSWELL PC, NEUBAUERA, KITCH B, PROKOP C, ESPINOSA R, LEBEAU MM, EARP HS, LIU ET: axl, a T r a n s f o r m i n g G e n e I s o l a t e d f r o m P r i m a r y H u m a n M y e l o i d L e u k e m i a Ceils, E n c o d e s a N o v e l R e c e p t o r T y r o s i n e K i n a s c . Mol Cell Bio11991, 11:5016-5031. OGAWA K: F o u r A T P - b i n d i n g Sites i n t h e M i d r e g i o n o f t h e ~ H e a v y C h a i n o f D y n e i n [Letter]. Nature 1991, 352:6434544. OGAWA W, SHII K, YONEZAWA K, BABA S, YOKONO K: Affmity Purification of Insulin-Degrading Enzyme a n d Its E n d o g e n o u s I n h i b i t o r f r o m R a t Liver. J Biol Chem 1992, 267:1310-1316. OH Y, BEUKERSM~V, PHA~MHM, SMANIKPA, SMITH MC, ROSENEELD RG: A l t e r e d A f f i n i t y o f I n s u l i n - L i k e G r o w t h F a c t o r - H (IGF-H) f o r R e c e p t o r s a n d IGF-Binding Proteins, Resulting from I2mited M o d i f i c a t i o n s o f t h e IGF-I1 M o l e c u l e . Biochem J 1991, 278:249-254. OHMICHI M, DECKER SJ, PANG L, SAL2~ELAR: I n h i b i t i o n o f t h e C e l l u l a r A c t i o n s o f Nerve G r o w t h F a c t o r by Staurosporine and K252A Results from the A t t e n u a t i o n o f t h e Activity o f t h e T r k T y r o s i n e Kinase. Biochemistry 1992, 31:40344039. OHTSUKI M, MASSAGUq~J: E v i d e n c e f o r t h e I n v o l v e m e n t o f P r o t e i n K i n a s e Activity i n T r a n s f o r m i n g G r o w t h F a c t o r - b e t a S i g n a l T r a n s d u c t i n n . Mol Cell Bio11992, 12:261-301. OKABE M, KUNIEDA Y, SUGIWURAT~ TANAKAM, MIYAGISHIMAT, SAIKI I, MINAGAWAT, KL~ROSAWA M, ITAYAT, MIYAZASLIT: I n h i b i t o r y Effect o f Interleukin-4 on the Invitro Growth of PhiP o s i t i v e Acute L y m p h o b i a s t i c L e u k e m i a Ceils. Blood 1991, 78:1574-1580. OKA3ZMAP, KONDO Y: S y n e r g i s m i n C y t o s o l i c Ca2+ Mobilization Between Bradykinin and Agonists for Pertussis Toxin-Sensitive G-Protein-Coupled R e c e p t o r s i n N G 108-15 Cells. FEBS Lett 1992, 301:223-226. OKAMOTO T, MIo~RAYAMAY, HAYASIE Y, INAGAK[ M, OGATA E, NISHIRIOTO h I d e n t i f i c a t i o n o f a GS A c t i v a t o r

R e g i o n o f t h e ~ 2 - a d r e n e r g i c R e c e p t o r t h a t is Autoregulated via Protein Kinase-A-depcndent P h o s p h o r y L a t i o n . Cell 1992, 67:723-730. OLDHELD EH ETAL.: P e t r o s a l S i n u s S a m p l i n g w i t h a n d Without Corticotropin-releasing Hormone for the Differential Diagnosis of Cushing's Syndrome. N Engl J Med 1991, 325:897-905. ORCHINIK M, ML~RRAYTF, MOORE FL: A C o r t i c o s t e r o i d R e c e p t o r i n N e u r o n a l M e m b r a n e s . Science 1991, 252:1848-1851. OSULLIVAND, ARRHENIUST~ SIDNEYJ, DELGLXRCIOMF, ALBERTSON M, WALL M, OSEROFF C, SOUTHWOOD S, COLON: SM, GAETA FCA, SET~ A: O n t h e I n t e r a c t i o n of Promiscuous Antigenic Peptidcs with Different D R Alleles - I d e n t i f i c a t i o n o f C o m m o n S t r u c t u r a l Motifs. J lmmuno11991, 147:2663-2669. OTA Y, ASAKL~A A. MATSUURAY, KONDO H, HITOSHIO A, IWANE A, TANAKAT, KIKUCHI M, IKEHARA M: H i g h Level Secretion of the Extracellular Domain of the Human Growth Hormone Receptor Using a B a c u l o v i r u s S y s t e m . Gene 1991, 106:159-164. OZYHAR A, STRANGMANNDIEKMANNM, KILTZ HH, PONGS O: C h a r a c t e r i z a t i o n o f a S p e c i f i c E c d y s t e r o t d Receptor-DNA Complex Reveals Common Properties for Invertebrate and Vertebrate H o r m o n e - R e c e p i n r DNA I n t e r a c t i o n s . EurJ Biochem 1991, 200:329-335. PACHOLCZYK T, BLAKELYRD, AMARA SG: E x p r e s s i o n • • Cloning of a Cocaine- and Antidepressantsensitive Human Noradrenaline Transporter. Nature 1991, 350:350-354. [36]. PM LH, GALLO MG, FITZGERALDDJ, PASTAN I: A ~ t i t u m o r Activity of a Transforming Growth Factor AlphaP s e u d o m o n a s E x o t o x i n F u s i o n P r o t e i n (TGFa l p h a - P E 4 0 ) . Cancer Res 1991, 51:280~2812. PAJOR AM, WRIGHT EM: C l o n i n g a n d F u n c t i o n a l • Expression of a Mnfnmalian Na + /Nuclcoside C o t r a n s p o r t e r . J Biol Chem I992, 267:3557-3560. [261. PAROLA AL, STUMP DG, pEPpERL DJ, KRUEGER KE, REGAN JW, LAIRD HE: C l o n i n g a q d E x p r e s s i o n o f a Pharmacologically Unique Bovine PeripheralType Benzodiazepine Receptor Isoquinoline B i n d i n g P r o t e i n . f B i o l Chem 1991, 266:14082-14087. PATSTON PA, GETITNS P, BEECHF~MJ, SC}LAPIRAM: Mechanism of Serpin Action - Evidence that C1 I n h i b i t o r F u n c t i o n s as a S u i c i d e S u b s t r a t e . Biochemistry 1991, 30:8876~882. PAYRE F, VINCENT A: G e n o m i c T a r g e t s o f t h e Serendipity ~ and ~ Zinc Finger Proteins and T h e i r R e s p e c t i v e D N A R e c o g n i t i o n Sites. EMBO J 1991, 10:2533-2542. PELLIZZAPd A, PANG H, LINGWOOD CA: B i n d i n g o f V e r o c y t o t o x i n - 1 t o Its R e c e p t o r is I n f l u e n c e d b y D i f f e r e n c e s I n R e c e p t o r F a t t y Acid C o n t e n t . Biochemistry 1992, 31:1363-1370. PENqqICA D, KOHR WJ, FENDLY BM, SHIRE SJ, RAAB HE, BORCHARDT PE, LEWIS M, GOEDDEL DV: Characterization of a Recombinant Exteacelluiar Domain of the Typ¢-I Tumor Necrosis Factor R e c e p t o r - E v i d e n c e f o r T u m o r N e c r o s i s Factora l p h a I n d u c e d R e c e p t o r A g g r e g a t i o n . Biocbemislry 1992, 31:1134-1141. PEPPER MS, PERRAJ~ N, ORCI L, MONTESANO R: V a s c u l a r E n d o t h e l i a l G r o w t h F a c t o r (VEGF) I n d u c e s piasminogen Activators and Plasminogen Activator Inhibitor-1 in Microvascular Endothelial Cells. Biochem Biophys Res Commun 1991, 181:902-906. PESSI A, BIANCHI E, CHIAPpINELLI L, NARDI A, FANALI S: Application of Capillary Zone Electrophoresis to the Characterization of Multiple Antigen Pcptides. J Chromatogr 1991, 557:307-313. PHAM TA, MCDON~'ELL DP, TSM MJ, OMALLEY BW: Modulation of Progesterone Receptor Binding to Progesterone Response Elements by Positioned N u c l e o s o m e s . Biochemistry 1992, 31:1570-1578. P[LAM "LA, MCDON%TIL DP, TSAI MJ, OMALLEYBW: M o d u l a t i o n o f P r o g e s t e r o n e R e c e p t o r B i n d i n g to Progesterone Response Elements by Positioned N u c l e o s o m e s . Biochemistry 1992~ 31:1570-1578. PIKAL MJ, DELLERMANKM, ROY ML, RIGGIN RM: T h e Effects of Formulation Variables on the Stability of F r e e z e - D r i e d H u m a n G r o w t h H o r m o n e . Pharm Res 1991, 8:427~i36. PI'TrMAN DD, W&NG JiI, KALTMANRJ: I d e n t i f i c a t i o n and Functional Importance of Tyrosine sulfate R e s i d u e s w i t h i n R e c o m b i n a n t Factor-VHL Biochemistry 1992, 31:3315 3325. PLUG MJ, DIJK J, MAASSENJA, MOLLER W: Art A n t i - P e p t i d e Antibody that Recognizes the Dopamine-D2 R e c e p t o r f r o m B o v i n e S t r i a t o n x EurJ Biochem 1992, 2 0 6 : 1 2 3 1 3 0 . PORTER AG: T h e P r o s p e c t s f o r T h e r a p y w i t h T u r n o u t N e c r o s i s F a c t o r s a n d T h e i r A n t a g o n i s t s . Trends Biotechno11991, 9:158-162.

Pharmaceutical applications Peptides, growth factors, hormones and receptors POWER RF, LYDONJP, CONNEELYOM, OMALLEYBW: D o p a m i n e Activation o f a n O r p h a n o f t h e S t e r o i d R e c e p t o r Superfamily. Science 1991, 252:1546-1548 POWER RF, MA~ SK, CODINAJ, CONNEELYOM, O'MALLEY BW: D o p a m i n e r g i c a n d L i g a n d - i n d e p e n d e n t Activation o f Steroid H o r m o n e Receptors. Science 1991, 254:1636-1638. POWIS SJ, DEVEILSONEV, COADWELLWJ, CIRU'ELAA, HUSKISSON NS, SMITH ~I, BUTCHERGW, HOWARD JC: Effect o f P o l y m o r p h i s m o f a n MItC-linked T r a n s p o r t e r o n t h e P e p t i d e Assembled i n a Class I Molecule. Nature 1992, 357:211 215. pILAF M, CREPALDIT, GANDINO L, GIORDANO S, LONGATIP, COMOGL]O P: C - t e r m i n a l T r u n c a t e d F o r m s o f Met, t h e H e p a t o c y t e G r o w t h F a c t o r Receptor. Mol Cell Bio11991, 11:5954-5962. PRATT LF, SZUBIN R, CARSONDA, KIPPS q]: M o l e c u l a r C h a r a c t e r i z a t i o n o f a S u p r a t y p i c Cross-Reactive Idiotype Associated w i t h IgM Autoantibodies. J l m m u n o 1 1 9 9 1 , 147:2041-2046. RADOLFJD, NORGARD MV, BRANDTME, ISKaCS RD, THO,VLPSONPA, BEL"IT.ERB: Lipoproteins o f B o r r e l i a b n r g d o r f e r i a n d T r e p o n e m a - p a l l i d u m Activate C a c h e c t i n / T u m o r Necrosis Factor Synthesis - Axlalysis U s i n g a CAT R e p o r t e r Construct. J l m m u n o 1 1 9 9 1 , 147:1968-1974. RAFALSKIM, ORTIZ A, ROCKWELI.A, VANGEx~LELLC, LEAR JD, DEGRADO \VF, WILSCHUTJ: M e m b r a n e F u s i o n Activity o f t h e I n f l u e n z a Virus H e m a g g l u t i n i n - I n t e r a c t i o n o f HA2 N - T e r m i n a l Peptides w i t h P h o s p h o l i p i d Vesicles. Biochemislry 1991, 30:10211-10220. RAINES EW, LANETF, IRU~TLAARISPEML, ROSS 1~, SAGE RH: T h e E x t r a c e I l u l a r G l y c o p r o t e i n SPARC I n t e r a c t s w i t h Platelet-Derivcd G r o w t h Factor (PDGF)-AB a n d (PDGF)-BB a n d I n h i b i t s t h e Binding o f PDGF to Its Receptors. Proc Nail A c a d Sci U S A 1992, 89:1281 1285. RAMACHANDRAN C, AEBERSOLDR, TONKS NK, POT DA: Sequential Dephosphorylation of a Multiply P h o s p h o r y l a t e d I n s u l i n R e c e p t o r Peptide b y P r o t e i n T y r o s i n e P h o s p h a t a s e s . Biochemistry 1992, 31:4232-4238. RAO KVS, PANDA SK, MAN]VELV: M a c r o m o l e c u l a r SelfAssociation o f a Synthetic Peptide D e r i v e d f r o m t h e Hepatitis-B Surface A n t i g e n - C o n s t r u c t i o n o f a Q u a t e r n a r y Epitope. Vaccine 1992, 10:204-208. RAY R, BOLqLLONR, VANBAELENH, HOLICK MF: P h o t o a f f l n i t y Labeling o f H u m a n S e r u m VitaminD B i n d i n g P r o t e i n a n d C h e m i c a l Cleavages o f t h e Labeled P r o t e i n - I d e n t i f i c a t i o n o f An 11.5-kDa P e p t i d e C o n t a i n i n g t h e Putative 25H y d r o x y v i t a m i n - D 3 B i n d i n g Site. Biochemistry 1991, 30:7638~7642. REDF~MANNN, HOLZMANNB, VONRUDEN "[~ \VAGN~IREF, SCHLESSINGERJ, ULLRICH A: Anti-Oncogenic Activity o f Signalling-Defective E p i d e r m a l G r o w t h F a c t o r R e c e p t o r Mutants. Mol Cell Bio11992, 12:491--498. REMILLARDB, PETRILLOR, MASLINSKIW, TSUDO M, STROMTB, CANTLEYL, VARTICOVSKIL: I n t e r l e u k i n - 2 R e c e p t o r Regulates Activation o f P h o s p h a t i d y i l n o s i t o l 3-Kinase. J Biol Chem 1991, 266:14167 14170. REN1A L, MARUSSIGMS, GRILLOTD, PIED S, CORRADIN G, MILTGEN F, DELGIUDICEG, MAZIERD: I n v i t r o Activity o f CD4+ a n d CD8+ Lymphocytes-T f r o m Mice I n n l l u n i z e d w i t h a S y n t h e t i c Malaria Peptide. Proc Natl A c a d Sci U S A 1991, 88:7963-7967. REVAH F, BERTRANDD, GALZIJL, DEVILLEILSTHIERYA, MULLE C, HUSSYN, BERTRANDS, BALLIVETM, C~LANGEUX JP: M n t a t i o n s i n t h e C h a t l n e l D o m a i n a f t e r D e s e n s i t i z a t i o n o f a N e u r o n a l Nicoth*ic Receptor. Nature 199i, 353:846. RIECKMANN P, POLl G, FOX CH, KEHRLJH, FAUCIAS: R e c o m b i n a n t Gp120 Specifically E n h a n c e s T u m o r N e c r o s i s F a c t o r - a l p h a P r o d u c t i o n a n d Ig S e c r e t i o n i n Lymphocytes-B f r o m HIV-Infected I n d i v i d u a l s But n o t f r o m Seronegative D o n o r s . J l m m u n o 1 1 9 9 1 , 147:2922-2927. RINAS U ET AL: Cysteine to S e r i n e Substitutions i n Basic F i b r o b l a s t G r o w t h Factor: Effect o n I n c l u s i o n B o d y F o r m a t i o n and P r o t e o l y t i c Susceptibility D u r i n g in V i t r o Refulding. Biotechnology 1992, 10:435-441. RIZZO T, METZGERBE, BLT~NSWJ, BURNSK: C o r r e l a t i o n B e t w e e n A n t e p a r t u m M a t e r n a l Metabolism a n d I n t e l l i g e n c e o f Offspring. N E n g l J M e d 1991, 325:911-916. ROBERTS SB, SEGIL N, HEI?~'rZN: D i f f e r e n t i a l P h o s p h o r y l a t i o n o f t h e T r a n s c r i p t i o n F a c t o r Oct1 D u r i n g t h e Ceil Cycle. Science 1991, 253:1022-1025. ROBSON MC, PHILLIPS LG, THOMASON A, ROBSON LE, PIERCE GF: Platelet-Derived G r o w t h Factor-BB f o r t h e T r e a t m e n t o f C h r o n i c P r e s s u r e Ulcers. Lancet 1992, 339:23-25. RODRIGUEZTEBARA, DECF1ANTG, GOTZ R, BARDE YA: B i n d i n g o f N e u r o t r o p h i n - 3 to Its N e u r o n a l

Receptors and Interactions with Nerve Growth Factor a n d B r a i n - d e r i v e d N e u r o t r o p h i c Factor. E M B O J 1992, 11:917-922. ROMERO p, EBERL G, CASANOVAJL, CORDEY AS, WIDMAN.~ C, LUESCHERIF, CORRADIN G, MARYANSKIJL: I m m u n i z a t i o n w i t h Synthetic P e p t i d e s C o n t a i n i n g a D e f i n e d M a l a r i a Epitope I n d u c e s a H i g h l y Diverse Cytotoxie L y m p h o c y t e - T R e s p o n s e E v i d e n c e t h a t Two Peptide R e s i d u e s are B u r i e d in t h e MItC Molecule. J l m m u n o l 1992, 148:1871-1878. ROMMENSJM, DHO S, BEAR CE, KARTNER N, KENTxrEDYD, RIORDAN JR, TSUI L C, FOSKVTfTJK: cAMP-inducible C h l o r i d e C o n d u c t a n c e in M o u s e F i b r o b l a s t Lines Stably E x p r e s s i n g t h e H u m a n Cystic Fibrosis T r a n s m e m b f a n e C o n d u c t a n c e Regulator. Proc Nail A c a d Sci U S A 1991, 88:7500-7504. ROSEN EM, GOLDBERG ID, IaU D, S ~ E R E, DONOVAN MA, BHARGAVAM, REISS M, KACINSKIBM: T u m o r Necrosis Factor Stinlulates E p i t h e l i a l T u m o r Cell Motility. Cancer Res 1991, 51:5315-5321. ROLI3INq E, DUONG LT, GIBBONS SW, LEU CT, CAUI,FIELD MP, CHOREV M, ROSENBLA'VfM: S y n t h e s i s o f Fully Active Biotinylatod Analogues o f P a r a t h y r o i d Hormone and Parathyroid Hormone-Related P r o t e i n as Tools f o r t h e C h a r a c t e r i z a t i o n o f P a r a t h y r o i d H o r m o n e Receptors. Biochemistry 1992, 31:4026--4033. RORAK]SADCOCKM , KELLYPA: M u t a t i o n a l Analysis o f t h e Ligand-Bindtng D o m a i n o f t h e P r o l a c t i n Receptor. J Biol Chem 1991, 266:16472-16477. SAAVEDRAR, DEMEL~ER F, DECOURTJL, HERION P: H u l l l a n T-Cell C l o n e Identifies a P o t e n t i a l l y Protective 54-kDa P r o t e i n A n t i g e n o f T o x o p l a s m a - g o n d i i C l o n e d a n d E x p r e s s e d in E s c h e r i c h i a - c o l i . J Immuno11991, 147:1975-1982. SAGO0 JK, BOSE C, BEELEY_N~RA,TENDLERSJB: Structural Studies o n file < But-Cysl8> ( 1 9 - 3 7 ) - F r a g m e n t o f H u m a n Beta.Calcitonin-Gene-Related Peptide. Biochem J 1991, 280:147-150. SAKALE, GERTLERA, SHECHTERY: B i o l o g i c a l Activity o f a F l u o r e s c e i n H u m a n G r o w t h H o r m o n e Derivative P r e p a r e d b y Specific Covalent L a b e l i n g o f Lysine70. Biochcenist~TF 1991, 30:8899-8904. SAKAMOTOA, YANAGISAWAM, SAKU'RAIT, TAKUWAY, YANAGISAWAH, MASAYdT: C l o n i n g a n d F u n c t i o n a l E x p r e s s i o n o f H u m a n CDNA f o r t h e ETB E n d o t h e i l n Receptor. Biochem Biophys Res C o m m u n 199X, 178:656-663. SAMUELSK, HURTA RAR, KONDMAII p, KHALILN, TURLEY EA, WPaGHT JA, GREENBERGAH: A u t o e r i n e I n d u c t i o n of Tumor Protease Production and Invasion by a M e t a l l o t h i o n e i n - r e g a l a t e d TGF-~I (Ser223, 225). E M B O J 1992, 11:1599-1606. SARKARG, KAPELNER S, GRANDYDK, MARCHIONNIM, OVELLI O, SOBELLJ, HESTON L, SOMMER SS: D i r e c t S e q u e n c i n g o f t h e D o p a m i n e - D 2 R e c e p t o r (DRD2) in S c h i z o p h r e n i c s Reveals T h r e e P o l y m o r p h i s m s But n o S t r u c t u r a l Change i n t h e Receptor. Genomics 1991, 11:8-14. SASAKI Y, AMBO A, SUZUK1K: < D-Ala2> D e l t o r p h i n H Analogs w i t h H i g h Affinity a n d Selectivity for Delta-Opioid Receptor. B i o c h e m Biopbys Res C o m m u n 1991, 180:822-827. SAULA. LORD R, JONES GL, SPENCERL: P r o t e c t i v e Immunization with Invariant Peptides of the Plasmodiuam-Falciparum A n t i g e n MSA2. J l m m u n o l 1992, 148:208-211. SCHIAVO G, DEMEL R, MONTECUCCOC: O n t h e Role o f P o l y a l a l o g l y c o s p h i n g o l i p i d s as T e t a n u s T o x i n R e c e p t o r s - a Study w i t h Lipid M o n o l a y e r s . Eur J Biochem 1991, 199:705-711. SCHILLERJH, STORERBE, WITr PL, ALBERTID, TOMBESMI3, ARZOOMANIAN R, PROCTOR RA, MCCARTHYD, BROWN RR, VOSS SD, REMICKSC, GI%EMJL, BORDEN EC, TRUMP DL: B i o l o g i c a l a n d Clinical Effects o f I n t r a v e n o u s T u m o r N e c r o s i s Factor-alpha A d m i n i s t e r e d T h r e e T i m e s Weekly. Cancer Res t991, 51:1651-1658. SCI~MIEDENV, KUHSEJ, BETR H: A g o n i s t P h a r m a c o l o g y o f N e o n a t a l a n d Adult Glycine R e c e p t o r cz Subunits: I d e n t i f i c a t i o n o f A m i n o Acid R e s i d u e s I n v o l v e d in T a u r i n e Activation. F~IBOJ 1992, 11:2025-2032. SCHNEIDER DJ, SOBEL BE: A u g m e n t a t i o n o f Synthesis o f P l a s m i n o g e n Activator I n h i b i t o r T y p e d by I n s u l i n a n d Insulin-Like G r o w t h F a c t o r Type-I - I m p l i c a t i o n s for V a s c u l a r Disease in H y p e r i n s u l i n e m i c States. Proc Natl A c a d Sci U S A 199I, 88:9959-9963. SCHOENLEIN RW, pEIEANU LA, MATHIES RA, SHAN~KCV: T h e 1st Step i n Vision - F e m t o s e c o n d I s o m e r i z a t i o n o f R h o d o p s i n . Science 1991, 2 5 4 : 4 1 2 ~ 1 5 . SCHOOLTINKH, STOYANT, LENZ D, SCI3aMITZH, HIRANO T, KISHLMOTOT, HEINRICH PC, ROSEJOHN S: Sttalctllral a n d F u n c t i o n a l Studies o n t h e H u m a n Hepatic i n t e r l e u k i n - 6 R e c e p t o r -Molecular C l o n i n g a n d O v e r e x p r e s s i o n i n HepG2 Cells. B i o c b e m j 1991, 277:659~64.

SCHRAMM llj, NAKASHLMAH~ SCHRAMMW, WAKAyAMA H, YAMAMOTON: ItlV-I R e p r o d u c t i o n is I n h i b i t e d b y Peptides D e r i v e d f r o m the N - T e r m i n i and CT e r m i n i o f HIV-1 Protease. Biochem Biophys Res C o m m u n 1991, 179:8474351. SCHLrLZEOSTHOFFK, BAKKERAC, VAaN]IAESEBROECKB, BEYAERTR, JACOB WA, FIEILSW: Cytotoxic Activity o f T u m o r N e c r o s i s FaCtor is M e d i a t e d b y E a r l y Damage o f M i t o c h o n d r i a l Functions - E v i d e n c e for the I n v o l v e m e n t o f M i t o c h o n d r i a l Radical Generation. J Biol Chem 1992, 267:5317-5323. SCHWABEJ~VR, RHODES D: B e y o n d Zinc F i n g e r s - Steroid H o r m o n e R e c e p t o r s h a v e a Novel S t r u c t u r a l Motif f o r DNA R e c o g n i t i o n . Trends Biochem Sci 1991, 16:291-297. SEEDORF K, FELDERS, M]LLALrERB, SCHLESSINGERJ, ULLPdCH A: Analysis o f Platclct-Derived G r o w t h Factor R e c e p t o r D o m a i n F u n c t i o n Using a Novel C h i m e r i c R e c e p t o r A p p r o a c h . J Biol Chem 1991, 266:12424-12431. SEKI T, [tAGIYAM, SI~MONISHI M, NAKAMURAT, SHIMIRUS: Organization of the Human Hepatocyte Growth Factor-Encoding Gene. Gene 1991, 102:213-219. SEI2vH S, S&MUELSHH: T h y r o i d H o r m o n e R e c e p t o r a n d V-erbA - a S i n g l e A m i n o Acid D i f f e r e n c e i n t h e CT e r m i n a l R e g i o n I n f l u e n c e s D o m i n a n t Negative Activity a n d R e c e p t o r D i m e r F o r m a t i o n , J Biol Cbem 1991, 266:11589-11593. SHAH M, FOREMANDM, FERGUSONMWJ: C o n t r o l o f Scarring i n A d u l t Wounds by N e u t r a l i s i n g Antibody to T r a n s f o r m i n g G r o w t h F a c t o r Beta. Lancet 1992, 339:213. SHANAFELTAB, IV~YAJIMAA, KITAML'RAT, KASTELANRA: T h e A m i n o T e r m i n a l H e l i x o f GM-CSF a n d IL5 G o v e r n s H i g h Affinity B i n d i n g to T h e i r Receptors. E M B O J 1 9 9 1 , 10:4105-4112. SHAI~EF MK, HENTGES R: Association B e t w e e n T u m o r Necrosis Factor-c~ a n d Disease P r o g r e s s i o n i n Patients w i t h M u l t i p l e Sclerosis. N E n g l J M e d 1991, 325:467-472. SHAW JP, AK~YOSHIDE, ARR2GO DA, RHOAD AE, SULLIVAN B, ]]-IOMASJ, GENBAUFFEFS, BAClIAp, NICHOLS JC: Cytotoxic P r o p e r t i e s o f DAB486EGF arid DAB389EGF, E p i d e r m a l G r o w t h F a c t o r (EGF) R e c e p t o r - T a r g e t e d Fusion Toxins. J Biol Chem 1991, 266:21118-21124. SHENDEROVICHMD, NIKIFOROV1CHGV, GOLBRAIKH AA: C o n f o r m a t i o n a l Features R e s p o n s i b l e for t h e B i n d i n g o f Cyclic Analogues o f E n k e p h a l i n to O p i o i d Receptors. 3. P r o b a b l e B i n d i n g C o n f o r m a t i o n s o f Mu-Agonists w i t h P h e n y l a l a n i n e i n Position-3. Int J Pept Protein Res 1991, 37:241-251. SHIMADAK, OE T, SUZUKIM: Effect o f D e r i v a t i z a t i o n o f Steroids o n T h e i r R e t e n t i o n B e h a v i o r i n I n c l u s i o n C h r o m a t o g r a p h y U s i n g C y c l o d e x t r i n as a Mobile Phase Additive. J Cbromatogr 1991, 558:306-310. SHLMADAS, KITAYAMA S, LIN CL, PATELA, NAN'THAKUMAR E, GREGOR P, KUHAR M, UHL G: C l o n i n g a n d E x p r e s s i o n o f a Cocaine-Sensitive D o p a m i n e T r a n s p O r t e r C o m p l e m e n t a r y DNA. Sc'i£-'nce 1991, 254:576-578. S~AWA R, SANDA R, MIZOGUCHI H, HASIRMOTO Y, IWASAKI S, TANAKA H, KAGECHIKAH, SHUDO K: F l u o r e s c e n t a n d PhotoRffinity L a b e l i n g P r o b e s f o r Retinoic Acid Receptors. Biochem Biopbl/s Res C b m m u n 1991, 179:259 265. SHIOTA G, RHOADS DB, WANG TC, NAKAMURA"]7,SCHMIDT EV: Hepatocyte G r o w t h Factor i n h i b i t s G r o w t h o f H e p a t o c e l i u l a r C a r c i n o m a Cells. Proc Nail A c a d Sci U S A 1992, 89:373-377. SHOELSON SE, LU ZX, PARLAUTANL, LYNCHCS, WEISS MA: Mutations at t h e Dimer, Hexamer, a n d ReceptorBinding Surfaces o f I n s u l i n I n d e p e n d e n t l y Affect I n s u l i n - I n s u l i n a n d lnsttlin-Receptor I n t e r a c t i o n s . Biocbemist~ 1992, 31:1757-1767. SHOEMAKERC, GROSS A, GEBRE~AICHAELA, HARN D: eDNA Cloning a n d F u n c t i o n a l E x p r e s s i o n o f t h e S c h i s t o s o m a - M a n s o n i Protective A n t i g e n TrioseP h o s p h a t e I s o m e r a s e . Proc Natl A c a d Sci U S A 1992, 89:1842-1846. SHOHAM M, PROCTOR P, HUGHES D, BALDW1NRT: Crystal P a r a m e t e r s a n d M o l e c u l a r R e p l a c e m e n t o f an A n t i c h u l e r a T o x i n Peptide Complex. Proteins 1991, 11:218-222. SIBLEY LD, ADAMS LB, FUKL~fOMIY, KRAHENBUt~JL: T u m o r Necrosis F a c t o r - a l p h a Triggers A n t i t o x o p l a s m a l Activity o f I F N - g a m m a p r i m e d M a c r o p h a g e s . J lmmuno11991, 147:2340-2345. SIHGARDI G, DRAKE AF, MASCAGNqP, ROWLANDS D, BROWN F, GIBBONS WA: C o r r e l a t i o n s B e t w e e n t h e C o n f o r m a t i o n s Elucidated by CD S p e c t r o s c o p y a n d the A n t i g e n i c P r o p e r t i e s o f F o u r P e p t i d e s o f t h e Foot-and-Mouth Disease Virus. E u r J Biochem 1991, 199:545-551. SINE SM, CIAU1)IO T: Stable E x p r e s s i o n o f t h e Mouse Nicotinic A c e t y l c h o l i n e R e c e p t o r I n Mouse

747

748

Pharmaceutical applications Peptides, growth factors, hormones and receptors F i b r o b l a s t s - C o m p a r i s o n o f R e c e p t o r s in Native a n d T r a n s f e c t e d Ceils. JBiol Cbem 1991, 266:13679-i3689. SINE SM, CLAUDIOT: g a m m a - S u b u f l i t a n d Delta-Subunit R e g u l a t e t h e Affinity a n d t h e C o o p e r a t i v i t y o f L i g a n d B i n d i n g to t h e A c e t y l c h o l i n e Receptor. J Biol Chem 1991, 266:19369-i9377. SIZON~N~O SV, ItALBAN PA: D i f f e r e n t i a l Rates o f C o n v e r s i o n o f Rat Prolnsulh-1-I a n d P r o i n s u l i n - l I - E v i d e n c e f o r Slow Cleavage at t h e B - C h a i n / C P e p t i d e J u n c t i o n o f P r o i n s u l i n - H . Biocbem J 1991, 278:621(o25. SKAFAR DF: D i f f e r e n c e s i n t h e B i n d i n g M e c h a n i s m o f R U 4 8 6 a n d P r o g e s t e r o n e to t h e P r o g e s t e r o n e R e c e p t o r . Biochemistry 1991, 30:i0829-10832. SLATERAFG, CERAMIA: I n h i b i t i o n b y C h l o r o q u i n e of a Novel Harm Polymerase E ~ e Activity i n M a l a r i a T r o p h o z o i t e s [Letter]. Nature 1992, 355:16%169 SLUZKYV, TAMADAJ ~ KLIBANOVAM, LANGERR: K i n e t i c s o f I n s u l i n A g g r e g a t i o n I n Aqueous S o l u t i o n s U p o n A g i t a t i o n in t h e P r e s e n c e o f H y d r o p h o b i c Surfaces. Proc Natl Acad Sci U S A 1991, 88:9377-9381. SMH"A~, GERAERTSxX/PM, MEESTER I, VANHEERIKHUIZEN H, jOOSSE J: C h a r a c t e r i z a t i o n o f a CDNA Clone E n c o d i n g M o l l u s c a n I n s u l i n - R e l a t e d PeptideII o f Lymnaea-Stagnalls. EurJ Biochern 1991, 199:699~03. SMITH DP: P r o d u c t i o n a n d Biolgical Activity o f Hybrid Growth Hormone-ReleasIng Hormone P r o p e p t i d e s . Biotechnology ~992, 10:315 319. SMITH DP, RANGA~rATHANR, t'IARDYRW, MARXJ, TSUCHIDA T, ZURER CS: P h o t o r e c e p t o r D e a c t i v a t i o n and Retinal Degeneration Mediated by a P h o t o r e c e p t o r - S p e c i f i e P r o t e I n Kinase-C. Science 1991, 254:1478-1484. SMITH FE, ROSEN K~M,VILLAKOMAROFFL, WEIR GC, BONNERWEIR S: E u h a n c e d Insulin-Like G r o w t h Factor-I G e n e E x p r e s s i o n i n R e g e n e r a t i n g Rat P a n c r e a s . Proc Nail Acad Sci U S A 1991, 88:6152-imoxication o f C u l t u r e d Cells b y C h o l e r a T o x i n - Evi denc e f o r D i f f e r e n t Pathways when Bound to Ganglioside-G(M1) o r N e o g a n g l i o p r o t e i n s . Biochemistry 1992, 31:4773-4778. PEETERS RA, ERA JM, VEERKAMPJ H: E x p r e s s i o n i n Eseheriehia-coll and Characterization of the F a t t y - A c i d - B i n d i n g P r o t e i n f r o m H u m a n Muscle. Biochem J 1991, 278:361-364. PIERARD L, BOLLEN A: D e v e l o p m e n t o f N e w Thrombolytic Agents Using Recombinant DNA T e c h n o l o g y . J Biolechno11990, 15:283 304. PINGEL S, DUSZENKO M: I d e n t i f i c a t i o n O f 2 D i s t i n c t G a l a c t o s y l t r a n s f e e a s e Activities A c t i n g o n t h e Variant Surface Glycoprotein of TrypanosomaBrucei. BfochemJ1992, 283:479485. PRINZ J ETAL.: C ~ e r i c CD4 Monodonal Antibody in Treatment of Generalised Pustular Psoriasis [Letter]. Lancet 1991, 338:320. QUON D, CATALANOI~(/R, SCARDINAJM, MURAKAMIK, • • COKDELLB: F o r m a t i o n o f ~ - A m y l o i d P r o t e i n D e p o s i t s i n t h e B r a i n s o f T r a n s g e n i c Mice. Nature 1991, 352:239-241. [18[. REINKE P ET AL.: A n ti- CD 4 T h e r a p y o f Acute R e j e c t i o n i n L o n g - t e r m R e n a l A l l o g r a f t R e c i p i e n t s [Letter]. Lancet 1991, 338:702. RICHARDS SJ, WATERSJJ, BEYRELr~ER K, MASTERSCL, • WISCHIKCAM,SPARK~LANDR, WHITE CL, ABRAHAM CR, DL2.r~TT SB: T r a n s p l a n t s o f Mous e T r i s o m y 16 Hippocampus Provide a Model of Alzheimer's D i s e a s e N e u r o p a t h o l o g y . EMBOJ 1991, 10:297-303.

[9]ROBERTS DJ, CRAIG AG, BEKENDT AR, PINCHES R, RASH G, MARSH K, NEWBOLD CI: R a p i d S w i t c h i n g t o M u l t i p l e Antigenic and Adhesive Phenotypes in Malaria. Nature 1992, 3 5 7 : 6 8 9 ~ 9 2 .

ROBERTS RG, BOBROW M, BEN"TLEYDR: P o i n t M u t a t i o n s i n t h e I ) y s t r o p h i n G e n e . Proc Nall A c a d Sci U S A 1992, 89:2331-2335. SAAVEDRAR, DEMEL'FV2RF, DECOURT JL, HEllION P: HLunalt T-Cell Clone Identifies a Potentially Protective 54-kDa Protein Antigen of Toxoplasma-gondli Cloned and Expressed in Escherichla-coli. J Immuno11991, 147:1975-1982. SACCI JB .JR, SCHRIEFERME, RESAUJtt, WIRTZ RA, DETOLLA LJ JR, ~ ' d RB, AZAD AF: M o u s e M o d e l for Exoerythrocytic Stages of Plasmodium F a l c i p a r u m M a l a r i a P a r a s i t e . Proc Natl A c a d 5ct U S A 1992, 89:3701 3705. SANDEIUFA, SALLMM, Z.MN SB: E x p r e s s i o n o f t h e • Human ~-Amyloid Protein of Alzheimer's Disease S p e c i f i c a l l y i n t h e B r a i n s o f T r a n s g e n i c Mice. J Biol Chem 1991, 266:21331-21334. [20]. SCHEP& A, CARTER R, PET~RSEN C~ ALANO P, NELSON R, AIKAWA M, MATTEI D, PEREIRA DA SILVAL, LEECH J: G e n e I n a c t i v a t i o n o f P i l l - 1 o f P l a s m o d i u m Faleiparum by Chromosome Breakage and Healing: Identification of a Gametocyte-specific P r o t e i n w i t h a P o t e n t i a l Role i n G a m e t o g e n e s i s . E M B O J 1992, 11:2293-2302. SCHN~EIDERJ8, POPE A, SIMPSON K, TAGGARTJ, SMI'I~ MG, DISTEPANO L: R e c o v e r y f r o m E x p e r i m e n t a l P a r k i n s o n i s m i n P r i m a t e s w i t h GM1 G a n g l i o s t d e T r e a t m e n t . Science 1992, 256:843-846. SCHULMANCA, ELIASRW, MAIGEq'TER RZ: P r o d u c t i o n o f H e p a t i t i s B Surface A n t i g e n ( P r e S 2 + S) b y H i g h c e l l D e n s i t y C u l t i v a t i o n s o f a R e c o m b i n a n t Yeast. J Biotechno11991, 21:109-126. SEDGWICK SG, MAN N, ELLISJM, CROWNE H, MORRIS GE: Rapid Mapping by Transposon Mutagenesis of E p i t o p e s On t h e M u s c u l a r D y s t r o p h y P r o t e i n , D y s t r o p h i n . Nucleic Acids Res 1991, 19:588%5894. SEYFANG A, DUSZENXOM: S p e c i f i c i t y o f G l u c o s e T r a n s p o r t i n T r y p a n o s o m a - B r u c e i - Effective I n h i b i t i o n b y P h l o r e t i n a n d C y t o c h a l a s i n - B . Eur J B i o c h e m t991, 202:191-196. SHIMANO H, Y%MADAN, KATSUVdM, SHIMADAM, GOTODA T, HARADA K, M~.ASE T, FUKAZAWAC, TAKAKU F, YAZAKI Y: O v e r e x p r e s s i n n o f A p o l i p o p r o t e i n E i n T r a t m g e u i c Mice - M a r k e d R e d u c t i o n i n Plasma Lipoproteins Except High Density Lipoprotein and Resistance Against Diet-Indnced H y p e r c h o l e s t e r o l e m i a . Proc Nail A c a d Sci U S A 1992, 89:175(>1754. SHYAMALAV, BAICHWAt V, BEALL E, A~mS GF: S t r u c t u r e Function Analysis of the Histidine Permease and C o m p a r i s o n w i t h C y s t i c F i b r o s i s M u t a t i o n s . J Biol Chem 1991, 266:1871/~18719. SINHA S, KNOPS J, ESCH F, MOVER ED, OLTERSDORFT: Conversion of the Alzheimer'R Beta-Amyloid P r e c u r s o r P r o t e i n (APP) K u n i t z D o m a i n i n t o a P o t e n t H u m a n N e u t r o p h i l Elastase I n h i b i t o r . J Biol CT~em 1991, 266:21011 21013. SMALL DH, MOIR RD, FULLER SJ, MICHAELSONS, BUSH AI, LI QX, MILWARD E, HILBICH C, WEIDEMANN A, BEYREUTHER K, MASTERSCL: A P r o t e a s e Activity Associated with Acetylcholinesterase Releases the Membrane-Bound Form of the Amyloid Protein P r e c u r s o r o f A l z h e i m e r ' s D i s e a s e . Biochemistry 1991, 30:10795-10799. SMI'IIq C ETAL.: M o n o e l o n a l A n t i b o d y HA-1A f o r G r a m n e g a t i v e S h o c k [Letter]. Lancet 1991, 338:695. SMITH CD, C A I ~ Y JM, STARKEREED PE, OLIVER CN, STADTMAN ER, FLOYD RA, MARKESBERYWR: E x c e s s Brain Protein Oxidation and Enzyme Dysfunction I n N o r m a l A g i n g a n d i n A l z h e i m e r D i s e a s e . Proc Natl A c a d Sci U S A 1991, 88:10540-10543. SOTO M, REQUENAJM, GOMEZ LC, NAVARRETEI, ALONSO C: M o l e c u l a r C h a r a c t e r i z a t i o n o f a t e i s h m a n t a D o n o v a n i - I n f a n t u m A n t i g e n I d e n t i f i e d as H i s t o n e H2A. E u r J B i o c h e m 1992, 205:211-216. SPENCER RGS, HALVERSONKJ, AUGER M. MCDERMOTT AE, GRIYFLNRG, LANSBORYPT: A n U n u s u a l Peptide Conformation May Precipitate Amyloid Formation in Alzheimer's Disease - Application o f Solid-State NMR t o t h e D e t e r m i n a t i o n o f P r o t e i n S e c o n d a r y S t r u c t u r e . Biochemist*7 1991, 30:10382-10387. STAPLES AJ, ROBERTSONEF, RANIERI E, RYALLRG, IIAAN EA: A Maternal Serum Screen for Trisomy-18 - an Extension of Maternal Serum Screening for Down S y n d r o m e . A m J H u m Genet 1991, 49:1025-1033. SUBRAMANYAMB, POND SM, EYLES DW, WHITEFORD HA, FOUDA HG, CASTAGNOLIN: I d e n t i f i c a t i o n o f Potentially Neurotoxie Pyridinium Metabolite in the Urine of Schizophrenic Patients Treated with H a l o p e r i d o L Biochem Biopt~les Res Commun 1991, 181:573-578. TARLE'FON RL, KOLLERBH, LATOURA, POSTER M: S u s c e p t i b i l i t y o f ~ 2 - m i c r o g i o b u i i n - d e f l c i e m Mice t o T r y p a n o s o m a C r u z i I n f e c t i o n [Letter]. Nature 1992, 356: 33 ~3 3 9 .

TAYLOR RFH, HODSON ME, PITF TL: A u x o t r o p h y o f P s e u d o m o n a s - A e r u g i n o s a i n Cystic F i b r o s i s . FEMS Microbiol Lett 1992, 92:243-246. "[IERCYJM, MOREL C, FRRIDEL AC, ZWAHLEN F, GEBUHRER L, BETL~L H, JEANN~TI"M, MACH B: S e l e c t i o n of Unrelated Donors for Bone Marrow T r a n s p l a n t a t i o n is I m p r o v e d b y H I A Claas-H Genotyping with OHgonucleotide Hybridization. Proc Nail A c a d Sci U S A 1991, 88:7121-7125. VANNOSTRANDWE, \Y/AGNERSL, SHANq~LEWR, FARROW JS, DICK M, ROZEMULLERJM, KUIPER MR, WOLTERS EC, ZIMMEP~MANJ, COT.MANOR, CLrN~qlNGHAMDD: D e c r e a s e d Levels o f S o l u b l e A m y / o i d BetaP r o t e i n P r e c u r s o r i n C e r e b r o s p i n a l F l u i d o f Live A l z h e i m e r D i s e a s e Patients. Proc Nail A c a d Sci U S A 1992, 89:2551-2555. VONFACHELSTREIBERC, LAUFEN~BERGFELDMANNR, SARTINGEN S, SCHULZEJ, SALFEPd3OI~NM: C o m p a r a t i v e S e q u e n c e Analysis of the Clostridinm-Diffieile Toxin-A and Toxin-B. Mol Gen Genet 1992, 233:26(~268. WEBER B, HEDRICK A, ANDREW S, RIESS O, COLLINS C, KOWBEL D, HAYDEN MR: I s o l a t i o n a n d Characterization of New Highly Polymorphic DNA M a r k e r s f r o m t h e H u n t i n g t o n D i s e a s e R e g i o n . A m J H u m Genet 1992, 50:382 393. WEILAND KL, DOOLEY TP: I n v i t r o a n d I n v i v o DNA B o n d i n g b y t h e CC-1065 A n a l o g u e U-73975. Biochemistry 1991, 30:7559-7565. WIDDICOMBE JH, WINE JJ: T h e B a s i c D e f e c t i n Cystic F i b r o s i s . Trends Biochem Sci 1991, 16:47/v477. WIDER G, WEBER C, WUTHRICH K: P r o t o n P r o t o n O v e r h a u s e r Effects o f R e c e p t o r - B o u n d Cyclosporin-A Observed with the use of a Heteronuelear-Resoived Half-Filter Experiment. J A m Chem Soc 1991, 113:46764678. WILSON DK, BOHREN RIM, GABBAY KH, QDtOCHIO FA: All u n l i k e l y S u g a r S u b s t r a t e Site i n t h e 1.65 a S t r u c t u r e o f t h e H u m a n A l d o s e Reductase Holoenzyme Implicated in Diabetic C o m p l i c a t i o n s . Science 1992, 257:81-84. WIRAK DO, BAYNEY R, KUNDEL CA, LEE A, SCANGOS GA, • '1"RAPEBD, UNX'ERBECKJA: R e g u l a t o r y R e g i o n o f H u m a n A m y l o i d P r e c u r s o r P r o t e i n (APP) G e n e Promotes Neuron-specific Gene Expression in the CNS o f T r a n s g e n i c Mice. EMI30J 1991, 10:289-296. [251. XVIRAKDO, 13AYIWEYR, RAMABHADRANWV, FRACASSORP, ~IARTJT, HAUER PE, HSIAU P, PEKAR SK. SCANGOS GA, TRAPP BD, UNTERBECKAJ: D e p o s i t s o f A m y l o i d beta Protein in the Central Nervous System of T r a n s g e n i e Mice. Science 1991, 253:323-325. WORRALL ~ EVANS C, WILTON DC: S y n t h e s i s o f a G e n e f o r Rat Liver Fatty-Acid-Binding P r o t e i n a n d Its E x p r e s s i o n i n E s c h e r i c h i a - c o l i . Biochem J 1991, 278:365-368. WRIGHT A, TAO M, KABAg EA, MORRISON SL: A n t i b o d y v a r i a b l e R e g i o n G l y c o s y l a t i o n : P o s i t i o n Effects on Antigen Binding and Carbohydrate Structure. EMBOJ 1991, 10:2717-2724. WRIGHT G, CARVERA, COTrOM D, REEVES D, SCOTT A, SIMONS P, WII~aUT I, GA~XrERI, COLMANA: H i g h Level E x p r e s s i o n o f Active H u m a n A l p h a - l - A n t i t r y p s i n i n t h e M i l k o f T r a n s g e n i c S h e e p . Biotechnology 1991, 9:830-834. WU QY, SHEEHANJP, TSIANG M, LENTZ SR, BIRKTOFT JJ, 8ADLERJE: S i n g l e A n l i n o Acid S u b s t i t u t i o n s Dissociate Fibrinogen-Clotting and T h r o m b o m o d u l i n - B i n d i n g Activities o f H u n l a ~ T h r o m b i n . Proc Nail A c a d Sci U S A 1991, 88:677545779. XIONG GM, LL~rZ F: Site-Directed M u t a g e n e s i s o f t h e Pseudomonas-aeruginosa Cytotoxin for Probing T o x i c Activity. E u r J B i o c h e m 1992, 204:789 792. YAMAGUCHI F, RIGHARDS S-J, BEYREUTHERK, SALBAUMM, • CARLSONGA, DLr~qVETr SA: T r a n s g e n i c Mice f o r t h e A m y l o i d P r e c u r s o r P r o t e i n 695 h a v e I m p a i r e d S p a t i a l M e m o r y . Neuroreports 1991, 2:781~84. [17]. YAMASAKIR, BACON BE, NASHOLDSW, SCFEqEIDER H, GRIFFISSJM: S t r u c t u r a l D e t e r m i n a t i o n of Ollgosaecharides Derived from Lipooligosaecharide of Neisseria-Gonorrhoeae F62 b y C h e m i c a l , E n z y m a t i c , a n d T w o D i m e n s i o n a l N M R M e t h o d s . Biochemistry 1991, 30:10566-10575. YAO S-N, WILSON JM, NABELEG, KURACHI S, HACHIYA HL, KL~RACHI K: E x p r e s s i o n o f H u m a n F a c t o r IX i n Rat C a p i l l a r y E n d o t h e l i a l Cells: T o w a r d S o m a t i c G e n e T h e r a p y f o r H e m o p h i l i a B. Proc Nail Acad Sci U S A 1991, 88:8101-8105 ZHANG Y, COYNE ,MY, WILI. SG, LEVENSONCH, KAWASAFa ES: S i n g l e - b a s e M u t a t i o n a l A n a l y s i s o f C a n c e r and Genetic Diseases Using Membrane Bound M o d i f i e d O l i g o n u c l e o t i d e s . Nucleic Acids Res 1991, 19:3929-3933. ZIELENSFaJ, .MARKIEWlCZD, RININSLA_NDF, ROMMENS J, TSL~ L-C: A C l u s t e r o f H i g l t i y P o l y m o r p h i c

751

752

Pharmaceutical applications Colony-stimulating factors • Drug design and delivery D i n u c l e o t i d e Repeats i n I n t r o n 17b o f t h e Cystic Fibrosis T r a n s m e m b r a n e C o n d u c t a n c e R e g u l a t o r (CFTR) Gene. A m J H u m Genet 1991, 49:1256-1262. ZYCItLINSKYA, PREVOSTMC, SANSONETIIPJ: Shigella F l e x n e r i induces A p o p t o s i s in I n f e c t e d M a c r o p h a g e s [Letter]. Nature 1992, 358:167 168

Colony-stimulating factors Related review: Colony-stimulating factors in the clinic (pp 687-692) BOCK SN, CAMERONRB, KRAGELP, Mt~E JJ, ROSENBERGSA: B i o l o g i c a l and A n t i t u m o r Effects o f R e c o m b i n a n t Human Macrophage Colony-Stimulating Factor in Mice. Cancer Res 1991, 51:2649-2654. BRITO-BABAPULLEF, ET AL.: BEAM R e g i m e n and C~CSF i n HTLV-I-associated T-cell L y m p h o m a [Letter]. Lancet 1992, 339:133. CA~'~XqSTRASA, DI CARLOJ, GROSHEK P, KANAKURAY, • BERGD, MAYERRJ, GB2FHNJD: S i m u l t a n e o u s Administration of Granulocyte-macrophage C o l o n y Stimulating F a c t o r and Cytosine A r a b i n o s i d e for t h e T r e a t m e n t o f R e l a p s e d Acute M y e l o i d Leukemia. Le uk e mi a 1991, 5:23~238. [14]. CHAO NJ ET AL.: G-CSE a n d P e r i p h e r a l B l o o d P r o g e n i t o r Cells [Letter]. Lancel 1992, 339:1410. CORBOZ VA, CECCHINqMG, FELIX R, FI,BISH H, VAN PER • PLU]JMG, LOW]K CWGM: Effect o f M a c r o p h a g e C o l o n y Stimulating F a c t o r o n I n Vi t r o O s t e o c l a s t G e n e r a t i o n and B o n e R e s o r p t i o n . Endocrinology 1992, 130:437442. [30]. CRAWFORDJ, OZER H, STOLLERR, JOHNSON D, LYMANG, • TABARNAI, KRIS M, GROUS J, PILOZZI V, RAUSH G, ET AL: R e d u c t i o n b y G r a n u l o c y t e C o l o n y S t i m u l a t i n g F a c t o r o f Fever a n d N e u t r o p e n i a I n d u c e d b y C h e m o t h e r a p y in P a t i e n t s w i t h s m a l l Cell L u n g Cancer. N e w E n g J M e d 1991, 325:164-170. [7]. CUR~S BM, WILLIAMSDE, BRO~MEYERHE, DUNN J, FARRAH T, JEFFERY E, CLEVENGERW~ DEROOS P, ~L~R~N U, FRIEND D, CRAIGV,-GAYLE R, PRICE V, COSM~N D, MARCH CJ, PARK LS: E n h a n c e d H e m a t o p o i e t i c Activity o f a H u m a n G r a n u l o c y t e M a c r o p h a g e colony-Stimulating Factor Interleukin-3 F u s i o n Protein. Proc Natl A c a d Sci U S A 1991, 88:5809-5813. DEMUYNCKH, PETFENGELLR, DE CAMPOS E, DEXTERTM, TESTA NG: The C a p a c i t y o f P e r i p h e r a l Blood S t e m Cells Mobilised w i t h C h e m o t h e r a p y Plus C~CSF to R e p o p u l a t e I r r a d i a t e d M a r r o w S t r o m a I n Vi t r o is S i m i l a r to t h a t o f B o n e M a r r o w . E u r J Cancer 1992, 28:381-386. [17]. DEWITTE "i~ GRATWOLA, VAN DEN' LELYN, BACIGALLrpO • A, STERN AC, SPECK B, SCHATTENBERGA, NISSEN C, GLUCKMANE, FIBBE XY~E:R e c o m b i n a n t H u n i a n Granulocyte-macrophage colony Stimulating F a c t o r Accelerated N e u t r o p h i l a n d M o n o c y t e R e c o v e r y after A l l o g e n e i c T-cell D e p l e t e d B o n e M a r r o w T r a n s p l a n t a t i o n . Blood 1992, 79:1359-t365. [6]. DIEDERICHS K, BOOix~ T, KARPLUSPA: N o v e l Fold a n d P u t a t i v e R e c e p t o r B i n d i n g Site o f Granulocytem a c r o p h a g e C o l o n y - s t i m u l a t i n g Factor. Science 1991, 254:1779-1781. ECCLES MR, KING FJ, COLE MD: A C o l o n y - s t i m u l a t i n g Factor- 1 (CSF-1) R e c e p t o r / P i a t e l e t - d e r i v e d G r o w t h Factor-beta R e c e p t o r G c n e F u s i o n Confers CSF-1 I n d e p e n d e n c e a n d T u m o r i g e n i c i t y o n a C-mycI m m o r t a l i z e d M o n o c y t e Cell Line. Mol Cell Biol 1992, 12:386-393. ESTEY E, THALLPF) KANI'ARJIANH, O'BRIEN S, KOLLER CA, BERAN M, GLTFERMK*NJ, DEISSRROTHA, KEATING M: T r e a t m e n t o f N e w l y D i a g n o s e d Acute M y e l o g e n o u s L e u k e m i a w i t h Ganulocytem a c r o p h a g e C o l o n y - a t i m u l a t i n g Factor (GMCSF) Before a n d D u r i n g C o n t i n u o u s - i n f u s i o n H i g h - d o s e Ara-C+ Daunorubtchm C o m p a r i s o n to P a t i e n t s T r e a t e d W i t h o u t GM-CSF. Blood 1992, 79:2246-2255. ETLINGERHM, KNORE R: M o d e l U s i n g a Peptide w i t h Carrier Function for Vaccination against D i f f e r e n t Pathogens. Vaccine 1991, 9:51~514. FUKUDA M, KOJLMAS, MATSUMOTOK, I~iATSUYAMA • T: A u t o t r a n s p l a n t a t i o n o f P e r i p h e r a l B l o o d S t e m Cells Mobllised b y C h e m o t h e r a p y a n d Recombinant Human Granulocyte Colony S t i m u l a t i n g Factors i n c h i l d h o o d N e u r o b l a s t o m a a n d N o n - H o d g k i n ' s L y m p h o m m B r J IIaematol 1992, 80:327-331. [18]. GANSER A, JANSSENfWG, OTFMAN OG, SEIPEI.TG, EDER • M, BECHER R, LINDEI~MANNA, HERRMANNF, SCHULTZ G, MERTELSMANNR, ETAL: I n ViVO Effects o f Granulocyte-maerophage Colony Stimulating F a c t o r a n d I n t e r l e u k i n 3 o n C l o n a l and None l o n a l Cell P o p u l a t i o n s i n Patients w i t h C l o n a l

H e m a t o p o i e t i c D i s o r d e r s . Leukemia 1991, 5:487-492. [20]. G&NSERA, LINDEMANNA, OT~MANNOG, SEIPEUFG, HESS U, GEISSLER G, K&NZ L, ~NISCtIJ, SCHULZ G, HERRMAh~ F, MERTSELSMANNR, HOELZERD: S e q u e n t i a l in Vivo T r e a t m e n t w i t h Two R e c o m b i n a n t H u m a n H e m a t o p i e t i c G r o w t h Factors ( i n t e r i e u k i n - 3 and Granulocyte-Maerophage Colony-Stimulating Factor) as a N e w T h e r a p e u t i c M o d a l i t y to Stimulate t l e m a t u p o i e s i s : Results o f a p h a s e I Study. Blood 1992, 79:2583-2591. GEARING DP, COMEAUMR, FRIEND DE, GLMPELSD, "I]IUT "" CJ, MCGOU1-yJ, BRASHERKK, KING JA, GILHS S, MSLEY B, ETAL: T h e 1L-6 Signal T r a n s d u c e r , G p l 3 0 , an O n c o s t a t i n M R e c e p t o r a n d Affinity C o n v e r t e r for the IAF Receptor. Science 1992, 255:1434-1437. [36]. LMASHHKUS, TSUCHIDAM, SASAFd M, SHIMOKAWAT, NAK&MURA]-I~ MATSUYAMAT, TANqGUCHIN~ ODA M, HIGUCHI S, ISHIMO'I~)K, ETA£: R e c o m b i n a n t H u m a n G r a n u l o c y t e - c o l o n y S t i m u l a t i n g Factor i n t h e T r e a t m e n t o f Patients w i t h C h r o n i c B e n i g n G r a n u l o c y t o p e n i a and C o n g e n i t a l Agranulocytosis ( K o s t m a n n ' s S y n d r o m e ) . Acta Pe d f a m c a 1992, 81:13~136. [12]. INOUE I, INABAT, MOTOYOSNI K, HASADA K, SHhMANO • H, KAWAMLrRAM, GOTODA T, OKA T, SHIOMI M, WATANABEy, ETAL: M a c r o p h a g e C o l o n y Stimulating F a c t o r P r e v e n t s t h e P r o g r e s s i o n o f A t h e r o s e l e r o s i s in W a t a n a b e H e r i t a b l e H y p e r l i p i d e m i c Rabbits. Atberosclerosis 1992, 93:245-254. [31]. KOBAYASHIM, IMAMU~RAM, GOTOHDA Y, MAEDA S, IWASAI~ • H, SARURADAK, KASAI M, HAPEL AJ, MIYAZAKIT: Synergistic Effects o f I n t e r i e u k i n - l ( x o n t h e Expansion of Human Hematopoietic Progenitor Cells i n Liquid Cultures. Blood 1991, 78:1947-1953. [23]. LEVINEJD, ALLANJD, TESSITOREJH, FALCONX N, GALASSO F, ISRAELRJ, GROOPM2LNJE: R e c o m b i n a n t Hi*man G r a n u l o c y t e - m a e r o p h a g e Colonystimulating Factor Ameliorates Zidovudinei n d u c e d N e u t r o p e n i a i n Patients w i t h A c q u i r e d I m m u n o d e f i c i e n c y S y n d r o m e (AIDS)/AIDS-related Complex. Blood 1991, 78:3148-3154. LIESCHKE FJ, BURGESSAW: D r u g T h e r a p y : G r a n u l o c y t e C o l o n y - s t i m u l a t i n g Factor and G r a n u l o c y t e M a c r o p h a g e C o l o n y - s t i m u l a t i o n g F a c t o r (First o f Two Parts). N E n g l J M e d 1992, 327:28-35. LIESCHKE GJ, BURGESSAW: D r u g T h e r a p y : G r a n u l o c y t e C o l o n y - s t i m u l a t i n g F a c t o r and G r a n u l o c y t e m a c r o p h a g e C o l o n y - s t i m u l a t i n g F a c t o r (Second o f TWo Parts). N E n g l J M e d 1992, 327:99-106. MEISENBERGBR, DAVIS TA, MELARAGNOAJ, STEAD R, MONROY RL: A C o m p a r i s o n o f T h e r a p e u t i c Schedules f o r A d m i n i s t e r i n g G r a n u l o c y t e Colonys t i m u l a t i n g F a c t o r to N o n h u m a n P r i m a t e s after High-Dose C h e m o t h e r a p y . Blood 1992, 79:2267-2272. MILES SA, LEE K, HUTLIN L, ZSEBO KM, MITSUYASU RT: P o t e n t i a l use o f H u m a n S t e m Cell Factor as Adjunctive T h e r a p y f o r H t t m a n i n l m u n o d e f i c i e n c y Virus-related Cytopenias. Blood 1991, 78:3200-3208. MILES SA, MITSUYARURT, MORENOJ, BALDWIN G, ALTON • NK, SOUZA L, GLASpYJA: C o m b i n e d T h e r a p y with Recombinant Granulocyte Colony Stimulating F a c t o r a n d E r y t h r o p o i e t i n D e c r e a s e s H e m a t o l o g i c a l T o x i c i t y f r o m G i d o v u d i n e . Blood 1991, 77:2109-2117. [13]. MIYATAKES, SHLOMAIJ, ARA] }~ ARAI N: C h a r a c t e r i z a t i o n o f t h e Mouse G r a n u l o c y t e - m a c r o p h a g e Colonys t i m u l a t i n g F a c t o r (GM-CSF) G e n e ]~rornoter - N u c l e a r Factors t h a t I n t e r a c t w i t h a n E l e m e n t S h a r e d b y T h r e e L y m p h o k i n e G e n e s - - t h o s e for GM-CSF, i n t e r i e u k i n - 4 (EL:4), a n d IL-5. Mol Cell Biol 1991, 11:5894-5909. NmauNmaas J, RABINOWE SN, SINGERja0g, BIERMK*N PJ, VOSE JM, FREEDMANAS, ONETrO N, GILLIS S, OETIZ D, GOLD M, BUCK~T-RCD, HANSENJA, RITZJ, A~PELBAUMFR, ARMITAGEJO, NADLER LM: R e c o m b i n a n t G r a n u l o c y t e - M a c r o p h a g e ColonyS t i m u l a t i n g F a c t o r after Autologous B o n e M a r r o w T r a n s p l a n t a t i o n for L y m p h o i d C a n c e r [in English]. N E n g l J M e d 1991, 324:1773-1778. NEMUNATISJ, ANASETYIC, STORB R, BL~NCOJA, BUCK.am CD, ONETTO N, MARTINP, SANDERSJ, SULLIVANK, MOIl/ M, SHANNON-DORCYK, BOWDEN R, APPELBAUMFR, HANSENJ, SINGERj~z: P h a s e H T r i a l o f R e c o m b i n a n t H u m a n G r a n u l o c y t e - M a e r o p h a g e ColonyStimulating F a c t o r in Patients U n d e r g o i n g ARogeneic B o n e M a r r o w T r a n s p l a n t a t i o n f r o m U n r e l a t e d D o n o r s . Blood 1992, 79:2572-2577. POCHEM ML, MCVIq'I~E "i~, WILLIAMSJL, SCHWARTZGM, • SOUZALM: A d m i n i s t r a t i o n o f l m e r l e u k i n - 6 stimulates Multilineage Hematupoiesis and Accelerates R e c o v e r y f r o m R a d i a t i o n - i n d u c e d

H e m a t o p o i e t i c D e p r e s s i o n . Blood 1991, 7 7 : 4 7 2 4 8 0 [26]. IiEIF~RS J ET AL.: G-CSF a n d P e r i p h e r a l B l o o d P r o g e n i t o r Cells [Letter]. Lancet 1992, 339:1410. SIIANAFELTAB, JOHNSON KE, KASq~LEINRA: I d e n t i f i c a t i o n o f Critical A m i n o Acid Residues i n H u m a n a n d Mouse G r a n u l o c y t e - M a c r o p h a g e ColonyStimulating Factor and Their Involvement i n Species Specificity. J Biol C~errl 1991, 266:13804-13810. SHEPdDK*N%~P, BEGLEYCG, JLqqTqER CA, SZERJ, TO LB, MAHER D, MCGRATH KM, MORSTYNG, FOX RM: Effect o f P e r i p h e r a l - b l o o d P r o g e n i t o r Cells M o b i l i s e d b y F i l g r a s t i m (G-CSF) o n Platelet R e c o v e r y a f t e r High-dose C h e m o t h e r a p y . Lancet 1992, 339:640~44. SVEBUYAA, TAGUCHI K, KOJIMA H, ABE T: I n h i b i t o r y Effect o f G r a n u l o c y t e - m a c r o p h a g e Colonystimulating Factor Therapy on the Generation o f Nanzral Killer Cells. Blood 1991, 78:3241 3247. SHIBLWA K, CHIBA S, MIYAGAWAK, KITAMURA~[; MIYAZONO K, TAKAKU F: S t r u c t u r a l a n d F u n c t i o n a l A n a l y s e s o f Glycosylatlon o n t h e Distinct Molecules o f H u m a n GM-CSF Receptors, E u r J Biochem 1991, 198:659-666. SICA S ET AL.: G-CSF a n d P e r i p h e r a l B l o o d P r o g e n i t o r Cells [Letter]. Lancet 1992, 339:1410. S71/WART CI,, KASPARP, BRUNET LJ, BHATT H, GADI • " I, KONTGEN F, ABBONDAUZOSJ: Blastocyst Implantation Depends on Maternal Expression o f L e u k a e m i a I n h i b i t o r y Factor. Nature 1992, 359:7(~79. [35]. "I~MNAKAH, SATAKEISHIKAWAR, ISHIKAWAM, MATSUK1S, ASANO K: P h a r m a c o k i n c t i c s o f R e c o m b i n a n t H u m a n G r a n u l o c y t e Colony-Stimulating F a c t o r C o n j u g a t e d to P o l y e t h y l e n e Glycol i n Rats. Cancer Res 1991, 51:3710-3714. THOMASSENIMJ, A}LMADM, BARNA BP, AN-iLLJ, WIEDEMANN HP, MEEKERDP, KLEINJ, BAUERL, GIBSON V, ANDRESEN S, BUKOWSKt RM: I n d u c t i o n o f C y t o k i n e M e s s e n g e r RNA a n d S e c r e t i o n i n Alveolar M a c r o p h a g e s a n d B l o o d Monocytes f r o m Patients w i t h L u n g C a n c e r R e c e i v i n g G r a n u l o c y t e - M a c r o p h a g e ColonyS t i m u l a t i n g F a c t o r T h e r a p y . CancerRes 1991, 51:857462. VREUGDEN'HIL, ET AL.: F e v e r in N e m r o p e n i c P a t i e n t s T r e a t e d w i t h GM-CSF R e p r e s e n t h a g E n h a n c e d H o s t Defenee [Letter]. Lancet t992, 339:1118. WALTER MR, COOK WJ, EALICKSE, NAGABHUSHANTL, TROTTA pp, BUGG CE: 3 - D i m e n s i o n a l S t r u c t u r e o f Recombinant Human Granuloeyte-Macrophage C o l o n y - S t i m u l a t i n g Factor. J Mol Bio11992, 224:1075-1085. WETTERS T~, HAWKINS SA, ROUSSELMF, SHIRR CJ: R a n d o m M u t a g e n e s i s o f CSF-1 R e c e p t o r (FMS) Reveals M u l t i p l e Sites f o r Activating Mutations w i t h i n t h e E x t r a e e l i u l a r D o m a i n . F ~ B O J 1992, 11:551-557. WILLIAMS DE, pARK LS: H e m a t o p o i e t i c Effects • . o f a G r a n u l o c y t e M a c r o p h a g e Colony Stimulating Faetor/Interleukin 3 F u s i o n Protein. Cancer t991, 67:27052707. [37].

Drug design and delivery ACKERMA_NSNIT, EVERAERTSFM, BECKERSJL: D c t e r n a i n a t i o n o f S o m e Drugs b y M i c e l l a r E l e e t r o k i n e t i c C a p i l l a r y C h r o m a t o g r a p h y - t h e Pseudo-Effective M o b i l i t y as P a r a m e t e r for Screening. J Cbromatogr 1991, 585:123-131. ANONYMOUS: E n c a p s u l a t e d Cells T a r g e t Diabetes a n d P a r k i n s o n s . Biotechnolog2 1991, 9:616. AIL4KAWAT, KITA Y, CARPENTERJF: P r o t e i n - S o l v e n t Interactions in Pharmaceutical Formulations [Review]. P h a r m Res 1991, 8:285-291. ASKONAS LJ, PENNING TM: D e v e l o p m e n t o f A f ~ n i t y L a b e l i n g Agents B a s e d o n N o n s t e r o i d a l Aaxti-Inflummatory D r u g s - Labeling o f t h e Nonsteroidal Anti-Inflammatory Drug Binding Site o f 3 - a l p h a - H y d r o x y s t e r o i d D e h y d r o g e n a s e . Biochemistry 1991, 30:11553-11560. ASKONAS LJ, RICIGLIANOJ-%V,PENNING TM: T h e K i n e t i c M e c h a n i s m Catulysed b y H o m o g e n e o u s Rat Liver 3-alpha-Hydroxyateroid Dehydrogenase - E v i d e n c e for B i n a r y a n d T e r n a r y D e a d - E n d C o m p l e x e s C o n t a i n i n g Non-Steroidal AntiI n f l a m m a t o r y Drugs. B i o c h e m J 1991, 278:835-841. AUGUSTEP, HUGUES M, MOURRE C, MOINIER D, TARTAR A, LAZDUNSK1M: S ~ l i a t o x i n , a B l o c k e r o f Ca2+Activated K+ C h a n n e l s - Structure- F u n c t i o n R e l a t i o n s h i p s a n d B r a i n Localization o f t h e B i n d i n g Sites. Biochemislry 1992, 31:648-654. BANKS WA, KAS~IN AJ, BARRERA CM: D e l i v e r i n g P e p t i d e s to t h e C e n t r a l N e r v o u s System - D l l e m m u g a n d Strategies. P h a r m Res 1991, 8:1345-1350.

Pharmaceutical applications Drug design and delivery BARWICZJ, GARg&U R, AIYDVTI"A, MORISSEWA, MILLIARDJ, GRL'DA h I l l l t i b i t i o u o f t h e I n t e r a c t i o n B e t w e e n Lipoproteins and Amphotericin-B by Some D e l i v e r y S y s t e m s . Biochem Biophys Res Commun 199i, 181:722-728. BIENZ TADMOR B, DICERBO PA, TADMOR G, LASAGNAL: Biopharmaeeuticals and Conventional Drugs: C l i n i c a l S u c c e s s Rates. Biotechnology 1992, 10:521-527. BLUMEN3~LALR, LOYTERA: R e c o n s t i t u t e d V i r a l E n v e l o p e s -- 'Trojan Horses' for Drug Delivery and Gene T h e r a p y ? Trends Biotechno11991, 9:41-44. CARMEI.I S, MOORE RE, PAYI'ERSON GMI,, CORBE77FTH, VALERIOTE FA: T a n t a z o l e s - U n u s u a l C y t o t o x i c Alkaloids from the Bhie-Green Alga ScytonemaM i r a b i l e . J A m Chem Soc 1990, 112:8195-8197. C A ~ d ~ MJ, CHATHELD SN, DOUGAN G, NOWlCKA UTA, OCALLAGI-IAN D, BEESLEYJE~ MJLANO S, CILLAIll E, LIEW FY: E x p r e s s i o n o f R u l n a n IL-l-beta i n SalnaoneliaTyphixnuriutn - a Model System for the Delivery o f R e c o m b i n a n t T h e r a p e u t i c Invivo. J Immunol 1992, 148:1176-1181. CHAPEKAR MS, HUGGEYI"AC, CHENG C: D e x a m e t h a s o n e P r e v e n t s t h e G r o w t h I n h i b i t o r y Effects o f R e c o m b i n a n t T u m o r N e c r o s i s F a c t o r i n a Rat H e p a t o m a Cell Line Reuber-RC-3 - a n A s s o c i a t i o n w i t h t h e C h a n g e s i n t h e M e s s e n g e r RNA Levels f o r M u l t i d r u g R e s i s t a n c e G e n e . Biochem Biophys Res C o m m u n 1991, 181:1524-1531. CHAUDHARY PM, RON~NSONIB: E x p r e s s i o n a n d Activity of P-Glycoprotein, a Multidrug Efllux Pump, i n H u m a n H e m a t o p o i e t i e S t e m Cells. C~l11991, 66:85-94. CHEKHON~N VP, KABANOVAV, ZHIRKOV YA, MOROZOV GV: F a t t y A c i d Acylated F a b - F r a g m e n t s o f A n t i b o d i e s t o N e u r o s p e c i f i c P r o t e i n s as C a r r i e r s f o r N e u r o l e p t i c T a r g e t e d D e l i v e r y i n Brain. FEBS Lett 1991, 28"7:149-152. CHEN SM, LEUPIN W, R&NEE M, CHAZIN WJ: E - D i m e n s i o n a l NMR S t u d i e s o f D(GGTTAATGCGGT)Bulletd(ACCGC~TTAACC) C o m p l e x e d w i t h t h e M i n o r G r o o v e B I n d i n g D r u g SN-6999. BiochemistrF 1992, 31:4406--4413. CLARKE RJ, MAYO G, PPdCE P, FITZGERALD GA: S u p p r e s s i o n o f T h r o n l b o x a n e A2 B u t n o t o f S y s t e m i c P r o s t a c y c l i n b y C o n t r o l l e d - r e l e a s e Aspirin. N Engl J M e d 1991, 325:1137-1141. COHEN S, BERNSTEIN H, HEWES C, CHOW M, LANGER R: T h e P h a r m a c o k i n e t i c s Of, a n d H u m o r a l R e s p o n s e s To, A n t i g e n D e l i v e r e d b y M i c r o e n c a p s n i a t e d L i p o s o m e s . Proc Natl A c a d Sci U S A 1991, 88:10440-10444. CONS BMG, FOX KR: Effects o f t h e A n t i t u m o r A n t i b i o t i c Mithramycin on the Structure of Repetitive DNA R e g i o n s A d j a c e n t t o Its GC-Rieh B i n d i n g Site. Biochemistry 1991, 30:631445321. DAUWOIS S, DANIELIAN PS, WHITE R~ PARKERMG: A n t i e s t r o g e n ICI-164,384 R e d u c e s C e l l u l a r Estrogen Receptor Content by Increasing Its T u r n o v e r . Proc Natl A c a d Sci U S A 1992, 89:4037~041. -DE,MANETC, BRISSINCKJ, VP.NMECHELENM, LEO O, THIELEMANS K: T r e a t m e n t o f M u r i n e B-Ce ll Lymphoma with Bispecific Monoclonal A n t i b o d i e s ( A n t i - I d l o t y p e X Anti-CD3). J Immunol 1991, 147:109t i097. DEMPCY RO, SKIBO EB: R a t i o n a l D e s i g n o f Q u i n a z o l i n e B a s ed I r r e v e r s i b l e I n h i b i t o r s o f H u m m n Erythrocyte Purine Nucleoside Phosphorylase. Biochemistry 1991, 30:8480-8487. DEPINA MZ, HERNANDEZTOBtASA, SALD#-NABALMORIY, DIAZBELMONTA, PINA E: B i o c h e l n i c a l E t h a n o l Effects A f f e c t e d b y a N o n - S t e r o i d a l AntiI n f l a m t t n a t o r y D r u g . FEBS Lett 1992, 298:I23 125. DICCIAN.~I MB, LILLYSTAUDERMANM, MCLEAN LR, BALASUBRAM&NL~aA, HARMONYJAK: H e p a r i n Prevents the Binding of Phospholipase-A2 to P h o s p h o l l p t d Micelies - I t n p o r t a n c e o f t h e A m i n o - T e r m i n u s . Biochemist~ 1991, 30:9090~097. DOEPdNG TL, RAPERJ, BL?ESAUMLU, ADAMS SP, GORDON JI, HART GW, ENGL[YNDPT: A n A n a l o g o f Myri s t i c A c i d with Selective Toxicity for African Trypanosomes. Science 1991, 252:1851-1854. DOHLSTEN M, HEDLUND G, AKERBLOM E, LANDO PA, KALLAND T: M o n o c l o n a l A n t i b o d y - T a r g e t e d S u p e r a n t i g e n s - a D i f f e r e n t Class o f A n t i - T u m o r A g e n t s . Proc Natt Acad Sct U S A 1991, 88:9287-9291. EASTMAN HB, SWICK AG, SCHMITr MC, AZIZKH&NJC: Stimulation of Dihydrofolate Reductase Promoter Activity b y A n t i n l e t a b o l i c D r u g s . Proc Natl A c a d Sci U S A 1991, 88:8572-8576. EDGINGTON SM: H o w Sw eet it Is: S e l e c t i n - M e d i a t i n g D r u g s . Biotechnology 1992, 10:383-389. EDWARDS PD, MEYER EF, VIJAYALAKSI-LMIJ, T(frHILL PA, ANDISIK DA, GOMES B, STRIMPLERA: D e s i g n , S y n t h e s i s , a n d Kinetic E v a l u a t i o n o f a U n i q u e Class o f E laatase I n h i b i t o r s , t h e P e p t i d y l A l p h a -

K e t o b e n z o x a z o l e s , a n d t h e X-Ray C r y s t a l Structure of the Covalent Complex Between P o r c i n e P a n c r e a t i c E l a s t a s e a n d Ae-Ala-Pro-Val2 - B e n z o x a z o l e . J A m Chem 3~c 1992, 114:1854-1863. EICKHOFF WM, LIVERSIDGE GG, MLWHARASANR: L i q u i d Chromatographic Arialysis of a Potential Pol yl ne ri c- P e n d a n t D r u g D e l i v e r y S y s t e m f o r P e p t i d e s - A p p l i c a t i o n o f H i g h - P e r f o r t n a n c e SizeE x c l u s i o n C l x r o m a t o g r a p h y , Reversed- P h a s e High-Performance Liquid Chromatography and Ion Chromatography to the Evaluation of B i o d e g r a d a b l e Poly< ( C h l o r o m e t h o x y t r i a l a n i n e M e t h y l Ester) P h o s p h a z e n e s > . J Chromatogr 1991, 536: 255~ 64. EIJDEMS EWHM, BOP.ST P, JONGSMA APM, DEJONG S, DEVRIES EGE, VANGROENIGEN M, VERSAaWINOORTCHM, NIEUWISFFAWM, BAAS F: G e n e t i c T r a n s f e r o f N o n P-Glycoprotein-Mediated Multidrug Resistance (MDR) i n S o m a t i c Cell F u s i o n - D i s s e c t i o n o f a C o m p o u n d M D R P h e n o t y p e . Proc Nail A c a d Sci U S A 1992, 89:349~3502. FAURE G, GUILLAL'MEJL, CAMOIN L, SALIOU B, BON C: Multiplicity of Acidic Subunit Isoforms of Crotoxin, the Phospholipase-A2 Neurotoxin from Crotalus-Durissus-Terrificus Venom, Results from P o s t t r a n s l a t i o n a l M o d i f i c a t i o n s . Biochemistry 1991, 30:80744~083. FIELDING PE, MIIDA T, FIELDING CJ: M e t a b o l i s m o f LowDensity Lipoprotein Free Chulesterol by Human PLasma L e c i t h i n - C h o l e s t e r o l A c y l t r a n s f e r a s e . Biochemistry 1991, 30:8551-8557. FRANSSFaX"EJF, VANAMSTERDAMRGM, VISSEBJ, MOOLENAAR F, DEZEEUW D, MEIJER DKF: LOw M o l e c u l a r W e i g h t P r o t e i n s as C a r r i e r s f o r R e n a l D r u g T a r g e t i n g N a p r o x e n - L y s o z T l n e . Pharm Res 1991, 8:1223 1230. GPoLNE SK, DECKMAN IC, MLNNICH MD, CULPJ, FRANKLIN S, DREYER GB, TOMASZEK TA, DEBOUCK C, MEEK ~ ) : Purification and Biochemical Characterization of Recombinant Simian Immunodefieiency V i r u s P r o t e a s e a n d C o m p a r i s o n to H u m a n I m m u n o d e f i c i e n c y V i r u s Type-1 P r o t e a s e . Biochemistry 1991, 30:842/~8434. GREENTIELD JC, LOUX SJ, SOOD VK, JENVdNS K~M, DAVIO SR: I n v i t r o E v a l u a t i o n o f t h e P l a s m a a n d B l o o d Compatibility of a Parenteral Formulation for Ditekiren, a Novel Renin Inhibitor P s e u d o p e p t i d e . Pharm Res 1991, 8:475-479. Gm~ITHS DA, BEST DJ, JEZEQUEL SG: T h e S c r e e n i n g o f Sel e c t e d M i c r o o r g a n i s n l s f o r u s e as M o d e l s o f M ~ m m M i a n D r u g M e t a b o l i s m . Appl Microbiol Biotechno11991, 35:373-381. GRIFFITHS E: E n v i r o n m e n t a l R e g u l a t i o n o f B a c t e r i a l V i r u l e n c e - - I m p l i c a t i o n s f o r Vaccine D e s i g n a n d P r o d u c t i o n . Trends Biotectonol 1991, 9:309-315. GROS P, TALBOT P, TANGWA/ D, BIBI E, KABACKHR: Lipophilic Cations - a Group of Model Substrates for the Multidrug-Resistanee Transporter. Biochemistry 1992, 31:1992-1998. Gu LC, ERDOS EA, CHIANG HS, CALDERWOOD T~ TSAI K, VISOR GC, DDWFYJ, HSU WC, FOS]~R LC: S t a b i l i t y of Interleukin-lbeta (IL-lgamma) in Aqueous S o l u t i o n - A n a l y t i c a l M e t h o d s , Kinetics, P r o d u c t s , a n d S o l u t i o n F o r m u l a t i o n I m p l i c a t i o n s . Pharm Res 1991, 8:485--490. GUZMAN NA, ALt H, MOSCHERAJ, IQBAL I{, MALICKAW: Assessment of Capillary Electrophoresis In Pharmaceutical Applications - Analysis and Quantification of a Recombinant Cytokine in a n I n j e c t a b l e D o s a g e F o r m . J Cbromatogr 1991, 559:307-315. HAYASHIBE K, MJSHIMAY, FERRONE S: C l o n i n g a n d I n v i t m Expression of a Melanoma-Associated Antigen Ilammunogenic i n P a t i e n t s w i t h M e l a n o m a . J Imrnuno11991, 147:1098-1104. HIGGINS CF, GOTIESMAN MM: Is t h e M n i t i d r u g T r a n s p o r t e r a F l i p p a s e . Trends Biochem Sci 1992, 17:18-21. HILL AVS, ALLSOPP CEM, KWIATKOWSKID, ANS~Y NM, TWUMASI p, ROWE PA, BENNETI" S, BREWS'I~R D, MCM]CHAELAJ, GREENWOOD BM: C o m m o n West A f r i c a n I-ILA A n t i g e n s a r e A s s o c i a t e d w i t h P r o t e c t i o n f r o m S e v e r e M a l a r i m Nature 1991, 352:5954300. HOP& MS, RANA RK, SMITH FOg: L y o p h i l i z e d Formulations of Recombinant Tumor Necrosis Factor. Pharm Res 1992, 9:33-36. HOUGH'YEN RA, FINILLA C, BLONDELLE SE, APPEI.JR, DOOLEY CT, CL~BVO JH: G e n e r a t i o n a n d u s e o f Synthetic Peptide Combinatorial Libraries for Bas i c R e s e a r c h a n d D r u g D i s c o v e r y . Nature 1991, 354:84. HUSSAJNAS, YU XQ, JOHNSON RD: A p p l i c a t i o n o f Neural Computing in Pharlnaceatieal Product D e v e l o p m e n t . Pharm Res 1991, 8:1248,1252. HUFCHINSON DW: Ne1~v A p p r o a c h e s t o the S y n t h e s i s o f A n t i v i r a l N u c l e o s i d e s . Trends Biotechnol 1990, 8:348-353.

HYLAND LJ, TOMASZEK TA, MEEK TD: H u l n a n I m m u n o d e f i c i e n c y Vlrns-1 P r o t e a s e . 2. u s e o f P H Rate S t u d i e s a n d S o l v e n t K i n e t i c I s o t o p e Effects t o E l u c i d a t e DetaiLs o f C h e m i c a l M e c h a n i s m . Biochemistry 1991, 30:8454~463. HYLAuNDLJ, TOMASZEKTA, ROBERTS GD, CARR SA, .MAGAARD VW, BRYAN HL, FAKIIOL~RYSA, MOORE ML, ~V~NZqlCH MD, CLrLpJS, DESlARLAISRL, MEEK TD: H u n l a n I m m u n o d e l i c t e n c y Virus-1 P r o t e a s e . 1. I n i t i a l Velocity Studies and Kinetic Characterization o f R e a c t i o n I n t e r m e d i a t e s b y O-18 I s o t o p e E x c h a n g e . Biochemistry 1991, 30:8441-8453. IKEGAMI S, ISOMURA H, TSUCtlIMORI N, OSANO YT, I-IAYASE "[; YUGAMI "I. OHKISHI H, MATSUZAKIT: S t r u c t u r e o f P y r r o l o s i n e - a N o v e l I n h i b i t o r o f RNA S y n t h e s i s , from the Actinomycete Streptumyces-Albus. J Am Chem Soc 1990, 112:9668,9669. ILEUM L: T h e N a s a l D e l i v e r y o f P e p t i d e s a n d P r o t e i n s . Trends Biotechno11991, 9:284-289. ISMAILA, HA1 OK, KADER ZA: D e m o n s t r a t i o n o f a n A n t i g e n i c P r o t e i n Specific f o r s a l m o n e l i a - Y y p h i . Biochem Biophys Res Commun 1991, 181:301 305. JACKSON AM, WHIPPS JM, LYNCHJM: P r o d u c t i o n , D e l i v e r y Systems, and Survival in Soil of 4 Fungi with D i s e a s e B i o c o n t r o l P o t e n t i a l Enzyme Microb Techno11991, 13:6364342. JAKES R, NOVAK M, DAVISONM, WISCHIK CM: I d e n t i f i c a t i o n o f 3- a n d 4 - r e p e a t T a u I s o f o r m s w i t h i n t h e P H F i n A l z h e i m e r ' s D i s e a s e . EMBOJ 1991, 10:2725-2730. JOHANSSON IM, PAVELKAR, HENION JD: D e t e r m i n a t i o n of Small Drug Molecules by Capillary Electrophoresis Atmospheric Pressure I o n i z a t i o n M a s s S p e c t r o m e t r y . J Chromatogr 1991, 559:515-528. JOI~NSTON TP, PUNJABI /VIA, FROELICH CJ: S u s t a i n e d Delivery of Interleukin-2 from a Poloxamer-407 Gel M a t r i x F o l l o w i n g I n t r a p e r i t o n e a l I n j e c t i o n i n Mice. P h a r m Res 1992, 9:425-434. EdJLMAy, OGUNBUNMI E, FLEISCHERS: D r u g Action o f T h a p s i g a r g i n o n t h e Ca2+ P u m p P r o t e i n o f S a r c o p l a s m i c R e t i c u l u m . J Biol Chem 1991, 266:22912-22918. KINGSMANAJ, ADAMS SE, BURNS NR, K/NGSMAN SM: R e t r o e l e m e n t P a r t i c l e s as P u r i f i c a t i o n , P r e s e n t a t i o n a n d T a r g e t i n g v e h i c l e s . Trends Biotechnol 1991, 9 : 3 0 3 3 0 8 . KLUGER R, HUANG Z: Acyl P y r o p h o s p h a t e s -Activated Analogues of Pyrophosphate Monoesters Permitting New Designs for Inactivation o f T a r g e t e d E n z y m e s . J A m Chem Soc 1991, 113:5124--5125. KONDO S, ZAHRINGER U, SEYDEL U, SlNNWELL V, HISATSUNE K, RIETSCHELET: C h e m i c a l Structure of the Carbohydrate Backbone of Vibrio-parahaemolyticus Serotype-012 L i p o p o l y s a c c h a r i d e . E u r J Bfochem 1991, 200:6894598. KOST J, LANGER R: R e s p o n s i v e P o l y m e r S y s t e m s f o r C o n t r o l l e d D e l i v e r y o f T h e r a p e u t i c s . Trends Biotechnol 1992, 10:12%131. LIU FY, K~LDSIGDO, MITRA AK: I n s u l i l l A g g r e g a t i o n i n A q u e o u s M e d i a a n d Its Effect o n AlphaChymotrypsin-Medlated Proteolytic Degradation. Pharm Res 1991, 8:925-929. I~uJ, FAI~MERJD, LANE WS, FPdEDMANJ, WEISSMANI, SCHRFJBER SL: C a l c t n e u r i n is a C o m m o n T a r g e t o f C y c l o p h i l i n - C y e l o s p o r i n - A a n d FKBP-FKS06 C o m p l e x e s . Cell 1991, 6 6 : 8 0 7 4 1 5 . MAR'I3NJL, VELURAJAK, ROSS K, JOHNSON LN, PLEET GWj, RAMSDEN NG, BRUCE I, ORCHARD MG, OIKONOMAKOS NG, PAPAGEORGIOU AC, INONXDASDD, TSITOURA HS: G l u c o s e A n a l o g u e I n h t b i t o r s o f G l y c o g e n Phosphorylase - the Design of Potential Drugs f o r D i a b e t e s . BiochemiStry 1991, 30:10101-10116. MCDONALD JJ, BROOKS CL: T h e o r e t i c a l A p p r o a c h t o D r u g D e s i g n . 2. Relative T h e r n l o d y n a m i c s o f Inhibitor Binding by Chicken Difiydrofolate Reductase to Ethyl Derivatives of Trimethoprim S u b s t i t u t e d at 3'-Pusifion, 4 ' - P o s i t i o n , A n d 5'P o s i t i o n . J A m Chem Soc 1991, 113:2295-2301. MCDONALDJJ, BROOKS CL: A T h e o r e t i c a l A p p r o a c h to D r u g D e s i g n . 3. Relative T h e r m o d y n a m i c s o f I n h i b i t o r B i n d i n g b y EoColi D i h y d r o f o l a t e Reductase to Ethyl Derivatives of Trimethoprim S u b s t i t u t e d at t h e 3'-Position, 4'-Position, A n d 5'P o s i t i o n . J A m Chem Soc 1992, 114:206~2072. METZENBAUM HM: P o o r Little R i c h D r u g s . Biotechnology 1992, 10:464. MORRIS DI, SPEICtlER LA, RUOHO AE, TEW KD, SEAMONKB: Interaction of Forskolin with the P-Glycoprotein M u l t i d r u g T r a n s p o r t e r . Biochemistry 1991, 30:8371-8379. MOSES MA, LANGER R: I n h i b i t o r s o f A n g i o g e n e s i s . Biotechnolog22 1991, 9:63C~63d. NACLERIO RM: D r u g T h e r a p y : A l l e r g i c R h i n i t i s . N E n g l J ivied 1991, 325:86(~869.

753

754

Pharmaceutical applications Cancer therapy NANAVATISM, SILVEPaMANRB: M e c h a n i s m s o f I n a c t i v a t i o n of Gamma-Aminobutyric Acid Aminotransferase b y t h e A n t i e p l l e p s y D r u g G a m m a - V i n y l GABA ( V i g a b a t r i n ) . J A m Chem Soc 1991, 113:9341-9349. NEDER KM, WtlI1ZOCK lIX~: I m p o r t a n c e o f H y d r o g e n Bond Acceptor Ability in Design of Host Molecules Capable of Molecular Recognition. J A m Chem Soc t990, 112:9412-9414. NEIDLE S: M i n o r - G r o o v e W i d t h a n d A c c e s s i b i l i t y i l l BDNA D r u g a n d P r o t e i n C o m p l e x e s . FEBS Lett i992, 298:97-99. NGLWEN Q, IauJ, ROUGHLEY l~J, MORT JS: L i n k P r o t e i n as a M o n i t o r I n s i t u o f E n d o g e n o u s P r o t e o l y s i s i n A d u l t H u m a n ArticuLar C a r t i l a g e . Bioch£ym J 1991, 278:143 147. NUNN CM, VAN MEERVELTL, ZHA~'G S, MOORE MH, KE.'~'ARD O: D N A - d r u g I n t e r a c t i o n s . T h e C r y s t a l S t r u c t u r e s o f D(TGTACA) a n d D(TGATCA) C o m p l e x e d w i t h D a u n o m y c i n . J Mol Bio11991, 222:167 177. PIKAL MJ, DELLERMANKM, ROY ML, I~IGGIN RM: T h e Effects of Formulation Variables on the Stability of F r e e z e - D r i e d H u m a n G r o w t h H o r m o n e . Pharra Res 1991, 8 : 4 2 7 ~ 3 6 . POGNONEC P, ROEDER RG: R e c o m b i n a n t 4 3 - k D a USE B i n d s t o DNA a n d A c t i v a t e s T r a n s c r i p t i o n I n a Manner Indistinguishable from that of Natural 4 3 / 4 4 - k D a USF. Mol Cell Biol 1991, 11:5125-5136. POUVELLE B, SPIEGEL R, HSIAO L, HOWARD RJ, MORRIS RL, THOMAS AP, TARASCHI TF: D i r e c t Access t o S e r u m M a c r o m o l e c u l e s b y I n t r a e r y t h r o c y t i c MaLaria Parasites. Nature 1991, 353:73-75. ROBER%BAUDOUYJ: M o l e c u l a r B i o l o g y f o r E r w i n a : f r o m Soft-rot to A n t i l c u k a e m i c s . Trends Biotechnol 1991, 9:325. ROBINSON DR, GULL K: B a s a l B o d y M o v e m e n t s as a Mechanism for Mitochondrial Genome S e g r e g a t i o n i n t h e T r y p a n o s o m e Cell Cyc l e [Letter]. Nature 1991, 352:731-732. ROQb~S PETAL.: N e o n a t a l D i a g n o s i s o f H l V I n f e c t i o n [Letter]. Lancet 1991, 338:631. SARAGOVI HU, ET AL.: Loops a n d S e c o n d a r y S t r u C t u r e Mimctics: Development and Application In Basic S c i e n c e a n d R a t i o n a l D r u g D e s i g n . Btotechnology 1992, 10:773-778. SCHULTE D, KNIPPERS R, I)REIER T, PROBST G, PROBST H: C y c l o h e x i m i d e I n h i b i t s C e l l u l a r , B u t n o t SV40, D N A R e p l i c a t i o n . FEBS Lett 1992, 299:149-154. SEARSJE, FIKRIG E, NAKAGAWATY, DEPONTE K, MARCAN~rONION, KANTOR FS, FLAVRELRA: M o l e c u l a r Mapping of Osp-A Mediated Immunity Against Borrelia-burgdorferi, the Agent of Lyme Disease. J lmmuno11991, 147:1995-2000. SINGER D, BIEL M, LOTAN I, FLOCKERZIV, HOFMANrN E, DASCAL N: T h e R o l e s o f t h e S u b u u l t s i n t h e F u n c t i o n o f t h e C a l c i u m c h a n n e L Science 1991, 253:1553-1557. SLUZKYV, TAMADAJA, Y~LIBANOVAM, LANGER R: Kinetics of Insulin Aggregation in Aqueous Solutions Upon Agitation In the Presence of H y d r o p h o b t c S u r f a c e s . Proe Nall A c a d Sci U S A 1991, 88:9377-9381. STEI~'~ PS: P r e d i c t i n g A n t i g e n i c Sites o n P r o t e i n s . Trends Biotechno11991, 9:163-168. SU~PERSAXOA, HRIN WR, STEFFEN H: M i x e d M i c e l l e s as a Proliposomal. Lymphotropic Drug Carrier. Pharm Res 1991, 8:1286-1291. TARASlUKJ, GARNIERSUILLEROTA: K i n e t i c P a r a m e t e r s f o r the Uptake of Anthracycline by Drug-Resistant a n d D r u g - S e n s i t i v e K 5 6 2 Cells. E u r J Biochem 1992, 204:693~598. "PRIGLIA T, FOOTE SJ, KEMP DJ, COWMAN AF: I m p l i c a t i o n of the Multidrug Resistance Gene Pfmdrl i n P l a s m o d i u m - F a l c i p a r u m H a s A r i s e n as M u l t i p l e I n d e p e n d e n t E v e n t s . Mol Cell Bio11991, 11:5244-5250. VERA JC, CAS~ILLOGR, ROSEN OM: A P o s s i b l e R o l e f o r a M~mmaHan Facilitative Hexose Transporter in t h e D e v e l o p m e n t o f R e s i s t a n c e t o D r u g s . Mol Cell Biol 1991, 11:3407-3418. VONGRAFENSTEINH, BORGES R, KNIGHT DE: T h e Effect o f Botulinum Toxin Type-D on the Triggered and C o n s t i t u t i v e E x o c y t o s i s E n d o c y t o s i s Cycles i n C u l t u r e s o f B o v i n e A d r e n a l M e d u l l a r y Cells. FEBS Lett 1992, 298:118-122. WADA R, ttYON SH, NAKAMURA"1; IKADA Y: I n v i t r o Evaluation of Sustained Drug Release from B i o d e g r a d a b l e ELastomer. P h a r m Res 1991, 8:1292-1296. WALSH C, BRADLEYM, NADEAU K: M o l e c u l a r S t u d i e s on Trypanothione Reductase, a Target for A n t i p a r a s i t i c D r u g s . Trends B iochem Sci 1991, 16:305-309. WILLIMANN HL, LUISI PL: L e c i t h i n O r g a n o g e i s as M a t r i x f o r t h e T r a n s d e r m a l T r a n s p o r t o f D r u g s . Biocbem Biophys Res C o m m u n 1991, 177:897-900.

WOLFF EA, ESSELSTYNJ, MALONEY G, RAW I-{V: H u m a n M o n o c l o n a l A n t i b o d y H o m o d i m e r s - Effect o f Valency on Invttro and Invivo Antibacterial Activity. J l m m u n o 1 1 9 9 2 , 148:2469 2474. WONG S, FREEMANJD, KELLEI~gR C, MAGER D, TAKEI F: Ly-49 M u l t i g e n e F a m i l y - N e w M e m b e r s o f a Superfamily of Type-H Membrane Proteins w i t h Lectin-Like D o m a i n s . J l m m u n o 1 1 9 9 1 , 147:1417-1423. WOOLF AD, SMITH TW, LOVFJOY FH JR: T h e u s e o f D i g o x i n - s p e c i f i c F a b F r a g m e n t s f o r Severe D i g i t a l i s I n t o x i c a t i o n i n C h i l d r e n . N EnglJ M e d 1992, 326:1739-1744. WU CT, BUDDING M, GRIFFIN MS, CROOP JM: I s o l a t i o n and Characterization of Drosophila Muhidrug R e s i s t a n c e G ~ n e H o m o l o g s . Mol Cell Biol 1991, 11:3940 3948. YARCHOAN R, PLLTJAJM, PERNO C F, MITSUWAH, BRODER S: A n t i - r c t r o v i r a l T h e r a p y o f H u m a n Immunodcficiency Virus Infection: Current S t r a t e g i e s a n d C h a l l e n g e s f o r t h e F u t u r e . Blood 1991, 78:859-884. ZH~NG ZY, REARDON IM, HU1JO, OCONNELL KL, POOP~MAN RA, TOMASSELLIAG, HEINRIKSON RL: Z I n c i n h i b i t i o n of Renin and the Protease from Human I m m u n o d e f i c i e n c y V i r u s Type-1. Biochemistry 1991, 30:8717-8721.

Cancer therapy ACKERSTEINA, KEDAR E, SLAVINS: U s e o f R e c o n l b i n a n t Human Interleukin 2 in Conjunction with Syneniee Bone Marrow Transplantation in Mice as a M o d e l f o r C o n t r o l o f M i n i m a l R e s i d u a l Disease in Malignant Hematologic Disorders. Blood 1991, 78:1212-1215. AOKI Y, TAKAKL,W/AK, KODAMA S, TANAKA K, TAKAHASHI M, TOKUNAGA A, TAKAHASHIT: U s e o f A d o p t i v e Transfer of Tumor-Infiltrating LymphoeTtes Alone or in Combination with CisplatinContaining Chemotherapy in Patients with E p i t h e l i a l O v a r i a n C a n c e r . Cancer Res 1991, 51:1934-1939. ARIGA ~i; YOSHtDA K, NEMOTO K, SEK1 M, ~YATANI N, YU I~: Glycolipid Changes in Murine Myelogenous L e u k e m i a s - N e u t r a l G l y c o l i p i d s as M a r k e r s f o r S p e c i f i c P o p u l a t i o n s o f L e u k e m i a s . Biochemistry 1991, 30:7953-7961. BAMIAS A, KEANE P, KRAUSZT, WILLIAMS G, EPEN~ETOS AA: I n t r a v e s i c a l A d m i n i s t r a t i o n o f R a d i o l a b e l e d Antitumor Monoclonal Antibody In Bladder C a r c i n o m a . CancerRes 1991, 51:724-728. BARLOGIE B: T o w a r d a C u r e f o r M u l t i p l e M y e l o m a ? [Editorial]. N E n g I f M e d 1991, 325:130/>1305. BELLACOSA A, TESTA JR, STAALSP, TSICHLISPN: A R e t r o v i r a l O n c o g e n e , Akt, E n c o d i n g a SerineT h r e o n i n c K i n a s e C o n t a i n i n g a n SH2-Like R e g i o n . Science 1991, 254:27+-277. BELLON SF, COLEMANJH, LIPPARD SJ: D N A U n w i n d i n g P r o d u c e d b y Site-Specific I n t r a s t r a n d C r o s s - L i n k s o f t h e A n t i t u m o r D r u g CISD i 2 m m i ~ e d i c h i o r o p l a t i n u m ( H ) . Biochemistry 1991, 30:802(:-8035. BIAS1 G, FACCHINETI1A, PANOZZO M, ZANOVELLOp, C~ECOBIANCHI L, COLLAVOD: M o l o n e y M u r i n e Leukemia virus Tolerance in Anti-CD4 M o n o c l o n a l A n t i b o d y - T r e a t e d A d u l t Mice. J I m m u n o 1 1 9 9 1 , 147:2284-2289. BOJANOWSKI K, LELIEVRE S, MARKOVITSJ, COUPRIE J, JACQUEMINSABLONA, IARSEN AK: S l l r a l ~ l isaan I n h i b i t o r o f DNA T o p o i s o m e r a s e - l l I n v i t r o a n d i n C h i n e s e H a m s t e r F i b r o s a r c o m a Cells. Proc Natl A c a d Sci U S A 1992, 89:3025-3029. BOURINBAIAR AS, NAGOP~NYR, TAN X: P r e g n a n c y Hormones, Estrogen and Progesterone, Prevent HIV-1 S y n t h e s i s i n M o n o c y t e s But n o t i n L y m p h o c y t e s . FEBS I.ett 1992, 302:206-208. BOIYlIN JA, CLARENCJP, FERRY G, ERNOULD AP, REMOND G, VINCENT M, ATASSI G: N - M y r ~ t o y l - T r a n s f e r a ~ e Activity i n C a n c e r Cells - S o l u b i l l z a t i o n , S p e c i f i c i t y a n d E n z y m a t i c I n h i b i t i o n o f a NM y r t s t o y l T r a n s f e r a s c f r o m L1210 M i c r o s o m e s . B u r J B i o c h e m 1991, 201:257-263. BRANDTCARLSONC, BbTEL JS: D e t e c t i o n a n d Characterization of a Glycoprotein Encoded by the Mouse mamma*'y Tumor Virus Long Terminal R e p e a t G e n e . J Vtro11991, 65:6051~5060. BRINKMAN'N U, pal LH, EITZGERALD DJ, WILLINGH~M M, P&STAN I: B3(Ev)-PE38KDEL, a S i n g l e - C h a i n Immunotoxin that Causes Complete Regression o f a H u m a n C a r c i n o m a i n Mice. Proc Naa A c a d Sci U S A 1991, 88:861(~8620. BRISSINCK,J, DI~M&NV71C, MOSRR M, LEO O, ~FHIELEMANS K: T r e a t m e n t o f Mice B e a r i n g BCL1 L y m p h o m a

w i t h Btspecific A n t i b o d i e s . J l m m u n o l 1991, 147:4019~i026. BUCHN'ER T, I~IDDEMANN W, KOENtGSMANNM, ZUHLSDORF M, WORM&NN B, BOECICMANNA, FREIRE EA, INNIG G, MASCHMEYERG, LUDWIG XXgD,SAU~RLANDMC, HEINECKE A~ SCHULZ G: R e c o t u b i n a t l t HuLtnan Granulocyte Macrophage Colony Stimulating F a c t o r a f t e r C h e m o t h e r a p y i n P a t i e n t s w i t h Acute M y e l o i d L e u k e m i a at H i g h e r Age o r a f t e r R e l a p s e . Blood 1991, 78:1190-1197. BUCK MR, KARUSTISDG, DAY NA, HONN KV, SLO&'CE BF: Degradation of Extracelinlar-Matrix Proteins by Human Cathepsin-B from Normal and Tumour T i s s u e s . B i o c h e m J 1992, 282:273-278. BUCKLEY RH, SCHIFF RI: D r u g T h e r a p y -the use of Intravenous lmmune Globulin in I m m u n o d e f i e i e n c y D i s e a s e s . NEng, l J M e d 1991, 325:110-117. BUKOWSKI RM, SERGIJS, SHARFM2LNWJ, BLrDD GT, ML~RTHY S, BARNA B, MEDENDORP SV, YENLIEBERMANB, GIBSO,X V, BAUER L, VALI~ZUELA R: P h a s e - I T r i a l o f N a t u r a l Human Interferon-beta in Metastatic Malignancy. CancerRes 1991, 51:836-840. BUKOWSKI RM, SHARFMANW, MURTHY S, RAYMAN P, TUBBS R, ALEXANDERJ, BUDD GT, SERGIJS, BAUER L, GIBSON V, STANLEYJ, BOYETr J, PON~FESE, FINKE J: C l i n i c a l R e s u l t s a n d C h a r a c t e r i z a t i o n of Tumor-Infiltrating Lymphocytes with or Without RecombInant Interleukin-2 in Human M e t a s t a t i c R e n a l C e l l C a r c i n o m a . C a n c e r R e s 1991, 51:4199-4205. CARTER P, PRESTA L, GORMAN CM, RIDGWAYJBB, HENNER D, WONG WLT, ROWLAND AM, KOTTS C, CARVER ME, SHEPARD HM: H u m a n i z a t i o n o f a n A n t i - p 1 8 5 H F ~ 2 A n t i b o d y f o r H u m a n C a n c e r T h e r a p y . Proc Natl A c a d Sci U S A 1992, 8 9 : 4 2 8 5 4 2 8 9 . CHANG GG, WANG JK, HUANG TM, LEE HJ, CHOU WY, MENG CL: P u r i f i c a t i o n a n d C h a r a c t e r i z a t i o n o f t h e Cytosollc NADP+-Dependent Malic Enzyme from H u m a n B r e a s t C a n c e r Cell Line. E u r J Biochem t991, 2 0 2 : 6 8 1 ~ 8 8 . CHARI RVJ, MARTELLBA, GROSS JL, COOK SB, SHAH SA, BLATI"LERWA, MCKENZlE SJ, GOLDMACHER VS: I m m u n o c o n j u g a t e s C o n t a i n i n g N o v e l Maytansinoids - Promising Anticancer Drugs. CancerRes 1992, 52:127-13i. C'HIZZONrlTER, TRUITT T, PODLASKI FJ, WOLITZKY AG, QL~NN PM, NLrNES P, STERN AS, GATELy MK: EL-12 Monoclonal Antibodies Specific for the 40-kDa Subunit Block Receptor Binding and Biologic Activity o n A c t i v a t e d H u m a n L y m p h o b l a s t s . J I m m u n o 1 1 9 9 1 , 147:1548-1556. C o x AD, HlSAKA MM, BUSS JE, DER CJ: S p e c i f i c I s o p r e n o i d M o d i f i c a t i o n is R e q u i r e d f o r F u n c t i o n o f N o r m a l , B u t n o t O n c o g e u l c , Ras P r o t e i n . Mol Cell Bio11992, 12:2606-2615. DAAR I, NEBREDAAN, YEW N, SASS P, PAULES R, SANTOS E, WIGLER M, VANDE\VOUDE GF: T h e Ras O n c o p r o t e i n a n d M - P h a s e Activity. Science 1991, 253:74--76. DALEY GQ, VtO~L*YIIeNRA, BALTIMORE D: m a s t C r i s i s i n a Murine Model of Chronic Myelogenous Leukemia. Proc N a d A c a d Sci U S A 1991, 88:11335 11338. DAMASIO EE, RESEGOTII L, CAPN]ST G, FEDERICO M, IVOA R, FRANCIA 13, LAMPARELLIT: H a i r y Cell L e u k e m i a -Splenectomy after Alpha-Interferon Therapy [Letter]. Blood 1992, 79:1381. DAVIDSON BS, MOLINSKI TE, BARROWS LR, IRELAND CM: Varacin - a Novel Benzopeotathiepin from L i s s o c l t n u m - V a r e a u t h a t is C y t o t o x i c T o w a r d a H u m a n C o l o n T u m o r . J A m Chem Soc 1991, 113:4709-4710. DE VRIES EGE, AND OTHERS: F l a r e U p o f R h e u m a t o i d A r t h r i t i s D u r i n g GM-CSF T r e a t m e n t a f t e r C h e m o t h e r a p y [Letter]. Lancet 1991, 338:517. DECLERCK YA, YEAN ~ ) , ('MAN D, SHIMADAI'I, LANGLEY KE: I n h i b i t i o n o f T u m o r I n v a s i o n o f S m o o t h Muscle Cell Layers by Recombinant Human M c t a l l o p r o t e i n a s e I n h i b i t o r . CancerRes 1991, 51:2151-2157. DEFRANCE T, FLUCYdGERA-C, ROSSIJ F~ MAGAISDJ-P, SOTFO J-J, BANCHEREAUJ: A n t i p r o l i f e r a t i v e Effects o f Interleukin-4 on Freshly Isolated Non-Hodgkin M a l i g n a n t B - l y m p h o m a Cells. Blood 1992, 79:990-996. DEMtCHELI C, ALBERTI1WIJP, GARNIERSUILLEROTA: Interaction of Mithramycin with DNA - Evidence t h a t M i t h r a m y c I n B i n d s to DNA as a D i m e r i n a R i g h t - H a n d e d S c r e w C o n f o r m a t i o n . E u r J Biochem 1991, 198:333-338. DEVINE PL, CLARKBA, BIRRELL GW, LAYFON GT, WARD BG, ALEWOOD PF, McKENZIE IFC: T h e Breast Tumor Associated Epitope Defined by M o n o c l o n a l A n t i b o d y 3E1.2 is a n O L i n k e d M u c i n carbohydrate Containing N Gylcolyineuraminic Acid. Cancer Res 1991, 51:5826-5836.

Pharmaceutical applications Cancer therapy DHONDT JL, t IAY~I~IJM, MILLOT F, KLEIN R, BLA]SJC, PFLEIDEKER W: 2 , 4 - D i a m i n o - 7 - H y d r o x y - P t e r i d i n e s , a New Class of Catabolites of Mcthotrexate. EurJ Biochem 1991, 200:23%244. EARLY BREAST C&NCERTRIALISTS' COLLABORATIVEGROUP: Systemic Treatment of Early Breast Cancer by H o r m o n a l . Cytotoxic, o r I m m u n e T h e r a p y - 133 R a n d o m i s e d Triads I n v o l v i n g 31,000 R e c u r r e n c e s a n d 2 4 , 0 0 0 Deaths A m o n g 75,000 W o m e n . 1.. Lancet 1992, 339:1-14. EARLY BREAST CANCERTRIALISTS'COLLABORATIVEGROL~P: Systemic Treatment of Early Breast Cancer by H o r m o n a l , Cytotoxic, o r I m m u n e T h e r a p y . Lancet 1992, 339:71-84. EDGINGTON SM: Taxol: O u t o f t h e Woods. Biotechnology ]991, 9:933-940. EDGINGTON SM: C o n q u e r i n g M u l t i d r u g R e s i s t a n c e i n C a n c e r C h e m o t h e r a p y . Biotecbnology 1992, 10:269-270. EGHBALI B, KESSLERJA, REID LM, ROY C, SPRAYDC: I n v o l v e m e n t o f Gap J u n c t i o n s i n T u m o r i g e n e s i s - Transfection of Tumor Cells w i t h C o n n e x i n - 3 2 CDNA R e t a r d s G r o w t h I n v i v o . Proc Natl A c a d Sci U S A 1991, 88:10701-10705. ENGELHARDT R, MACKENSENA, GALANOS C: Phase-I Trial of Intravenously Administered Endotoxin (SalmonelLa-Abortus-Eqni) in Cancer Patients. Cancer Res 1991, 51:2524-2530. EP~NSTOFFMS, GOODING W, NAIR S, BAHNSON RR, MIKE'I~C LM, BANNER B, DAY R, WHITESlDE T, TITUSEKNSTOFFL, KIRKWOOD JM: I m m u n o l o g i c a l Effects o f T r e a t m e n t with Sequential Administration of Recombinant Interferon-gnmmu and Interferon-alpha in P a t i e n t s w i t h Metastatic R e n a l Cell C a r c i n o m a D u r i n g a Phase-I TriaL Cancer Res 1992, 52:851-856. ESTROV Z, KD~RZROCKR, ESTEY E, WETZLERM, FERR&JOLI A, HARRIS D, BLAKEM, GUT~KM&N JU, TALPAZ M: I n h i b i t i o n o f Acute M y e l o g e n o u s L e u k e m i a B l a s t P r o l i f e r a t i o n b y i n t e r l e u k i n - 1 (EL-l) R e c e p t o r A n t a g o n i s t a n d S o l u b l e EL-1 R e c e p t o r s . Blood 1992, 79:1938-1945. EWEL CH, UPdBAXX0, KOPP WC, SMI~-I JW, STEIS RG, ROSSIO JL, LONGO DL, JONES MJ, ALVORDWG, PINSKY CaM, BEVERIDGEJM, MC~X~TTKL, CREEKMORESP: P o l y i n o s i n l c - P o l y c y t i d y l i c Acid C o m p l e x e d w i t h Poly-L-lysine a n d C a r b o x y m c t h y l c e l l u l o s e i n C o m b i n a t i o n w i t h I n t e r l e u k i n - 2 i n Pat i e nt s w i t h C a n c e r - C l i n i c a l a n d I m n l u n o l o g i c a l Effects. C~ncer Res 1992, 52:3005-3010. FISHW1LD DM, ABERLE S, BEK~'HARD SL, KUNG AHC: E f f i c a c y o f a n Anti-CD7-Ricln-A C h a i n Immtmoconjugate in a Novel Murine Model o f H u m a n T-Cell L e u k e m i a . Cancer Res i992, 52:3056-3062. FOA R, GUAPdNI A, TOS AG, CARDONA S, FIERRO MT, MELON~ G, TOSTI S, MANDELLIF, GAVOSTO F: P e r i p h e r a l Blood and Bone Marrow Immunophenotypie a n d F u n c t i o n a l M o d i f i c a t i o n s I n d u c e d i n Ac ut e L e u k e m i a Patients T r e a t e d w i t h I n t e r i e u k i n - 2 E v i d e n c e o f Invivo L y m p h o k i n e Activated K i l l e r Cell G e n e r a t i o n . C~ancer Res 1991, 51:964-968. FREED E, HUNTER T: A 4 I - K i l o d a l t o n P r o t e i n is a Potential Substrate for the P210hcr-abl ProteinT y r o s i n e K i n a s e in C h r o n i c M y e l o g e n o u s L e u k e m i a Cells. Mol Cell Bio11992, 12:1312-1323. FRENCH RR, COURTENAYAE, INGAMELLSS, STEVENSONGT, GLENN1E MJ: C o o p e r a t i v e M i x t u r e s o f Bispecific F(ab')2 Antibodies for Delivering Saporin to L y m p h o m a I n v i t r o a n d Invivo, Cancer Res 1991, 51:2353-2361. GAO YG, VANDERMARELGA, VANBOOM JH, WgNG AHJ: M o l e c u l a r S t r u c t u r e o f a DNA D e c a m e r Containing an Anticancer Nucleoside Aa'abinosylcytosine - Conformational P e r t u r b a t i o n b y A r a b i n o s y l e y t o s i n e i n B-DNA. Biochemistry 1991, 30:9922-9931. GARCIA M, SEIGNER C, BASTID C, CHOUX R, PAYAN Mj, REGGIO H: Carcinoell~thr~ronic A n t i g e n H a s a Different Molecular Weight in Normal Colon a n d I n C a n c e r Cells D u e t o N - G l y c o s y l a t i o n D i f f e r e n c e s . CancerRes 1991, 51:5679-5686. GELB BD, ADAMS V, JONES SN, GRIFHN LD, MACGREGORGR, MCCABE ERB: T a r g e t i n g o f H e x o k i n a s e - 1 t o Liver a n d H e p a t o m a M i t o c h o n d r i a . Proc Natl A c a d .Ski U S A 1992, 89:202-206. GILLIES SD, REILLY EB, LO KM, KEISFELDPOX:A n t i b o d y T a r g e t e d I n t e r l e u k i n - 2 S t i m u l a t e s T-Cell K i l l i n g o f A u t o l o g o u s T u m o r Cells. Proc Natl Acad &:i U S A 1992, 89:1428-1432. GIVON T, SLAVINS, HARAN-GHERAN, MICHALEVICZR, REVEl. M: A n t i t u m o u r Effects o f H u m a n R e c o m b i n a n t I n t e r l e u k i n - 6 o n A cu te M y c l o i d L e u k e m i a i n Mice a n d i n C e l l Cultures. Blood 1992, 79:2392 2398. GLUCKMAN E, HOROWrrz MM, CHAMPLIN RE, HOWS JM, BACIGALUPO A, BIGGS JC, CAMITTABM, GALE RP, GORDONSMITH EC, MARMONT AM, MASAORAT, RAMSAY .N-KC, RIMM AA, ROZMAN C, SOBOCINSK] KA, SPECK

BORTIN MM: B o n e M a r r o w T r a n s p l a n t a t i o n for Severe Aplastic Anemia - Influence of Conditioning and Grail-Versus-Host Disease P r o p h y l a x i s R e g i m e n s o n O u t c o m e . Blood 1992, 79:269-275. GODDARD AD, BORROW J, FREEMON~rPS, SOLOMON E: Characterization of a Zinc Finger Gene Disrupted by the T(15,17) in Acute Promyelocytic Leukemia. Science 1991, 254:1371-i374. GODWIN AK, MEISTERA, ODWYER PJ, HUANG CS, HAMIUFON TC, ANDERSON M~: H i g h R e s i s t a n c e t o C i s p l a t i n i n H u m a n O v a r i a n C a n c e r Cell L i n e s is A s s o c i a t e d with Marked increase of Glutathione Synthesis. Proc Natl A c a d Sci U S A 1992, 89:3070-3074. GOLUMBEK PT, LAZENBY AJ, LEVITSKYH, JAFFEE L3d, KARASLWAMAH, BAKER M, PARDOLLDM: T r e a t m e n t of Estahllshed Renal Cancer by Tumor Cells E n g i n e e r e d t o S e c r e t e I n t e r l e u l d n - 4 . Science 1991, 254:713. GRAND RJA, OWEN D: T h e B i o c h e m i s t r y o f R a s P21. Biochem J 1991, 279:6094531. GROSSBARD MI., FREEDMANAS, RITZ J, CORM. F, GOLDMACHER VS, ELISEO"L, SPECTOR N, DEAR K, LAMBERTJM, BLATTERWA, TAYLORJA, NADLER LM: S e r o t h e r a p y o f B-cell N e o p l a s m s W i h Anti-B4blocked Ricin: a Phase I Trial of Daily Bolus I n f u s i o n . Blood 1992, 79:576 585. GULLICK WJ, BOTTOMLEY AC, LOFTS FJ, DOAK DG, MULVEY D, NEX~dN R, CRLrMPTONMJ, STERNBERGMJE, CAMPBELL ID: T h r e e D i m e n s i o n a l S t r u c t u r e o f t h e Transmembrane Region of the Proto Oncogene F o r m s o f t h e N c u P r o t e i n . EMBOJ 1992, 1 1 : 4 3 4 8 . GUNZBURG W I t , S A L M O N S B : F a c t o r s C o n t r o l l i n g t h e Expression of Mouse Mammat'y Tumour Virus. Biochem J 1992, 283:625@32. HAGIWARA A, TAKAHASHIT, KOJIMA O, SAW~ K, YAMAGUCHI T, YAMANE T, TAN~GUCHIH, KITAMURAK, NOGUCFE A, SEIKI K, SAKAKURAC: P r o p h y l a x i s w i t h Carbon-adsorhed Mitomycin Against Peritoneal R e c u r r e n c e o f G a s t r i c C a n c e r . Lancet 1992, 339:629-631. HANCOCK MC, LANGTON BC, CHKN T, TOY P, MONAHAN JJ, MASCHAKRP, SHAWVERLK: A M o n o c l o n a l A n t i b o d y A g a i n s t t h e C-erbB-2 P r o t e i n E n h a n c e s t h e Cytotoxicity of Cis-D~ammlnedichloroplatinum A g a i n s t H u m a n B r e a s t a n d O v a r i a n T u m o r Cell Lines. CancerRes 1991, 51:4575~4580. HANSK[ C, SHEEHANJ, KIEI~NTOPF M, STOLZEB, STEIN H, KIECKEN EO: i n c r e a s e d N u m b e r o f A c c e s s i b l e S u g a r E p i t o p e s D e f i n e d w i t h M o n o c l o n a l A n t i b o d y AM3 o n C o l o n i c M u c i n s is A s s o c i a t e d w i t h M a l i g n a n t T r a n s f o r m a t i o n o f C o l o n i c i u e o s a . Cancer Res 1991, 51:5342 534% HAREUVENI M, WRESCHNER DH, KIENY MP, DOTT K, GALrlIER C, TOMASET]?OC, KEYDAR I, CHAMBONP, LATHE R: VaccinLa R e e o m b i n a n t s E x p r e s s i n g S e c r e t e d and Transmcmbranc Forms of Breast CancerA s s o c i a t e d E p i t h e l i a l T u r n o u t A n t i g e n (ETA). Vaccine 1991, 9:618~626, HARKER WG, SLADE DL, DBAKE FH, PARR RL: M i t o x a n t r o n e R e s i s t a n c e i n HL-60 L e u k e m i a Cells - Reduced Nuclear Topoisomerase-H Catalytic Ac t i vi t y a n d D r u g - i n d u c e d DNA C l e a v a g e i n Association with Reduced Expression of the T o p o i s o m e r a s e - I I B c t a - I s o f o r m . Biochemistry 1991, 30:9953-9961. HATANO M, ROBERTS CWM, MINDEN M, CRIST WM, KORSMEYER 8J: D e r e g u l a t i o n o f a H o m e o b o x Gene, H O X l l , b y t h e T ( 1 0 - 1 4 ) i n T-Cell L e u k e m i a . Science 1991, 253:79-82. IIAUSEN HZ: V i r u s e s i n H u m m a C a n c e r s . Science 1991, 254:1167-1173. HENDERSON BE, ROSS RK, PIKE MC: T o w a r d t h e P r i m a r y P r e v e n t i o n o f C a n c e r . Science 1991, 254:1131-1138. HERMANN GG, GEERTSEN PF, VONDERMAASEH, STEVEN K, ANDERSEN C, HALD T, ZEUqTIENj: R e c o m b i n a n t Interleukin-2 and Lymphokine-Activated Killer Ceil Treatment of Advanced Bladder Cancer - c l i n i c a l R e s u l t s a n d I m m u n o l o g i c a l Effects. CancerRes 1992, 52:726--733. HOLLSTEIN M, SIDRANSKYD, VOGELSTEINB, HARRIS CC: p 5 3 M u t a t i o n s I n H u m a n C a n c e r s . Science 1991, 253:49-53. HLq3ER BE, PdCI4ARDS CA, KRENITSKYTA: R e t r o v i r a l mediated Gene Therapy for the Treatment of Hepatocellular Carcinoma: an Innovative A p p r o a c h f o r C a n c e r T h e r a p y . Proc Natl A c a d Sci U S A 1991~ 88:8039-8043. HL~X~TERT, PINES J: C y c l l n s a n d Cancer. Cell 1991, 66:1071 1074. IIJLMA S, TERAOKA H, DATE T, TSLT.ADAK: DNA-Activated P r o t e i n K i n a s e i n B u r k i t t , R a j i L y m p h o m a CeLls - P h o s p h o r y l a t i o n o f C-Myc O n c o p r o t e i n . E u r J Biochem 1992, 2 0 6 : 5 9 5 ~ 0 3 . ITO T, QIU H, COLLINSJA, BRILL AB, JOHNSON DK, GRIFHN TW: P r e c l i n i c a l A s s e s s m e n t s o f Y-90-Labeled C I I 0 Anti- C a r c i n o e m b r y o n i c A n t i g e n I m m u n o t o x i n B,

a Therapeutic Immunoconjugate for Human C o l o n Cancer. Cancer Res 1991, 51:255~260. JANSEN B, VALLERADA, JASZCZ WB, NGUYEN D, KERSEY JH: S u c c e s s f u l T r e a t m e n t o f H u m a n Acute TCell L e u k e m i a i n SCID Mice U s i n g t h e Anti-CD7D e g l y c o s y l a t e d R i c i n A - C h a i n I m m u n o t o x i n Da7. CancerRes 1992, 52:1314-1321. JENSEN PB, JENSEN PS, DF~Vt~'T EJF, FRICHE E, SORENSEN BS, SEHESTEDM, WASSERMANNK, VINDELOVL, WESTERGAARD O, IIANSEN HH: A n t a g o n i s t i c Effect o f AcLarubicln o n D a u n o r u b i c i n - I n d u c e d C y t o t o x i c i t y i n H u m a n S m a l l Cell L u n g C a n c e r Cells - R e l a t i o n s h i p t o DNA i n t e g r i t y a n d T o p o i s o m e r a s e - H . Cancer Res 1991, 51:5093-5099. KASPREYK PG, SONG SU, DIFIORE Pp, KING CR: T h e r a p y of an Animal Model of Human Gastric Cancer U s i n g a C o m b i n a t i o n o f Anti-erbB-2 M o n o c l o n a l A n t i b o d i e s . Cancer Res 1992, 52:2771-2776. KENNEL SJ: Effects o f T a r g e t A n t i g e n C o m p e t i t i o n o n D i s t r i b u t i o n o f M o n o c l o n a l A n t i b o d y to S o l i d T u m o r s . Cancer Res 1992, 52:1284-1290. KILL&'~ PL, KAFFKAKL, BIONDI DA, LIPMANJM, BENJAMIN X~fR, FELDMAN D, CAMPEN CA: A n t i p r o l i f e r a t i v e Effect o f l n t e r l e u k i n - 1 o n H u m a n O v a r i a n C a r c i n o m a Ceil Line (NIH:OVCAR-3). Cancer Res 1991, 51:1823-1828. KLEIN B, WIJDENESJ, ZHANG XG, JOURDAN M, BOIRON JM, BROCHIERJ, LIATARDJ, MERLIN M, CLI~MENTC, MOREL FOURNIER B, LLI ZY, MAN.ONE P, SANYJ, BATAILLER: Murine Anti interleukin 6 Monoclonal Antibody T h e r a p y f o r a P a t i e n t w i t h P l a s m a Cell L e u k e m i a . Blood 1991, 78:1198-1204. KLUGE M, ELGER B, ENGEL T, SCHAEFERC, SEEGAJ, VAUPEL P: Acute Effects o f T u m o r N e c r o s i s Factoralpha or Lymphotoxin on Global Blood Flow, L a s e r D o p p l e r F l u x , a n d B i o e n e r g e t i c Status o f S u b c u t a n e o u s R o d e n t T u m o r s . Cancer Res 1992, 52:2167-2173. KOLLER E ETAL.: R e s t o r a t i o n o f All-trans R e t i n o i c Acid S e n s i t i v i t y b y i n t e r f e r o n i n Acute P r o m y e l o c y t i c L e u k a e m i a [Letter]. Lancet 1991, 338:1154. KUNIMI K, BERGERHEIM USR, LARSSONIL, EICvIANP, COLLINS VP: A l l c l o t y p i n g o f H u m a n P r o s t a t i c A d e n o c a r c i n o m a . Genomics 1991, 11:530 536. LAZARO E, VANDENBROEK LAGM, FELIX AS, OTI~NHEIJM HCJ, BALLESTAJPG: B i o c h e m i c a l a n d K i n e t i c Characteristics of the interaction of the Antitumor Antibiotic Sparsomycin with Prokaryotic and Eukaryotic Ribosomes. Biochemistry 1991, 30:9642-9648. LAZARUSHIVe, ANDERSENJ, CHEN MG, VARIAKOJISD, MANSOUR EG, OETFE D, ARCE CA, OKEN MM, GERSON SL: R e c o m b i a l a n t G r a n u l o c y t e - m a e r o p h a g e C o l o n y - s t L m u l a r i n g F a c t o r after A u t o l o g o u s B o n e M a r r o w T r a n s p L a n t a t i o n f o r ReLapsed NonHodgkin's Lymphoma: Blood and Bone Marrow P r o g e n i t o r G r o w t h S t u d i e s : a P h a s e II E a s t e r n C o o p e r a t i v e O n c o l o g y G r o u p T r i a l Blood 1991, 78:830-837. LEBERTHON B, KHAWLI LA, ALAUDDIN M, MILLER GK, CHARAK BS, MAZUMDERA, EPSTEINAL: E n h a n c e d Tumor Uptake of Maeromoleeules Induced by a Novel Vasoactive Interleukin-2 Immunoconjugate. Cancer Res 1991, 51:2694-2698. LEONARD GA, BROWN T, HUNTER VJN: A n t h r a c y c l i n e B i n d i n g t o DNA - H i g h - R e s o l u t i o n S t r u c t u r e o f D(TGTACA) C o m p l e x e d w i t h 4 ' - E p i a d r i a m y c i n . E u r J B i o c h e m 1992, 2 0 4 : 6 ~ 7 4 . LETESSIEREM, HEO DS, OKARM~ T, JOHNSON"J~. HERBEI~MAN RB, WEIITESIDE TL: E n r i c h m e n t i n T u m o r - R e a c t i v e CD8+ L y m p h o c y t e s - T b y Positive S e l e c t i o n from the Blood and Lymph Nodes of Patients w i t h H e a d a n d N e c k C a n c e r . Cancer Res 1991, 51:3891 3899. LISTJ, MOSER RP, STEUER M, LOUDON WG, BLACKLOCKJB, GRIMM EA: C y t o k i n e R e s p o n s e s t o I n t r a v e n t r i c u l a r Injection of Interleukin-2 into Patients with Leptomeningeal Careinomatosis - Rapid induction of Tumor Necrosis Factor-alpha, I n t e r l e u k i n - l b e t a , Inter~eukin-6, G a m m a Interferon, and Soluble Interleukin-2 Receptor ( M r 5 5 , 0 0 0 - P r o t e i n ) . CancerRes 1992, 52:1i23-1128, LORD KA, ABDOLLAHt A, THOMAS SM, DEMARCO M, BRUGGE JS, HOFFMANLIEBERMANNB, LIEBERMANNDA: L e u k e m i a inhibitory Factor and Interleukin-6 Trigger the Same Immediate Early Response, Including Tyrosine Phosphorylation, Upon Induction of M y c l o i d L e u k e m i a D i f f e r e n t i a t i o n . Mol Cell Biot 1991, 11:4371~i379. *rViAGNUSP, LEW~S R, BENrN~ETfF: S y n t h e t i c a n d Mechanistic Studies on the Antitumor Antibiotics Esperamiein-A1 and Calicheamicin-gammal - O x i d a t i v e F u n c t i o n a l i z a t i o n o f T h e 13K e t o b i c y c l o < 7.3.1> T r i d e c e n e d i y n e C o r e S t r u c t u r e - C o n s t r u c t i o n o f t h e AllyHc T r i s u l f i d e T r i g g e r . J A m Chem Soc i992, 114:2560-2567. -

755

756

Pharmaceutical applications Cancer therapy ~kGNL'S P, STAMFORDA, LADI.OW M: S y n t h e s i s o f t h e Antitumor Bisindole Alkaloid Vinblaatine D i a s t e r e o s e l e c t i v i t y a n d S o l v e n t Effect o n t h e S t e r e o c h e m i s t r y o f t h e C r u c i a l C-15-C-18' B o n d . J A m Chem Soc 1990, 112:8210-8212. MAINE IP, SUN D, HLT.LEY LH, KODADEK T: T h e A n t i t u m o r A g e n t CC-1065 I n h i b i t s H e l l c a s e - C a t a l y z e d U n w i n d i n g o f D u p l e x DNA. Biochemistry 1992, 31:3968-3975. NLMONETE, GRAY GS, HUN~f AJ, SHARPE RJ: I n h i b i t i o n o f T u m o r G r o w t h i n Mice b y a n A n a l o g u e o f Platelet Facto r - 4 t h a t Lacks A f f i n i t y f o r H e p a r i n a n d R e t a i n s P o t e n t A n g i o s t a t i c Activity. Cancer Res 1991, 51:2077-2083. MAR/ H, SEKIGUCHI M: M u t t P r o t e i n S p e c i f i c a l l y H y d r o l y s e s a P o t e n t M u t a g e n i c S o b s t r a t e f o r DNA S y n t h e s i s [Letter]. Nature 1992, 355:273-274. MALINS De, HA]MANOT R: M a j o r A l t e r a t i o n s i n t h e Nucleotide Structure of DNA in Cancer of the F e m a l e Breast. Cancer Res 1991, 51:5430-5432. MASSON N, ELLIS M, GOODBOUKN S, LEE KAW: Cyclic AMP R e s p o n s e E l e m e n t - B i n d i n g P r o t e i n a n d t h e Catalytic S u b u n i t o f P r o t e i n K i n a s e - A a r e P r e s e n t i n F9 E m b r y o n a l C a r c i n o m a Cells B u t a r e U n a b l e to A ctiv ate t h e S o m a t o s t a t i n P r o m o t e r . Mol Cell Bio11992, 12:1096-1106. 1VbXTSL'IM, YOSHIMURA S, NAK&N1SHIT, FERRONE S: Effect o f T u m o r Size o n t h e E n h a n c e m e n t b y G a m m a Interferon of the Localization of Radiolabeled F(ab')2 Fragments of Antiintereelldiar Adhesion Molecule-1 Monoelonal Antibodies in Human C o l o n C a r c i n o m a Ceils G r a f t e d i n N u d e Mice. Cancer Res 1992, 52:1309-1313. MATrHEWS DC, BADGER CC, FISHER DR, HIN TE, NOUR/GAT C, APPELBAUM FR, MARTIN PJ, BERNSTEINID: Selective Radiation of Hematolymphoid Tissue Delivered b y A n t i - C D 4 5 A n t i b o d y . Cancer Res 1992, 52:1228-1234. MCIAUGHLIN ML, CRONANJM, SCHALLERTR, SN~ELLING RD: D N A M e t a l B i n d i n g b y A n t i t u m o r - A c t i v e Metalloeene Dichlorides from Inductively Coupled Plasma Spectroscopy Analysis T i t a n o c e n e D i c h l o r i d e F o r n l s D N A C p 2 T i o r DNA CpTi A d d u c t s D e p e n d i n g o n PH. J A m Chem Soc 1990, 112:8949-8952. MELCHIOR/ A, ALBINI A, RAY JM~ STETLR/~STEVENSONWG: I n h i b i t i o n o f T u m o r Cefi I n v a s i o n b y a H i g h l y Conserved Peptide Sequence from the Matrix M e t a l l o p r o t e i n a s e E n z y m e P r o s e g m e n L Cancer Res 1992, 52:2353-2356. MONNOT M, MAUFFRET O, LESCOT E, FERMANDJIAN S: Probing Intercalation and Conformational Effects o f t h e A n t i c a n c e r D r u g 2-Methyl-9H y d r o x y e l l i p t i c i n i u m Acetate i n D N A F r a g m e n t s w i t h C i r c u l a r D i c h r o i s m . E u r J Biochem 1992, 204:1035-1039. MLTO0 K, ROSENBLUMMG, MURRAYJL: A u g m e n t e d Binding of Radiolabeled Monoclonal Antibodies to M e l a n o m a Cells U s i n g S p e c i f i c A n t i b o d y C o m b i n a t i o n s . CancerRes 1991, 51:2768-2772. MLXUNDAN S, XU YH, ZON G, MARZILLI LG: H e t e r o n u c l e a r C-13-H-1 NMR I n v e s t i g a t i o n o f t h e Effects o n a n Ollgodeoxyribonucleotide of Intrastrand CrossL i n k i n g b y a Pt A n t i c a n e e r D r u g - a L a r g e S h i f i o f C3' A c c o m p a n i e s a n S - C o n f o r m a t i o n a l In NC o n f o r m a t i o n a l C h a n g e . J A m Chem Soc 1991, 113:3021-3027. MULEjj, CUSTER MC, TRAVISWD, ROSENBERGSA: C e l l u l a r M e c h a n i s m s o f t h e A n t i t u m o r Ac t i vi t y o f R e c o m b i n a n t I D 6 i n Mice. J Immuno11992, 148:2622-2629. MULSHIN~;JL, CARRASQL~LLOJA, WEINSTFANJN, KEENAN AM, REYNOLDSJC, HERDT J, BUNN PA, SAUSVILLEE, EDDY J, COTELINGAMJD, PERENWESISP, PINSKY C, LARSON SM: Direct Intralymphatic Injection of Radiolabeled I n - I l l - T 1 0 1 i n P a t i e n t s w i t h C u t a n e o u s T-Cell L y m p h o m a . Cancer Res 1991, 51:6884595. MURARO R, FRATI L, BEI R, FICAR/ F, VALLI C, FRENCH D, MAMMAREt~ S, CARAMIAF, FEGIZ G, MAR/ANICOSTANI1NIR: R e g i o n a l H e t e r o g e n e i t y and Complementation in the Expression of the Tumor-Associated Glycoprotein-72 Epitopes in C o l o r e c t a l C a n c e r . Cancer Res 1991, 51:5378-5383 NAKAMURAN, TSL~RUA, HIRAYOSHI K, NAGATA K: Purification and Characterization of a VimentinSpecific Protease in Mouse Myeloid Leukemia Cells - R e g u l a t i o n D u r i n g D i f f e r e n t i a t i o n a n d I d e n t i t y w i t h C a t h e p s i n - G . E u r J Bioctoem 1992, 205:947-954. NASSANDERUK, STEERENBERGPA, POPPE FI, S~ORM G, POETS LG, DEJONG Xy~I, CROMMELIN a J a : I n v i v o T a r g e t i n g o f OV-TL-3 l m m u n o l i p o s o m e s t o Ascitic O v a r i a n C a r c i n o m a Cells (OVCAR-3) i n A t h y m i c N u d e Mice. Cancer Res 1992, 52:646~53. NICOLAOU KC, MALIGRESP, SHIN J, DELEON E, RIDEOUT D: DNA C l e a v a g e a n d A n t i t u m o r Activity o f D e s i g n e d Molecules with Conjugated Phosphine Oxide-

Afiene-Ene-Yne F u o c t i o n a l l t i e s . J A m Cbem 5~c 1990, 112:7825 7826. ONG GL, ETI~NSON D, SHARKEYRM, MARKSA, BAU~tAL R, GOLDENBERG DM, MATTES MJ: G a l a c t o s e - C o n j o g a t e d Antibodies in Cancer Therapy - Properties and P r i n c i p l e s o f Action. CancerRes 1991, 51:1619-1626. OPALKA B~ WANDL UB, BECHER R, I4A.OKEO, NAGEL-HIEMKJd M, MOREIZ T, BEER U, SEEBER S, NIEDERLE N: M i r t | m ~ l Residual Disease in Patients with Chronic Myelogenous Leukemia Undergoing Long-term Treatment with Recombinant Interferon ~-2b A l o n e o r i n C o m b i n a t i o n w i t h I n t e r f e r o n Y- Blood 1991, 78:2188-2t93. PAGANELLI G, MAGNANI P, ZITO F, VILLAE, SUDATI F, LOPALCO L, ROSSETII C, MALCOVATIM, CHIOLER/O F, SECCAMAN~E ET AL.: T h r e e S t e p M o n o c l o n a l Antibody Tumor Targeting in Carrinoembryonic A n t i g e n Positive P a t i e n t s . Cancer Res I991, 51:5960-5966. PASTAN [, FITZGERALDD: R e c o m b i n a n t T o x i n s f o r C a n c e r T r e a t m e n t . Science 1991, 254:1173-1177. PATEL N, BERGLUND H, NILSSON L, RIGLER R, MCLAUGHLIN L\V, GRASLUND A: T h e r m o d y n a m i c s o f I n t e r a c t i o n o f a F l u o r e s c e n t DNA O l l g o m e r w i t h t h e AntiT u m o u r D r u g N e t r o p s i n . E u r J B i o c b e m 1992, 203:361-366. PELES E, BACUS SS, KOSR/ RA, LU HS, WEN DZ, OGDEN SG, BENLEVY R, YARDEN Y: I s o l a t i o n o f t h e N e u / H E R 2 S t i m u l a t o r y IAgand - a 4 4 k d G l y c o p r o t e i n t h a t I n d u c e s D i f f e r e n t i a t i o n o f M a m m a r y T u m o r Cells. Cell 1992, 69:205-2t6. PEREY L, HAYES DF, MMMOHIS P, ABE M, OHARA C, KIFFE DW: T u m o r Selective R e a c t i v i t y o f a M o n o c l o n a l Antibody Prepared Against a Recombinant Peptide Derived from the DF3 Human Breast C a r c i n o m a - A s s o c i a t e d A n t i g e n . Cancer Res 1992, 52:2563-2568. PORSCHKE D: N a t u r e o f P r o t a m i n e - D N A C o m p l e x e s . A Special Type of IAgand Binding Co-operativity. J Mol Bio1199i, 222:423-433. PROCHASKA HJ, S~N~FAMAPdAAB, TALALAYP: R a p i d Detection of Inducers of Enzymes that Protect A g a i n s t C a r c i n o g e n s . Froc Natl A c a d Sci U S A 1992, 89:2394-2398. Pure RK, OGATA M, LELAND P, FELDMAN GM, FITZGERALD D, PASTAN I: E x p r e s s i o n o f Higia-Affmity I n t e r l e u l d n 4 R e c e p t o r s o n M u r i n e S a r c o m a Cells a n d R e c e p t o r - M e d i a t e d C y t o t o x i c i t y o f T u m o r Cells to Chimeric Protein Between Interieukin-4 a n d P s e u d o m o n a s E x o t u x i n . Cancer Res 1991, 51:3011-3017. QIN X-Q, CHITIENDEN T, IAVINGSTONDM, KAELIN WG JR: Identification of a Growth Suppression Domain W i t h i n t h e R e t i n o b l a s t o m a tT~ene P r o d u c t . Genes Dev 1992, 6-5:953-964. RAMBALDI A, TORCIA M, BETrON~ S, VANNIERE, BARBU1T, SHAW AR, DINARELLO CA, COZZOHNO F: M o d u l a t i o n o f Cell P r o l i f e r a t i o n a n d C y t o k i n e P r o d u c t i o n in Acute Myeloblastic Leukemia by Interleukin1 R e c e p t o r A n t a g o n i s t a n d Lack o f Its E x p r e s s i o n b y L e u k e m i c Cells. Blood 1991, 78:3248-3253. RANDO RR, KISHI Y: S t r u c t u r a l B a s i s o f P r o t e i n K i n a s e C Activation by Diacylglycerols and Tumor P r o m o t e r s . Biochemistry 1992, 31:2211-2218. RANSOMJtt, PELLE B, HANNA MG: E x p r e s s i o n o f c l a s s H Major Histocompatibility Complex Molecules Correlates with Human Colon Tumor Vaccine Et~c a c y . Cancer Res 1992, 52:3460-3466. REMETA DP, MUDD CP, BERGER ILL, BRESLAUER KJ: T h e r m o d y n a m i c C h a r a c t e r i z a t i o n of Daunomycin-DNA Interactions Microcalorimetric Measurements of D~unomycinDNA B i n d i n g E n t h a l p i e s . Biochemistry i991, I 30:9799-9809. RESNITZKY D~ TIEFENBRUNN, BER/SSI H, KhMCHI A: Interferons and Interleukin-6 Suppress Phosphorylation of the Retinoblastuma Protein i n G r o w t h - S e n s i t i v e H e m a t o p o i e t i c Cells. Proc Natl A c a d Sci U S A 1992, 8 9 : 4 0 2 ~ 0 6 . ROBERTSON MJ, SOIFFERRJ, FREEDMANAS, RABINOWE SL, ANDERSON KC, ERVIN"I3, MURRAY C, DEAR K, GRIFFIN JD, NADLER LM, PdTZ J: M y e l o i d L e u k e m i a . Blood 1992, 79:2229-2236. ROR/NS RA, DENTON G\VL, HARDCASTLEJD, AUS~N EB, BALDWIN RW, DURRANTLG: A n t i t u m o r I m m u n e Response and interieukin-2 Production Induced In C o l o r e c t a l C a n c e r P a t i e n t s b y l m m t l n i z a t i o n with Human Monoelonal Anti-Idiotypic Antibody. Cancer Res 1991, 51:5425 5429. ROBINS RA, DENTON G\VL, HARDCASTLEJD, AUSTIN EB, BALDWIN RW, DURRANTLG: A n t i t u m o r I m m u n e Response and Interieukin-2 Production Induced in Colorectal Cancer Patients by Immtlnization with Human Monoclonal Anti-Idiotypic Antibody. Cancer Res 1991, 51:5425-5429. ROFPZER SR, YU MH, CHEN BM, TUNG E, YEH MY: T h e r a p y of Human Cervical Carcinoma with Monoclonal

Antibody-Pseudomonas Exotoxin Conjugates. Cancer Res 1991, 51:4001M007. ROSS RK, YUAN J-M; YU MC, WOG~N GN, QIAN G S, l ~ J T, GROOP~L~NJD, GAO Y T, HENDERSON BE: U r i n a r y Aflatoxin Biomarkers and Risk of Hepatocellular C a r c i n o m a . Lancet 1992, 339:943@45. SALAA, GRESSER I, CHASSOUXD, MAURY C, SANrFODONATO L, E m P, MAUNOLmY MT, BARCA S, CIANFRIGLIA M, BEtARDELLI F: I n h i b i t i o n o f F r i e n d L e u k e m i a Cell V i s c e r a l M e t a s t a s e s b y a N e w M o n o c l o n a l A n t i b o d y a n d Role o f t h e I m m u n e S y s t e m o f t h e H o s t i n Its A c t i o n . Cancer Res 1992, 52:2880-2889. 8ATOH K, NARUMI K, ISEMURAM, SAKA[ T, ABE T, MATSUSHIMAK, OKDrDAK, MOTOMIYA M: I n c r e a s e d E x p r e s s i o n o f T h e 67kDa-I a m i q i n R e c e p t o r G e n e i n H u m a n S m a l l Cell L u n g C a n c e r . Biochem Biophys Res Commun 1992, 182:746-752. SATYASWAROOPPG, TABIBZADEHSS: E x t r a c d l u l a r M a t r i x and the Patterns of Differentiation of Human Endometrial Carcinomas Invitro and Invivo. Cancer Res 1991, 51:5661 5666. SCHEFFNER M, MUNGER K, HL~BREGTSEJM, HOWLEy PM: Targeted Degradation of the Retinoblastoma Protein by Human Papillomavtrus-E7-E6 Fusion P r o t e i n s . ~ B O J 1 9 9 2 , 11:2425-2431. SCHLOMJ, ~GGENSPERGER D, COLCHER D, MOLINOLO A, HOUCHENS D, MILLER LS, HIN~LLEG, SILER K: T h e r a p e u t i c A d v a n t a g e o f H i g h - A f f i n i t y A n t i c a r c i n o m a R a d i o i m m u n o c o n j u g a t e s . Cancer Res 1992, 52:3067-1072. SCHLOMJ, SILER K, MILENIC DE, EGGENSPERGER D, COLCHER D, IX4ILLERLS, HOUCHENS D, QIENG R, KAPLAN D, GOECKELER W: M o n o e l o n a l A n t i b o d y - B a s e d Therapy of a Human Tumor Xenograft with a L u t e t i u m - 1 7 7 - L a b e l e d I m m u n o c o n j u g a t e . Cancer Res 1991, 51:2889-2896. SC~hMIDBERGERH, BUCHSBAUMDJ, BLAZARBR, EVERSON p, VALLERADA: R a d i o t h e r a p y i n M i c e w i t h Y t t r i u m 90-Labeled AJrtti-Lyl M o n o c l o n a l A n t i b o d y T h e r a p y o f t h e T-Cell L y m p h o m a - E L 4 . Cancer Res 1991, 51:1883-1890. SCHOMBURGAG ET AL., DENqS M, GREGG EO: C y t o k i n e s a n d I n f e c t i o n i n C a n c e r P a t i e n t s [Letter]. Lancet 1992, 339:1061. SCHREIBER GJ, HELLSTROMKE, HELLSTROMh All U n m o d i f i e d A n t i c a r c i n o m a A n t i b o d y , BR96, Localizes to and Inhibits the Outgrowth of H u m a n T u m o r s i n N u d e Mice. Cancer Res 1992, 52:3262-3266. SELIGER B, PFIZENMAIER K, SCHAFERR: S h o r t T e r m T r e a t m e n t w i t h G ~ m m ~ I n t e r f e r o n I n d u c e s Stable R e v e r s i o n o f Ras T r a n s f o r m e d M o u s e F i b r o b l a s t s . J Viro11991, 65:6307. SELVAKUMARANM, LIEBERMANNDA, HOFFMANLtEBERMANN B: D e r e g u l a t e d C - m y b D i s r u p t s I n t e r l e t t k i n - 6 Induced or Leukemia Inhibitory Factor-Induced M y e l o i d D i f f e r e n t i a t i o n P r i o r t o C - m y c - Role i n L e u k e m o g e n e s i s . Mol Cell Bio11992, 12:2493-2500. SHIOTA G, RHOADS DB, WANG TC, NAKAMURAT, SCHMIDT EV: H e p a t o c y t e G r o w t h F a c t o r I n h i b i t s G r o w t h o f H e p a t o c e l l u l a r C a r c i n o m a Cells. Proc Natl A c a d Set U S A 1992, 89:373-377. SHOCKLEYTR, LIN JK, NAGYJA, TOMPKINS RG, YAP~MUSH ML, DVORAK HF: Spatial D i s t r i b u t i o n o f TimaorSpecific Monoclonal Antibodies in Human M e l a n o m a X e n o g r a f t s . Cancer Res 1992, 52:367-376. SHOCKLEYTR, LIN K, SUNG C, NAGYJA, TOMPKINS RG, DEDR/CK RL, DVOEAK HF, YARMUSH ML: A Quantitative Analysis of Tumor-Specific Monoclonal Antibody Uptake by Human M e l a n o m a X e n o g r a f t s - Effects o f A n t i b o d y Immunological Properties and Tumor Antigen E x p r e s s i o n Levels. Cancer Res 1992, 52:357-366. SIEGALL CB, KREITNLANRJ, FITZGERALD DJ~ PASTAN h A n t i t u m o r Effects o f I n t e r l e u k i n - 6 - P s e u d o m o n a s Exotoxin Chimeric Molecules Against the Human H e p a t o c e l l u l a r C a r c i n o m a , P L C / P R F / 5 i n Mice. Cancer Res 199I, 51:2831~836. SIMON D, REST RF: E s c h e r i c h l a - C o l l E x p r e s s i n g a Neisseria-Gonorrhoeae Opacity-Associated Outer Membrane Protein Invade Human Cervical and E n d o m c t r i a l E p i t h e l i a l Ccfi Lines. Proc Natl A c a d Sci U S A 1992, 89:5512-5516. SIRBASKUDA, PAKAIA R, SATO H, EBY JE: T h y r o i d Hormone Dependent Pituitary Tumor Cell G r o w t h I n S e r u m - F r e e C h e m i c a l l y Defined Culture - a New Regulatory Role for A p o t r a n s f e r r i n . Biocloemtstry 1991, 30:7466-7477. SMALLEYRV, ANDERSON SA, TU'I~LE RL, COmXORS J, "I}IUP~MONDL_M, HU&NG A, CASIZE K, MAGERS C, WHISNAN-fJK: A R a n d o m i z e d C o m p a r i s o n o f T w o D o s e s o f H u m a n L y m p h o b l a s t o i d Interferon-c~ i n H a i r y Cell L e u k e m i a . Blood 1991, 78:3133-3141. SMITVIJW, LONGO DL, URSA WJ, CIARK JW, WATSON T, BEVERIDGEJ, CONLON KC, SZNOL M, CREEKMORE SP, ALVORD WG, LAWRENCEJB, STETSRG: P r o l o n g e d , C o n t i n u o u s T r e a t m e n t o f H a i r y Cell L e u k e m i a

Pharmaceutical applications Ischaemic and cardiovascular disease Patients with Recombinant Interferon-alpha2a. Blood 1991, 78:1664-1671. SOLOMON E, BORROW J, GODDARD AD: C h r o m o s o m e A b e r r a t i o n s a n d C a n c e r . Science 199i, 254:1153-1160. STARldNGJJ, MACIAK RS, LAW KL, H]NSON NA, BRIGGS SL, LAGUZZABC, JOHNSON DA: I n v i v o A n t i t u m o r Activity o f a M o n o c l o n a l A n t i b o d y Vinca Alkaloid Imnlunoconjugate Directed Against a Solid Tumor Membrane Antigen Characterized by Heterogeneous Expression and Noninternalization of Antibody-Antigen C o m p l e x e s . Cancer Res 1991, 51:2965-2972. STERN~ECKE, MULLERC, KATZ S, LEL~I'ZA: A u t o c r i n e G r o w t h I n d u c e d b y K i n a s e Type O n c o g e n e s i n M y e l o i d Cells R e q u i r e s AP1 a n d NFM a M y e l o i d S p e c i f i c C/E BP Like Factor. F~vIBOJ 1992, 11:115-126. SUGAHARAK, MIZUNO N, OKUMURA y, KAWASAKIT: T h e P h o s p h o r y l a t e d a n d o r Sul fat e d S t r u c t u r e of the Carbohydrate Protein-Linkage Region I s o l a t e d f r o m C h o n d r o l t i n Sulfate i n t h e H y b r i d Proteogiycans of Engelbrcth-Holm-Swarm Mouse T u m o r . E u r J B i o c h e m 1992, 2 0 4 : 4 0 1 4 0 6 . SUNG C, SHOCKLEYTR, MORRISON PF, DVORAK HF, YARMUSH ML, DEDRICK RL: P r e d i c t e d a n d O b s e r v e d Effects of Antibody Affinity and Antigen Density on Monoclonal Antibody Uptake in Solid Tumors. Cancer Res 1992, 52:377-384. TABATAY, UNO K, YAMAOKA T, IKADA Y, MURAMATSUS: Effects o f R e c o m b i n a n t A l p h a - i n t e r f e r o n G e l a t i n C o n j u g a t e o n I n v i v o M u r i n e T u m o r Cell G r o w t h . CancerRes 1991, 51:5532-5538. TSUfiSAKIM, IMAI K, TOKUCHI S, HANZAWAY, ISHIDA T, KITAGAWA H, HINODA Y, YACIE A: I n d n c t i o n o f Antigen-Specific Immune Response with use of A n t i - I d i o t y p i c M o n o c l o n a l A n t i b o d i e s t o AntiC a r c i n o e m b r y o n i c A n t i g e n A n t i b o d i e s . Cancer Res 1991, 51:2599-2604. UCKUN FM, CHELSTROMLM, IRVIN JD, FINNEG~N D, GUNTHER R, YOUNG J, KUELBELBECKV, MYERS DE, ItOUSTON LL: I n V i v o E f f i c a c y o r B 4 3 ( a n t i CD19) Pokeweed Antiviral Protein Immunotoxin Against BCL-1 M u r i n e B Cell L e u k e m i a . Blood 1992, 79:2649-2661. UCKUN FM, KERSEYJtt, HAAKER, WEISDORF D, RAMSAY Nq~C: A u t o 1 o g o u s B o n e M a r r o w T r a n s p l a n t a t i o n i n H i g h - r i s k R e m i s s i o n B - l i n e a g e Ac ut e Lymphoblastic Leukemia Using a Cocktail of T h r e e M o n o c l o n a l A n t i b o d i e s (BA-1/CD24, BA2/CD9, a n d B A - 3 / C D I O ) P l u s C o m p l e m e n t a n d 4hydroperoxycyelophosphamide for Ex Vlvo Bone M a r r o w P u r g i n g . Blood 1992, 79:1094-1104. UCKUN FM, MANIVEL C, ARTHUR D, CHELSTROM LM, FINN~GAN D, TUEL AHLGREN L, IRVINJD, MYERS DE, GUSNTI~RR: L y m p h o b l a s t i c L e u k e m i a i n Mice w i t h S e v e r e C o m b i n e d I m m u n o d e f i e i e n c y . Blood 1992, 79:2201-2214. VACHINO G, GELFANDJA, ATKINS MB, TAMERIUSJD, DEMCHAK P, MIER j~7: C o m p l e m e n t A c t i v a t i o n i n Cancer Patients Undergoing Immunotherapy with I n t e r l e u k i n - 2 (ED2) - B i n d i n g o f C o m p l e m e n t a n d C-Reactive P r o t e i n b y 11:2-Activated L y m p h o c y t e s . Blood 1991, 78:2505-2513. VANMOORSELAARRJA, I~ENDRIKSBT. VANSTRATUMP, VANDERMEIDE PH, DEBRU'~NE FMJ, SCHALKENJA: S y n e r g i s t i c A n t i t u m o r Effects o f Rat G ~ m m ~ i n t e r f e r o n a n d H u m a n T u m o r N e c r o s i s Factoralpha Against Androgen-Dependent and A n d r o g e n - i n d e p e n d e n t Rat P r o s t a t i c T u m o r s . Cancer Res 1991, 51:2329-2334. VEDANTHAM S, GAMLIEL H, GOLOMB HM: M e c h a n i s m o f I n t e r f e r o n A c t i o n i n H a i r y Ceil L e u k e m i a - a M o d e l o f Effective C a n c e r B i o t h e r a p y . Cancer Res 1992, 52:1056-1066. VELO'ITI F, STOPPACCIAROA, RUCO L, TUBARO A, PETTINATO A, MORRONE S, NAPOLITANO T, BOSSOLA PC, FRANKS CR, PALMERP, pOURREAU CN, PICCOLI M, BARON~ CD, FRATI L, MIANO L, SANTONI A: l o c a l A c t i v a t i o n of tramline Response in Bladder Cancer Patients Treated with Intraarterial Infusion of R e c o m b i n a n t I n t e r l e u k i n - 2 . Cancer Res 1991, 51:2456-2462. VITETfA ES, STOgiE M, AMLOT P, FAY J, MAY R, TILL M, NEWMANJ, CLARK P, COLLINS R, CUN2~NGHAM D, GHETIE V, UHR JW, THORPE PE: P h a s e - I I m m u n o t o x i n T r i a l i n P a t i e n t s w i t h B-Cell L y m p h o m a . Cancer Res 1991, 5 1 : 4 0 5 2 4 0 5 8 . VONWUSSOW P, PRALLE H, HOCHKEPpEL HK, JAKSCHIES D, SONNEN S, SCHJMIDTH, MULLERROSENAUD, FR~N~E M, HAFERLACH~I; ZWINGERS T, RAPP U, DEICHER H: Effective N a t u r a l I n t e r f e r o n - a l p h a T h e r a p y i n Recombinant Interferon-alpha Resistant Patients w i t h H a i r y Cell L e u k e m i a . Blood 1991, 7 8 : 3 ~ 4 3 , WANDL UB, ET AL.: ]Liver F a i l u r e D u e to R e c o m b i n a n t Alpha Interferon for Chronic Myelogenous L e u k a e m l a [Letter]. Lancet 1992, 339:123.

WANK R, THOMSSEN C: H i g h R i s k o f S q u a t n o u s Ceil C a r c i n o m a o f t h e C e r v i x f o r W o m e n w i t h HLAD Q w 3 [Letter]. Nature 1991, 352:723--724. \VEEKBJC, TIERNEYMR, \X}EINSTEINMC: C o s t E f f e c t i v e n e s s of Prophylactic Intravenous Immune Globulin i n C h r o n i c L y m p h o c y t i c L e u k e m i a . N Engl J Med 1991, 325:81~36. WEINER GJ, HILLSTROMJR: B i s p e c i f i c A n t i - I d i o t y p e Ant i -CD3 A n t i b o d y T h e r a p y o f M u r i n e B CeB L y m p h o m a . J Immunol 1~)1, 147:4035~044. \VEINERLM, PADAV]CSHALLERK, KITSON J, WATTS P, KRIGEL RL, UTWIN S: Phase-I E v a l u a t i o n o f C o m b i n a t i o n Therapy with Interleukin-2 and GammaI n t e r f e r o n . Cancer Res 1991, 51:3910-3918. WENZEL A, CZIEPLUCH C, SCHOMA~NNJ, SCHWAB M: T h e N-Myc O n c o p r o t e i n is A s s o c i a t e d i n Vivo w i t h the Phosphoprotein Max(p20/22) in Human N e u r o b l a s t o m a Cells. E M B O J 1991, 10:3703-3712. YAMASHITAY, KAWADA SZ, FUJII N, NAKANO H: I n d u c t i o n o f M a m m a l i a n DNA T o p o i s o m e r a s e - I a n d T o p o i s o m e r a s e - R M e d i a t e d DNA Cleavage b y Saintopin, a New Antiinmor Agent from Fungus. Biochemistry 1991, 3 0 : 5 8 3 ~ 5 8 4 5 . Y&NG SC, GRIMM EA, PARKINSON DR, CARINHASJ, FRY KD, MENDIGURENEODPdGIJEZA, LICCIARDELLOJ, OWENSCHAUB LB, HONG WK, ROTH JA: c l i n i c a l a n d l m m ~ l n o m o d u l a t o r y Effects o f C o m b i n a t i o n Immunotherapy with Low-Dose interleukin-2 and Tumor Necrosis Factor-alpha in Patients with Advanced Non-Small-Cell Lung Cancer - a Phase-I T r i a l Cancer Res 1991, 51:3669-3676. YAP EPH, MCGEE j O D : N o n i s o t o p i c SSCP a n d C o m p e t i t i v e PCR f o r D N A Q u a n t i f i c a t i o n : P53 i n B r e a s t C a n c e r Cells. Nucleic Acids Res 1992, 20:145-146. YOSHIZAWA I'I, CHANG AE, SHU SY: C e l l u l a r I n t e r a c t i o n s i n Effector Ceil G e n e r a t i o n a n d T u m o r Regression Mediated by Anti-CD3/Interleukin2-Activated T u n l o r - D r a i l l i n g L y m p h N o d e Cells. CancerRes 1992, 52:1129-i136. ZAMANDMNM, LATHANGL'ENB: A d e n o v i r u s - E l a Prevents the Retinoblastoma Gene Product from Repressing the Activity of a Celhdar T r a n s c r i p t i o n Factor. E M B O J 1992, 11:2603-2610.

Ischaemic and cardiovascular disease ABEL L, COT M, MULDER L, CARNEVALEP, FEINGOLDJ: Segregation Analysis Detects a Major Gene C o n t r o l l i n g B l o o d I n f e c t i o n Levels i n H u m a n Malaria. A m J Hum Genet 1992, 50:1308.1317. ABRAMOWICZ D, PRADIER O, MARCHANTA, FLORQU1N S, DE PAUW L, VEREERSTRAETENP, KINLNAERTP, VANHERWEGHGMJL, GOLDMAN M: I n d u c t i o n o f T h r o m b o s e s w i t h i n R e n a l Grafts b y H i g h - d o s e P r o p h y l a c t i c OKT3. Lancet 1992, 3 3 9 : 7 7 7 ~7 8 . ADLER M, WAGNER G: S e q u e n t i a l H-1 NMR A s s i g n m e n t s of Kistrin, a Potent Platelet Aggregation Inhibitor a n d G l y c o p r o t e i n - n b - E R a A n t a g o n i s t . Biochemistry 1992, 31:1031-1039. ASCENZI P, AMICON~ G, COLETI"AM, LLrPIDI G, MENEGATII E, ONES11 S, BOLOGNESI M: B i n d i n g o f H i r u d i n t o H u m a n A l p h a , Beta a n d G a m m a T h r o l n b i n . A Comparative Kinetic and Thermodynamic Study. J Mol Bio11992, 225:177-184. AUKflN RC, SHEFFIELDWP, RACHUBINSK/ RA, BLAJCHMAN MA: T h e N - T e r m i n u l D o m a i n o f A n t i t h r o m b i n - I R is E s s e n t i a l f o r H e p a r i n B i n d i n g a n d C o m p l e x F o r m a t i o n W i t h , But n o t C l e a v a g e By, A l p h a T h r o m b i n . BiochemJ 1992, 282:345-351. BARTSCH P ETA&: P r e v e n t i o n o f H i g h - a l t i t u d e Poh~onary Edema by Nifedipine. NEnglJMed i991, 325:1284-1289. BEACIIAM DA, WISE RJ, TURCI SM, HANDIN RI: Selective I n a c t i v a t i o n o f t h e A r g - G l y - A s p - S e r (RGDS) B i n d i n g Site i n V o n w l l l e b r a n d F a c t o r b y S i t e - D i r e c t e d M u t a g e n e s l s . J Biol Chem 1992, 267:3409-3415. BETZ A, HOFSTEENGEJ, STONE SR: p H D e p e n d e n c e of the Interaction of Hirudin with Thrombin. Biochemistry 1992, 31:1168-1172. BETZ A, HOFSTEENGEJ, STONE SR: I n t e r a c t i o n o f t h e NT e r m i n a l R e g i o n o f H i r u d i n w i t h t h e Active-Site Cleft o f T h r o m b i n . Biochemistry 1992, 31:4557~562. BIHAIN BE, YEN FI': F r e e F a t t y A c i d s Activate a H i g h Affinity Saturable Pathway for Degradation of Low-Density Lipoproteins in Fibroblasts from a Subject Homozygous for Fam|l|al H y p e r e h o l e s t e r o l e m i a . Biochemistry 1992, 31:46284636. BOCK LC, GRIFFIN LC, LATHAMJA, VERMAASEH, TOOLE JJ: S e l e c t i o n o f S i n g i e - a t r a n d e d DNA M o l e c u l e s t h a t B i n d a n d i n h i b i t H u m a n T h r o m b i n [Letter]. Naturp 1992, 335:564-566. BUSBY SI, MULVIHILLE, RAO D, KU3aARAA, LIOL~IN P~ HEIPEL M, SPRECHER C, HALFPAP L, PRU~O.RD D,

GAMBEEJ, FOSTER DC: E x p r e s s i o n o f R e c o m b i n a n t H u m a n P l a s m t n o g e n i n M a m m a l i a n Cells is A u g m e n t e d b y S u p p r e s s i o n o f P l a s m i n Activity. J Btol Chem 1991, 266:15286-15292. CAZVETEJJ, MANN K, ALVAREZMV, LOPEZ /VIM, GONZALEZRODRIGUEZJ: P r o t c o l y t i c D i s s e c t i o n o f t h e I s o l a t e d Platelet F i b r i n o g e n R e c e p t o r , I n t e g r i n G P R b / I R a - L o c a l i z a t i o n o f GPE[b a l l d G P I l l a Sequences Putatively Involved in the Subtmit Interface and in Intrasubunit and Intrachain Contacts. BiochemJ 1992, 282:523 532. CARRELL RW, EVANS DL, STEIN PE: M o b i l e Reactive Centre of Serpins and the Control of Thrombosis [Letter]. Nature 1991, 353:576 578, CAZZOLA M, PONCHIO L, BEGUIN Y, ROS~ V, BERGAMASCHI G, LIBERATONL, FREGONI V, NALLI G, BAROSI G, ASCARI E: S u b c u t a n e o u s E r y t h r o p o i e t i n f o r T r e a t m e n t of Refractory Anemia in Hematologic Disorders - Results o f a P h a s e - I / R C l i n i c a l T r i a l Blood 1992, 79:29-37. CRON~U~2) AL, \VALSH PN: A L o w M o l e c u l a r W e i g h t Platelct I n h i b i t o r o f Factor-Xaa - P u r i f i c a t i o n , Characterization, and Possible Role in Blood C o a g u l a t i o n . Biochemistry 1992, 31:1685-1694. DECPJSTOFARO R, DICERA E: M o d u l a t i o n o f T h r o m b i n F i b r i n o g e n I n t e r a c t i o n b y S p e c i f i c I o n Effects. Biochemistry 1992, 31:257-265. DEEB SS, CHEUNG MC, PF~NGR, WOLF AC, STERN R, ALBERSJJ, KNOPP RH: A M u t a t i o n i n t h e H u m a n A p o i l p o p r o t e i n - A - I G e n e - D o m i n a n t Effect o n t h e Level a n d C h a r a c t e r i s t i c s o f P l a s m a H i g h D e n s i t y Lipoproteins'. J Biol Chem 1991, 266:13654-13660. DEVOS AM, LJLTSCHMH, KELLEY RF, PADMANABHANK, TULINSKYA, WESTBROOK ML, KOSSIAKOFFAA: C r y s t a l Structure of the Kringle-2 Domain of Tissue P l a s m i n o g e n A c t i v a t o r at 2.4-A R e s o l u t i o n . Biochemistry 1992, 31:270-279. DUTCH TIA TRIAL STUDY GROIn: A C o m p a r i s o n o f T w o D o s e s o f A s p i r i n (30 M g VS. 283 M g a D a y ) in Patients after a Transient Ischemie Attach o r M i n o r I s c h e m i c S t r o k e . N E n g l J Med 1991, 325:1261-1266. EASTMAND, WURM FM, VANREISR, HIGGINS DL: A R e g i o n o f T i s s u e P l a s m i n o g e n A c t i v a t o r t h a t Affects Plasminogen Activation Differentially with Various Fibrin(ogen)-Related Stitnulators. Biochemistry 1992, 31:419-422. FEDEPdCI AB, BERKOWITZ SD, ZIMME~MA_NTS, MAN~RJCCI PM: P r o t e o l y s i s o f V o n W i l l e b r a n d F a c t o r a f t e r T h r o m b o l y t i c T h e r a p y i n P a t i e n t s w i t h Acute M y o c a r d i a l I n f a r c t i o n . Blood 1992, 7 9 : 3 8 ~ 4 . FERRAN DS, SOBEL M, HARRIS RB: D e s i g n a n d S y n t h e s i s o f a H e l i x H e p a r i n - B i n d i n g P e p t i d e . Biochemistry 1992, 31:5010-5016. GREENWIELDJC, LOL~ SJ, SOOD VK, JENKINS tGM, DA~O SR: I n v i t r o E v a l u a t i o n o f t h e P l a s m a a n d B l o o d Compatibility of a Parenteral Formulation for Diteldren, a Novel Renin Inhibitor P s e u d o p e p t i d e . P h a r m Res 1991, 8 : 4 7 5 4 7 9 . GRONBERG L, RUAN ZS, BITIMAN R, SLOTTEJP: I n t e r a c t i o n of Cholesterol with Synthetic Sphingomyelin D e r i v a t i v e s i n M i x e d M o n o l a y e r s . Biochemistry 1991, 30:10746 10754. HIRSH J, LEV~NZMN: L o w M o l e c u l a r W e i g h t H e p a r i n . Blood 1992, 79:1-17. HOGG PJ, STENFLOJ, MOSHEB DF: T h r o m b o s p o n d i n is a S l o w T i g h t - B i n d i n g i n h i b i t o r o f P l a s m i n . Biochemistry 1992, 31:265-269. HON~DAJ ETAL.: BM-1, a p l a t e l c t A g g r e g a t i o n I n h i b i t o r f r o m M a c k e r e l [Letter]. Lancet 1991, 338:817. HORNE A, GE1TINS P: H-1 1NrMRS p e c t r o s c o p i c S t u d i e s on the Interactions Between Human Plasma Antithrombin-lll and Defined Low Molecular W e i g h t H e p a r i n F r a g m e n t s . Biochemistry 1992, 31:2286-2294. HOROWITZ B, BONOMO R, PRINCE AM, CHIN SN, BROTMAN B, SCHUI.UA_NRW: S o t v e n t J d e t e r g e n t - t r e a t e d Plasma: a virus-inactivated Substitute for Fresh F r o z e n P l a s m a . Blood 1992, 79:826-831. KALLENJ, SPITZFADENC, Z L r ~? MGM, WIDER G, WIDMER H, WUTHRICH K, WALKINSHAWMD: S t r u c t u r e o f H u m a n C y c I o p h i f i n a n d Its B i n d i n g Site f o r C y d o s p o r i n A D e t e r m i n e d b y X-Ray C r y s t a l l o g r a p h y a n d NMR S p e c t r o s c o p y . Nature 1991, 353:276-279. KAUFMANRJ: D e v e l o p i n g RDNA P r o d u c t s f o r T r e a t m e n t o f H e m o p h i l i a A. Trends Biotecbno11991, 9:353-359. LAWLERJ, FERRO P, DLJQU~'TI'EM: E x p r e s s i o n a n d M u t a g e n e s i s o f T h r o m b o s p o n d i n . Biochemistry 1992, 31:1173-1180. LEBONN~EC BF~ ESMON CT: Glu-192-> G i n S u b s t i t u t i o n i n T h r o m b i n M i m i c s t h e Catalytic S w i t c h I n d u c e d b y T h r o m b o m o d u l l n . Proc Nail A c a d Sci U S A 1991, 88:7371~375. LECHLEITNER P, GENSER N, MAIRJ, HARING C, DIF~NSTLF, SARIAA: C a l c i t o n i n G e n e - R e l a t e d P e p t i d e a n d Fluid Overload in Congestive Heart Failure [Letter]. Lancel 1991, 338:955.

757

758

Pharmaceutical applications Miscellaneous LELLOUCH AC, LANSBURYPT: A P e p t i d e M o d e l f o r t h e H e p a r t n B i n d i n g Site o f A n t i t h r o m b i n - B l . Biochemistry 1992, 3 1 : 2 2 7 ~ 2 2 8 5 . LEONG L, I~ENRIKSENRA, KERMODE JC, ]~TTENHOUSE SE, "I~ACY PB: T h e T h r o m b I n H i g h - A f f i n i t y B i n d i n g Site o n P l a t e l e t s is a Negative ReguLator of Thrombin-Induced Platelet Activation Structure- Function Studies Using Two Mutant T h r o m b i n s , Quick-I a n d Qnick-H. Biochemistry 1992, 31:2567-2576. LOOKER D, ABBOTI'-BROWN D, COZART P, DURFEE S, HOFFMAN S~ MAYHEWSAJ, MILLER ROEHRICHJ, SHOLMAKER S. TRLMBLES, FERMI G~ KOMIY~.MANH, NAGAI K, STETLERGL: A H u m a n R e c o m b i n a n t H a e m o g l o b i n D e s i g n e d f o r u s e as a B l o o d S u b s t i t u t e . Nature 1992, 356:258-259. MANAVAIu~" P, PRABHAKAK~NM, JOHNSON ME: L o c a t i o n o f P o t e n t i a l B i n d i n g Sites o n D e o x y H e m o g l o b i n f o r t h e D e s i g n o f A n t i g e l l i n g Agents. J Mol Bio11992, 223:791~00. MAST AE, ENGHILDJJ, NAGASE H, SUZUKI K, PIZZO SV, SALVESENG: K i n e t i c s a n d P h y s i o l o g i c R e l e v a n c e of the Inactivation of Alphal-Proteinase Inhibitor, Alphal-Antichymotrypsin, and Antithrombin-Hi by Matrix Metalloproteinases1 (Tissue Collagenase), Metalloproteinases-2 (72-kDa Gelatinase Type-IV Collagenase), and M e t a l l o p r o t e i n a s e s - 3 ( S t r o m e l y s i n ) . J Biol Chem 1991, 266:15810-15816. MAZIm P, HENZEL WJ, SEYMOURJL, LAZARUSRA: O r n a t i n s - Potent Glycoprotein-Hb-IHa Antagonists a n d Platelet A g g r e g a t i o n I n h i b i t o r s f r o m t h e L e e c h P l a c o b d e l l a - O r n a t a . EurJ Biochera 1991, 202:1073-1082. MCDOWELL RS, DENNIS MS, LOUIE A, SHUSTERM, MULKERRIN MG, LAZARUSRA: M a m b i n , a P o t e n t G l y c o p r o t e i n H b - H i a A n t a g o n i s t a n d Pl a t e l c t A g g r e g a t i o n I n h i b i t o r S t r u c t u r a l l y R e l a t e d to t h e S h o r t N e u r o t o x i n s . Biochemistry 1992, 31:4766~i772. MEADE T~V, ET AL.: A n t i t h r o l n b i n Hi a n d A r t e r i a l D i s e a s e [Letter]. Lancet 1992, 339:182. MEIJERSJCM, MULVI}~LLER, DAVIE EW, CHUNG DW: A p p l e 4 in Human Blood Coagulation Factor-XI Mediates D i m c r F o r m a t i o n . Biochemistry 1992, 3 1 : 4 6 8 0 4 6 8 4 . MILLSJA: A s p i r i n , t h e A g e l e s s R e m e d y ? [Editorial]. X EnglJMed 1991, 325:1303. MORGAN BP: I s o l a t i o n a n d C h a r a c t e r i z a t i o n o f t h e C o m p l e m e n t - I n h i b i t i n g P r o t e i n CD59 A n t i g e n f r o m Platelet M e m b r a n e s . Biochem J 1992, 282:409~413. NESS GC, KELLER RK, PENDLETON LC: F e e d b a c k R e g u l a t i o n of Hepatic 3-Hydroxy-3-Methylgltaaryl-CoA R e d u c t a s e Activity b y D i e t a r y C h o l e s t e r o l is n o t D u c to A l t e r e d M e s s e n g e r RNA Levels. JBiol Chem 1991, 266:14854-14857. NI F, RIEOLI. DR, PU~SIMA EO: C o n f o r m a t i o n a l S t a b i l i t y of a Thrombin-Binding Peptide Derived from t h e H i r u d i n C - T e r m i n u s . Biochemistry 1992, 31:2545 2554. NIENABER VL, YOIJ.~G SL, BIRKTOFT JJ, HIGGINS DL, BEPa/NER LJ: C o n f o r m a t i o n a l S i m i l a r i t i e s B e t w e e n One-Chain and 2-Chain Tissue Plasminogen A c t i v a t o r (t-PA) - I m p l i c a t i o n s to t h e A c t i v a t i o n M e c h a n i s m o n O n e - C h a i n T-PA. Biochemistry 1992, 31:3852 3861. NONOGUCHI H ET AI..: R e c o m b I n a n t H u m a n Erythropoictin for Autulogous Blood Donation [Letter]. Lancet 1992, 339:1483. OBRIEN DP, JOHNSON D, BYFIELD P, TLrDDENHAMEGD: I n a c t i v a t i o n o f Factor-VIII b y Factor-lXa. Biochemistry 1992, 31:2805-2812. OFOSU FA, FAREEDJ, SMITII LM, ANVARI N, HOPPENSTEADT D, BLAJCFDAANMA: I n h i b i t i o n o f Factor-X, Factor-V and Prothrombin Activation by the B i s ( I a c t o h i o n i c Acid A m i d e ) LW10082. EurJ Biochem 1992, 203:121-125. OGDEN JE: R e c o m b i n a n t H a e m o g l o b i n i n t h e D e v e l o p m e n t o f R e d - b l o o d - c e l l S u b s t i t u t e s . Trends Biotechno11992, 10:91-95. PAIZKINSONJF, VLAHOS CJ, YAN SCB, BANG NU: Recombinant Human Thrombomodulln R e g u l a t i o n o f C o f a c t o r Activity a n d A n t i c o a g u l a n t Function by a Glycosaminoglycan Side Chain. BiochemJ 1992, 283:151-157. PENG ML, LU WQ, KIRBY EP: A l b o a g g r e g i n - B - a N e w P l a t e l c t A g o n i s t t h a t B i n d s to Platelct M e m b r a n e G l y c o p r o t e i n - I b . Biochemistry 1991, 30:11529-11536. PENNY WF, WAREjA: Platelct A c t i v a t i o n a n d S u b s e q u e n t Inhibition by Plasmin and Recombinant TissueT y p e P l a s m i n o g e n Activator. Blood 1992, 79:91-98. PIRIESHEPHERD SR, ~LLER HRP, RYLE A: D i f f e r e n t i a l I n h i b i t i o n o f Rat M a s t C e l l P r o t e i n a s e - I a n d P r o t e i n a s e - l l b y M e m b e r s o f t h e Al pha -1Proteinase Inhibitor Family of Serine Proteinase I n h i b i t o r s . JBiol Cbem 1991, 266:17314-17319. PRIOR C, CHU V, HOLT J, WINDISCH V, LEE T, MITSCHELEN J, NEWMAN J, RICCA G, TARR C, HRINDA M:

Production and Functional Characterization of a Recombinant Fragment of Vonwillebrand Factor (vWF) - a n A n t a g o n i s t t o P l a t e l e t R e c e p t o r GP-lb. Biotechnology 1992, 10:66-75. PROCYK R, MEDVED L, ENGELKE KJ, KUDRYK B, BLOMBACK B: N o n c l o t t a b l e F i b r i n O b t a i n e d f r o m p a r t i a l l y Reduced Fibrinogen - Characterization and Tissue P l a s m i n o g e n A c t i v a t o r S t i m u l a t i o n . Biochemistry 1992, 31:2273 2278. ~vETZIOSAD, ~VLAd~ND FS: P u r i f i c a t i o n , C h a r a c t e r i z a t i o n , a n d F i b r i n o g e n C l e a v a g e Sites of 3 Fibrinolytic Enzymes from the Venom of C r o t a l u s - B a s i l i s c u s - B a s l l i s c u s . Biochemistry 1992, 31:45474557. PdCH S, KAtWMANNE, LEVY PS: T h e Effect o f H i g h D o s e s of Calcinm-Channel Blockers on Survival in P r i m a r y P u l m o n a r y H y p e r t e n s i o n . N Engl J Med 1992, 3 2 7 : 7 6 ~ 1 . RL~GE MS, QUERTERMOUST, ZAVODNYPJ, LOVE TV~, BODE C, FR~TAG M, SHAW SY, HUANG PL, CHOU CC, MULLINS D, SCHNEEJM, SAVARDCE, ROTHENBERG ME, NEWELL JB, MATSUEDAGR, HABER E: A R e c o m b i n a n t Chilneric Plasminogen Activator with High Afiqnity f o r F i b r i n H a s I n c r e a s e d T h r o m b o l y t i c P o t e n c y I n v i t r o a n d Invivo. Proc Natl Acad Sci U S A 1991, 88:10337--10341. SCIIOHELD AE, REARDON DM, T#_NN2ZRMJA: D e f e c t i v e Anion Transport Activity of the Abnormal Band 3 i n H e r e d i t a r y O v a l o c y t i c R e d B l o o d Cells [Letter]. Nature 1992, 335:836-837. SCHOHELD AE, TANNER MJA, PINDERJC, CLOUGH B, BAYLEY PM, NASH GB, DLUZEWSK1AR, REARDON DM, COX TM, WILSON RJM, GRATZERWB: B a s i s o f U n i q u e R e d C e l l Membrane Properties in Hereditary Ovalocytosis. J Mol Biol 1992, 223:949-958. SIMMONS DL, SATIERTHW~dTEAB, TENEN DG, SEED B: M o l e c u l a r C l o n i n g o f a CDNA E n c o d i n g CD34, a S i a l o m u c i n o f H t l m a n H e m a t o p o i e t i c S t e m Cells. J Immunol I992, 148:267-271. SN'YDER}I'~ JR, COCHR&N SK. BALINTJP, BERTRAMJ H JR, MITI~LMAN A, GUTHRIE TH JR, JONES FR: E x p e r i e n c e with Protein A-immunoadsorption in Treatmentr e s i s t a n t A d u l t I m t n l l n e T h r o m b o c y t o p e n i c . Blood 1992, 79:2237-2245. SORIANOGARCIAM, PADMANABHANK, DEVOS AM, TULINSKY A: T h e Ca2+ I o n a n d M e m b r a n e B i n d i n g S t r u c t u r e of the Gla Domain of CA-Prothrombin Fragment1. Biochemistry 1992, 31:255~2566. STEINER V, KNECHT R, BORNSEN KO, GASSMANNE, STONE SR, RASCHDORFF, SCtILAEPPI JM, MASCHLERR: P r i m a r y Structure and Function of Novel O-Glycosylated Hirndins from the Leech Hirudinaria-manillensis. Biochemistry 1992, 31:2294-2298. STR&NDBERG L, LAWRENCEDA, JOHANSSON LBA, NY T: T h e Oxidative Inactivation of Plasminogen Activator I n h i b i t o r Type-1 R e s u l t s f r o m a C o n f o r m a t i o n a l Change in the Molecule and Does not Require the I n v o l v e m e n t o f t h e P I ' M e t h i o n i n e . J Biol Chem 1991, 266:13852 13858. STUBBSMT, OSCFIKINATH, IV[AYR1, HUBER R, ANGLIKERH, STON~ SR, BODE W: T h e I n t e r a c t i o n o f T h r o m b i n w i t h F i b r i n o g e n - a S t r u c t u r a l B a s i s f o r Its Specificity. EurJBiochem 1992, 206:187-195. TASAKI"]7, OHTO H, HASHIMOTO C, ABE R, SMTOH A, KIKUCHI S: R e c o m b i n a n t H u m a n E r y t h r o p o i e t i n f o r A u t o l o g o u s B l o o d D o n a t i o n : Effects o n Perioperative Red-blood-cell and Serum E r y t h r o p o i e t i n P r o d u c t i o n . Lancet 1992, 339:773-775. THIRD INWERNATIONALSTUDY OF INFARCT SURVIVAL COLLABORA~VE GROUP: ISIS-3: a R a n d o m i s e d C o m p a r i s o n o f S t r e p t o k i n a s e Vs T i s s u e P l a s m i n o g e n A c t i v a t o r Vs A n i s t r e p l a s e arfd o f A s p i r i n P l u s H e p a r i n Vs A s p i r i n A l o n e M o n g 41 299 C a s e s o f S u s p e c t e d A c u t e M y o c a r d i a l I n f a r c t i o n . Lancet 1992, 339:753-769. MONHEIJNE G, LILJESTROMP, MIKUS P, ANDERSSON H, NY T: The Efficiency of the Uncleared Secretion Signal i n t h e P l a s m i n o g e n A c t i v a t o r I n h i b i t o r Type-2 Protein can be Enhanced by Point Mutations that I n c r e a s e Its H y d r o p h o b i c i t y . JBiol Chem 1991, 266:15240-15243. VU ~K}{, WEIEATON Vl, HUNG DT, CHARO I, COUGFILIN SR: D o m a i n s S p e c i f y i n g T h r o m b i n - r e c e p t o r I n t e r a c t i o n [Letter]. Nature 1991, 3 5 3 : 6 7 ~ 6 7 7 . WILSON JM, GROSSM&NM, WU CH, CHOWDHURY NR, WU GY, CHOWDHL3~YJR: H e p a t o c y t e - D i r c c t e d G e n e T r a n s f e r I n v i v o Leads t o T r a n s i e n t I m p r o v e m e n t of Hypercholesterulemia in Low Density L i p o p r o t e i n R e c e p t o r - D e f i c i e n t R a b b i t s . J Biol Chem 1992, 267:963-967. WU WG, C'~E LM: C o n f o r m a t i o n a l C h a n g e o f Cholesterol Side Chain in Lipid Bilayers. J A m Chem Soc 1991, 113:4683~1685, YONEKAWA O, VOSKUILENM, NIEUWENHLqZENW: Localization in the Fibrinogen Gamma-Chain of a N e w Site t h a t is I n v o l v e d i n t h e A c c e l e r a t i o n o f

the Tissue-Type Plasminogen Activator-Catalysed A c t i v a t i o n o f P l a s m i n o g e n . Biochem J 1992, 283:187-191. ZAMENCN1K PC, KU~aB, GAO MJ, TAYLOR G, BLACKBISP~N GM: A n a l o g u e s o f D i a d e n o s i n e 5 ' , 5 " -P1, P4t e t r a p h o s p h a t e ( A p 4 A ) as P o t e n t i a l A n t i - p l a t e l e t a g g r e g a t i o n A g e n t s . Proc Natl Acad Sci U S A 1992, 89:2370-2373.

Miscellaneous ABRA~L~MSJP, VA~mAM.IMJ, O ~ G, KRAAL B, BOSCH L: Kirromycin Drastically Reduces the Aftinity of EschcrichtaoColi Elongation Factor Tu for A m i n o a c y l - T r a n s f e r RNA. Biochemistry 1991, 30:6705~6710. ADAM M, DAMBLON C, JAMIN M, ZORZI W, DUSART V, GALLENI M, ELKHARROUBIA, PIRAS G, SPRATTBG, KECK W, COYETTEJ, GHUYSEN JM, NGUYENDISTECHE M, FREREJM: A c y l t r a n s f e r a s ¢ Activities o f t h e High-Molecular-Mass Essential Penicillin-Binding P r o t e i n s . BiochemJ 1991, 2 7 9 : 6 0 1 4 0 4 . ADJADJ E, QuI~qOU E, MISPELTERJ, FAVAUDONV, LHOSTE JM: T h r e e - D i m e n s i o n a l S o l u t i o n Structure of Apo-Neocarzinostatin from Str eptomyees-Carzinost aticus Determined b y N M R S p e c t r o s c o p y . EurJ Biochem 1992, 203:505-511. ALBERTS B, MIAKELYE R: U n s c r a m b l i n g t h e P u z z l e o f Biological Machines - the Inlportance of the D e t a i l s . Cell 1992, 68:415-420. ANONYMOUS: P r o d u c t s i n t h e U.S. P i p e l i n e . Biotechnology 1991, 9:947-950. ANONYMOUS: P r o c e e d i n g s o f t h e E i g h t I n t e r n a t i o n a l C o n g r e s s o f H u m a n G e n e t i c s - - 6-11 O c t o b e r 1991, t h e w a s h i n g t o n C o n v e n t i o n C e n t e r , W a s h i n g t o n , DC, U S A - Abstracts. Am J Hum Genet 1991, 4 9 ( s u p p l ) : l 504. ARAMOPd I, FUKAGAWAM, TSUMURAM, IWAM[ M, ONO H, KOJO H, KOHSAKAM, UEDA Y, IMANAKAH: C l o n i n g and Nucleotide Sequencing of a Novel 7beta(4 - c a r b o x y b u t a n a m i d o ) c e p h a l o s p o r a n i c A c i d A c y l a s e G e n e o f B a c i l l u s - L a t e r o s p o r u s a n d Its Expression in Escherichla-Coli and BacillusS u b t i l i s . JBacterio11991, 173:784~7855. BAILLY C, I)ENNW WA, MELLOR LE, WAKELIN LPG, WARING MJ: S e q u e n c e S p e c i f i c i t y o f t h e B i n d i n g O f 9Aminoacridine-Carboxamide and Amsacrine4-Carboxamide to DNA Studied by DNase-I F o o t p r i n t i n g . Biochemistry 1992, 31:3514-3524. BAKALARAN, KENDALL G, MICHELS PAM, OPPERDOES FR: Trypanosoma Brucei Glycosomal Glyceraldehydc3 - p h o s p h a t e D e h y d r o g e n a s e G e n e s a r e Stager e g u l a t e d at t h e T r a n s c r i p t i o n a l L e v e l EMBO J 1991, 10:3861-3868. BASU A, KOZIKOWSK1AP, LAZO JS: S t r u c t u r a l Requirements of Lyngbyatoxin-A for Activation a n d D o w n r e g u l a t i o n o f P r o t e i n Kinase-C. Biochemistry 1992, 31:3824-3830. BELIZANJM, VILLARJ, GONZALEZ L, CAMPODONICO L, BERGEL E: C a l c i u t n S u p p l e m e n t a t i o n t o P r e v e n t H y p e r t e n s i v e D i s o r d e r s o f P r e g n a n c y . N Engl J Med 1991, 325:1399-1405. BERENDT AR, MCDOWALLA, CRAIG AG, BATES PA, STERNBERGMJE, MARSH K, NEWBOLD CI, HOGG N: T h e B i n d i n g Site o n ICAM-1 f o r P l a s m o d i u m Falciparum Infected Erythrocytes Overlaps, But is D i s t i n c t F r o m , t h e LFA-1-Binding Site. Cell 1992, 68:71-81. BERTAUX O, FOURNIERT, CHAUVELOTMOACHONL, PORQUET D, VALENCIA R, DURAND G: M o d i f i c a t i o n s o f H e p a t i c Alpha-l-Acid Glycoprotein and Albumin Gene E x p r e s s i o n i n Rats T r e a t e d w i t h P h e n o b a r b i t a L EurJBiochem 1992, 2 0 3 : 6 5 5 4 6 1 . BHAT SP, HORWITZ J, SRINIVASANA, DING LL: a l p h a B C r y s t a l l i n Exists as a n I n d e p e n d e n t P r o t e i n i n t h e H e a r t a n d I n t h e Lens. EurJBiocbem 1991, 202:775-78I. BIRKETr CR, PAP~MAAE, GERKEBONET R, WOODWARD R, GIY~. K: I s o l a t i o n o f CDNA C l o n e s E n c o d i n g Proteins of Complex Structure - Analysis of the T r y p a n o s o m a - b r u c e i C y t o s k e l e t o n . Gene 1992, 110:65 70. BL~NCO L, BEP~'AD A, SALAS M: E v i d e n c e F a v o u r i n g t h e H y p o t h e s i s o f a C o n s e r v e d 3'-5' E x o n u c l e a s e Active Site i n D N A - D e p e n d e n t DNA P o l y n l e r a s e s [Letter]. Gene 1992, 112:139-144. BOECIGMAN RK, CHAI~TIE AB, ASBEROMT, JOtLNSTON BH: T h e C h e m i s t r y o f Cyclic V i n y l Ethers. 6. T o t a l Synthesis of Polyether Ionophore Antibiotics of t h e C a l c i n l y e i n ( A - 2 3 1 8 7 ) Class. J A m Cbem Soc 1991, 113:5337-5353. BOGER DL, ISHIZAm T, ZARRINMAYEHH, ML~'K SA, KITOS PA, SUNTORNWATO: D u o e a r m y c i n Pyrindamycin DNA Alkylation Properties and Identification, Synthesis, and Evaluation of

Pharmaceutical applications Miscellaneous Agents Incorporating the Pharmacophore of the Duocarmycin Pyrindamycin Alkylation Subunit - I d e n t i f i c a t i o n o f t h e CC- 1 0 6 5 - D u o c a r m y e i n C o m m o n P h a r m a c o p h o r e . J A m Chem Soc 1990, 112:8961-8971. BOMAN HG, FAYE I, GLrDMb*'NDSSONGII, LEE JY, LIDHOLM DA: Cell-Free I m m u n i t y i n C e c r o p i a - a M o d e l S y s t e m f o r A n t i b a c t e r i a l P r o t e i n s . E u r J Biochem 1991, 2 0 1 : 2 3 ~ 1 , BRA.N.'NIGANJ, MATAGNEA, JACOB F, DAMBLON C, JORIS B, KLEIN D, SPRATr BG, FRF2.EJM: T h e M u t a t i o n L y s 2 3 4 H i s Y i e l d s a Class-A Beta-Lactamase w i t h a N o v e l P H - D e p e n d e n c e . Biochem J 1991, 278:673~578. BRAUNSCHWEIGERPG, JONES SA, JOHNSON CS, I~'La/M&NSKIP: Potentiation of Mliomycin-C and Poriflromycin A n t i t u m o r Activity I n S o l i d T u m o r M o d e l s b y R e c o m b i n a n t H u m a n I n t e r l e u k i n 1-al pha . Cancer Res 1991, 51:5454-5460. BUGG TDH, WRIGHT GD, DUTKAMALENS, ARTHIYRM, COURVALINP, WALSH CT: M o l e c u l a r Ba s i s f o r Vancomycin Resistance in EnterocoecusFaecinm BM4147 - Biosynthesis of a Depsipeptide Peptidoglycan Precursor by Vancomycin R e s i s t a n c e P r o t e i n s V a n H a n d VatlA. Biochemistry 199i, 30:10408-10415. BUTCHER S, SARVASM, RUNEBERGNWMANK: Class-3 P o r i n Protein of Neisseria-Meningitidis - Cloning and S t r u c t u r e o f t h e G en e. Gene 1991, 105:125 128. CABALLEROJL, MALPARIIDA F, HOPWOOD DA: Transcriptional Organization and Regulation of an Antibiotic Export Complex in the Producing S t r e p t o m y c e s Cu ltu r e. Mol Gen Genet 1991, 228:372 380. CARREROVALENZUELARD, QUA2,"F, LIGHTOWLERS R, KENNAWAY NG, LITT M, FORTE M: H u l n a n Cytochrome-e Oxidase Subunit-VIb Characterization and Mapping of a Multigene F a m i l y . Gene 1991, 102:229 236, CARRINGTON M, MILLER N, BLUM M, RODITI i, WILEY D, TL1LWERM: V a r i a n t S p e c i f i c G l y c o p r o t e i n o f Trypanosoma Brocei Consists of Two Domains Each Having an Independently Conserved Pattern C y s t e i n R e s i d u e s . J Mol Bie11991, 221:823-835. CHAO CCK: D a m a g e - R e c o g n i t i o n P r o t e i n s as a Potential Indicator of DNA-Damage-Mediated S e n s i t i v i t y o r R e s i s t a n c e o f H u m a n Cells t o U l t r a v i o l e t R a d i a t i o n . B i o c h e m J 1992, 282:203-207. CH2~ Y, PITZENBERGER SM, GARSKY VM, LUMMA PK, SANYAL G, BAUM J: P r o t o n N M R A s s i g n m e n t s a n d Secondary Structure of the Snake Venom Protein E e h i s t a t i n . Biochemistry 1991, 30:11625-11636. CHOE S, BENNETt MJ, FL~II G, CURMI PMG, KANTARDJIEFE KA, COLLIER RJ, EISENBERG D: T h e C r y s t a l S t r u c t u r e o f D i p h t h e r i a T o x i n . Nature i992, 357:216-221. CIBOTYI R, KANELLOPOULOSJM, CABANIOLSJ]~, HALLEPANENKO O, KOSMATOPOULOSK, SERCARZE, KOURILSKYP: T o l e r a n c e t o a S e l f - P r o t e i n I n v o l v e s Its I m m u n o d o m i n a n t B u t D o e s n o t I n v o l v e Its S u b d o m i n a n t D e t e r m i n a n t s . Proc Natl A c a d Sci U S A 1992, 89:416-420. COMESS KM, BURSTY1RJN, ESSIGMANNjM, LIPPARD SJ: Replication Inhibition and Translesion Synthesis o n T e m p l a t e s C o n t a i n i n g Site-Specifically P l a c e d C i s - D i a m m h l e d i c h l o r o p l a t i n u m ( I I ) DNA A d d u c t s . Biochemistry 1992, 31:3975-3990. CONNOLLY T~ RAPIEJKO PJ, GILMORE R: R e q u i r e m e n t o f GTP H y d r o l y s i s f o r D i s s o c i a t i o n o f t h e S i g n a l R e c o g n i t i o n p a r t i c l e f r o m Its R e c e p t o r . Science 1991, 252:t171-1173. CRAM DJ: M o l e c u l a r C o n t a i n e r C o m p o u n d s [Review]. Nature 1992, 356:29-36. CPdTTENDEN PD, PORTER N: L i c h e n - f o r m i n g F u n g i : P o t e n t i a l S o u r c e s o f N o v e l Metabolites. Trends Biotechno11991, 9:409-414. CROSS M, GUNZL A, PALFI Z, BINDEREIF A: A n a l y s i s o f S m a l I N u c l e a r R i b o n u c l e o p r o t e i n s (RNPs) i n Trypanosoma-Brucel - Structural Organization and Protein Components of the Spliced Leader RNP. Mol Cell Bie11991, 11:5516-5526. DELECLUSE A, CHARLESJF, KLIER A, RAPOPORT G: D e l e t i o n b y I n v i v o R e c o m b i n a t i o n S h o w s t h a t t h e 28K i l o d a l t o n Cytolytic P u l y p e p t i d e f r o m BaetllasT h u r t n g i e n s i s S u b s p I s r a e l e n s i s is n o t E s s e n t i a l f o r M o s q u i t o c i d a l Activity. J Bacteriol 199i, 173:3374-3381. DGMICHI~I C, ALBERTINIJP, GARNIERSUILLEROTA: I n t e r a c t i o n o f M i t h r a m y c i n w i t h DNA - E v i d e n c e t h a t M i t h r a m y e i n B i n d s t o DNA as a D i m e r i n a R i g h t - H a n d e d S c r e w C o n f o r m a t i o n . E u r J Biechem 1991, 198:333-338. DENAMOR AFD, TRABOULSSIR, LEWIS DFV: H o s t p r o p e r t i e s of Cyclodextrins Toward Anion Constituents of Antigenic Determinants - a Thermodynamic Study in Water and in N,N-Dimethylformamide. J A m Chem Soc 1990, 112:8442-8447.

DORN A, APFOLTERM, MULLER M, GEHRING WJ, LELq'IN W: Diatamycin Induced Inhibition of Homeodomain D N A C o m p l e x e s . E M B O J 1992, 11:279-286. DOUGLAS CW~, HEATH J, GWYN,~qJP: E n z y m i c A c t i v i t y of salivary Amylase when Bound to the Surface o f O r a l S t r e p t o c o c c i . FEMS Microbiol Lett 1992, 92:i93-197. DOWD P, HAM SW, GEIB SJ: M e c h a n i s m o f A c t i o n o f Vitamin-IG J A m Chem 3~c 1991, 113:7734-7743. EALICK SE, BABU YS, BUGG CE, EPdON MD, GUIDA WC, MO>-fGOMERYJA, SECRISTJA: A p p l i c a t i o n o f Crystallographic and Modeling Methods In the Design of Purine Nueleoside Phosphorylase I n h i b l t o r s . Proc Natl A c a d Sci U S A 1991, 88:11540.11544. ELBEIN AD: T h e R o l e o f N - l i n k e d O l i g o s a c c h a r i d e s i n G l y c o p r o t e i n F u n c t i o n . Trends Biotechnol 1991, 9:346-352. ELKHARROUBI A, JACQUES P, PIRAS G, VANBEEUMENJ, COYETTE J, GHUYSENJM: T h e E n t e r o e o c c u s H i r a e R40 P e n i c i l l i n - B i n d i n g P r o t e i n - 5 a n d t h e M e t h i c i l l i n - R e s t s t a n t St a p h y l o c o e e u s - A u r e u s P e n i c i l l i n - B i n d i n g P r o t e i n 2' a r e S;mil=~. Biochem J 1991, 280:463-469. EWLNS DA, KALDOR SW, JOIX'ESTK, CLARDYJ, STOLFI'~J: Total Synthesis of the Macrolide Antibiotic C y t o v a r i c i n . J A m Chem Soc 1990, 1 1 2 : 7 0 0 1 ~ 0 3 i . EVANS DA, POLNIASZEKRP, DEVI~ES KM, GL1NN DE, MA~IJRE DJ: S y n t h e t i c S t u d i e s i n t h e L y s o c e l l i n Family of Polyether Antibiotics - the Total S y n t h e s i s o f F e r e n a l m y c i n - B . J A m Chem Soc 199i, 113:7613-7630. FMNZILBER M, GORDON D, HASSON A, SPIRA ME, ZLOTKIN E: Mol l us c-S p e c i f i c T o x i n s f r o m t h e V e n o m o f C o n u s - T e x t i l e - N e o v i c a r i u s . E u r J B i o c h e m 1991, 202:589-595. FALKOW S: Bacterial E n t r y i n t o E u k a r y o t i c Cells. Cell 1991, 65:1099-1102. FASEL N, BEGDADIRAIS C, BERNARD M, BRON C, CORRADIN G, REYMOND CD: D i c t y o a t e l i t t m - D i s c o i d e u x n as an Expression Host for the Circumsporozoite P r o t e i n o f P l a s m o d i u m - F a l c i p a r l m m Gene 1992, 111:157-163. FERNANDEZMORENO MA, CABALLEROJL, HOPWOOD DA, IVIALPARTIDAF: T h e ACt C l u s t e r C o n t a i n s R e g u l a t o r y and Antibiotic Export Genes, Direct Targets for T r a n s l a t i o n a l C o n t r o l b y t h e BldA T r a n s f e r R N A G e n e o f S t r e p t o m y c e s . Cell 1991, 66:769-780. FRANCISCOJA, EARIIARTCF, GEORGIOU G: T r a n s p o r t a n d Anchoring of Beta-Lactamase to the External S u r f a c e o f E s c h e r i c h i a - C o l i . Proc Natl A c a d Sci U S A i992, 89:27i3-2717. FREYTAG SO, GEDDES TJ: R e c t p r o e a l R e g u l a t i o n o f A d i p o g e n e s i s b y M y c a n d C / E B P a l p h a . Science 1992, 256:379-381. FUKUYAMAT, XU Lti, GOTO S: T o t a l S y n t h e s i s o f (+/-)-FR9 0 0 4 8 2 . J A m Chem Soc 1992, 114:383-385. GOODISM2UNJ, REHFUSSR, WARD B, DABROWIAKJC: SiteSpecific Binding Constants for Actinomycin-D o n DNA D e t e r m i n e d f r o m F o o t p r i n t i n g S t u d i e s . BiochemislEy 1992, 31:1046-1058. GOULD JH, HARTLEYMR, WELSH PC, HOSHIZAgd DK, FRANKEL A, ROBERTS LM, LORD JM: A l t e r a t i o n o f a n A m i n o Acid R e s i d u e O u t s i d e t h e Active Site o f t h e R i c i n A - C h a i n R e d u c e s Its T o x i c i t y T o w a r d s Yeast R i b o s o m e s . Mol Gen Genet 1991, 230:81--90. GRAM H, MARCON1LA, BARBAS CF, COLLETTA, LERNER RA, KANG AS: I n v i t r o S e l e c t i o n a n d A f f i n i t y M a t u r a t i o n of Antibodies from a Naive Combinatorial l m m ~ l n o g l o b u l i n L i b r a r y . Proc Nail A c a d Sci U S A 1992, 89:3576-3580. GUDMUNDSSONGI1, LIDHOLM DA, ASLING B, GAN RB, BOM&~ HG: T h e C e c r o p i n L o c u s - C l o n i n g and Expression of a Gene Cluster Encoding 3 Antibacterial Peptides in Hyalophora-Cecropia. J B i o l Chem 1991, 266:11510-11517. GUO Q, LU M, SHAHRESTANIFARM, SHEARDYRD, KALLEN13ACHNR: D r u g B i n d i n g t o a D N A BZ Molecule - Analysis by Chemical Footprinting. Biochemistry 1991, 30:11735 11741. GUPTA S, KRASNOFFSB, ROBERTS DW, RENWICKJAA, Bm.'mN LS, CLAm)YJ: S t r u c t u r e s o f t h e E f r a p e p t i n s - P o t e n t I n h i b i t o r s o f M i t u c h o n d r i a l ATPase f r o m t h e F u n g u s T o l y p o c l a d i u m - N i v e u 1 I L J A m Chem Soc 1991, 113:707 709. HAASS C, KOO EH, MELLON A, HUNG AY, SELKOE DJ: Targeting of CelLsurface ~-amyloid Precursor P r o t e i n to L y s o s o m c s : A l t e r n a t i v e P r o c e s s i n g i n t o A n l y l o i d - b e a r i n g F r a g m e n t s [Letter]. N a t u r e 1992, 357:500-502. tLAGIWARA A, TAKAHASHIT, KOJIMA O, SAWM K, YAMAGUCHI T, YAM&NET, TANIGUCHI H, KITAMUa~AK, NOGUCIII A, SEIK/ K, SAKAKURAC: P r o p h y l a x i s w i t h Carbon-adsorbed MitomyeIn Against Peritoneal R e c u r r e n c e o f G a s t r i c C a n c e r . Lancet 1992, 339:629-631.

HAHN GM, SHIU EC, AUGER EA: M a m m a l i a n Stress Proteins liSP70 and HSP28 Coinduced by Nicotine a n d E i t h e r E t h a n o l o r Heat. Mol Cell Bio11991, 11:6034~5049. HASUq~I1K, SHINOHARA C, NAGKNUMAS, ENDO A: Inhibition of the Uptake of Oxidized Low-Density Lipoprotein in Macrophage-J774 by the Antibiotic I k a r u g a m y c i n . E u r J B i o c b e m 1992, 205:841-846. HEFFERNAN EJ, HARWOOD J, F1ERERJ, GUIN'EY D: T h e salmonella-Typhimurium Virlflence Plasmid Complement Resistance Gent Rck is Homologous to a F a m i l y o f V i r u l e n c e - R e l a t e d O u t e r M e m b r a n e P r o t e i n G e n e s , I n c l u d i n g PagC a n d AlL J Bacteriol 1992, 174:84-91. HEGETRESKA~ISD, KING R, WOLF H, GILES ED: N u t r i t i o n a l Control of Nikkomycin and Juglomycin Production by Streptumyces Tendae in C o n t i n u o u s C u l t u r e . Appl Microbiol Biotechnol 1992, 36:440-445. HEREDIA NL, [~BBE RG, RODRIGUEZMA, GARC]AALVARADO JS: G r o w t h , S p o r u l a t i o n a n d E n t e r o t o x i n P r o d u c t i o n b y C l o s t r i d i u m - P e r f r i n g e n s Type-A i n t h e P r e s e n c e o f H u m a n Bile Salts. FEagSMicrobiol Lett 1991, 84:15 21. HERMOSOS T, FICHELSON Z, BECKER SI, HIRSCHBERG K, JAFFE CL: L e i s h m a n i a l P r o t e i n K i n a s e s P h o s p h o r y l a t e C o m p o n e n t s o f t h e C o m p l e m e n t S y s t e m . I~VIBO J 1991, 10:4061-4068. HICKS KE, READ M, HOLLOWAY SP, SIMS PFG, HYDE JE: G l y c o l y t i c P a t h w a y o f t h e H u m a n M a l a r i a Parasite Plasmodium-Falclparum - Primary S e q u e n c e A n a l y s i s o f t h e G e n e E n c o d i n g 3Phosphoglyceratc Kinase and Chromosomal M a p p i n g S t u d i e s . Gene 1991, 100:123-129. HILl. RE, FAVORJ, HOG&N BLM, TON, CCT, SAIo~DERS GF~ HANSON LM, PROSSERJ, JORD&N T, HAS~IE ND, VAN HEYNINGEN V: M o u s e S m a l l Eye R e s u l t s f r o m M u t a t i o n s i n a P a i r e d Like H o m e o b o x C o n t a i n i n g G e n e [Letter]. Nature 1991, 354:522-525. HOBBS G, OBANWEAIC, PETIT J, MASON JC, BARRATTE, GARDNER DCJ, FLE'IT F, SMITH CP, BRODA P, OLIVER SG: An integrated Approach to Studying Regulation of Production of the Antibiotic Methylenomycin b y S t r e p t o m y c c s - c o e l i c o l o r A3(2). J Bacterio11992, 174:1487-1494. HOFFENBERG SI, EYBIN VO, E~FIMENKOAN, KUTiOCHKININ, TKACttLrK VA: T h e 6 5 - k D a P r o t e i n f r o m P i g H e a r t - a N e w S u b s t r a t e f o r C l o s t r i d i u m - B o t u l i n u m ADPR i b o s y l t r a n s f e r a s e ( E x o e n z y m e - C 3 ) . FEBS Lett 1991, 293:59451. HU Q, LEESJA, BUCHKOVICH KJ, HAP.LOW E: T h e Rctinoblaatoma Protein Physically Associates w i t h t h e H u m a n Cde2 K i n a s e . Mol Cell Bie11992, 12:971-980. HU S, WEISZ K, JAMES TL, SHAVERRH: H-1-NMR S t u d i e s o n D ( G C I T A A G C ) 2 a n d Its C o m p l e x w i t h B e r e n i l . E u r J B i o c h e m 1992, 204:3i 38. HUGHES D, BUCKINGHAMRH: T h e N u c l e o t i d c S e q u e n c e o f R p s L a n d Its F l a n k i n g R e g i o n s i n s a l m o n e l l a T y p h i m u r i u m . Gene 1991, 104:123-124. HWANG JJ, PERERA S, SHAPIRO RA, CURTHOYS NP: Mechanism of Altered Renal Glutaminase Gene E x p r e s s i o n i n R e s p o n s e t o C h r o n i c Acidosis. Biochemistry 1991, 30:7522-7526. ICmEA 2, YOSHIDA x0(/Y, SCHEUERpJ, HIGA T, GRAVALOS DG: H e n n o x a z o l e s - B i o a c t i v e B i s o x a z o l e s f r o m a M a r i n e S p o n g e . J A m Chem Soc i991, 113:3173-3174. tlRI T, OHOKA Y, UI M, KATADAT: F u n c t i o n a l M o d i f i c a t i o n b y C h o l e r a - T o x i n - C a t a l y z e d ADPRibosylation of a Guanine-Nucleotide-Binding R e g u l a t o r y P r o t e i n S e r v i n g as t h e S u b s t r a t c o f P e r t u s s i s T o x i n . E u r J B i o c h e m 1991, 202:6354541. IKEMOTO N, SCHREIBER SL: T o t a l S y n t h e s i s o f t h e A n t h c l m i n t i c A g e n t H i k i z i m y c i n . J A m Chem Soc 1990, 112:9657-9659. IRRGANG S, SCHLOSSERD, SCFLMAUDERHP: T h e S t e r o i d 15alpha-Hydroxylase of Penictllium-Raistriekii 1-477 is I n d u c i b l e . Bietechnol Lett 1992, 1 4 : 3 3 ~ 8 . JENNERWEIN MM, EASTMANA: A P o l y m e r a s e C h a i n Reaction Based Method to Detect Cisplatin A d d u c t s i n S p e c i f i c G e n e s . Nucleic Acids Res 1991, 19:62094213. JENSEN PB, JENS~X PS, DEMAN~ EJF, PRICHE E, SORENSEN BS, SEHESTED M, WASSEPaMAN.~qI{, VlNDELOV L, WESTERGAARD O, HANSEN HH: A n t a g o n i s t i c Effect of Aclarubiein on Daunorubicin-induced C y t o t o x i c i t y i n H u m a n S m a l l Ceil L u n g C a n c e r Cells - R e l a t i o n s h i p t o DNA I n t e g r i t y a n d T o p o i s o m e r a s e - I I . Cancer Res 1991, 51:5093-5099. JIANG JX, CHUNG LA, LONDON E: S e l f - T r a n s l o e a t i o n o f D i p h t h e r i a T o x i n A c r o s s M o d e l M e m b r a n e s . J Biol Cbem 1991, 266:24003-24010. JONES C, STANLEYJ: S a l m o n e l l a P l a s m i d s o f t h e P r e a n t i b i o t i c Era. J Gen Microbiol 1992, 138:189-197.

759

760

Pharmaceutical applications Miscellaneous KALETTAC, E~'rI&N KD, JUNG G: P r e p e p t i d e S e q u e n c e o f C i n n a m y c i n (Ro 0 9 - 0 1 9 8 ) - t h e First S t r u c t u r a l G e n e o f a D u r a m y c i n - T y p e Lantibiotic. E u r J Biochem 1991, 199:411~i15. KA~NTORAB, STALL/UX/I,ADAMS S, HERZENBERGLA, HERZENBERG LA: D i f f e r e n t i a l D e v e l o p m e n t o f P r o g e n i t o r Activity f o r 3 B-Cell Lineages. Proc Natl A c a d Sci U S A 1992, 89:3320-3324. KESSLER DA, TAYLORMR, MARYANSKIJH, FL&MMEL, KAHL LS: The Safety o f F o o d s D e v e l o p e d b y Biotechnology. Science 1992, 256:1747-1751. KL'A HB, K&~G C: S t r o n g S u p p r e s s i o n o f Chloramphenicol Acetyltransferase Expression b y I n d u c i n g T7 RNA P o l y m e r a s e . Biotechnol Lett 1991, 13:751-754. KIM JM, BOGDtLNMA, MARIANO PS: SET P h o t o c h e m i s t r y o f F l a v i n C y c l o p r u p y l a m i , l e Systems - Models f o r P r o p o s e d M o n o a m i n e Oxidase I n h i b i t i o n M e c h a n i s m s . J A m Chem Soc 1991, 113:9251~257. KIOKA N, YAMANOY, KOMANO T, UEDA K: H e a t - S h o c k Responsive Elements in the Induction of the M u l t i d r u g Resistance G e n e (MDR1). FEBS Lett 1992, 301:3740, KIRK2IAM PM, MORTAR] F, NEWTON JA, SCHROEDER HW: I m l n u n o g l o b n l i n V< H> Clan a n d P a m i l y I d e n t i t y Predicts V a r i a b l e D o m a i n S t r u c t u r e a n d M a y I n f l u e n c e A n t i g e n B i n d i n g . E M B O J 1992, 11:603~510. KLEIN A, CARNOYC, L&MBLING, ROUSSELP, VANKUIK JA, DEWAARDP, VLIEGENTHARTJFG: I s o l a t i o n a n d S t r u c t u r a l C h a r a c t e r i z a t i o n o f Novel N e u t r a l Oligosaccharide-Alditols f r o m RespiratoryMucus G l y c o p r o t e i n s o f a Patient S u f f e r i n g f r o m Bronchiectasis. 1. S t r u c t u r e o f 11 Oligosaccharides H a v i n g t h e GlcNAcbeta(1> 3)Galbetu(1-> 4)GlcNAcbeta(1-> 6)GalNAc-ol Structural Element in Common. EurJ Biochem 1991, 198:151-168. KLUGE M, SIEGMUNDD, DIEKMANN H, TtlOMA M: A M o d e l f o r P e n i c i l l i n P r o d u c t i o n w i t h and w i t h o u t T e m p e r a t u r e Shift a f t e r t h e G r o w t h P h a s e . Appl Microbiol Biotechno11992, 36:446-451. KNIGHTON DR, ZHENGJ, TEN EYCK LF, ASHEORD VA, XUONG N, TAYLORSS, SOWADSKIJM: Crystal S t r u c t u r e o f t h e Catalytic S u b u n i t o f Cyclic A d e n o s i n e Monophosphate-dependent Protein Kinase. Science 1991, 253:407-413. KRAMER W, GIRBIGF, GL~rJAHR U, KOWALEWSKIS~ ADAM F, SCtIIEBLERW: I n t e s t i n a l A b s o r p t i o n o f Bcta-Lactam Antibiotics and O l i g o p e p t i d e s - F u n c t i o n a l a n d Stereospecific R e c o n s t i t n t i o n o f the O l i g o p e p t i d e T r a n s p o r t System f r o m R a b b i t Small I n t e s t i n e . E u r J Biochem 1992, 204:923-930. KRIZAJ I, BIEBERAL, RITONJAA, GLrBENSEKF: T h e P r i m a r y Structure o f .Ammodytin-L, a M y o t o x i e Phospholipase-A2 H o m o l o g n e f r o m ViperaA m m o d y t e s Venom. E u r J B i o c h e m 199i, 202:1165-1168. KRIZAJ [, LIANG NS, PUNGERCARJ, STRLq~ELJB, RITONJA A, GUBENSEKF: Alnino Acid a n d CDNA S e q u e n c e s o f a N e u t r a l P b o s p h o l i p a s e A2 f r o m t h e Long-Nosed Viper (Vipera-Ammodytes-Ammodytes) Venom. E u r J Biochem 1992, 204:105%1062. KTISTAYdSNT, LANDERME, ROTH MG: Action o f B r e f e l d i n a B l o c k e d by Activation o f a Pertussis-toxins e n s i t i v e G p r o t e i n [Letter]. Nature 1992, 356:344-346. KUEHN MJ, HEUSERJ, NORMARK S, HULTGRENSJ: P P i l l i n U r o p a t h o g e n i c E. C o l i a r e C o m p o s i t e F i b r e s w i t h Distinct F i b r i l l a r A d h e s i v e Tips. N a t u r e 1992, 356:252-254. KUMAR S, LIPMANR, TOMASZ M: R e c o g n i t i o n o f Specific DNA Sequences b y M i t o m y c i n - C for A l k y l a t i o n . Biochemistry 1992, 31:1399-1407. LACALLERA, TERCEROJA, JIMENEZ A: Cloning o f t h e C o m p l e t e Biosynthetic G e n e Cluster f o r a n A m t n o n u c l e o s i d e Antibiotic, P u r o m y c i n , a n d Its Regulated E x p r e s s i o n i n H e t e r o l o g o u s Hosts. E M B O J 1992, 11:785-792. LACHAPELLEJ, DUFRESNEJ, LEVESQUERC: C h a r a c t e r i z a t i o n o f t h e Bla(CARB-3) G e n e E n c o d i n g t h e c a r b e n i c t l l i n a s e - 3 Betu-Lactamase o f P s e o d o m o n a s - A e r u g i n o s a . Gene 1991, 102:7-12. LAMOTTEBRASSEURJ, DIVE G, DIDEBERG O, CHARLIER P, FREREJM, GHUYSENJM: M e c h a n i s m o f Acyl T r a n s f e r by t h e Class-A S e r i n e Beta-Lactamase o f Streptomyccs-Albus-G. Biochem J 1991, 279:21 3-221. LANDERSJP, BLTXCENJ: T h e A h R e c e p t o r a n d t h e M e c h a n i s m o f D i o x i n Toxicity. B i o c h e m J 1991, 276:273-287. LANDINI P, BANDERAM, GOLDSTEIN BP, PdPAMO>rlI F, SOFP1ENIIN[ A, ISLAMK, DENARO M: I n h i b i t i o n o f Bacterial p r o t e i n S y n t h e s i s b y E l o n g a t i o n Factor-to-Binding A n t i b i o t i c s MDL-62,879 a n d E f r o t o m y c i n . Biochem J 1992, 283:649~552. LAZARO E, VANT)ENBROEKLAGM, FELIXAS, OTI'ENt~IJM HCJ, BALLESTAJPG: B i o c h e m i c a l and K i n e t i c

characteristics of the Interaction of the A n t i t u m o r Antibiotic S p a r s o m y c i n w i t h P r o k a r y o t i c and E u k a r y o t i c Ribosomes. Biochemistry 1991, 30:9642-9648. LEEVERS SI, MARSHALLCJ: Activation o f E x t r a c e l l a l a r Signal-regulated Kinase, ERK2, b y P 2 1 r a s O e o p r o t e i n . EMBOJ 1992, 11:569-574. LEWUS CB, KAISERA, MON~WILLETJ: I n h i b i t i o n o f FoodB o r n e Bacterial P a t h o g e n s b y Bacteriocins f r o m Lactic Acid Bacteria I s o l a t e d f r o m Meat. Appl Environ Microblo11991, 57:1683>1688. LINDQUqSTN, FENtCALW, VANDLrYNEGD, CLARDYJ: I s o l a t i o n a n d Structure D e t e r m i n a t i o n o f D i a z o n a m i d e - A a n d Diazonamtde-B, U n u s u a l Cytotoxic Metabolites f r o m t h e M a r i n e Ascidian Diazona-Chinensis. J A m Chem Soc 1991, 113:2303-2304. LINDSAYCD, PAIN RH: R e f o l d i n g a n d A s s e m b l y o f P e n i c i l l i n Acylase, a n E n z y m e C o m p o s e d o f 2 P o l y p e p t i d e Chains t h a t Result f r o m Proteolytic Activation. Biochemistry 1991, 30:9034--9040. LIU DTY: G l y c o p r o t e i n P h a r m a c e u t i c a l s : Scientific a n d R e g u l a t o r y C o n s i d e r a t i o n s a n d t h e US o r p h a n D r u g Act. Trends Biotechno11992, 10:114-119. LU S, REYESVE, TORGERSONRR, id!W RE, HUMPHREYS RE: C o m m o n P r i n c i p l e s in P r o t e i n Folding a n d A n t i g e n P r e s e n t a t i o n . Trends Biotechno11991, 9:238-242. MAGNUS P, CARTERP, ELLIOTTJ, LE\vas R, HARLINGJ, PITTERNAT, BAUFAW~, FOR'IT S: S y n t h e t i c a n d M e c h a n i s t i c Studies o n t h e A n t i t u m o r Antibiotics Esperamicin-A1 a n d c a l i c h e a t n i c i n - g a m m a l S y n t h e s i s o f 2-Ketobicyclo< 7.3.1> E n e d i y n e A n d 13-Ketocyclo< 7.3.1> E n e d i y n e Cores M e d i a t e d b y Eta2 D i c o b a l t H e x a c a r b o n y l A l k y n e C o m p l e x e s - C y c l o a r o m a t i z a t i o n Rate Studies. J A m Chem Soc 1992, 114:2544-2559. MAGNUS P, LEWIS R, BENNI~" F: Synthetic a n d M e c h a n i s t i c Studies o n t h e A n t i t u m o r Antibiotics Espcramicin-A1 a n d C a l i c h e a m i c i n - g n m m a l - O x i d a t i v e F u n c t i o n a l i z a t i o n o f T h e 13Kctohicyclo< 7.3.1> T r i d e c e n e d i y n e Core S t r u c t u r e - C o n s t r u c t i o n o f t h e Allylic T r i s u l f i d e Trigger. J A m Chem Soc 1992, 114:2560-2567. MAGNUSSON S, BERG T, TURPlN E, FRENOYJP: I n t e r a c t i o n s o f R i c i n w i t h Sinusoldal E n d o t h e l i a l Rat Liver Cells -Different i n v o l v e m e n t o f Two Distinct Carbohydrate-Specific M e c h a n i s m s i n Surface B i n d i n g a n d I n t e r n a l i z a t i o n . Biochem J 1991, 277:855-861. .DL~NSOURIK, PIEPERSBERGW: Genetics o f S t r e p t o m y c i n P r o d u c t i o n i n Streptomyces-Griseus - Nucleotide S e q u e n c e o f Five Genes, StrFGItEK. I n c l u d i n g a P h o s p h a t a s e Gene. Mol Gen Genet 1991, 228:459-469. MARRA MN, WILDE CG, COLLINSMS, SNABLEJL, THORNTON MB, SCO~T RW: T h e Role o f Bactericidal/lPer m e ability-iner e a s i n g P r o t e i n as a N a t u r a l I n h i b i t o r o f B a c t e r i a l E n d o t o x i n . J l m m u n o 1 1 9 9 2 , 148:532-537. .'VL~RTINSF, YAMASHITAM: Novel M a e r o l a c t o n t z a t i o n S t r a t e g y for t h e Synthesis o f E r y t h r o m y c i n A n t i b i o t i c s . J A m Chem abe I991, 113:547~5480. MASAm H, AKIYrSUA, UOZUMI T, OHTA T: I d e n t i f i c a t i o n o f a U n i q u e Specificity D e t e r m i n a n t o f t h e C o l i c i n E3 I m m u n i t y P r o t e i n . Gene 1991, 107:133-138. MASSIAS M, REBUFFATS, MOIMO L, CHIARONIA~ RICHE C, BODO B: Expansolide-A a n d ExpansoitdeB - Tetracyclic S e s q u i t e r p e n e Lactones f r o m Pcnicillium-Expansut~x J A m Chem Soc 1990, 112:8112-8115. * e MAZUMDARM, PARRACKPK. BHATTACHARYYAB: Interaction of Prodan with Tubulin - a F l u o r e s c e n c e S p e c t r o s c o p i c Study. E u r J Biochem 1992, 204:127-132. MEKALANOSJJ: E n v i r o n m e n t a l Signals C o n t r o l l i n g E x p r e s s i o n o f Virulence D e t e r m i n a n t s in Bacteria. J Bacte~o11992, 1 7 4 : 1 ~ . MIAO MP, COVERT SF~ VAN ETYENHD: A F u n g a l G e n e for Antibiotic Resistance o n a D i s p e n s a b l e ('B') C h r o m o s o m e . Science 1991, 254:1773 1775. MILI~RJBA, BLEVITTJ, GERACE L, SADI{U K, FENI'HERSTONE C , R U S S E L L P: p55 cDc2s is a N u c l e a r P r o t e i n R e q u i r e d f o r t h e I n i t i a t i o n o f Mitosis i n H u m a n Cells. Proc Naa A c a d Sci U S A 1991, 88:10500-10504. MILLERES: C l o n i n g Vectors, Mutagenesis, a n d G e n e D i s r u p t i o n (erroR) for t h e E r y t h r o m y c i n producing Bacterium Aeromtcrobium-Erythreum. Appl Environ Microbio1199I, 57:2758-2761. MING LJ, QUE L, KRIAUCIUNASA, FROLIK CA, CItEN VJ: NMR Studies o f t h e Active Site o f IsopeniciliinN Synthase, a Non-Heine I r o n ( H ) Enzynle. Biochemistry 1991, 30:11653-11659. M/NN~CK MF, SMALLCL, bRAZIERME, MALLAVIALP: Analysis o f t h e CbhE' p l a s m i d G e n e f r o m Acute Disease-

C a u s i n g Isolates o f Coxiella-BurnetiL Gene 1991, 103:113-118. Yn~rz IM, VENEMAVJ, SWIDEREK KM, LEE TI), BEAN BP, ADAMS ME: P-type C a l c i u m C h a n n e l s B l o c k e d b y t h e S p i d e r T o x i n Omega-Aga-lVA [Letter]. Nature 2992, 335:827-829. MIKESLI0~SAR, THORPE R: I n t e r l e u k i n - 4 P r o l i f e r a t i v e Signal T r a n s d u c t i o l l Involves the A c t i v a t i o n o f a Tyrosine-Specific P h o s p h a t a s e a n d t h e D e p h o s p h o r y l a t i o n o f a n 80-kDa P r o t e i n . J Biol Chem 1991, 266:18113-18118. MOORE KS, BEVINS CL, BRASSEURMM, TOMASSININ, TUP~NER K, ECK H, ZASLOFFM: A n t i m i c r o b i a l P e p t i d e s in t h e S t o m a c h o f Xenopus-Laevis. J Biol Chem 1991, 266:19851-19857. MULDERSJWM, BOERRIGTERIJ, ROLLEMAHS, SIEZF~\"RJ, DEVOS WM: I d e n t i f i c a t i o n and C h a r a c t e r i z a t i o n o f t h e I.antibiotic Nlsin-Z, a Natural N l s i n Variant. E u r J B i o c h e m 1991, 201:581-584. NEHER E: Ion C h a n n e l s f o r C o m m u n i c a t i o n B e t w e e n a n d W i t h i n Cells. Science 1992, 256:498-502. NILSSON B, GROSSBERGERD, EKDAHLK.N, RIEGERT P, BECHERERDJ, NILSSON UR, L&MBRISJD: C o n f o r m a t i o n a l D i f f e r e n c e s Between SurfaceB o u n d a n d Fluid-Phase C o m p l e m e n t - C o m p o n e n t C3 F r a g m e n t s - E p i t o p e M a p p i n g b y CDNA E x p r e s s i o n . B i o c h e m J 1992, 282:715-721. OCKENHOUSE CF, BETAGERIR, SPRINGERTA, STAUNTONDE: P l a s m o d i u m Falctparum-Infected E r y t h r o c y t e s B i n d ICAM-1 at a Site Distinct f r o m LFA-1, Mac-l, a n d H u m a n R h i n o v i r u s . Cell 1992, 68:63~59. OHSHITA T, IKE ¥, KATUNUMAN: i n c o r p o r a t i o n a n d D e g r a d a t i o n b y K i d n e y Lysosomes o f Cystatina l p h a i n j e c t e d I n t r a v e n o u s l y . E u r J B i o c h e m 1992, 205:347-353. OIKAWA T, t-[ASEGAWAM, SHIMAML~A M, ASHINO H, MUROTA S , M O R I T A I: E p o n e m y c i n , a N o v e l Antibiotic, is a H i g h l y P o w e r f u l A n g i o g e n e s l s Inhibitor. Biochem Biophys Re.~ C o m m u n 1991, 181:1070-1076. ORTEGABARRIAE, PEREIRAMEA: A Novel T-Cruzi l t e p a r i n B i n d i n g P r o t e i n P r o m o t e s Fibroblast A d h e s i o n and Penetration of Engineered Bacteria and T r y p a n o s o m e s i n t o m ~ m m a l l a n Cells. Cell 1991, 67:411~421. OR~Z AR, PISABARRO MT, GALLEGOJ, GAGO F: I m p l i c a t i o n s o f a C o n s e n s u s R e c o g n i t i o n Site f o r P h o s p h a t i d y l c h o l i n e Separate f r o m t h e Active Site i n C o b r a V e n o m Phospholipases-A2. Biochemistry 1992, 31:2887-2896. PA£OMEQUEMESSIAP, ENGLEBERTS, LEYHBOU~LLEM, NGUYENDISTECHEM, DUEZ C, HOUBA S, DIDEBERG O, VANBREUMENJ, GHLTSEN JM: Amino Acid S e q u e n c e of the Penicillin-Binding Protein/DD-Peptidase o f Streptomyces-K15 - P r e d i c t e d S e c o n d a r y Structures o f t h e Low-Mr P e u i c i l l i n - B i n d i n g P r o t e i n s o f Class-A. Biocbem J 1991, 279:223-230. PANDA DK, DASGUt~A U, DAS J: T r a n s f o r m a t i o n o f V i b r i o - C h o l e r a e b y P l a s m i d DNA. Gene 1991, 105:107-111. PAQUETTELA, MACDONALDD, ANDERSONLG: T o t a l Synthesis o f (+)-Ikarugamycin. 2. E l a b o r a t i o n o f t h e Macrocyclic L a c t a m and T e t r a m i c Acid Substructures and Complete Assembly of the Antibiotic. J A m Chem Soc 1990, 112:92929299. PAQUETYELA, ROMINEJL, LIN HS, WRIGHTJ: T o t a l Synthesis o f ( + ) - l k a r u g a m y c i n . 1. Stereocontrolled Construction of the DeeahydroAs-Indacene Subunit. J A m Chem Soc 1990, 112:9284-9292. PEKIC B, LEPOJEVlCZ: EnZymatic T r a n s f o r m a t i o n o f D e s a c e t y l - l a n a t o s i d e - A i n t o D i g i t o x i n b y BetaGlucosidase Action i n Cyclodextrin Solutions. Biotechnol Lett 1991, 13:399-404. PETRICH AK, WU XN, ROY KL~ JENSEN SE: T r a n s c r i p t i o n a l Analysis o f t h e Isopeniclilin-N S y n t h a s e - E n c o d i n g G e n e o f Streptomyces-Clavuligerus. Gene 1992, 111:7744. PISSOWOTZKI K, MANSOURIK, PlEPERSBERGW: G e n e t i c s of Streptomycin Production in StreptomycesGriseus -Molecular S t r u c t u r e and P u t a t i v e F u n c t i o n o f Genes StrELMB2N. Mol Gen Genet 1991, 231:113-123. POPIENIEK PH, PRATt RF: K i n e t i c s a n d M e c h a n i s m o f B i n d i n g o f Specific P e p t i d e s to V a n c o m y e i n a n d O t h e r Glycopeptide Antibiotics. J A m Chem Soc 1991, 113:2264-2270. PRINSZE C, DUBBELMANTMAR, V/LNSTEVE~N~NCKJ: P o t e n t i a t i o n o f T h e r m a l Inactivation o f Glycer aldehyde-3 - P h o s p h a t e D e h y d r o g e n a s e b y P h o t o d y n a m i c T r e a t m e n t -a Possible M o d e l f o r t h e Synergistic I n t e r a c t i o n B e t w e e n Photodynamic Therapy and Hyperthermia. B i o c h e m J 1991, 276:357-362. PYLES EA, RAVARP, ttASTre SB: Effect o f B-Ring Substituents o n A b s o r p t i o n and C i r c u l a r D i c h r o i c

Pharmaceutical applications Miscellaneous S p e c t r a o f C o l c h i c i n e A n a l o g u e s . Biochemistry 1992, 31:2034-2039. RAMIREZSAa\~FOSJ, ALVAREZ G, CISNEROS E, GOMEZEICHELMANN MC: D i s t r i b u t i o n o f I n s e r t i o n S e q u e n c e IS1 ha M u l t i p l e - A n t i b i o t i c R e s i s t a n t C l i n i c a l E n t e r o b a c t e r i a c e a e S t r a i n s . FEMS Microbiol Letl 1992, 93:189-193. RAMPERSAL~DA, INOUYE M: P r o c a i n e , a Loca l A n e s t h e t i c , Signals Through the EnvZ Receptor to Change t h e DNA B i n d i n g A f f i n i t y o f t h e T r a n s c r i p t i o n a l A c t i v a t o r P r o t e i n O m p R . J Bacterl'ol 1991, 173:6882-6888. BASICJL, VLTICIC IF, SKRINJARM, VIYLICM: A s s i m i l a t i o n o f C h o l e s t e r o l b y S o m e C u l t u r e s o f Lactic Acid B acter ia a n d B i f i d o b a c t e r i a . Biotechnol Lett 1992, 14:39-44. REYES F, ALFONSO C, MAWHNEZ MJ, PRIETO A, SANTAMARIA F, LEALJA: P u r i f i c a t i o n o f a N e w G a l a c t a n a s e f r o m PeniciIlinm-Oxalieum Catalysing the Hydrolysis o f Beta-(1-> 5 ) - G a l a c t o f u r a n L i n k a g e s . Biochem J 1992, 2 8 1 : 6 5 7 ~ 6 0 . RIKITAKE Y, MORAN E: D N A - B i n d i n g P r o p e r t i e s o f t h e E1A-Associated 3 0 0 - K i l o d a l t o n P r o t e i n . Mol Cell Bio11992, 12:2826-2836. ROSENSTOCKL, KEIFER M, DANIELL WE, MCCONNELL R, CLAYPOOLE K: C h r o n i c C e n t r a l N e r v o u s S y s t e m Effects o f A cu te O r g a n o p h o s p h a t e P e s t i c i d e I n t o x i c a t i o n . Lancet 1991, 338:223-227. ROTHMAN DL, MAGNUSSON I, KATZ LD, SHLrLM~" RG, SHULM~N GI: Q u a n t i t a t i o n o f H e p a t i c Glycogenolysis and Glueoneogenesis in Fasting H u m a n s w i t h C-13 NMIL Science 1991, 254:573-576 RUDN~CK G, WALL SC: T h e M o l e c u l a r M e c h a n i s m o f Ecstasy < 3 , 4 - m e t h y l e n e d i o x y - m e t h a m p h c t a m i n e (MDMA)>-Serotonin Transporters are Targets for M D M A - i n d u e e d S e r o t o n i n Re l e a s e . Proc Natl Acad Sci U S A 1992, 89:1817-1821. RyAN At, SQUIRES S, STRLWFHL, JOHNSON RT: C a m p t o t h e c h a C y t o t o x i c i t y In M a m m a l i a n Cells is A s s o c i a t e d w i t h t h e I n d u c t i o n o f P e r s i s t e n t D o u b l e S t r a n d B r e a k s ha R e p l i c a t i n g DNA. Nucleic Acids Res 1991, 19:329~3300. RYA~" PC, LU M, DRAPER DE: R e c o g n i t i o n o f t h e H i g h l y C o n s e r v e d G T P a s e C e n t e r o f 23-S R i b o s o m a l RNA b y R i b o s o m a l Pr o tein - L 1 1 a n d t h e A n t i b i o t i c T h l o s t r e p t o n . JMol Biol 1991, 221:125%1268. RYSER HJP, MANDEL R, GHANI F: Cell S u r f a c e S u l f h y d r y l s are Required for the Cytotoxicity of Diphtheria T o x i n But n o t o f R i c i n i n c h i n e s e H a m s t e r O v a r y Cells. J Biol Cbem 1991, 266:18439-18442. SANCHEZMONGER, GOMEZ L, BARBER D, LOPEZOTIN C, ARMENTIAA, SALCEDOG: W h e a t a n d B a r l e y Allergens Associated with Baker's Asthma Glycosylated Subunits of the Alpha-AmylaseInhibitor Family have Enhanced IgE-Binding Capacity. Biochem J 1992, 2 8 1 : 4 0 1 4 0 5 . SCHMEICHEL CJ: M o l e c u l a r M e d i c I n e : T o o M u c h , T o o Soon. Biotechnology 1991, 9:1063-1066. SC>hMIDW, WHITESIDBS GM: A N e w A p p r o a c h t o CycHtols B a s e d o n R a b b i t M u s c l e A l d o l a s e (RAMA). J A m Chem Soc 1990, 112:9670-9671. SCI~NELL N, ENGELKE G, AUGUS'ITNJ, ROSENSTEINR, UNGET~MA~.~NV, GOTZ F, EN~IAN KD: A n a l y s i s o f G e n e s I n v o l v e d ha t h e B i o s y n t h e s i s o f L a n t i b i o t i c E p i d e r m i n . EurJBiochem 1992, 2 0 4 : 5 7 4 8 . SCHWAEBLEW, SCHWAIGER H, BROOLM~NS RA, BARBIERI MOST J, HIRSCHKAUFFMA~NNM, TIEFENTtIALERM, LAPPIN DF, DAHA MR, WHALEY K, DIERICH MP: H u m a n C o m p l e m e n t F a c t o r - H -Tissue S p e c i f i c i t y i n t h e E x p r e s s i o n o f T h r e e D i f f e r e n t M e s s e n g e r RNA Species. EurJBiochera 1991, 198:399~404. SEABROOK RN, ATKINSON T, IRONS LI: A S p e c t r o s c o p i c a n d C o n f o r m a t i o n a l S t u d y o f P e r t u s s i s T o x i n . Eur J Biochem 1991, 198:741-747. SEARLE MS, BICKNTLL W: I n t e r a c t i o n o f t h e Anthracycline Antibiotic Nogalamycin with the H e x a m c r D u p l e x D(5'-GACGTC)2 - a n N M R a n d M o l e c u l a r M o d e B i n g S t u d y . EurJBiochem 1992, 205:45-58. SF~TZ U, BONN G, OEFNER P, POPP M: I s o t a c h o p h o r c t i c Analysis of Flavonoids and Phenolcarboxylic Acids o f R e l e v a n c e to P h y t o p h a r m a c c u t i c a l I n d u s t r y . J Chromatogr 1991, 559:499-504. SIDDIQI AR, ZAIDI ZH, JORNVALLH: P u r i f i c a t i o n a n d Characterization of Two Highly Different GroupII P h o s p h o l i p a s e - A 2 I s o z y m e s f r o m a S I n g l e V i p e r i d ( E r i s t o c o p h i s - M a c m a h o n i ) V e n o m - EurJ Biochem 1991, 2 0 1 : 6 7 5 ~ 7 9 . SKELTON NJ, \VILLIAMS DH, RANCE MJ, RUDDOCK JC: Structure Elucidation of a Novel Antibiotic of the Vancomycin Group - the Influence of Ion Dipole Interactions on Peptide Backbone Conformation. J A m Chem Soc 1991, 113:3757-3765. SKOUtqAS DA, WILSON L: M e c h a n i s m o f I n h i b i t i o n o f Microtubule Polymerization by Colehichae Inhibitory Potencies of Unliganded Colchlcine

a n d T u b u l i n - C o l c h l c i n e C o m p l e x e s . Biochemist~ 1992, 31:738-746. SPdRIAM M, VAN DER MAP.EL GA, ROELEN H, VAN BOOM JH, WANG AH: C o n f o r m a t i o n o f B DNA C o n t a i n i n g 06 Ethyl G C base Pairs Stabilized by MInor Groove Binding Drugs: Molecular Structure of D(CGC[e6G]AATTCGCG) C o m p l e x e d w i t h H o e c h s t 3 3 2 5 8 o r H o e c h s t 33342. EMBOJ1992, 11:225 232, STAHL F, WETTERGRENY, LEVAN G: A m p l i c o n S t r u c t u r e ha M u l t i d r u g - R e s i s t a n t M u r i n e Ceils - a N o n r e a r r a n g e d R e g i o n o f G e u o m i c DNA C o r r e s p o n d i n g t o L a r g e C i r c u l a r DNA. Mol Cell Bio11992, 12:11791187. STEIN PE, BOODHOO A, TYRRELL GJ, BRL2X-rONJL, READ RJ: Crystal Structure of the Cell-binding B Ohgomer o f V e r o t o x i n - 1 f r o m E. CoB [Letter]. Nature 1992, 335:748-749. STEINMANN B, WES'FERFIAUSF~NA, CONSTAN~NOU CD, Sb'PERTIFURGAA, PROCKOP DJ: S u b s t i t u t i o n o f C y s t e i n e f o r G l y c i n e - a l p h a - l - 6 9 1 ha t h e P r o alpha-l(I) Chain of Type-I Procollagen in a Proband with Lethal Osteogenesis Imperfecta D e s t a b i l i z e s t h e T r i p l e H e l i x at a Site C - t e r m i n a l t o t h e S u b s t i t u t i o n . Biochem J 1991, 279:747 752. STUART PM, WOODWARD JG: Y e r s h a i a - E n t e r o c o l i t i c a P r o d u c e s S u p e r a n t i g e n i e Activity. J Immuno/1992, 148:225-233. SUTCLIFFEMJ, DOBSON CM, OSWALD RE: S o l u t i o n Structure of Neuronal Rungarotoxin Determined by Two-Dimensional NMR Spectroscopy Calculation of Tertiary Structure Using Systematic Homologous Model Ruilding, Dynamical Simulated Annealing, and Restrained Molecular D y n a m i c s . Biochemistry 1992, 31:2962-2970. TAANMANJW, SCHRAGE C, REUVEKAMPP, BIJLJ, HARTOG M, DEVRIESH, AGSTERIBBE E: I d e n t i f i c a t i o n o f Three Human Pseudogenes for Subunit-VIb of Cytochrome-c Oxidase - a Molecular Record of G e n e E v o l u t i o n . Gene 1991, 102:237-244. TANG CM, SIB QY, KATCFLMANA, LYNCH G: M o d u l a t i o n o f t h e T i m e C o u r s e o f F a s t EPSCs a n d G l u t a m a t e C h a n n e l K i n e t i c s b y A n i r a e c t a m . . S c i e n c e 1991, 254:288-290. *P/IORNTONMANNINGJR, RUANGYUTTIKARaNW, GONZALEZ ]2j, YOST GS: M e t a b o l i c A c t i v a t i o n o f t h e P n e u m o t o x i n , 3 - M e t h y l i n d o l e , b y Vacciniae x p r e s s e d C y t o c h r o m e P 4 5 0 s . Biocbem Biophys Res Commun 1991, 181:100-107. "DVERON M-C, BARBONI E, PUEGO PdVERO FB, GORMLEY AM, SEELEYPJ, GROSVELD F, MORPdS R: S e l e c t i v e Inhibition of Ncurite Outgrowth on Mature A s t r o c y t e s b y T h y - 1 G l y c o p c o t e h a [Letter]. Nature 1992, 335:745-747. TJUKAVKINANA, GEODAKYAaNSV, KtlVOSTOVA AI, KOLESNIK JA, GLYZIN VI: S i m p l e H i g h - P e r f o r m a o e e L i q u i d Chromatographic Method for the Determination o f a N e w P h y t o e h e m i c a l D r u g , Fellavine, a n d Its M e t a b o l i t e s i n H u m a n a n d Rat P l a s m a a n d U r i n e . J Chromatogr [Biomed Appl] 1991, 571:312-317. TRAUNXCKERA, OLIVERI F, KARJALAtNENK: M y e l o m a B a s e d Expression System for Production of Large M a m m a l i a n P r o t e i n s . Trends Bgotechno11991, 9:109-112. TSEN ~IY, WANG St, ROE BA, GREEN SS: DNA S e q u e n c e o f a SaLmonella-Specific DNA F r a g m e n t a n d t h e use of Oligonucleotide Probes for Salmonella D e t e c t i o n . Appl Microbiol Biotechno11991, 35:339-347. UCHIMURAM, YAMAMOTOT: P r o d u c t i o n o f Hemagglutinins and Pili by Vibrio-mlmicus and Its A d h e r e n c e t o H u m a n a n d R a b b i t S m a l l I n t e s t i n e s Invitco. FEMS Microbiol Lett 1992, 91:73-78. UESAWA Y, SUGIURAY: H e a t - I n d u c e d D N A C l e a v a g e b y E s p e r a m i e i n A n t i t u m o r A n t i b i o t i c s . Biochemistry 1991, 30:9242-9246. UESUGI M, SEK2DAT, MATSLrK~S, SUGILT.AY: Selective D N A Cleavage by ElsamicIn-A and Switch Function o f Its A m i n o S u g a r G r o u p . Biochemistry 1991, 50:6711~5715. VALVERDEMA, DIAZ M, SEPULVEDAFV, GILL DR, HYDE SC, t-IIGGINS CF: V o l u m e - r e g u l a t e d C h l o r i d e C h a n n e l s Associated with the Human Multidrug-resistance P - g l y c o p r o t c i n [Letter]. Nature 1992, 335:830~332. VANDERLINDENMPG, MOTTL H, KECK W: C y t o p l a s m i c High-Level Expression of a Soluble, Enzymatically Active F o r m o f t h e E s c h e r i c h i a - C o l i P e n i c i l l i n Binding Protein-5 and Purification by Dye C h r o m a t o g r a p h y . EurJBiochem 1992, 204:197-202. VANDEVEN FJM, VANDENHOOVENHX~, KONINGS RNH, I-IILBERS CW: N M R S t u d i e s o f L a n t i b i o t i c s - t h e S t r u c t u r e o f N i s i n ha A q u e o u s S o l u t i o n . EurJ Biochem 1991, 202:1181-1188. VANKUIKJA, DEWAARD p, VLIEGENTHARTJFG, KLEIN A, CAIL*qOy C, LAMBLIN G, ROUSSEL P: I s o l a t i o n a n d Structural Characterization of Novel Neutral

OUgosaccharide-Alditols from RespiratoryMucus Glycoproteins of a Patient Suffering from B r o n c h i e c t a s i s . 2. S t r u c t u r e o f T w e l v e Heptato-Nonasaccharides, Six of Which Possess the GlcNAebeta(1-> 3)< Galbeta(1-> 4)GlcNAcbeta(1> 6)> Galbeta(1-> 3)GalNAc-ol C o m m o n S t r u c t u r a l E l e m e n t . EurJBiochem 1991, 198:169-182. VARE~'ro L, DEMEESTER F, MO~xHAIE D, MARCHANDBRYNAERT J, DIVE G, JACOB F, FP&:m,:JM: T h e I m p o r t a n c e o f the Negative Charge of Beta-Lactam Compounds i n t h e I n t e r a c t i o n s w i t h Active-Site S e r i n e DDP e p t i d a s e s a n d Beta-Lactamascs. Biochem J 1991, 278:801407 VEH.A PP, STAL73JM, ELLIS RW: B i o l o g i c a l Activity o f H i b C o n j u g a t e s . Vaccine 1991, 9:$26-$29. VILLACOBTAJM, ARRIAGA P, IAYNEZ J, .~/LENENDEZM: I n t e r a c t i o n o f Bcta-Lactammse-I a n d BetaLaCtarn~*e-ll f r o m BaciLlus-Cereus w i t h S e m i s y n t h e t i c C e p h a m y c i n s - K i n e t i c Studies. Biocbem J1991, 279:111-114. VINELLA D, D'ARI R, BOULOC P: P e n i c i l l i n B i n d i n g P r o t e i n 2 is D i s p e n s a b l e i n E s e h e r i e h i a Cold w h e n P p G p p S y n t h e s i s is I n d u c e d . ~ B O J 1992, 11:1493-1502. VON AHSEN U, DAVIESJ, SCHROEDERR: A n t i b i o t i c I n h i b i t i o n o f G r o u p 1 R i b o z y m e F u n c t i o n [Letter]. Nature 1991, 353:368. WALDMAN AS, WALDMAN BC: S t i m u l a t i o n o f Intrachromosomal Homologous Recombination i n M a r n m a l l a q Cells b y aft I n h i b i t o r o f Poly(ADPr i b o s y l a t i o n ) . Nucleic Acids Res 1991, 19:5943-5947. WALI•CE DC: M i t o c h o n d r i a l G e n e t i c s - a P a r a d i g m f o r A g i n g a n d D e g e n e r a t i v e D i s e a s e s . Science 1992, 256:628~32. WELFLE H, MISSELWITZR, WELFI,E K, GROCII N, HEINEMANN U: S a l t - D e p e n d e n t a n d P r o t e i n - C o n c e n t r a t i o n Dependent Changes in the Solution Structure of the DNA-Binding Histone-Like Protein, HBsu, f r o m Bacillus-Subtilis. EurJBiochem 1992, 204:1049-1055. WERY JP, SCHEVITZ RW, CKAWSONDK, ]3OBBIXTJL, DOW ER, GAMBOA G, GOODSON T, HERMANN RB, KRAMER RM, MCCLURE DB, MIHELICH ED, PUTNAMJE, SHARP JD, STARK DH, TEATER C, WARRICK ~ , JONES ND: Structure of Recombinant Human Rheumatoid A r t h r i t i c S y n o v i a l F l u i d P h o s p h o l i p a s e - A 2 at 2.2 a R e s o l u t i o n . Nature 1991, 3 5 2 : 7 9 4 2 . WHELAN SM, ELMORE MJ, BODSWORTII NJ, A'fKINSON T, MJNTON NP: T h e C o m p l e t e A m i n o Acid S e q u e n c e of the Clostridium-botulinum Type-E Neuroinxin, Derived by Nucleotide-Sequence Analysis of the E n c o d i n g Gene. EurJBiochem 1992, 204:657-4567. WHITWORTH JAG, GILBERT CE, MABEY DM, MAUDE GH, MORGAN D, TAYLOR DW: Effects o f R e p e a t e d Doses of Ivermectin on Ocular Onchocerciasis: C o m m u n i t y - b a s e d T r i a l ha S i e r r a Leone. Lancet 1991, 338:1100-1103. WOODCOCK J, MOAZED D, CANNON M, DAVIESJ, NOLLER HF: I n t e r a c t i o n o f Axttibioties w i t h A- a n d P-sites p e c i f i c B a s e s i n 168 R i b o s o m a l RNA. EMBOJ 1991, 10:3099-3104. WU S-M, CHEUNG W-F, FRAZIERD, STAFFORD DW: C l o n i n g a n d E x p r e s s i o n o f t h e CDNA f o r H u m a n yg l u t a m y l C a r b o x y l a s e . Science 1991, 254:1634-1635. X&Xq~IOUDAKISS, CURRANT: I d e n t i f i c a t i o n a n d C h a r a c t e r i z a t i o n o f Ref-1, a N u c l e a r P r o t e i n t h a t Facilitates AP-1 D N A - b i n d i n g Activity. ~9i/30 J 1992, 11:643 556. XuEI XL, BHAIm S, STAPLESRC, YODER OC: C h a r a c t e r i z a t i o n o f INF56, a G e n e E x p r e s s e d During Infection Structure Development of U r o m y c e s - a p p e n d i c u l a t u s . Gene 1992, 110:49-55. YAMADA F. KOZIKOWSKI AP, REDDY ER, pANG YP, MILLER JH, MClm~'ZY M: A R o u t e t o O p t i c a l l y P u r e (-)Huperzine-A - Molecular Modeling and Invitro P h a r m a c o l o g y . J A m Chem Soc 1991, 113:46954696. YAMAGUCHI S, MASE T, TAKEUCHI K: C l o n i n g a n d Structure of the Monocylglycerol and Diacylglycerol Lipase-Encoding Gene from P e n i c i l l i u m - C a m e m b e r t i i 1.1-150. Gene 1991, 103:61~7. YEO SK, LEE HK, Id SFY: S e p a r a t i o n o f A n t i b i o t i c s b y High-Performance Capillary Elcctrophoresis with P h o t o d i o d e - A r r a y D e t e c t i o n . J Chromatogr 1991, 585:133-137. YEUNG }IX3ff,I2 WW, NG TB: I s o l a t i o n o f a R i b o s o m e Inactivating and Abortifaeient Protein from Seeds o f L u f f a - A e u t a n g a l a . Int J Pept Protein Res 1991, 38:15 1 9 YI CK, CIIAP.AL~MBOUSBM, EMERYVC, BALDWIN SA: C h a r a c t e r i z a t i o n o f F u n c t i o n a l H u m a n E r y t h r o c y t e - T y p e G l u c o s e T r a n s p o r t e r (GLUT1) E x p r e s s e d ha I n s e c t Cells U s i n g a R e c o m b i n a n t B a c u l o v i r u s . BiochemJ 1992, 283:643-646. YOGEV D, ROSENGARTENR, WATSON MCKOW?q R, WISE KS: M o l e c u l a r B a s i s o f M y c o p l a s m a Surface

761

762

Pharmaceutical applications Miscellaneous Antigenic Variation: a novel Set of Divergent Genes Undergo Spontaneous Mutation o f Periodic Coding Regions and 5' Regulatory Sequences. E M B O J 1991, 10:4069--4080. YONEZAWAA, KUWAHARAJ, FUdIIN, SUGIURAY: Binding o f Tachyplesin-I to DNA Revealed by Footprinting Analysis - Significant Contribution of Secondary Structure to DNA Binding and Inlplication f or Biological Action. Biochemistry 1992, 31:2998-3004.

ZEMBO?(qCZA, VANEJR: Induction o f Nitric Oxide Synthase Activity by Toxic Shock Syndrome Toxin 1 in a maerophage-monocyte Cell Line. Proc Nall Acad Sci U S A 1992, 89:2051 2055. ZHANGY, COYNEMY, WILLSG, LEVENSONCH, IC&WASAKI ES: SingJe-base Mutational Analysis of Cancer and Genetic Diseases Using Membrane Bound Modified Oligonucleotides. Nucleic Acids Res 1991, 19:3929-3933.

ZOMERDUKJCBM, KIEFTR, SHILLSPG, BORSTP: Alphaamanitin-resistant Transcription Units i n Trypanosomes: a Comparison of P r o m o t e r Sequences f o r a VSG Gene Expression Site and Forf the Ribosonaal RNA Genes. Nucleic Acid_~ Res 1991, 19:5153-5158

Pharmaceutical applications. - PDF Download Free (2024)

FAQs

What are the pharmaceutical applications? ›

Pharmaceutical Application means any product that (i) requires and is indicated for the treatment of a specific medical condition by a regulatory agency and (ii) is administered under the supervision of a clinician.

What is pharmaceutics pdf? ›

Pharmaceutics is the discipline of pharmacy that deals with the process of turning a new chemical entity (NCE) or old drugs into a medication to be used safely and effectively by patients.

What is the introduction of pharmaceutical manufacturing? ›

Pharmaceutical manufacturing comprises physical processes such as blending, compression, filtration, heating, encapsulation, shearing, tableting, granulation, coating, and drying.

What are the pharmaceutical applications of collagen? ›

The main applications of collagen as drug delivery systems are collagen shields in ophthalmology, sponges for burns/wounds, mini-pellets and tablets for protein delivery, gel formulation in combination with liposomes for sustained drug delivery, as controlling material for transdermal delivery, and nanoparticles for ...

What is pharmacological application? ›

Pharmacology can be applied within clinical sciences. Clinical pharmacology is the application of pharmacological methods and principles in the study of drugs in humans. An example of this is posology, which is the study of how medicines are dosed. Pharmacology is closely related to toxicology.

What is the new drug application in pharma? ›

New Drug Application (NDA) is a type of application in which a pharmaceutical manufacturer or its agent requests permission from the U.S. Food and Drug Administration (FDA) for a license to market a drug for one or more specified indications.

What is the basic knowledge of pharmaceutics? ›

Pharmaceutics is the overall process of developing a new chemical entity into an approved therapy that is safe and effective in treating or preventing disease. It is a complex process requiring multiple scientific, medical, legal, commercial, and regulatory expertise.

What is the difference between pharmaceutics and pharmaceutical? ›

In general, both terms relate to medicinal chemistry and applications of it. Pharmaceuticals are the “what”, meaning the dosage form, the finished drug. It's more the end point. Pharmaceutics refers more about the “how”, meaning how you make the drug in pure form into a finished dosage form.

Who is the father of pharmaceutics? ›

Professor William Procter is known as the father of pharmacy. Procter was born in the year 1817 on May 3, in Baltimore.

What is the basic pharmaceutical process? ›

It includes harvest, purification, and viral clearance steps. Different and multiple steps are usually arranged and/or combined to purify the product of interest. Tools and process conditions (i.e., the critical process parameters, or CPPs) are defined during downstream process development.

What are the basic of pharmaceutical? ›

Pharmaceuticals are used to diagnose, treat or prevent illness in a form that matches each purpose, such as internal use, external use, and injection.

What is the world's first pharmaceutical company? ›

Merck was founded in 1668 and is the world's oldest operating chemical and pharmaceutical company, as well as one of the largest pharmaceutical companies globally. Merck operates in Europe, Africa, Asia, Oceania and the Americas.

What organs use collagen? ›

Collagen is the primary building block of your body's skin, muscles, bones, tendons and ligaments, and other connective tissues. It's also found in your organs, blood vessels and intestinal lining. Proteins are made from amino acids.

What type of drug is collagen? ›

Collagen is a nutritional supplement made from animal or fish materials. It's rich in amino acids that play an important role in the building of joint cartilage and it may have anti-inflammatory effects. Trials into collagen's role in treating osteoarthritis give mixed results.

What are the applications of polymers in healthcare? ›

In the medical industry, synthetic polymers such as polylactides (PLA), polyglycolides (PGA), and polylactide-coglycolide co-polymers (PLGA) are used to produce sutures and medical implants. These biopolymers are non-toxic and well-tolerated by the body [8]. ... ...

What are the applications of pharmaceutical solutions? ›

Solutions have a wide variety of uses in the pharmaceutical industry. They are used therapeutically as vehicles for oral, parenteral, topical, otic, ophthalmic, and nasal products. They are also used as flavorings, buffers, preservatives, and suspending agents for a variety of liquid dosage forms.

What are the applications of pharmaceutical chemistry? ›

The applications of chemistry in medicine include the processes of designing and producing medicines, conducting research on medicines, using drugs in medicines, producing vaccines, etc. The scientific study of the application of chemistry in medicine is known as Medicinal Chemistry.

What are the applications of pharmaceutical analysis? ›

The pharmaceutical analysis is a branch of chemistry, which involves the series of process for the identification, determination, quantitation, and purification. This is mainly used for the separation of the components from the mixture and for the determination of the structure of the compounds.

What are the applications of biopharmaceuticals? ›

Uses for biopharmaceuticals include the manufacture of vaccines, blood and blood components, allergenics that treat allergies, body cells and tissues, living cells used in cell therapies, gene therapies, and recombinant therapeutic proteins.

References

Top Articles
Latest Posts
Recommended Articles
Article information

Author: The Hon. Margery Christiansen

Last Updated:

Views: 5525

Rating: 5 / 5 (70 voted)

Reviews: 85% of readers found this page helpful

Author information

Name: The Hon. Margery Christiansen

Birthday: 2000-07-07

Address: 5050 Breitenberg Knoll, New Robert, MI 45409

Phone: +2556892639372

Job: Investor Mining Engineer

Hobby: Sketching, Cosplaying, Glassblowing, Genealogy, Crocheting, Archery, Skateboarding

Introduction: My name is The Hon. Margery Christiansen, I am a bright, adorable, precious, inexpensive, gorgeous, comfortable, happy person who loves writing and wants to share my knowledge and understanding with you.